CN1047938C - 一种治疗头痛的中药 - Google Patents
一种治疗头痛的中药 Download PDFInfo
- Publication number
- CN1047938C CN1047938C CN93100050A CN93100050A CN1047938C CN 1047938 C CN1047938 C CN 1047938C CN 93100050 A CN93100050 A CN 93100050A CN 93100050 A CN93100050 A CN 93100050A CN 1047938 C CN1047938 C CN 1047938C
- Authority
- CN
- China
- Prior art keywords
- blood
- medicine
- headache
- chinese patent
- patent medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title claims abstract description 34
- 229940079593 drug Drugs 0.000 title claims description 6
- 239000008280 blood Substances 0.000 title abstract description 24
- 210000004369 blood Anatomy 0.000 title abstract description 24
- 210000004556 brain Anatomy 0.000 title description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title description 4
- 230000004087 circulation Effects 0.000 title description 3
- 238000009835 boiling Methods 0.000 title 1
- 206010019233 Headaches Diseases 0.000 claims abstract description 26
- 231100000869 headache Toxicity 0.000 claims abstract description 26
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 7
- 241000218176 Corydalis Species 0.000 claims abstract description 6
- 210000000582 semen Anatomy 0.000 claims abstract description 6
- 241000217407 Margaritifera Species 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 4
- 239000000796 flavoring agent Substances 0.000 claims description 2
- 235000019634 flavors Nutrition 0.000 claims description 2
- 230000017531 blood circulation Effects 0.000 abstract description 9
- 208000002193 Pain Diseases 0.000 abstract description 8
- 230000001737 promoting effect Effects 0.000 abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 6
- 208000019695 Migraine disease Diseases 0.000 abstract description 4
- 206010027599 migraine Diseases 0.000 abstract description 4
- 206010020772 Hypertension Diseases 0.000 abstract description 3
- 230000001631 hypertensive effect Effects 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract description 2
- 238000005469 granulation Methods 0.000 abstract description 2
- 230000003179 granulation Effects 0.000 abstract description 2
- 210000002418 meninge Anatomy 0.000 abstract description 2
- 229960002748 norepinephrine Drugs 0.000 abstract description 2
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract description 2
- 238000001556 precipitation Methods 0.000 abstract description 2
- 238000011084 recovery Methods 0.000 abstract description 2
- 230000001502 supplementing effect Effects 0.000 abstract description 2
- 238000002474 experimental method Methods 0.000 abstract 2
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 235000017965 Asarum canadense Nutrition 0.000 abstract 1
- 241000510667 Conioselinum Species 0.000 abstract 1
- 235000000385 Costus speciosus Nutrition 0.000 abstract 1
