RU93053497A - Новые пептиды-агонисты и их использование - Google Patents
Новые пептиды-агонисты и их использованиеInfo
- Publication number
- RU93053497A RU93053497A RU93053497/04A RU93053497A RU93053497A RU 93053497 A RU93053497 A RU 93053497A RU 93053497/04 A RU93053497/04 A RU 93053497/04A RU 93053497 A RU93053497 A RU 93053497A RU 93053497 A RU93053497 A RU 93053497A
- Authority
- RU
- Russia
- Prior art keywords
- agonists
- new peptides
- methods
- treating
- peptides
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 206010020993 Hypoglycaemia Diseases 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 102000036849 Islet amyloid polypeptide Human genes 0.000 claims 1
- 108010041872 Islet amyloid polypeptide Proteins 0.000 claims 1
- 230000002218 hypoglycaemic Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Claims (1)
- Предложены аналоги-агонисты амилина и содержащие их фармацевтические композиции, способы лечения диабета и других состояний, связанных с недостаточностью инсулина в организме, а также способы лечения гипогликемии.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79426691A | 1991-11-19 | 1991-11-19 | |
| US07/794,266 | 1991-11-19 | ||
| US07/794266 | 1991-11-19 | ||
| PCT/US1992/009842 WO1993010146A1 (en) | 1991-11-19 | 1992-11-19 | Amylin agonist peptides and uses therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93053497A true RU93053497A (ru) | 1996-03-20 |
| RU2130463C1 RU2130463C1 (ru) | 1999-05-20 |
Family
ID=25162163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93053497A RU2130463C1 (ru) | 1991-11-19 | 1992-11-19 | Аналог-агонист амилина, его фармацевтически приемлемые соли, композиция, проявляющая свойства агониста амилина |
Country Status (17)
| Country | Link |
|---|---|
| EP (2) | EP1162207A1 (ru) |
| JP (4) | JP2902115B2 (ru) |
| AT (1) | ATE205854T1 (ru) |
| AU (1) | AU714439B2 (ru) |
| CA (1) | CA2100745C (ru) |
| CZ (1) | CZ288029B6 (ru) |
| DE (1) | DE69232064T2 (ru) |
| DK (1) | DK0567626T3 (ru) |
| ES (1) | ES2161697T3 (ru) |
| FI (1) | FI118601B (ru) |
| GR (1) | GR3036794T3 (ru) |
| HK (1) | HK1041891A1 (ru) |
| MD (1) | MD960317A (ru) |
| NO (2) | NO324405B1 (ru) |
| RU (1) | RU2130463C1 (ru) |
| SK (1) | SK88793A3 (ru) |
| WO (1) | WO1993010146A1 (ru) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU222249B1 (hu) | 1991-03-08 | 2003-05-28 | Amylin Pharmaceuticals Inc. | Eljárás amilin agonista peptidszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
| US5625032A (en) * | 1993-07-21 | 1997-04-29 | Amylin Pharmaceuticals, Inc. | Selective amylin antagonist peptides and uses therefor |
| RU2177331C2 (ru) | 1993-09-07 | 2001-12-27 | Амилин Фармасьютикалз, Инк. | Способы регулирования моторики желудочно-кишечного тракта |
| US6143718A (en) | 1995-06-07 | 2000-11-07 | Amylin Pharmaceuticals, Inc. | Treatment of Type II diabetes mellutis with amylin agonists |
| US5739106A (en) * | 1995-06-07 | 1998-04-14 | Rink; Timothy J. | Appetite regulating compositions |
| US6410511B2 (en) | 1997-01-08 | 2002-06-25 | Amylin Pharmaceuticals, Inc. | Formulations for amylin agonist peptides |
| US7312196B2 (en) | 1997-01-08 | 2007-12-25 | Amylin Pharmaceuticals, Inc. | Formulations for amylin agonist peptides |
| US7101853B2 (en) * | 1997-05-06 | 2006-09-05 | Amylin Pharmaceuticals, Inc. | Method for treating or preventing gastritis using amylin or amylin agonists |
| US7910548B2 (en) | 1997-06-06 | 2011-03-22 | Amylin Pharmaceuticals, Inc. | Methods for treating obesity |
| ES2316161T3 (es) * | 1998-01-09 | 2009-04-01 | Amylin Pharmaceuticals, Inc. | Formulaciones para peptidos agonistas de amilina con insulina. |
| GB0128583D0 (en) | 2001-11-28 | 2002-01-23 | Rsr Ltd | Detection of autoantibodies indicative of diabetes |
| AU2003278929A1 (en) | 2002-10-18 | 2004-05-13 | Amylin Pharmaceuticals, Inc. | Treatment of pancreatitis with amylin |
| AU2004222110A1 (en) * | 2003-03-18 | 2004-09-30 | Laboratoires Serono Sa | Amylin aggregation inhibitors and use thereof. |
| BRPI0518390A2 (pt) * | 2004-10-26 | 2008-11-18 | Lonza Ag | mÉtodo de sÍntese de peptÍdeo, e respectivo peptÍdeo |
| EP1814590B2 (en) | 2004-11-01 | 2013-12-11 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and related disorders |
