RU93042474A - 7-(замещенные)-9-(замещенные-глицил)-амидо-6-деметил-6-дезокситетрациклины, промежуточные соединения, способы их получения, способ лечения и композиция - Google Patents
7-(замещенные)-9-(замещенные-глицил)-амидо-6-деметил-6-дезокситетрациклины, промежуточные соединения, способы их получения, способ лечения и композицияInfo
- Publication number
- RU93042474A RU93042474A RU93042474/04A RU93042474A RU93042474A RU 93042474 A RU93042474 A RU 93042474A RU 93042474/04 A RU93042474/04 A RU 93042474/04A RU 93042474 A RU93042474 A RU 93042474A RU 93042474 A RU93042474 A RU 93042474A
- Authority
- RU
- Russia
- Prior art keywords
- substituted
- compounds
- useful
- relates
- antibiotic agents
- Prior art date
Links
- 230000003115 biocidal Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
Claims (1)
- Изобретение касается соединений, которые являются полезными в качестве антибиотических средств.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/928,589 US5328902A (en) | 1992-08-13 | 1992-08-13 | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
US07/928.589 | 1992-08-13 | ||
US07/928,589 | 1992-08-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93042474A true RU93042474A (ru) | 1996-06-20 |
RU2125986C1 RU2125986C1 (ru) | 1999-02-10 |
Family
ID=25456485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93042474A RU2125986C1 (ru) | 1992-08-13 | 1993-08-12 | 7-(замещенные)-9-(замещенные-глицил)амидо-6-деметил-6-дезокситетрациклины, промежуточные соединения, способы их получения, способ лечения и композиция |
Country Status (26)
Country | Link |
---|---|
US (5) | US5328902A (ru) |
EP (1) | EP0582788B1 (ru) |
JP (1) | JP3583449B2 (ru) |
KR (1) | KR100309539B1 (ru) |
CN (1) | CN1034216C (ru) |
AT (1) | ATE168992T1 (ru) |
AU (1) | AU674690B2 (ru) |
CA (1) | CA2103836C (ru) |
CZ (1) | CZ288152B6 (ru) |
DE (1) | DE69319976T2 (ru) |
DK (1) | DK0582788T3 (ru) |
ES (1) | ES2119831T3 (ru) |
FI (1) | FI115523B (ru) |
HK (1) | HK1009598A1 (ru) |
HU (2) | HUT64943A (ru) |
IL (3) | IL119118A (ru) |
LV (1) | LV12358B (ru) |
MX (1) | MX9304647A (ru) |
NO (1) | NO302359B1 (ru) |
NZ (1) | NZ248357A (ru) |
PH (1) | PH30007A (ru) |
PL (3) | PL174116B1 (ru) |
RU (1) | RU2125986C1 (ru) |
SG (1) | SG47559A1 (ru) |
SK (1) | SK281705B6 (ru) |
ZA (1) | ZA935894B (ru) |
Families Citing this family (67)
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USRE40183E1 (en) | 1991-10-04 | 2008-03-25 | Wyeth Holdings Corporation | 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
US5494903A (en) * | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
US5284963A (en) * | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
US5442059A (en) * | 1992-08-13 | 1995-08-15 | American Cyanamid Company | 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines |
US5371076A (en) * | 1993-04-02 | 1994-12-06 | American Cyanamid Company | 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines |
EP0745065A1 (en) * | 1994-02-17 | 1996-12-04 | Pfizer Inc. | 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics |
US5675030A (en) * | 1994-11-16 | 1997-10-07 | American Cyanamid Company | Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound |
US5843925A (en) * | 1994-12-13 | 1998-12-01 | American Cyanamid Company | Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
WO1999037307A1 (en) * | 1998-01-23 | 1999-07-29 | Trustees Of Tufts College | Pharmaceutically active compounds and methods of use thereof |
US6946118B1 (en) * | 1999-09-14 | 2005-09-20 | Orapharma, Inc. | Formulations for treating or preventing mucositis |
US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
EP2327687A3 (en) * | 1999-09-14 | 2012-08-15 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
IL151971A0 (en) * | 2000-03-31 | 2003-04-10 | Tufts College | 7-and 9-carbamate, urea, thiourea, thiocarbabamate, and heteroaryl-amino substituted tetracycline compounds |
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AU2001268475A1 (en) * | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