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 1
- 244000236658 Paeonia lactiflora Species 0.000 abstract 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 1
- 244000179560 Prunella vulgaris Species 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 241000913745 Spatholobus Species 0.000 abstract 1
- 241000606265 Valeriana jatamansi Species 0.000 abstract 1
- 208000012886 Vertigo Diseases 0.000 abstract 1
- 235000014687 Zingiber zerumbet Nutrition 0.000 abstract 1
- 210000001367 artery Anatomy 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 210000001715 carotid artery Anatomy 0.000 abstract 1
- 235000005272 common selfheal Nutrition 0.000 abstract 1
- 230000004089 microcirculation Effects 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 210000002385 vertebral artery Anatomy 0.000 abstract 1
- 231100000889 vertigo Toxicity 0.000 abstract 1
- 238000003809 water extraction Methods 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 206010061245 Internal injury Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000013403 hyperactivity Diseases 0.000 description 3
- 241000721047 Danaus plexippus Species 0.000 description 2
- 229940095559 cafergot Drugs 0.000 description 2
- CJMJLDQKTOJACI-SEUSHGJOSA-N chembl2448612 Chemical compound OC(=O)C(O)C(O)C(O)=O.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C=3C=CC=C4NC=C(C=34)C2)=C1)C)C1=CC=CC=C1.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C=3C=CC=C4NC=C(C=34)C2)=C1)C)C1=CC=CC=C1 CJMJLDQKTOJACI-SEUSHGJOSA-N 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- PUQSUZTXKPLAPR-UJPOAAIJSA-N Gastrodin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(CO)C=C1 PUQSUZTXKPLAPR-UJPOAAIJSA-N 0.000 description 1
- 206010019705 Hepatic pain Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000001168 carotid artery common Anatomy 0.000 description 1
- 210000001627 cerebral artery Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000000599 controlled substance Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000012869 ethanol precipitation Methods 0.000 description 1
- SMANXXCATUTDDT-QPJJXVBHSA-N flunarizine Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)N1CCN(C\C=C\C=2C=CC=CC=2)CC1 SMANXXCATUTDDT-QPJJXVBHSA-N 0.000 description 1
- 229960000326 flunarizine Drugs 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- -1 gastrodine Chemical compound 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
本发明属中成药。该制剂是由当归、川芎、白芍、熟地、勾藤、鸡血藤、夏枯草、决明子、珍珠母、元胡、细辛所组成，其功能为补血养阴、活血止痛，主治血管神经性头痛、偏头痛及高血压性头晕头痛。经动物试验可增加颈动脉及椎动脉的血流量，扩张血管增强脑膜微循环，增强离体动脉条对去甲肾上腺素引起的收缩，临床总有效率高达95%。
Description
本发明属纯中药植物制成的中成药，它具体涉及一种新型治头痛中成药的组成成份。
血管神经性头痛是一种常见病，虽有部分中西药物可用，但效果均不甚理想，尤其是对治疗血虚、血瘀型的肝阳头痛的药物，在国内外的文献中尚未见报导。现常用的治疗头痛的西药有麦角胺咖啡因，它是一种血管扩张剂，只适合于脑动脉缺血性疾病。另外，88年才生产的氟桂嗪胶囊，其作用机理是选择性的抑制钙进入细胞，以减少静脉的收缩。目前报导的治疗头痛的中成药有正无丸，它是中西药合方，其机理是活血化瘀，并配有西药的止痛剂，此药只适合于外感头痛之类，而对中医称谓的内伤型头痛、血虚血瘀肝阳头痛则效果不佳。