| US8394765B2 (en) | 2004-11-01 | 2013-03-12 | Amylin Pharmaceuticals Llc | Methods of treating obesity with two different anti-obesity agents |
| EP1888094B1 (en) | 2005-03-31 | 2009-08-12 | Amylin Pharmaceuticals, Inc. | Amylin and amylin agonists for treating psychiatric diseases and disorders |
| US8168592B2 (en) | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
| EA200900392A1 (ru) | 2006-09-07 | 2010-06-30 | Никомед Гмбх | Комбинированное лечение сахарного диабета |
| WO2008097536A2 (en) | 2007-02-05 | 2008-08-14 | Amylin Pharmaceuticals, Inc. | Compositions and methods for treating psychiatric diseases and disorders |
| JP2009149684A (ja) * | 2009-03-11 | 2009-07-09 | Amylin Pharmaceut Inc | アミリン作動薬ペプチド用製剤 |
| MX2011009559A (es) | 2009-03-12 | 2012-01-12 | Nordic Bioscience As | Tratamiento de la diabetes y el sindrome metabolico. |
| AR097701A1 (es) * | 2013-09-19 | 2016-04-13 | Zealand Pharma As | Análogos de amilina |
| AU2014347668A1 (en) | 2013-11-05 | 2016-05-19 | Ben-Gurion University Of The Negev Research And Development Authority | Compounds for the treatment of diabetes and disease complications arising from same |
| CA2947587C (en) * | 2014-05-02 | 2022-10-18 | The Research Foundation For The State University Of New York | Islet amyloid polypeptides with improved solubility |
| BR112017019378A2 (pt) | 2015-03-18 | 2019-02-19 | Zealand Pharma A/S | análogos de amilina |
| TWI784968B (zh) | 2016-09-09 | 2022-12-01 | 丹麥商西蘭製藥公司 | 澱粉素類似物 |
| US11028137B2 (en) | 2017-02-01 | 2021-06-08 | The Research Foundation For The State University Of New York | Mutant islet amyloid polypeptides with improved solubility and methods for using the same |
| KR102130354B1 (ko) * | 2019-08-14 | 2020-07-06 | 엘아이지넥스원 주식회사 | 코어 제거용 이형장치 |
| EP4319798A1 (en) | 2022-05-30 | 2024-02-14 | Zealand Pharma A/S | Liquid formulations of amylin analogues |
| WO2024061919A1 (en) | 2022-09-19 | 2024-03-28 | Zealand Pharma A/S | Combination therapy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8720115D0 (en) * | 1987-08-26 | 1987-09-30 | Cooper G J S | Treatment of diabetes mellitus |
| WO1989006135A1 (en) * | 1988-01-11 | 1989-07-13 | Amylin Corporation | Treatment of type 2 diabetes mellitus |
| DK0408294T3 (da) * | 1989-07-10 | 1996-01-15 | Amylin Pharmaceuticals Inc | Anvendelse af en amylinantagonist til fremstilling af et lægemiddel til behandling af fedme og essentiel hypertension og beslægtede lidelser |
| US5234906A (en) * | 1991-01-10 | 1993-08-10 | Amylin Pharmaceuticals, Inc. | Hyperglycemic compositions |
| WO1992015317A1 (en) * | 1991-03-08 | 1992-09-17 | Amylin Pharmaceuticals, Inc. | Synthetic preparation of amylin and amylin analogues |
-
1992
- 1992-11-19 WO PCT/US1992/009842 patent/WO1993010146A1/en active IP Right Grant
- 1992-11-19 EP EP01114132A patent/EP1162207A1/en not_active Ceased
- 1992-11-19 DK DK92924442T patent/DK0567626T3/da active
- 1992-11-19 EP EP92924442A patent/EP0567626B1/en not_active Expired - Lifetime
- 1992-11-19 RU RU93053497A patent/RU2130463C1/ru active
- 1992-11-19 CA CA002100745A patent/CA2100745C/en not_active Expired - Lifetime
- 1992-11-19 DE DE69232064T patent/DE69232064T2/de not_active Expired - Lifetime
- 1992-11-19 JP JP5509441A patent/JP2902115B2/ja not_active Expired - Lifetime
- 1992-11-19 SK SK887-93A patent/SK88793A3/sk unknown
- 1992-11-19 MD MD96-0317A patent/MD960317A/ru unknown
- 1992-11-19 CZ CZ19931689A patent/CZ288029B6/cs not_active IP Right Cessation
- 1992-11-19 ES ES92924442T patent/ES2161697T3/es not_active Expired - Lifetime
- 1992-11-19 AT AT92924442T patent/ATE205854T1/de active
-
1993
- 1993-07-16 FI FI933252A patent/FI118601B/fi not_active IP Right Cessation
- 1993-07-19 NO NO19932603A patent/NO324405B1/no not_active IP Right Cessation
-
1997
- 1997-01-31 AU AU12456/97A patent/AU714439B2/en not_active Expired
-
1998
- 1998-09-30 JP JP10277573A patent/JPH11152299A/ja not_active Withdrawn
-
2001
- 2001-10-04 GR GR20010401656T patent/GR3036794T3/el unknown
-
2002
- 2002-05-02 HK HK02103291.8A patent/HK1041891A1/zh unknown
-
2003
- 2003-01-15 JP JP2003007228A patent/JP2003238594A/ja not_active Withdrawn
-
2006
- 2006-02-03 JP JP2006027334A patent/JP4018116B2/ja not_active Expired - Lifetime
-
2007
- 2007-06-25 NO NO20073265A patent/NO20073265L/no not_active Application Discontinuation
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