SA06270470B1 - تركيب من الطب الصيني التقليدي لعلاج الصداع، مستحضرات وعملية لتصنيع التركيب نفسه - Google Patents
تركيب من الطب الصيني التقليدي لعلاج الصداع، مستحضرات وعملية لتصنيع التركيب نفسه Download PDFInfo
- Publication number
- SA06270470B1 SA06270470B1 SA6270470A SA06270470A SA06270470B1 SA 06270470 B1 SA06270470 B1 SA 06270470B1 SA 6270470 A SA6270470 A SA 6270470A SA 06270470 A SA06270470 A SA 06270470A SA 06270470 B1 SA06270470 B1 SA 06270470B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- radix
- ethanol
- protected
- tablets
- weight
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 63
- 238000002360 preparation method Methods 0.000 title claims abstract description 50
- 239000003814 drug Substances 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 title claims abstract description 38
- 206010019233 Headaches Diseases 0.000 title claims abstract description 17
- 231100000869 headache Toxicity 0.000 title claims abstract description 17
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 40
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 187
- 239000003826 tablet Substances 0.000 claims description 101
- 239000000284 extract Substances 0.000 claims description 94
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 54
- 239000000843 powder Substances 0.000 claims description 50
- 241000218176 Corydalis Species 0.000 claims description 48
- 238000010992 reflux Methods 0.000 claims description 45
- 238000000605 extraction Methods 0.000 claims description 39
- 229940079593 drug Drugs 0.000 claims description 33
- 210000002784 stomach Anatomy 0.000 claims description 32
- 239000000463 material Substances 0.000 claims description 18
- 238000009835 boiling Methods 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 16
- 239000006187 pill Substances 0.000 claims description 15
- 239000007921 spray Substances 0.000 claims description 14
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 13
- 239000002904 solvent Substances 0.000 claims description 13
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 10
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 10
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 10
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 10
- 238000001694 spray drying Methods 0.000 claims description 10
- 239000011230 binding agent Substances 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- 229920002472 Starch Polymers 0.000 claims description 5
- 241001199012 Usta Species 0.000 claims description 5
- 210000000582 semen Anatomy 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 229920001353 Dextrin Polymers 0.000 claims description 4
- 239000004375 Dextrin Substances 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- 235000010980 cellulose Nutrition 0.000 claims description 4
- 235000019425 dextrin Nutrition 0.000 claims description 4
- 239000007941 film coated tablet Substances 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- 238000004062 sedimentation Methods 0.000 claims description 4
- 239000006228 supernatant Substances 0.000 claims description 4
- 238000001556 precipitation Methods 0.000 claims description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 3
- 210000000569 greater omentum Anatomy 0.000 claims 3
- 235000015001 Cucumis melo var inodorus Nutrition 0.000 claims 1
- 240000002495 Cucumis melo var. inodorus Species 0.000 claims 1
- 101150076621 Radx gene Proteins 0.000 claims 1
- 239000002274 desiccant Substances 0.000 claims 1
- 239000012567 medical material Substances 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000004584 weight gain Effects 0.000 claims 1
- 235000019786 weight gain Nutrition 0.000 claims 1
- 238000009434 installation Methods 0.000 abstract description 2
- 241000382455 Angelica sinensis Species 0.000 description 44
- 238000004806 packaging method and process Methods 0.000 description 39
- 239000008187 granular material Substances 0.000 description 29
- 238000002156 mixing Methods 0.000 description 21
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 19
- 239000000706 filtrate Substances 0.000 description 17
- 239000000126 substance Substances 0.000 description 16
- 241001132374 Asta Species 0.000 description 13
- 239000011248 coating agent Substances 0.000 description 11
- 238000000576 coating method Methods 0.000 description 11
- 230000000694 effects Effects 0.000 description 11
- 238000001914 filtration Methods 0.000 description 11
- 208000000114 Pain Threshold Diseases 0.000 description 10