本发明的目的在于提供一种纯中药制剂的一种治疗头痛的中药，它能治疗内伤头痛范畴，适应血管神经性头痛、偏头痛、及高血压的头晕、头痛等症。
按如上构思，本方案所提供的治疗头痛的中药的特征是它由下列的原料制成的，各药味的重量配比如下：
当归 4～9％
川芎 4～9％
白芍 2～8％
熟地 2～8％
勾藤 10～15％
鸡血藤 10～15％
夏枯草 10～15％
决明子 10～15％
珍珠母 10～15％
元胡 4～9％
细辛 0.5～2％。
在本方案中，其最佳的原料重量配比为
当归 6.75％
川芎 6.75％
白芍 5.4％
熟地 5.4％
勾藤 13.5％
鸡血藤 13.5％
夏枯草 13.5％
决明子 13.5％
珍珠母 13.5％
元胡 6.75％
细辛 1.34％。
本方案涉及的治疗头痛的中药适应于治疗内伤头痛的范畴，盖因“脑为髓之海”，主要依赖肝、肾，精血濡养及脾胃运化水谷精微，输怖气血上充于脑，故内伤头痛与肝、脾、肾三脏密切相关。若为血虚血瘀、阴虚肝阳升腾所致之头痛，需宜养血活血、滋阴平阳为法。而这在国内的药品中是没有报导的。
本药的同伍之中兼有活血养气、滋阴填精之中兼有潜阳平肝，静中有动协调阴阳。它以当归为君药主要为养血、活血、止痛，熟地为滋阴补血、益精填髓，因“脑为髓之海”，精髓不足则脑髓失养而作痛，用之相宜。白芍为平肝止痛、养血调经，用于阳血虚而肝阳亢所致头痛最佳，川芎活血行气，人血分行血中之气，祛风止痛为治疗血瘀肝阳所致头痛的常用药，熟地、白芍、川芎合用协助君药，其作用为养血活血、滋阴平肝、祛风止痛。勾藤、珍珠母、夏枯草、决明子为镇静安神，为补治药，佐协鸡血藤补血行血、舒筋活络，元胡活血行气止痛，细辛芳香走窜、祛风散寒止痛共为佐使。全方总的功能为补血养阴、活血止痛。
本药除主治血管神经性头痛、偏头痛外，亦可治疗高血压性的头晕头痛。
本药经药理试验：①对猫口服或静脉注射，能增加颈总动脉、椎动脉的血流量；②对小鼠静脉注射可使其毛细血管网交点增多，血管口径变粗，有增强脑膜微循环的作用；③服药或注射可使家兔离体动脉条能对抗去甲肾上腺素所引起的收缩。
本药经92年前的临床试验：应用1000例，男性400例、女性600例，年龄14～65岁，病程2个月～26年，均为头痛或偏头痛，全部病例无神经系统异常体征，其中部分病人均曾服过麦角胺咖啡因，天麻素、去痛片等药物，其临床观察结果：
疗效 例数 百分率
治愈 450 45％
有效 100 10％
显效 400 40％
无效 50 5％ 总有效率95％。
在本药的制作过程中，药材经前序处理→水提→浓缩→乙醇沉淀→回收乙醇→浓缩成膏→混合制粒→成品包装。即按比例取上述各药，加水煮三次，每次1小时，合并煎液，浓缩适量，加2倍量的乙醇，静置24小时沉淀，取上清液浓缩成膏，相对密度为1.3～1.4，出膏率10％，再取清膏、蔗糖、糊精按1∶3∶1混合烘干制成颗粒。此种产品为冲剂的剂型，它还可以按常规的工艺方法作成其它适当的剂型。
由前述的各种实践证明本药具有性能好、易制作、成本低的特点。
Claims (2)
1.一种治疗头痛的药物，其特征是它由下列的原料制成的，各药味的重量配比如下
当归 4～9％、
川芎 4～9％、
白芍 2～8％、
熟地 2～8％、
勾藤 10～15％、
鸡血藤 10～15％、
夏枯草 10～15％
决明子 10～15％、
珍珠母 10～15％、
元胡 4～9％、
细辛 0.5～2％。
2.按照权利要求1所述的药物，其特征是各原料的重量配比为
当归 6.75％、
川芎 6.75％、
白芍 5.4％、
熟地 5.4％
勾藤 13.5％、
鸡血藤 13.5％.
夏枯草 13.5％、
决明子 13.5％、
珍珠母 13.5％、
元胡 6.75％、
细辛 1.34％。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93100050A CN1047938C (zh) | 1992-11-14 | 1993-01-09 | 一种治疗头痛的中药 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92112924 | 1992-11-14 | ||
| CN92112924.6 | 1992-11-14 | ||
| CN93100050A CN1047938C (zh) | 1992-11-14 | 1993-01-09 | 一种治疗头痛的中药 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1073874A CN1073874A (zh) | 1993-07-07 |
| CN1047938C true CN1047938C (zh) | 2000-01-05 |
Family
ID=25742830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93100050A Expired - Lifetime CN1047938C (zh) | 1992-11-14 | 1993-01-09 | 一种治疗头痛的中药 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1047938C (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007022710A1 (fr) * | 2005-08-24 | 2007-03-01 | Tianjin Tasly Pharmaceutical Co. Ltd. | Compositions a base de medecine chinoise pour le traitement de cephalees, formulations et procedes de preparation |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1318020C (zh) * | 2004-06-25 | 2007-05-30 | 广东天之骄生命科技有限公司<Del/> | 一种养血清脑口腔崩解片及其制备方法 |
| CN100411652C (zh) * | 2004-06-30 | 2008-08-20 | 天津天士力制药股份有限公司 | 一种药物组合物在制备治疗慢性脑供血不足药物中的应用 |
| CN1872216B (zh) * | 2005-06-03 | 2011-07-13 | 天津天士力制药股份有限公司 | 一种治疗头痛的药物组合物及其制备方法 |
