SA519410903B1 - خلايا التدفق ذات غطاء جل مائي - Google Patents
خلايا التدفق ذات غطاء جل مائيInfo
- Publication number
- SA519410903B1 SA519410903B1 SA519410903A SA519410903A SA519410903B1 SA 519410903 B1 SA519410903 B1 SA 519410903B1 SA 519410903 A SA519410903 A SA 519410903A SA 519410903 A SA519410903 A SA 519410903A SA 519410903 B1 SA519410903 B1 SA 519410903B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- flow cells
- coating layer
- hydrogel coating
- depressions
- functionalized coating
- Prior art date
Links
- 239000000017 hydrogel Substances 0.000 title abstract 2
- 239000011248 coating agent Substances 0.000 title 1
- 238000000576 coating method Methods 0.000 title 1
- 239000011247 coating layer Substances 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/56—Acrylamide; Methacrylamide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/58—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing oxygen in addition to the carbonamido oxygen, e.g. N-methylolacrylamide, N-(meth)acryloylmorpholine
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
- C08F220/603—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen and containing oxygen in addition to the carbonamido oxygen and nitrogen
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D105/00—Coating compositions based on polysaccharides or on their derivatives, not provided for in groups C09D101/00 or C09D103/00
- C09D105/12—Agar-agar; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
- C09D133/24—Homopolymers or copolymers of amides or imides
- C09D133/26—Homopolymers or copolymers of acrylamide or methacrylamide
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D171/00—Coating compositions based on polyethers obtained by reactions forming an ether link in the main chain; Coating compositions based on derivatives of such polymers
- C09D171/02—Polyalkylene oxides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00286—Reactor vessels with top and bottom openings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
- B01J2219/00317—Microwell devices, i.e. having large numbers of wells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00457—Dispensing or evacuation of the solid phase support
- B01J2219/00475—Sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
- B01J2219/00529—DNA chips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00614—Delimitation of the attachment areas
- B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/00626—Covalent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
- B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00729—Peptide nucleic acids [PNA]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/069—Absorbents; Gels to retain a fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Materials Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Optical Measuring Cells (AREA)
- Microscoopes, Condenser (AREA)
- Laminated Bodies (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
يتعلق الاختراع الحالي بمثال للطريقة، حيث يتم وضع طبقة تغطية وظيفية functionalized coating layer في تجاويف ركيزة substrate خلية التدفق flow cell المنظمة. تنفصل التجاويف بواسطة المناطق الخلالية. يتم تثبيت البادئة primer على طبقة التغطية الوظيفية لتكوين طبقة تغطية وظيفية مطعمة في التجاويف. يتم إضافة جل مائي hydrogel على طبقة التغطية الوظيفية المطعمة على الأقل. شكل1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762609105P | 2017-12-21 | 2017-12-21 | |
PCT/US2018/066011 WO2019126040A1 (en) | 2017-12-21 | 2018-12-17 | Flow cells with hydrogel coating |
Publications (1)
Publication Number | Publication Date |
---|---|
SA519410903B1 true SA519410903B1 (ar) | 2022-07-05 |
Family
