RU2765231C2 - Мягкие жевательные фармацевтические продукты - Google Patents

Мягкие жевательные фармацевтические продукты Download PDF

Info

Publication number
RU2765231C2
RU2765231C2 RU2017133665A RU2017133665A RU2765231C2 RU 2765231 C2 RU2765231 C2 RU 2765231C2 RU 2017133665 A RU2017133665 A RU 2017133665A RU 2017133665 A RU2017133665 A RU 2017133665A RU 2765231 C2 RU2765231 C2 RU 2765231C2
Authority
RU
Russia
Prior art keywords
trifluoromethyl
methyl
product
dichlorophenyl
soft
Prior art date
Application number
RU2017133665A
Other languages
English (en)
Russian (ru)
Other versions
RU2017133665A (ru
RU2017133665A3 (enExample
Inventor
Зузи АЛЬТЕХЕЛЬД
Штефан ФУКС
Карина ХАНГ
Юрген ЛУТЦ
Original Assignee
Интервет Интернэшнл Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49300034&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2765231(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Интервет Интернэшнл Б.В. filed Critical Интервет Интернэшнл Б.В.
Publication of RU2017133665A publication Critical patent/RU2017133665A/ru
Publication of RU2017133665A3 publication Critical patent/RU2017133665A3/ru
Application granted granted Critical
Publication of RU2765231C2 publication Critical patent/RU2765231C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Botany (AREA)
  • Mechanical Engineering (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
RU2017133665A 2012-04-04 2013-04-03 Мягкие жевательные фармацевтические продукты RU2765231C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP12163198 2012-04-04
EP12163198.0 2012-04-04
US201361782434P 2013-03-14 2013-03-14
US61/782,434 2013-03-14

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2014144001A Division RU2632965C2 (ru) 2012-04-04 2013-04-03 Мягкие жевательные фармацевтические продукты

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2022101135A Division RU2022101135A (ru) 2012-04-04 2022-01-19 Мягкие жевательные фармацевтические продукты

Publications (3)

Publication Number Publication Date
RU2017133665A RU2017133665A (ru) 2019-02-07
RU2017133665A3 RU2017133665A3 (enExample) 2021-01-25
RU2765231C2 true RU2765231C2 (ru) 2022-01-26

Family

ID=49300034

Family Applications (3)

Application Number Title Priority Date Filing Date
RU2014144001A RU2632965C2 (ru) 2012-04-04 2013-04-03 Мягкие жевательные фармацевтические продукты
RU2017133665A RU2765231C2 (ru) 2012-04-04 2013-04-03 Мягкие жевательные фармацевтические продукты
RU2014144360A RU2646483C2 (ru) 2012-04-04 2013-04-03 Твердые фармацевтические композиции для перорального введения на основе изоксазолиновых соединений

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RU2014144001A RU2632965C2 (ru) 2012-04-04 2013-04-03 Мягкие жевательные фармацевтические продукты

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2014144360A RU2646483C2 (ru) 2012-04-04 2013-04-03 Твердые фармацевтические композиции для перорального введения на основе изоксазолиновых соединений

Country Status (14)

Country Link
US (15) US9770440B2 (enExample)
EP (2) EP2833866B2 (enExample)
JP (2) JP6088637B2 (enExample)
KR (1) KR102077874B1 (enExample)
CN (4) CN104334159A (enExample)
AU (7) AU2013245008B2 (enExample)
BR (3) BR122022008957B1 (enExample)
CA (2) CA2868381C (enExample)
ES (1) ES2633611T5 (enExample)
FI (1) FI2833866T4 (enExample)
NZ (1) NZ631100A (enExample)
RU (3) RU2632965C2 (enExample)
WO (2) WO2013150055A1 (enExample)
ZA (2) ZA201406968B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2847348C1 (ru) * 2024-04-27 2025-10-03 Общество С Ограниченной Ответственностью "Научно-Исследовательский Центр "Фарматол" Противопаразитарное средство для лечения и профилактики эктопаразитозов собак.