MXPA03000055A (es) | 2000-07-07 | 2003-07-14 | Tufts College | Compuestos de monociclina sustituidos en posicion 9.. |
HUP0301163A3 (en) * | 2000-07-07 | 2008-08-28 | Tufts College | 7-substituted tetracycline dervatives, pharmaceutical compositions containing them and their use |
US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
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EP1241160A1 (en) * | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracycline derivatives and their use as antibiotic agents |
EP2329828A1 (en) | 2001-07-13 | 2011-06-08 | Paratek Pharmaceuticals, Inc. | Tetracyclines for the treatment of ischaemia |
US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
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EP1474380A4 (en) * | 2002-01-08 | 2007-04-18 | Paratek Pharm Innc | 4-DESDIMETHYL AMINO TETRA CYCLINE COMPOUNDS |
KR101093842B1 (ko) * | 2002-03-08 | 2011-12-13 | 파라테크 파마슈티컬스, 인크. | 아미노-메틸 치환된 테트라시클린 화합물 |
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WO2004000223A2 (en) * | 2002-06-20 | 2003-12-31 | Orapharma, Inc. | Rapidly disintegrating formulations for treating or preventing mucositis |
AU2003261161B2 (en) | 2002-07-12 | 2009-09-10 | Paratek Pharmaceuticals, Inc | 3, 10, and 12a substituted tetracycline compounds |
JP4928261B2 (ja) | 2003-06-18 | 2012-05-09 | トランザイム・ファーマ・インコーポレイテッド | モチリン受容体の大環状拮抗薬 |
CN1845897A (zh) * | 2003-07-09 | 2006-10-11 | 帕拉特克药品公司 | 取代的四环素化合物 |
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UA83266C2 (en) | 2003-12-08 | 2008-06-25 | Уайет | Oxazole derivatives of tetracyclines |
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EP2284153A3 (en) | 2004-10-25 | 2012-03-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
JP2008518025A (ja) | 2004-10-25 | 2008-05-29 | パラテック ファーマシューティカルズ インコーポレイテッド | 4−アミノテトラサイクリンおよびその使用の方法 |
US7534766B2 (en) | 2004-11-05 | 2009-05-19 | Wyeth | Glucuronide metabolites and epimers thereof of tigecycline |
JP2008530023A (ja) * | 2005-02-04 | 2008-08-07 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物の11a,12−誘導体 |
AU2006214543A1 (en) * | 2005-02-15 | 2006-08-24 | Wyeth | 9-substituted tetracyclines |
AR057033A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
AR057649A1 (es) | 2005-05-27 | 2007-12-12 | Wyeth Corp | Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas |
AR057032A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos de preparacion |
AR057034A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Metodos para purificar tigeciclina |
AR057324A1 (es) * | 2005-05-27 | 2007-11-28 | Wyeth Corp | Tigeciclina y metodos para preparar 9-aminominociclina |
CA2616224A1 (en) * | 2005-07-21 | 2007-02-01 | Paratek Pharmaceuticals, Inc. | 10-substituted tetracyclines and methods of use thereof |
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PL2016045T3 (pl) * | 2006-04-24 | 2015-04-30 | Teva Pharma | Krystaliczna postać tygecykliny i sposoby jej otrzymywania |
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US8198469B2 (en) * | 2006-11-29 | 2012-06-12 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of tigecycline and processes for preparation thereof |
WO2008066908A1 (en) * | 2006-11-30 | 2008-06-05 | Teva Pharmaceutical Industries Ltd. | Processes for preparation of 9-haloacetamidominocyclines |
FR2912133B1 (fr) * | 2007-02-01 | 2009-04-24 | Univ Grenoble 1 | Nouveaux derives indoliques,leurs procedes de preparation et leurs utilisations notamment en tant qu'antibacteriens |
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ES2655911T3 (es) | 2008-08-08 | 2018-02-22 | Tetraphase Pharmaceuticals, Inc. | Compuestos de tetraciclina sustituidos con C7-fluoro |
CN102459153A (zh) | 2009-05-08 | 2012-05-16 | 四相制药公司 | 四环素类化合物 |
PL2470500T3 (pl) | 2009-08-28 | 2018-03-30 | Tetraphase Pharmaceuticals, Inc. | Związki tetracyklinowe |
CN103635456B (zh) * | 2011-07-26 | 2016-03-09 | 山东亨利医药科技有限责任公司 | 替加环素衍生物 |
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FR1430859A (ru) * | 1960-05-23 | 1966-05-25 | ||