ID=66995032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SA519410903A SA519410903B1 (ar) | 2017-12-21 | 2019-12-25 | خلايا التدفق ذات غطاء جل مائي |
Country Status (13)
Country | Link |
---|---|
US (2) | US10919033B2 (ar) |
EP (1) | EP3727674A4 (ar) |
JP (1) | JP7087010B2 (ar) |
KR (2) | KR102313291B1 (ar) |
CN (2) | CN111093819B (ar) |
AU (2) | AU2018392919B2 (ar) |
CA (1) | CA3066535C (ar) |
IL (1) | IL271026A (ar) |
NZ (1) | NZ759626A (ar) |
RU (1) | RU2751517C2 (ar) |
SA (1) | SA519410903B1 (ar) |
SG (1) | SG11201911590VA (ar) |
WO (1) | WO2019126040A1 (ar) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2754808C2 (ru) | 2016-12-22 | 2021-09-07 | Иллюмина, Инк. | Модуль проточной ячейки и способ его получения |
TW202045709A (zh) | 2019-01-29 | 2020-12-16 | 美商伊路米納有限公司 | 流體槽 |
TW202043486A (zh) * | 2019-01-29 | 2020-12-01 | 美商伊路米納有限公司 | 定序套組 |
MX2021006297A (es) * | 2019-08-01 | 2021-09-08 | Illumina Inc | Celdas de flujo. |
NL2023679B1 (en) * | 2019-08-09 | 2021-04-13 | Illumina Inc | System and method for patterning flow cell substrates |
WO2021028815A1 (en) * | 2019-08-09 | 2021-02-18 | Illumina Inc. | System and method for patterning flow cell substrates |
US11287422B2 (en) | 2019-09-23 | 2022-03-29 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
KR20220115857A (ko) * | 2019-12-16 | 2022-08-19 | 일루미나, 인코포레이티드 | 키트 및 플로우 셀 |
EP4077344A1 (en) | 2019-12-18 | 2022-10-26 | F. Hoffmann-La Roche AG | Methods of sequencing by synthesis using a consecutive labeling scheme |
US11198121B1 (en) | 2020-06-10 | 2021-12-14 | Element Biosciences, Inc. | Flow cell systems and devices |
WO2022101401A1 (en) * | 2020-11-16 | 2022-05-19 | Illumina Cambridge Limited | Altering flow cell signals |
US20220228210A1 (en) * | 2020-12-30 | 2022-07-21 | 10X Genomics, Inc. | Molecular array generation using photoresist |
CN117677435A (zh) * | 2021-06-15 | 2024-03-08 | 伊鲁米纳公司 | 用于测序的不含水凝胶的表面官能化 |
US20240167077A1 (en) * | 2022-06-29 | 2024-05-23 | 10X Genomics, Inc. | Covalent attachment of splint oligonucleotides for molecular array generation using ligation |
WO2024061799A1 (en) * | 2022-09-19 | 2024-03-28 | Illumina, Inc. | Deformable polymers comprising immobilised primers |
US20240117426A1 (en) | 2022-09-19 | 2024-04-11 | Illumina, Inc. | Nanogel particles having dual functionality and temperature responsiveness for particle clustering in nucleic acid sequencing systems |
WO2024081563A1 (en) | 2022-10-10 | 2024-04-18 | Illumina, Inc. | Photo-switchable chemistry for reversible hydrogels and reusable flow cells |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004194652A (ja) * | 2002-12-06 | 2004-07-15 | Dainippon Ink & Chem Inc | 溶解性物質付着流路を有するマイクロ流体素子及びその使用方法 |
JP2007525571A (ja) * | 2004-01-07 | 2007-09-06 | ソレクサ リミテッド | 修飾分子アレイ |
KR20070116585A (ko) * | 2005-01-18 | 2007-12-10 | 바이오셉트 인코포레이티드 | 패턴화된 포스트를 갖는 마이크로채널을 이용하는 세포분리법 |
GB0507835D0 (en) * | 2005-04-18 | 2005-05-25 | Solexa Ltd | Method and device for nucleic acid sequencing using a planar wave guide |
KR101416475B1 (ko) * | 2006-02-27 | 2014-07-16 | 사회복지법인 삼성생명공익재단 | 암진단용 마커 단백질, 그리고 이를 이용한 암진단방법 및암 진단키트 |
EP1845374A1 (en) * | 2006-04-14 | 2007-10-17 | Koninklijke Philips Electronics N.V. | Form inhibitor membrane for a flow-through cell |
US20080095988A1 (en) * | 2006-10-18 | 2008-04-24 | 3M Innovative Properties Company | Methods of patterning a deposit metal on a polymeric substrate |
CN100460028C (zh) * | 2006-12-08 | 2009-02-11 | 中国科学院上海微系统与信息技术研究所 | 一种用于药物传输的微针阵列及其制作方法 |
WO2008109207A2 (en) * | 2007-01-30 | 2008-09-12 | The Regents Of The University Of California | Methods and devices for biomolecular arrays |
CA2699569A1 (en) * | 2007-09-17 | 2009-03-26 | Twof, Inc. | Hydrogel labeled primer extension method for microarrays |