- 241001529739 Prunella <angiosperm> Species 0.000 description 10
- 241000700159 Rattus Species 0.000 description 10
- 230000037040 pain threshold Effects 0.000 description 10
- 238000001035 drying Methods 0.000 description 9
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 8
- 238000005538 encapsulation Methods 0.000 description 8
- 238000002844 melting Methods 0.000 description 8
- 230000008018 melting Effects 0.000 description 8
- 239000012153 distilled water Substances 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 241000736199 Paeonia Species 0.000 description 6
- 229960001138 acetylsalicylic acid Drugs 0.000 description 6
- 238000004090 dissolution Methods 0.000 description 6
- 238000004821 distillation Methods 0.000 description 6
- 208000002193 Pain Diseases 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000012141 concentrate Substances 0.000 description 5
- 230000036407 pain Effects 0.000 description 5
- 244000182067 Fraxinus ornus Species 0.000 description 4
- 235000002917 Fraxinus ornus Nutrition 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 230000001186 cumulative effect Effects 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 3
- 235000019658 bitter taste Nutrition 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000005352 clarification Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 238000007619 statistical method Methods 0.000 description 3
- 238000000194 supercritical-fluid extraction Methods 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 238000002137 ultrasound extraction Methods 0.000 description 3
- 239000000341 volatile oil Substances 0.000 description 3
- MCCYTOKKEWJAMY-UHFFFAOYSA-N 4-amino-n-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine Chemical compound COC1=NSN=C1NS(=O)(=O)C1=CC=C(N)C=C1.COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 MCCYTOKKEWJAMY-UHFFFAOYSA-N 0.000 description 2
- 241000125175 Angelica Species 0.000 description 2
- 235000001287 Guettarda speciosa Nutrition 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 244000046052 Phaseolus vulgaris Species 0.000 description 2
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 2
- MYEJFUXQJGHEQK-ALRJYLEOSA-N Proscillaridin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C=C2CC[C@H]3[C@@]4(O)CC[C@H](C5=COC(=O)C=C5)[C@@]4(C)CC[C@@H]3[C@@]2(C)CC1 MYEJFUXQJGHEQK-ALRJYLEOSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000012907 medicinal substance Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 238000005498 polishing Methods 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241001093575 Alma Species 0.000 description 1
- 101100234822 Caenorhabditis elegans ltd-1 gene Proteins 0.000 description 1
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010028347 Muscle twitching Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000010476 Respiratory Paralysis Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000037007 arousal Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical class [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 239000012738 dissolution medium Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 238000002481 ethanol extraction Methods 0.000 description 1
- 238000012869 ethanol precipitation Methods 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 238000005188 flotation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000010247 gou-teng Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000000321 herbal drug Substances 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 description 1
- 229960004171 hydroxychloroquine Drugs 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 238000004969 ion scattering spectroscopy Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000008775 paternal effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- JOHZPMXAZQZXHR-UHFFFAOYSA-N pipemidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCNCC1 JOHZPMXAZQZXHR-UHFFFAOYSA-N 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229960003712 propranolol Drugs 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- HUAUNKAZQWMVFY-UHFFFAOYSA-M sodium;oxocalcium;hydroxide Chemical compound [OH-].[Na+].[Ca]=O HUAUNKAZQWMVFY-UHFFFAOYSA-M 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 230000021542 voluntary musculoskeletal movement Effects 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/50—Fumariaceae (Fumitory family), e.g. bleeding heart
- A61K36/505—Corydalis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005100148298A CN1919273B (zh) | 2005-08-24 | 2005-08-24 | 一种治疗头痛的中药组合物 |