| CN1872218B (zh) * | 2005-06-03 | 2011-10-05 | 天津天士力制药股份有限公司 | 一种治疗头痛的泡腾剂及其制备方法 |
| CN1872215B (zh) * | 2005-06-03 | 2012-02-15 | 天津天士力制药股份有限公司 | 一种治疗头痛的滴丸及其制备方法 |
| CN1919272B (zh) * | 2005-08-24 | 2011-08-10 | 天津天士力制药股份有限公司 | 一种中药浓缩丸 |
| CN1919273B (zh) * | 2005-08-24 | 2011-02-16 | 天津天士力制药股份有限公司 | 一种治疗头痛的中药组合物 |
| CN100356938C (zh) * | 2005-12-29 | 2007-12-26 | 颜怀伟 | 防治风热头痛药食兼用中药及制造方法 |
| CN101194961B (zh) * | 2006-12-08 | 2013-06-05 | 天士力制药集团股份有限公司 | 一种治疗头痛的气雾剂及其制备方法 |
| CN101194964B (zh) * | 2006-12-08 | 2013-08-21 | 天士力制药集团股份有限公司 | 一种治疗头痛的包衣片剂及其制备方法 |
| CN101194958B (zh) * | 2006-12-08 | 2013-03-27 | 天士力制药集团股份有限公司 | 一种治疗头痛的煎膏剂的制备方法 |
| CN101194945B (zh) * | 2006-12-08 | 2013-06-05 | 天士力制药集团股份有限公司 | 一种治疗头痛的片剂及其制备方法 |
| CN101194965B (zh) * | 2006-12-08 | 2013-06-05 | 天士力制药集团股份有限公司 | 一种治疗头痛的咀嚼片及其制备方法 |
| CN101428094B (zh) * | 2007-11-06 | 2012-05-09 | 天津天士力制药股份有限公司 | 一种药物组合物在制备改善脑微循环障碍药物中的应用 |
| CN101244207B (zh) * | 2008-01-31 | 2011-01-19 | 临沂市欧克姆内分泌与糖尿病医学研究所 | 一种舌底刺血给药治疗心脑血管疾病的中药药物 |
| CN101804108B (zh) * | 2009-09-25 | 2012-05-16 | 孙红梅 | 一种治疗神经性头痛的中药组合物 |
| LT2937094T (lt) * | 2012-12-21 | 2018-06-11 | Tasly Pharmaceutical Group Co., Ltd. | Farmacinė kompozicija, skirta galvos skausmo gydymui, ir jos gavimo būdas |
-
1993
- 1993-01-09 CN CN93100050A patent/CN1047938C/zh not_active Expired - Lifetime
Non-Patent Citations (4)
| Title |
|---|
| 《人民军医》1990年第3期 1990.3.1 张金兰，中西医结合治疗神经血管性头痛48例 * |
| 《陕西中医》1988年9卷第7期 1988.7.1 张兆湘，祛瘀驱风汤治疗偏头痛120例 * |
| 《青海医药杂志》1986年第3期 1986.3.1 俞子彬等，中药头痛停糖浆治疗高海拔地区血管性头痛 * |
| 《青海医药杂志》1986年第3期 1986.3.1 俞子彬等，中药头痛停糖浆治疗高海拔地区血管性头痛;《人民军医》1990年第3期 1990.3.1 张金兰，中西医结合治疗神经血管性头痛48例;《陕西中医》1988年9卷第7期 1988.7.1 张兆湘，祛瘀驱风汤治疗偏头痛120例 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007022710A1 (fr) * | 2005-08-24 | 2007-03-01 | Tianjin Tasly Pharmaceutical Co. Ltd. | Compositions a base de medecine chinoise pour le traitement de cephalees, formulations et procedes de preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1073874A (zh) | 1993-07-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1047938C (zh) | 一种治疗头痛的中药 | |
| CN1151811C (zh) | 三七复方止痛合剂 | |
| CN100342891C (zh) | 一种治疗高血压的药物组合物及其制备方法 | |
| CN100406050C (zh) | 一种主要改善亚健康症状的中药制剂 | |
| CN101549105A (zh) | 一种用于治疗偏头痛的中药组合物 | |
| CN1418683A (zh) | 一种治疗乳腺增生的药物组合物及其制备方法 | |
| CN1275636C (zh) | 一种治疗风湿及类风湿的口服中药散剂和膏药制剂的制法 | |
| CN101239134B (zh) | 祛斑药物组合物 | |
| CN1500513A (zh) | 治疗头痛的中药冲剂 | |
| CN1462625A (zh) | 灵麻中药酒 | |
| CN1544038A (zh) | 一种黑发生发保健药物及制备工艺 | |
| CN1317315A (zh) | 安筋止痛制剂 | |
| CN104225507A (zh) | 一种治疗脑溢血所致的肢体麻痹和疼痛的中药 | |
| CN1907480A (zh) | 一种治疗类风湿性关节炎的汤剂药物及制备方法 | |
| CN1823925A (zh) | 一种治疗肝气不舒的新制剂 | |
| CN1530122A (zh) | 一种治疗伤痛的中药 | |
| CN1269231A (zh) | 三痹丸 | |
| CN1045893C (zh) | 一种治疗妇女子宫肌瘤的药物 | |
| CN1051933C (zh) | 一种治疗顽固性头痛的中药组合物 | |
| CN104984094A (zh) | 一种治疗缺血性眩晕症的中药组合物及其制备方法 | |