US8680026B2 (en) * | 2008-05-09 | 2014-03-25 | Akonni Biosystems, Inc. | Flow cell device |
US8680025B2 (en) * | 2008-05-09 | 2014-03-25 | Akonni Biosystems, Inc. | Microarray system |
US8822346B1 (en) | 2008-06-10 | 2014-09-02 | Intermolecular, Inc. | Method and apparatus for self-aligned layer removal |
US8592158B2 (en) * | 2009-07-10 | 2013-11-26 | Perkinelmer Health Sciences, Inc. | Detecting multinucleotide repeats |
US20120252686A1 (en) * | 2011-03-31 | 2012-10-04 | Good Start Genetics | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
EP2718465B1 (en) | 2011-06-09 | 2022-04-13 | Illumina, Inc. | Method of making an analyte array |
EP3305400A3 (en) * | 2011-10-28 | 2018-06-06 | Illumina, Inc. | Microarray fabrication system and method |
WO2013128493A1 (en) * | 2012-03-02 | 2013-09-06 | Sekisui Integrated Research Inc. | Nucleic acid amplification reactor |
NO2694769T3 (ar) * | 2012-03-06 | 2018-03-03 | ||
CA2870160C (en) | 2012-04-16 | 2021-08-24 | Biological Dynamics, Inc. | Nucleic acid sample preparation |
US9012022B2 (en) * | 2012-06-08 | 2015-04-21 | Illumina, Inc. | Polymer coatings |
US9683230B2 (en) * | 2013-01-09 | 2017-06-20 | Illumina Cambridge Limited | Sample preparation on a solid support |
US9512422B2 (en) * | 2013-02-26 | 2016-12-06 | Illumina, Inc. | Gel patterned surfaces |
DK3431614T3 (da) * | 2013-07-01 | 2021-12-06 | Illumina Inc | Katalysator fri overfladefunktionalisering og polymerpodning |
US10577638B2 (en) * | 2013-09-23 | 2020-03-03 | Board Of Regents, The University Of Texas System | Systems, devices, and methods for microbial detection and identification, and antimicrobial susceptibility testing |
EP3572875A1 (en) * | 2013-12-19 | 2019-11-27 | Illumina, Inc. | Roll-to-roll process of preparing a patterned substrate and patterned substrate prepared by the same process |
BR112016014923B1 (pt) * | 2013-12-23 | 2022-11-16 | Illumina, Inc | Arranjo, método para produção de um arranjo e método para detecção de ácidos nucleicos |
JP6759197B2 (ja) * | 2014-10-31 | 2020-09-23 | イルミナ ケンブリッジ リミテッド | 新規のポリマーおよびdnaコポリマーコーティング |
ES2802405T3 (es) * | 2014-11-11 | 2021-01-19 | Illumina Cambridge Ltd | Métodos y matrices para producir y secuenciar agrupaciones monoclonales de ácido nucleico |
WO2016151719A1 (ja) * | 2015-03-23 | 2016-09-29 | 株式会社日立製作所 | 核酸反応デバイス |
EP3325648B1 (en) | 2015-07-17 | 2023-03-29 | Illumina, Inc. | Polymer sheets for sequencing applications |
ES2861478T3 (es) * | 2016-05-18 | 2021-10-06 | Illumina Inc | Estampación de autoensamblado que utiliza superficies hidrófobas estampadas |
NL2019044B1 (en) | 2017-05-11 | 2018-11-15 | Illumina Inc | Protective surface coatings for flow cells |
-
2018
- 2018-12-17 US US16/626,393 patent/US10919033B2/en active Active
- 2018-12-17 SG SG11201911590VA patent/SG11201911590VA/en unknown
- 2018-12-17 AU AU2018392919A patent/AU2018392919B2/en active Active
- 2018-12-17 EP EP18892345.2A patent/EP3727674A4/en active Pending
- 2018-12-17 NZ NZ759626A patent/NZ759626A/en unknown
- 2018-12-17 KR KR1020197036403A patent/KR102313291B1/ko active IP Right Grant
- 2018-12-17 KR KR1020217032249A patent/KR20210133298A/ko not_active Application Discontinuation
- 2018-12-17 JP JP2019571312A patent/JP7087010B2/ja active Active
- 2018-12-17 RU RU2019139643A patent/RU2751517C2/ru active
- 2018-12-17 WO PCT/US2018/066011 patent/WO2019126040A1/en active Application Filing
- 2018-12-17 CA CA3066535A patent/CA3066535C/en active Active
- 2018-12-17 CN CN201880044290.6A patent/CN111093819B/zh active Active
- 2018-12-17 CN CN202210303552.4A patent/CN115106030A/zh active Pending
-
2019
- 2019-11-28 IL IL271026A patent/IL271026A/en unknown