| CN2005100148283A CN1919272B (zh) | 2005-08-24 | 2005-08-24 | 一种中药浓缩丸 |
| PCT/CN2006/002135 WO2007022710A1 (en) | 2005-08-24 | 2006-08-22 | Chinese medicinal compositions for treating headache, formulations and processes for preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA06270470B1 true SA06270470B1 (ar) | 2010-06-22 |
Family
ID=37771232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA6270470A SA06270470B1 (ar) | 2005-08-24 | 2006-12-18 | تركيب من الطب الصيني التقليدي لعلاج الصداع، مستحضرات وعملية لتصنيع التركيب نفسه |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1930020B1 (enExample) |
| JP (1) | JP5162457B2 (enExample) |
| KR (1) | KR101088539B1 (enExample) |
| AR (1) | AR055386A1 (enExample) |
| JO (1) | JO2763B1 (enExample) |
| SA (1) | SA06270470B1 (enExample) |
| WO (1) | WO2007022710A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102370754B (zh) * | 2010-08-11 | 2014-01-01 | 叶志平 | 一种治疗血虚头痛的中药制剂 |
| CN102441057B (zh) * | 2010-10-14 | 2014-12-03 | 天士力制药集团股份有限公司 | 一种养血清脑颗粒的hplc指纹图谱检测方法 |
| CN103083494B (zh) * | 2012-12-11 | 2015-05-06 | 宋协勘 | 一种治疗血管性头痛的中药 |
| US9795648B2 (en) * | 2012-12-21 | 2017-10-24 | Tasly Pharmaceutical Group Co., Ltd. | Pharmaceutical composition for treating headache, and preparation method thereof |
| CN103893247A (zh) * | 2013-12-05 | 2014-07-02 | 人福医药集团股份公司 | 药物组合物及其制备方法和用途 |
| CN104225128A (zh) * | 2014-09-03 | 2014-12-24 | 张士远 | 缓解颈椎病所致头痛的药物制剂及制备方法 |
| CN104398861A (zh) * | 2014-12-18 | 2015-03-11 | 青岛百瑞吉生物工程有限公司 | 用于治疗偏头痛的中药制剂及其制作方法和应用 |
| SG10201507607RA (en) | 2015-09-14 | 2017-04-27 | Moleac Pte Ltd | Process For Producing Traditional Chinese Medicine Compositions, And Compositions Obtainable By The Process |
| CN106138419A (zh) * | 2016-09-19 | 2016-11-23 | 四川易创生物科技有限公司 | 一种治疗血虚肝旺所致头痛、失眠多梦的中药组合物 |
| CN120154581A (zh) * | 2021-08-18 | 2025-06-17 | 越洋医药开发(广州)有限公司 | 允许睡眠调节类药物分段释放的片剂及其制备方法 |
| CN115054584A (zh) * | 2022-07-08 | 2022-09-16 | 上海和黄药业有限公司 | 一种中药丸剂包衣组合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1047938C (zh) * | 1992-11-14 | 2000-01-05 | 中国人民解放军第二五四医院 | 一种治疗头痛的中药 |
| CN1160556A (zh) * | 1996-03-21 | 1997-10-01 | 孔繁营 | 中药镇脑丸及其配制方法 |
| CN1631399A (zh) * | 2003-12-24 | 2005-06-29 | 李建华 | 健脑止痛饮 |
-
2006
- 2006-08-22 KR KR1020087006829A patent/KR101088539B1/ko active Active
- 2006-08-22 WO PCT/CN2006/002135 patent/WO2007022710A1/zh not_active Ceased
- 2006-08-22 EP EP06775453A patent/EP1930020B1/en active Active
- 2006-08-22 JO JO2006278A patent/JO2763B1/en active
- 2006-08-22 JP JP2008527290A patent/JP5162457B2/ja active Active
- 2006-08-23 AR ARP060103669A patent/AR055386A1/es not_active Application Discontinuation
- 2006-12-18 SA SA6270470A patent/SA06270470B1/ar unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1930020A1 (en) | 2008-06-11 |
| JP2009505991A (ja) | 2009-02-12 |
| HK1116426A1 (en) | 2008-12-24 |
| EP1930020A4 (en) | 2010-04-14 |
| EP1930020B1 (en) | 2011-06-01 |
| AR055386A1 (es) | 2007-08-22 |
| JP5162457B2 (ja) | 2013-03-13 |
| WO2007022710A1 (en) | 2007-03-01 |
| KR101088539B1 (ko) | 2011-12-05 |
| KR20080038424A (ko) | 2008-05-06 |
| JO2763B1 (en) | 2014-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112972547A (zh) | 一种治疗气血两虚症候的中药组合物及其制备方法和应用 | |
| CN112915187B (zh) | 一种可散寒除湿的中药组合物、制备方法和应用 | |
| SA06270470B1 (ar) | تركيب من الطب الصيني التقليدي لعلاج الصداع، مستحضرات وعملية لتصنيع التركيب نفسه | |
| JP2017537150A (ja) | 肝臓及び腎臓の損傷関連疾患を予防し又は治療する薬物又は保健品とその応用法 | |
| CN103520357B (zh) | 一种补气益血的八珍丸(微丸) | |
| CN101199639B (zh) | 一种治疗易激症的中药 | |
| CN101278958A (zh) | 肺宁滴丸及其制备方法 | |
| CN111358906B (zh) | 一种适用于外感症的中药组合物 | |
| CN103271978A (zh) | 一种用于抗缺氧、缺糖及治疗高原病的银杏叶复方制剂 | |
| CN115212277B (zh) | 一种参茸卫生丸的制备方法 | |
| CN105434738A (zh) | 一种治疗小儿多动症的中药组合物及其制备方法 | |
| CN102670999A (zh) | 一种金钗石斛丸配方及其加工工艺 | |
| JP2001302535A (ja) | 医療用組成物 | |
| CN102416093B (zh) | 一种消炎利喉中药组合物 | |
| RU2430734C1 (ru) | Гранулы с растительным экстрактом для профилактики и комплексного лечения язвенной болезни желудка | |
| TWI379686B (enExample) | ||
| CN110652554A (zh) | 一种补心解郁安眠合剂及其制备方法 | |
| CN102973624B (zh) | 一种复方银杏叶制剂及其制备方法 | |
| CN101574454B (zh) | 一种复原再造中药 | |
| CN100482267C (zh) | 消渴制剂及其制备方法 | |
| CN107997170A (zh) | 一种具有降血脂功能的组合物及其制备方法 | |
| CN106389820A (zh) | 天王补心丹及生脉饮药方的萃取方法 | |
| CN107158017A (zh) | 一种药物组合物及其制备方法和用途 | |
| HK40054479B (en) | Traditional chinese medicine composition capable of dispelling cold and removing dampness, preparation method and application | |
| CN101745002B (zh) | 一种麦冬、人参和五味子的提取方法及其制剂 |