SA519400868B1 - معدلات عطرية غير متجانسة لأشعة جاما لمستقبل يتيم ذي علاقة بريتينويد - Google Patents

معدلات عطرية غير متجانسة لأشعة جاما لمستقبل يتيم ذي علاقة بريتينويد

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Publication number
SA519400868B1
SA519400868B1 SA519400868A SA519400868A SA519400868B1 SA 519400868 B1 SA519400868 B1 SA 519400868B1 SA 519400868 A SA519400868 A SA 519400868A SA 519400868 A SA519400868 A SA 519400868A SA 519400868 B1 SA519400868 B1 SA 519400868B1
Authority
SA
Saudi Arabia
Prior art keywords
alkyl
cycloalkyl
membered
retinoid
heteroaromatic
Prior art date
Application number
SA519400868A
Other languages
English (en)
Inventor
باتريك ستيفين جوهنسون،
الان ستوارت جيسيمان،
مورتين داهى سورينسين،
كريستوفير مانسون،
Original Assignee
ليو فارما ايه/ اس
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ليو فارما ايه/ اس filed Critical ليو فارما ايه/ اس
Publication of SA519400868B1 publication Critical patent/SA519400868B1/ar

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

يتعلق الاختراع الحالي بمركب وفقًا للصيغة العامة (‏I‏)‏ ‏ ‏ حيث ‏X‏ تمثل ‏N‏ أو ‏CH؛ ‏R1‎‏ تكون ‏‎-CN، (‏C1–C6‎‏)ألكيل ‏‎(C1–C6)alkyl‎، (‏C3–C7‎‏)سيكلو ألكيل ‏‎(C3–C7)cycloalkyl‎، سيكلو ألكيل غير متجانس (3-7 ذرات) ‏‎(3-7 ‎membered)heterocycloalkyl، أريل غير متجانس (5-6 ذرات) ‏‎(5-6 membered)heteroaryl‎، ‏‏(‏C3–C7‎‏)سيكلو ألكيل(‏C1–C4‎‏)ألكيل ‏‎(C3–C7)cycloalkyl(C1–C4)alkyl‎، سيكلو ألكيل غير ‏متجانس (3-7 ذرات)‏‎-‎‏(‏C1–C4‎‏)ألكيل ‏‎(3-7 membered)heterocycloalkyl-(C1–C4)alkyl‎‏ أو أريل ‏غير متجانس (5-6 ذرات)‏‎-‎‏(‏C1–C4‎‏)ألكيل ‏‎(5-6 membered)heteroaryl-(C1–C4)alkyl‎؛ ‏R2‎‏ تكون ‏هالوجين ‏halogen، سيانو ‏cyano، (‏C1–C4‎‏)ألكيل أو (‏C3–C7‎‏)سيكلو ألكيل؛ ‏R3‎‏ تكون هالوجين، ‏سيانو، (‏C1–C4‎‏)ألكيل، (‏C1–C4‎‏)هالو ألكيل ‏‎(C1–C4)haloalkyl‎‏ أو (‏C3–C7‎‏)سيكلو ألكيل؛ ‏R4‎‏ تكون ‏‏(‏C1–C4‎‏)ألكيل أو (‏C1–C4‎‏)هالو ألكيل؛ ‏R5‎‏ تكون (‏C1–C6‎‏)ألكيل، (‏C3–C7‎‏)سيكلو ألكيل، (‏C1–‎C6‎‏)ألكيل‎-‎‏(‏C3–C7‎‏)سيكلو ألكيل ‏‎(C1–C6)alkyl-(C3–C7)cycloalkyl‎، (‏C3–C7‎‏)سيكلو ألكيل‎-‎‏(‏C1–‎C6‎‏)ألكيل ‏
SA519400868A 2016-07-13 2019-01-13 معدلات عطرية غير متجانسة لأشعة جاما لمستقبل يتيم ذي علاقة بريتينويد SA519400868B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16020268 2016-07-13
PCT/EP2017/067390 WO2018011201A1 (en) 2016-07-13 2017-07-11 Heteroaromatic modulators of the retinoid-related orphan receptor gamma

Publications (1)

Publication Number Publication Date
SA519400868B1 true SA519400868B1 (ar) 2022-06-13

Family

ID=56511303

Family Applications (1)

Application Number Title Priority Date Filing Date
SA519400868A SA519400868B1 (ar) 2016-07-13 2019-01-13 معدلات عطرية غير متجانسة لأشعة جاما لمستقبل يتيم ذي علاقة بريتينويد

Country Status (21)