- 2019-12-25 SA SA519410903A patent/SA519410903B1/ar unknown
-
2020
- 2020-12-07 US US17/114,134 patent/US11938475B2/en active Active
-
2021
- 2021-06-21 AU AU2021204165A patent/AU2021204165B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2020534509A (ja) | 2020-11-26 |
CN111093819A (zh) | 2020-05-01 |
BR112019026796A8 (pt) | 2020-07-28 |
US20200129974A1 (en) | 2020-04-30 |
BR112019026796A2 (pt) | 2020-06-30 |
RU2019139643A (ru) | 2021-06-07 |
SG11201911590VA (en) | 2020-01-30 |
EP3727674A1 (en) | 2020-10-28 |
EP3727674A4 (en) | 2021-10-13 |
RU2751517C2 (ru) | 2021-07-14 |
KR20210133298A (ko) | 2021-11-05 |
AU2021204165B2 (en) | 2023-04-27 |
KR20200016859A (ko) | 2020-02-17 |
NZ759626A (en) | 2023-03-31 |
AU2021204165A1 (en) | 2021-07-15 |
US20210086174A1 (en) | 2021-03-25 |
CA3066535C (en) | 2022-08-02 |
CN111093819B (zh) | 2022-04-05 |
AU2018392919A1 (en) | 2019-12-19 |
IL271026A (en) | 2020-01-30 |
CN115106030A (zh) | 2022-09-27 |
US11938475B2 (en) | 2024-03-26 |
US10919033B2 (en) | 2021-02-16 |
CA3066535A1 (en) | 2019-06-27 |
JP7087010B2 (ja) | 2022-06-20 |
AU2018392919B2 (en) | 2021-04-15 |
RU2019139643A3 (ar) | 2021-06-07 |
WO2019126040A1 (en) | 2019-06-27 |
KR102313291B1 (ko) | 2021-10-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SA519410903B1 (ar) | خلايا التدفق ذات غطاء جل مائي | |
MX2020014066A (es) | Celdas de flujo y kits de secuenciacion. | |
PH12019502897A1 (en) | Flow cells | |
PH12019501507A1 (en) | Flow cell package and method for making the same | |
WO2018184000A3 (en) | ORGANIC SUBSTRATES WITH ENHANCED RESISTANCE TO WEATHER AND ABRASION | |
EP3428929A4 (en) | FESTELECTROLYTIC, SOLID BODY, FETELECTROLYTHIC PROCESSING AND SOLID BODY MANUFACTURING METHOD | |
WO2015123248A3 (en) | Methods for printing on glass | |
WO2011159922A3 (en) | Graphene films and methods of making thereof | |
TW201613116A (en) | Perovskite solar cell | |
MX2020013413A (es) | Celdas de flujo. | |
WO2014179550A3 (en) | Hydrocolloid dressing and method for preparing the same | |
EP3605655A4 (en) | POROUS COMPOSITE FILM, SEPARATOR FOR BATTERY, BATTERY AND PRODUCTION METHOD FOR POROUS COMPOSITE FILM | |
WO2016062880A3 (de) | Nicht-ampholytische, quaternierbare und wasserlösliche polymere zur modifikation der oberflächenladung fester teilchen | |
GB2561775A (en) | Electrode integration into organs on chip devices | |
MA39974A (fr) | Beton photovoltaïque, son procede de fabrication et element de construction comprenant un tel beton | |
GB2546935A (en) | Method for producing a flexible electro-optic cell | |
WO2009040668A3 (en) | Positive electrode active material, method for manufacturing positive electrode active material, lithium secondary battery, and method for manufacturing lithium secondary battery | |
EP3214678A4 (en) | Electrode catalyst for fuel cell, production method thereof, fuel cell electrode catalyst layer containing said catalyst, fuel cell membrane-electrode assembly using said catalyst or catalyst layer, and fuel cell | |
EP3217456A4 (en) | Porous electrode substrate, membrane/electrode assembly using same, and solid polymer fuel cell using same | |
WO2014042779A9 (en) | Conformal porous thin layer coating and method of making | |
EP3474333A4 (en) | SOLAR CELL AND PRODUCTION METHOD THEREFOR AND SOLAR CELL MODULE | |
EP3211697A4 (en) | Fuel cell electrode catalyst layer, production method therefor, membrane electrode assembly, and solid polymer fuel cell | |
WO2015177748A3 (en) | Fabricating thin-film optoelectronic devices with modified surface | |
WO2015116770A3 (en) | Bottom-up ultra-thin functional optoelectronic films and devices | |
WO2016060769A3 (en) | Integrated super-capacitor |