| CN101244197A (zh) | 一种治疗慢性偏正头痛的药物 | |
| CN1063949C (zh) | 一种治疗母牛不孕症的中药制剂 | |
| CN1174081A (zh) | 龙藤药酒 | |
| CN102813811A (zh) | 一种促进剖宫产术后切口愈合的外用膏剂 | |
| CN1353998A (zh) | 治疗痔疮的中药制剂 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent for invention or patent application | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: PATENTEE; FROM: NO.254 HOSPITAL, PLA TO: TIANSHILI DRUG RESEARCH AND DEVELOPMENT LTD. |
|
| CP03 | Change of name, title or address |
Address after: 300142 Tianjin City, Hebei District Huang Wei Lu No. 60 Patentee after: Angel Drug Research Development Co Ltd Address before: 300142 Tianjin Hebei District City, Huang Wei Lu five road No. 160 Patentee before: No.254 Hospital, PLA |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C53 | Correction of patent for invention or patent application | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: PATENTEE; FROM: TIANJIN CITY TIANSHILI DRUG RESEARCH AND DEVELOPMENT CO., LTD. TO: TIANJINTASY PHARMACEUTICAL GROUP CO., LTD. |
|
| CP03 | Change of name, title or address |
Address after: 300402 Beichen science and Technology Park, Tianjin Patentee after: Tianjin Tasly Pharmaceutical Group Co., Ltd. Address before: 300192 Tianjin city Torch Hotel, Huayuan Industrial Zone on the 840 Patentee before: Tianjin Angel pharmaceutical research and Development Co., Ltd. |
|
| C53 | Correction of patent for invention or patent application | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: PATENTEE; FROM: TIANJIN TASY PHARMACEUTICAL GROUP CO., LTD. TO: TIANJIN TASLY PHARMACEUTICAL CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Patentee after: Tianjin Tianshili Pharmaceutical Co., Ltd. Patentee before: Tianjin Tasly Pharmaceutical Group Co., Ltd. |
|
| PD01 | Discharge of preservation of patent |
Date of registration: 20061008 Pledge (preservation): Preservation |
|
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Tianjin Tasly Modern Chinese Medicine Resource Co., Ltd. Assignor: Tianjin Tianshili Pharmaceutical Co., Ltd. Contract record no.: 2011120000155 Denomination of invention: Traditional Chinese medicine for treating headache Granted publication date: 20000105 License type: Exclusive License Open date: 19930707 Record date: 20110824 |
|
| C56 | Change in the name or address of the patentee |
Owner name: TASLY PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER NAME: TIANJIN TASLY PHARM. CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 300402 Beichen science and Technology Park, Tianjin Patentee after: Tasly Pharmaceutical Group Co., Ltd. Address before: 300402 Beichen science and Technology Park, Tianjin Patentee before: Tianjin Tianshili Pharmaceutical Co., Ltd. |
|
| C17 | Cessation of patent right | ||
| CX01 | Expiry of patent term |
Expiration termination date: 20130109 Granted publication date: 20000105 |