Country Link
US (2) US10662181B2 (ar)
EP (1) EP3484880B1 (ar)
JP (1) JP7016344B2 (ar)
KR (1) KR102490140B1 (ar)
CN (1) CN109476653B (ar)
AU (1) AU2017294969B2 (ar)
BR (1) BR112019000486A2 (ar)
CA (1) CA3030370A1 (ar)
DK (1) DK3484880T3 (ar)
ES (1) ES2834009T3 (ar)
IL (1) IL264141B (ar)
MX (1) MX2019000361A (ar)
MY (1) MY196990A (ar)
PL (1) PL3484880T3 (ar)
PT (1) PT3484880T (ar)
RU (1) RU2771280C2 (ar)
SA (1) SA519400868B1 (ar)
SG (1) SG11201811107WA (ar)
UA (1) UA123330C2 (ar)
WO (1) WO2018011201A1 (ar)
ZA (1) ZA201808436B (ar)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA123330C2 (uk) * 2016-07-13 2021-03-17 Лео Фарма А/С Гетероароматичні модулятори ретинол-зв'язаного орфанного рецептора гамма
CN111825654A (zh) * 2019-04-19 2020-10-27 北京酷瓴生物技术有限公司 苯甲烯哌啶衍生物及其制备方法、中间体和用途
CN112898292A (zh) * 2019-12-03 2021-06-04 微境生物医药科技(上海)有限公司 新型极光激酶抑制剂及其用途

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WO2004073612A2 (en) 2003-02-13 2004-09-02 Merck & Co. Inc. Estrogen receptor modulators
FR2879381B1 (fr) 2004-12-15 2008-12-26 Thales Sa Systeme de distribution quantique de cle de cryptage a variables continues
US20080242704A1 (en) * 2005-04-04 2008-10-02 Ab Science Substituted Oxazole Derivatives and their Use as Tyrosine Kinase Inhibitors
EP2511275A1 (en) 2011-04-12 2012-10-17 Bioprojet Novel piperidinyl monocarboxylic acids as S1P1 receptor agonists
EA026437B1 (ru) * 2012-12-06 2017-04-28 Глэксо Груп Лимитед N-(3-((4-ацилпиперазин-1-ил)метил)фенил)амиды в качестве модуляторов сиротских гамма-рецепторов ретиноидов (ror-гамма) и их применение для лечения рассеянного склероза и псориаза
KR20160070162A (ko) * 2013-11-05 2016-06-17 에프. 호프만-라 로슈 아게 자가면역 질병의 치료를 위한 RORc 조절인자로서 5,6,7,8-테트라하이드로-5,8-메타노신놀린 유도체
WO2015180614A1 (en) * 2014-05-28 2015-12-03 Glaxosmithkline Intellectual Property Development Limited Novel compounds
CN106536489B (zh) * 2014-05-28 2020-02-07 葛兰素史密斯克莱知识产权发展有限公司 类视黄醇相关孤儿受体γ调节剂及其用途
EP3148985A4 (en) * 2014-05-28 2018-01-17 GlaxoSmithKline Intellectual Property Development Limited Novel compounds
UA123330C2 (uk) * 2016-07-13 2021-03-17 Лео Фарма А/С Гетероароматичні модулятори ретинол-зв'язаного орфанного рецептора гамма

Also Published As

Publication number Publication date
UA123330C2 (uk) 2021-03-17
MY196990A (en) 2023-05-17
MX2019000361A (es) 2019-05-23
DK3484880T3 (da) 2020-11-09
RU2019103883A (ru) 2020-08-13
BR112019000486A2 (pt) 2019-04-24
KR20190026872A (ko) 2019-03-13
PL3484880T3 (pl) 2021-04-06
US20190284177A1 (en) 2019-09-19
KR102490140B1 (ko) 2023-01-19
JP7016344B2 (ja) 2022-02-04
CN109476653B (zh) 2022-04-22
NZ749301A (en) 2021-03-26
US10662181B2 (en) 2020-05-26
SG11201811107WA (en) 2019-01-30
IL264141A (en) 2019-02-28
JP2019521137A (ja) 2019-07-25
IL264141B (en) 2021-09-30
ES2834009T3 (es) 2021-06-16
EP3484880A1 (en) 2019-05-22
WO2018011201A1 (en) 2018-01-18
ZA201808436B (en) 2020-05-27
US10934282B2 (en) 2021-03-02
RU2771280C2 (ru) 2022-04-29
RU2019103883A3 (ar) 2020-09-23
AU2017294969A1 (en) 2019-01-17
PT3484880T (pt) 2020-12-07
US20200291010A1 (en) 2020-09-17
EP3484880B1 (en) 2020-09-02
AU2017294969B2 (en) 2021-03-25
CN109476653A (zh) 2019-03-15
CA3030370A1 (en) 2018-01-18

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