RU2766086C2 - Противогрибковые сухие порошки - Google Patents

Противогрибковые сухие порошки Download PDF

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Publication number
RU2766086C2
RU2766086C2 RU2019114112A RU2019114112A RU2766086C2 RU 2766086 C2 RU2766086 C2 RU 2766086C2 RU 2019114112 A RU2019114112 A RU 2019114112A RU 2019114112 A RU2019114112 A RU 2019114112A RU 2766086 C2 RU2766086 C2 RU 2766086C2
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RU
Russia
Prior art keywords
dry powder
antifungal
itraconazole
powder according
respirable dry
Prior art date
Application number
RU2019114112A
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English (en)
Russian (ru)
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RU2019114112A3 (enExample
RU2019114112A (ru
Inventor
Джэйсон М. ПЕРРИ
Джин К. СУНГ
Дэвид Л. ХЭЙВА
Роберт Клиффорд САУНДЕРС
Хиллари С. ТРЭЙСИ
Эндрю Эммет О'КОННОР
Original Assignee
Пулматрикс Оперэйтинг Компани, Инк.
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Publication of RU2019114112A publication Critical patent/RU2019114112A/ru
Publication of RU2019114112A3 publication Critical patent/RU2019114112A3/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
RU2019114112A 2016-10-14 2017-10-13 Противогрибковые сухие порошки RU2766086C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662408376P 2016-10-14 2016-10-14
US62/408,376 2016-10-14
PCT/US2017/056497 WO2018071757A1 (en) 2016-10-14 2017-10-13 Antifungal dry powders

Publications (3)

Publication Number Publication Date
RU2019114112A RU2019114112A (ru) 2020-11-16
RU2019114112A3 RU2019114112A3 (enExample) 2021-02-12
RU2766086C2 true RU2766086C2 (ru) 2022-02-07

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Application Number Title Priority Date Filing Date
RU2019114112A RU2766086C2 (ru) 2016-10-14 2017-10-13 Противогрибковые сухие порошки

Country Status (11)

Country Link
US (3) US11116722B2 (enExample)
EP (1) EP3525759A1 (enExample)
JP (1) JP7085538B2 (enExample)
KR (1) KR102408798B1 (enExample)
CN (1) CN109996536B (enExample)
AU (1) AU2017341815B2 (enExample)
IL (1) IL265913B2 (enExample)
MX (1) MX388733B (enExample)
NZ (1) NZ752353A (enExample)
RU (1) RU2766086C2 (enExample)
WO (1) WO2018071757A1 (enExample)

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WO2019204583A1 (en) * 2018-04-18 2019-10-24 Pulmatrix Operating Company, Inc. Antifungal formulations for pulmonary administration comprising itraconazole
KR20210014629A (ko) * 2018-04-18 2021-02-09 시플라 테크놀로지스 엘엘씨 진균 감염의 치료방법
WO2021092349A1 (en) * 2019-11-08 2021-05-14 Scynexis, Inc. Lipid-based formulations of scy-078 salts
CN111658610B (zh) * 2020-07-31 2022-05-24 上海方予健康医药科技有限公司 一种供雾化器用的三氮唑类抗真菌药物的混悬液
IT202000030437A1 (it) 2020-12-10 2022-06-10 Zambon Spa Metodo per la realizzazione di una polvere inalabile comprendente voriconazolo
IT202000030443A1 (it) 2020-12-10 2022-06-10 Zambon Spa Polvere inalabile comprendente voriconazolo in forma cristallina
WO2022187222A1 (en) * 2021-03-03 2022-09-09 Pulmatrix Operating Company, Inc. Dihydroergotamine dry power formulations and methods of use
US20260158005A1 (en) * 2021-11-09 2026-06-11 Agency For Science, Technology And Research A salt-based antifungal powder platform formulation for aerosolization
US20250049717A1 (en) * 2021-12-20 2025-02-13 Pulmatrix Operating Company, Inc. Dry powder formulations of narrow spectrum kinase inhibitors
AU2023288123A1 (en) 2022-06-21 2025-01-16 Hovione Scientia Limited Crystalline pharmaceutical composition for inhalation comprising sugar and lipid composite particles and process for manufacture
WO2024040175A1 (en) 2022-08-18 2024-02-22 Pulmatrix Operating Company, Inc. Methods for treating cancer using inhaled angiogenesis inhibitor
EP4580632A2 (en) 2022-08-31 2025-07-09 Pulmatrix Operating Company, Inc. Methods of using itraconazole dry powders
EP4780464A1 (en) * 2023-09-20 2026-07-29 The Board Of Trustees Of The University Of Illinois Use of a dry powder inhaler to treat or prevent pulmonary fungal infections

Citations (4)

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WO2012030664A1 (en) * 2010-08-30 2012-03-08 Pulmatrix, Inc. Dry powder formulations and methods for treating pulmonary diseases
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CN104398497A (zh) * 2014-10-29 2015-03-11 中山大学 伊曲康唑吸入粉雾剂及其制备方法

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WO2012030664A1 (en) * 2010-08-30 2012-03-08 Pulmatrix, Inc. Dry powder formulations and methods for treating pulmonary diseases
EA201400679A1 (ru) * 2011-12-09 2014-10-30 Лаборатуар Смб Са Композиция сухого порошка производного азола для ингаляции
CN104398497A (zh) * 2014-10-29 2015-03-11 中山大学 伊曲康唑吸入粉雾剂及其制备方法

Also Published As

Publication number Publication date
RU2019114112A3 (enExample) 2021-02-12
MX2019004322A (es) 2019-12-11
KR20190068591A (ko) 2019-06-18
IL265913B1 (en) 2024-03-01
KR102408798B1 (ko) 2022-06-13
CA3039485A1 (en) 2018-04-19
US20250221928A1 (en) 2025-07-10
CN109996536A (zh) 2019-07-09
AU2017341815A1 (en) 2019-05-02
AU2017341815B2 (en) 2023-06-15
IL265913B2 (en) 2024-07-01
JP7085538B2 (ja) 2022-06-16
NZ752353A (en) 2023-06-30
WO2018071757A1 (en) 2018-04-19
EP3525759A1 (en) 2019-08-21
US11116722B2 (en) 2021-09-14
US20240285523A1 (en) 2024-08-29
JP2019534270A (ja) 2019-11-28
MX388733B (es) 2025-03-20
US20200129428A1 (en) 2020-04-30
CN109996536B (zh) 2023-03-07
RU2019114112A (ru) 2020-11-16
IL265913A (en) 2019-06-30
BR112019007459A2 (pt) 2019-07-16

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