RU95107703A - Ацетатцеллюлозная полупроницаемая мембрана, содержащая полое волокно, способ изготовления половолоконной полупроницаемой ацетилцеллюлозной мембраны, гемодиализатор, прибор для обработки экстракорпоральной крови - Google Patents

Ацетатцеллюлозная полупроницаемая мембрана, содержащая полое волокно, способ изготовления половолоконной полупроницаемой ацетилцеллюлозной мембраны, гемодиализатор, прибор для обработки экстракорпоральной крови

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Publication number
RU95107703A
RU95107703A RU95107703/04A RU95107703A RU95107703A RU 95107703 A RU95107703 A RU 95107703A RU 95107703/04 A RU95107703/04 A RU 95107703/04A RU 95107703 A RU95107703 A RU 95107703A RU 95107703 A RU95107703 A RU 95107703A
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RU
Russia
Prior art keywords
membranes
hollow fibers
acetate cellulose
semipermeable
membrane
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Application number
RU95107703/04A
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English (en)
Other versions
RU2108144C1 (ru
Inventor
Алтин Андэрс
Us]
Фернандес Бен
Элсен Раймонд
Русиус Кис
Сильва Лалит
Вашингтон Джордж
Original Assignee
Алтин Медикал
Алтин Медикал, Инк.
Инк. (US)
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Publication of RU95107703A publication Critical patent/RU95107703A/ru
Application granted granted Critical
Publication of RU2108144C1 publication Critical patent/RU2108144C1/ru

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/08—Polysaccharides
    • B01D71/12—Cellulose derivatives
    • B01D71/14—Esters of organic acids
    • B01D71/16—Cellulose acetate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0088—Physical treatment with compounds, e.g. swelling, coating or impregnation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/168—Sterilisation or cleaning before or after use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/168—Sterilisation or cleaning before or after use
    • A61M1/1682—Sterilisation or cleaning before or after use both machine and membrane module, i.e. also the module blood side
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/168—Sterilisation or cleaning before or after use
    • A61M1/169—Sterilisation or cleaning before or after use using chemical substances
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B01D63/022—Encapsulating hollow fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/003—Membrane bonding or sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0023—Organic membrane manufacture by inducing porosity into non porous precursor membranes
    • B01D67/0025—Organic membrane manufacture by inducing porosity into non porous precursor membranes by mechanical treatment, e.g. pore-stretching
    • B01D67/0027—Organic membrane manufacture by inducing porosity into non porous precursor membranes by mechanical treatment, e.g. pore-stretching by stretching
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0023—Organic membrane manufacture by inducing porosity into non porous precursor membranes
    • B01D67/003—Organic membrane manufacture by inducing porosity into non porous precursor membranes by selective elimination of components, e.g. by leaching
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0097—Storing or preservation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/08—Hollow fibre membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/02—Forward flushing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/04—Backflushing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/16—Use of chemical agents
    • B01D2321/168—Use of other chemical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/20—By influencing the flow
    • B01D2321/2008—By influencing the flow statically
    • B01D2321/2025—Tangential inlet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/20—Specific permeability or cut-off range
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/34—Molecular weight or degree of polymerisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/36—Hydrophilic membranes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Manufacturing & Machinery (AREA)
  • Anesthesiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Artificial Filaments (AREA)
  • External Artificial Organs (AREA)
  • Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)

Abstract

Описаны полупроницаемые мембраны для очистки водных биологических жидкостей. Эти мембраны, в частности, пригодны для очищения экстракорпоральной крови посредством гемодиализа. Мембраны, предпочтительно имеющие форму полых волокон, изготавливают из гидрофильного полимерного материала, предпочтительно ацетата целлюлозы. Мембраны имеют следующие характеристики: коэффициент ультрафильтрации K = 15 - 55 мл/ч • мм рт.ст. • м(так называемые "высокопроизводительные" мембраны), коэффициент массопередачи для мочевины K ≥38•10 см/мин и отношение K /K ≥2,5•10 . Полые волокна таких мембран, пригодных для гемодиализа, имеют диаметр внутреннего канала 175 - 210 мкм и толщину стенок 10 - 35 мкм. В соответствии с описанными методами изготовления мембран расплав, содержащий 32 - 40 мас.% ацетата целлюлозы, 5 - 10 мас.% глицерина и 50 65 мас.% полиэтиленгликоля, экструдируют, получая полые волокна; волокна охлаждают, подвергают холодной вытяжке, отмывают водой и репластифицируют раствором глицерина.

Claims (1)

  1. Описаны полупроницаемые мембраны для очистки водных биологических жидкостей. Эти мембраны, в частности, пригодны для очищения экстракорпоральной крови посредством гемодиализа. Мембраны, предпочтительно имеющие форму полых волокон, изготавливают из гидрофильного полимерного материала, предпочтительно ацетата целлюлозы. Мембраны имеют следующие характеристики: коэффициент ультрафильтрации KU F = 15 - 55 мл/ч • мм рт.ст. • м2 (так называемые "высокопроизводительные" мембраны), коэффициент массопередачи для мочевины KO V≥38•10- 3 см/мин и отношение KO V/KU F≥2,5•10- 3. Полые волокна таких мембран, пригодных для гемодиализа, имеют диаметр внутреннего канала 175 - 210 мкм и толщину стенок 10 - 35 мкм. В соответствии с описанными методами изготовления мембран расплав, содержащий 32 - 40 мас.% ацетата целлюлозы, 5 - 10 мас.% глицерина и 50 65 мас.% полиэтиленгликоля, экструдируют, получая полые волокна; волокна охлаждают, подвергают холодной вытяжке, отмывают водой и репластифицируют раствором глицерина.
RU95107703/04A 1992-11-16 1993-11-10 Ацетатцеллюлозная полупроницаемая мембрана в виде полого волокна, способ изготовления половолоконной полупроницаемой ацетатцеллюлозной мембраны, гемодиализатор и прибор для обработки экстракорпоральной крови RU2108144C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US97694992A 1992-11-16 1992-11-16
US976.949 1992-11-16
US976,949 1992-11-16
PCT/US1993/010826 WO1994011095A1 (en) 1992-11-16 1993-11-10 High flux hollow fiber membrane