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US3509184A (en) * | 1961-08-18 | 1970-04-28 | Pfizer & Co C | Anthracyclidine-acetic acid derivatives |
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US3829453A (en) * | 1961-08-18 | 1974-08-13 | Pfizer | Octahydroanthracene-2-aminoacetic acids and esters and mixed anhydrides thereof |
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US3341585A (en) * | 1966-05-06 | 1967-09-12 | American Cyanamid Co | Substituted 7-and/or 9-amino-6-deoxytetracyclines |
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US3345410A (en) * | 1966-12-01 | 1967-10-03 | American Cyanamid Co | Substituted 7- and/or 9-amino tetracyclines |
US3360561A (en) * | 1967-06-19 | 1967-12-26 | American Cyanamid Co | Nitration of tetracyclines |
US3518306A (en) * | 1968-02-19 | 1970-06-30 | American Cyanamid Co | 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines |
US4806529A (en) * | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
DE69232302T4 (de) * | 1991-10-04 | 2003-02-13 | American Cyanamid Co | 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline |
US5281628A (en) * | 1991-10-04 | 1994-01-25 | American Cyanamid Company | 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines |
US5284963A (en) * | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
-
1992
- 1992-08-13 US US07/928,589 patent/US5328902A/en not_active Expired - Lifetime
-
1993
- 1993-05-12 EP EP93107717A patent/EP0582788B1/en not_active Expired - Lifetime
- 1993-05-12 AT AT93107717T patent/ATE168992T1/de not_active IP Right Cessation
- 1993-05-12 DK DK93107717T patent/DK0582788T3/da active
- 1993-05-12 DE DE69319976T patent/DE69319976T2/de not_active Expired - Fee Related
- 1993-05-12 SG SG1996002832A patent/SG47559A1/en unknown
- 1993-05-12 ES ES93107717T patent/ES2119831T3/es not_active Expired - Lifetime
- 1993-07-01 CN CN93108134A patent/CN1034216C/zh not_active Expired - Fee Related
- 1993-08-02 MX MX9304647A patent/MX9304647A/es not_active IP Right Cessation
- 1993-08-05 CZ CZ19931599A patent/CZ288152B6/cs not_active IP Right Cessation
- 1993-08-09 NZ NZ248357A patent/NZ248357A/en not_active IP Right Cessation
- 1993-08-11 PH PH46666A patent/PH30007A/en unknown
- 1993-08-11 JP JP21907393A patent/JP3583449B2/ja not_active Expired - Fee Related
- 1993-08-11 CA CA002103836A patent/CA2103836C/en not_active Expired - Fee Related
- 1993-08-12 ZA ZA935894A patent/ZA935894B/xx unknown
- 1993-08-12 IL IL119118A patent/IL119118A/en not_active IP Right Cessation
- 1993-08-12 FI FI933565A patent/FI115523B/fi not_active IP Right Cessation
- 1993-08-12 AU AU44612/93A patent/AU674690B2/en not_active Ceased
- 1993-08-12 PL PL93300063A patent/PL174116B1/pl not_active IP Right Cessation
- 1993-08-12 PL PL93316752A patent/PL174115B1/pl not_active IP Right Cessation
- 1993-08-12 NO NO932869A patent/NO302359B1/no unknown
- 1993-08-12 PL PL93316753A patent/PL173904B1/pl not_active IP Right Cessation
- 1993-08-12 KR KR1019930015644A patent/KR100309539B1/ko not_active IP Right Cessation
- 1993-08-12 HU HU9302330A patent/HUT64943A/hu unknown
- 1993-08-12 IL IL106673A patent/IL106673A/xx not_active IP Right Cessation
- 1993-08-12 RU RU93042474A patent/RU2125986C1/ru not_active IP Right Cessation
- 1993-09-08 SK SK856-93A patent/SK281705B6/sk unknown
-
1994
- 1994-02-24 US US08/201,306 patent/US5401729A/en not_active Expired - Lifetime
- 1994-03-02 US US08/205,009 patent/US5380888A/en not_active Expired - Lifetime
- 1994-09-12 US US08/304,731 patent/US5466684A/en not_active Expired - Lifetime
- 1994-09-13 US US08/304,913 patent/US5495031A/en not_active Expired - Lifetime
-
1995
- 1995-06-30 HU HU95P/P00629P patent/HU211946A9/hu unknown
-
1996
- 1996-08-22 IL IL11911896A patent/IL119118A0/xx unknown
-
1998
- 1998-09-04 HK HK98110470A patent/HK1009598A1/xx not_active IP Right Cessation
-
1999
- 1999-07-26 LV LVP-99-112A patent/LV12358B/en unknown
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