Publications (2)

Publication Number Publication Date
RU95107703A true RU95107703A (ru) 1997-03-20
RU2108144C1 RU2108144C1 (ru) 1998-04-10

Family

ID=25524658

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95107703/04A RU2108144C1 (ru) 1992-11-16 1993-11-10 Ацетатцеллюлозная полупроницаемая мембрана в виде полого волокна, способ изготовления половолоконной полупроницаемой ацетатцеллюлозной мембраны, гемодиализатор и прибор для обработки экстракорпоральной крови

Country Status (17)

Country Link
US (2) US5643452A (ru)
EP (1) EP0598690B1 (ru)
JP (1) JP3392141B2 (ru)
KR (1) KR100224115B1 (ru)
CN (1) CN1041173C (ru)
AT (1) ATE168902T1 (ru)
AU (1) AU672856B2 (ru)
BR (1) BR9307461A (ru)
CA (1) CA2149418C (ru)
DE (1) DE69320000T2 (ru)
DK (1) DK0598690T3 (ru)
ES (1) ES2121980T3 (ru)
PL (1) PL173020B1 (ru)
RU (1) RU2108144C1 (ru)
SG (1) SG47875A1 (ru)
UA (1) UA29462C2 (ru)
WO (1) WO1994011095A1 (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2202969C (en) * 1996-04-19 2001-07-24 Shingo Emi Selectively permeable hollow fiber membrane and process for producing same
US6218441B1 (en) 1997-09-18 2001-04-17 Timothy B. Meluch Melt-spun polysulfone semipermeable membranes and methods for making the same
US7144505B2 (en) 1997-09-18 2006-12-05 Baxter International Inc. Melt-spun polysulfone semipermeable membranes and methods for making the same
FR2815886B1 (fr) * 2000-10-30 2002-12-06 Hospal Ind Faisceau de fibres creuses pour un appareil pour le traitement extracorporel du sang et du plasma et son procede de fabrication
US6444435B1 (en) * 2000-11-30 2002-09-03 Serim Research Corporation Test strip for determining dialysate composition
FR2817769B1 (fr) * 2000-12-08 2003-09-12 Hospal Ind Appareil pour le traitement extracorporel du sang ou du plasma comprenant une membrane semi-permeable humide et procedes de fabrication
AUPS046602A0 (en) * 2002-02-12 2002-03-07 U.S. Filter Wastewater Group, Inc. Halar membranes
KR20120059755A (ko) * 2010-12-01 2012-06-11 엘지전자 주식회사 셀룰로오스계 수지를 이용한 수처리용 중공사막의 제조방법
CN103111190B (zh) * 2013-03-05 2014-11-19 天津工业大学 一种熔融挤出法制备中空纤维膜的方法
CN104906971A (zh) * 2015-05-20 2015-09-16 苏州市贝克生物科技有限公司 一种醋酸纤维素/聚乙二醇血液透析膜及其制备方法
CN109922876B (zh) 2016-10-31 2022-06-28 东洋纺株式会社 醋酸纤维素系中空纤维膜
CN109890490B (zh) 2016-10-31 2021-10-12 东洋纺株式会社 醋酸纤维素系非对称中空纤维膜
CN114588783B (zh) * 2022-03-21 2023-08-01 山东水利建设集团有限公司 一种泵房多级反冲洗系统

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276173A (en) * 1977-07-05 1981-06-30 Cordis Dow Corp. Cellulose acetate hollow fiber and method for making same
US4543221A (en) * 1979-12-17 1985-09-24 Cd Medical, Inc. Method for making cellulose semipermeable hollow fibers
CA1272139C (en) * 1984-11-16 1990-07-31 FLUID SEPARATOR, HOLLOW FIBERS USED FOR ITS MANUFACTURE, AND PREPARATION OF SAID HOLLOW FIBERS

Also Published As

Publication number Publication date
CA2149418C (en) 2002-01-01
AU672856B2 (en) 1996-10-17
EP0598690A3 (en) 1995-02-15
KR950704026A (ko) 1995-11-17
US5736046A (en) 1998-04-07
WO1994011095A1 (en) 1994-05-26
AU5597894A (en) 1994-06-08
DE69320000D1 (de) 1998-09-03
EP0598690B1 (en) 1998-07-29
DE69320000T2 (de) 1999-04-15
BR9307461A (pt) 1999-06-01
ATE168902T1 (de) 1998-08-15
SG47875A1 (en) 1998-04-17
ES2121980T3 (es) 1998-12-16
CN1093018A (zh) 1994-10-05
CN1041173C (zh) 1998-12-16
UA29462C2 (ru) 2000-11-15
PL308999A1 (en) 1995-09-18
JP3392141B2 (ja) 2003-03-31
EP0598690A2 (en) 1994-05-25
JPH08503413A (ja) 1996-04-16
DK0598690T3 (da) 1999-04-26
RU2108144C1 (ru) 1998-04-10
US5643452A (en) 1997-07-01
PL173020B1 (pl) 1998-01-30
CA2149418A1 (en) 1994-05-26
KR100224115B1 (ko) 1999-10-15

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Effective date: 20031111