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201404595TA (en) 2012-02-06 2014-09-26 Merial Ltd Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof
WO2013150055A1 (en) 2012-04-04 2013-10-10 Intervet International B.V. Solid oral pharmaceutical compositions for isoxazoline compounds
US9532946B2 (en) 2012-11-20 2017-01-03 Intervet Inc. Manufacturing of semi-plastic pharmaceutical dosage units
RU2673723C1 (ru) * 2013-12-10 2018-11-29 Интервет Интернэшнл Б.В. Применение содержащих изоксазолин соединений в качестве противопаразитарных средств
MX376210B (es) 2013-12-20 2025-03-07 Intervet Int Bv Uso de derivados de isoxazolina para el tratamiento o prevención de infestaciones por artrópodos en aves de corral.
JP6581586B2 (ja) 2013-12-20 2019-09-25 インターベット インターナショナル ベー． フェー． イソオキサゾリン組成物および動物における寄生虫侵襲の予防または処置におけるその使用
EP3215120A1 (en) * 2014-11-03 2017-09-13 Zoetis Services LLC Palatable chewable veterinary composition
PL3236960T3 (pl) 2014-12-22 2025-07-07 Intervet International B.V. Fluralaner do zastosowania w leczeniu demodekozy
UY36570A (es) 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
AU2017347886A1 (en) * 2016-10-31 2019-06-20 The Scripps Research Institute Methods and compositions for preventing vector-borne disease transmission
CA3049952A1 (en) 2017-07-26 2019-01-31 Tgx Soft Chew, Llc Starch-free soft chew for veterinary applications
AR113997A1 (es) 2017-12-21 2020-07-08 Intervet Int Bv Composiciones antiparasitarias para unción dorsal continua
MX2021002606A (es) * 2018-09-05 2021-05-12 Zoetis Services Llc Formulaciones antiparasitarias agradables al paladar.
BR112021021649A2 (pt) * 2019-05-03 2021-12-21 Intervet Int Bv Composições farmacêuticas injetáveis e usos das mesmas
BR112022000982A2 (pt) * 2019-07-22 2022-03-08 Intervet Int Bv Forma de dosagem veterinária mastigável macia
WO2021122513A1 (en) * 2019-12-16 2021-06-24 Intervet International B.V. Composition for lice control
EP4077286A1 (en) 2019-12-18 2022-10-26 Elanco Tiergesundheit AG Isoxazoline derivatives as pesticides
WO2022020585A1 (en) 2020-07-24 2022-01-27 Elanco Us Inc. Process for making an isoxazoline compound and intermediate thereof
CA3191671A1 (en) * 2020-09-04 2022-03-10 Elanco Us Inc. Palatable formulations
AU2022232440A1 (en) * 2021-03-11 2023-09-21 In The Bowl Animal Health, Inc. Oral canine feed and methods for controlling tick infestations in a canine
CN117412673A (zh) * 2021-03-11 2024-01-16 碗中动物健康公司 犬科动物口服饲料和在犬科动物中控制蚤侵袭的方法
WO2022271961A1 (en) * 2021-06-25 2022-12-29 In The Bowl Animal Health, Inc. Oral feline feed and methods for controlling tick infestations in a feline
CA3224225A1 (en) * 2021-06-25 2022-12-29 In The Bowl Animal Health, Inc. Oral feline feed and methods for controlling flea infestations in a feline
CN113476419A (zh) * 2021-08-17 2021-10-08 江苏恒丰强生物技术有限公司 一种宠物用氟雷拉纳咀嚼片及其制备方法
EP4429475A4 (en) * 2021-11-11 2025-04-16 Nutramax Laboratories, Inc. SOFT CHEW
WO2023198476A1 (en) 2022-04-15 2023-10-19 Krka, D.D., Novo Mesto Soft chewable veterinary dosage form
CN117122571A (zh) * 2022-05-20 2023-11-28 天津瑞普生物技术股份有限公司 一种抗寄生虫感染的口服药物制剂及其制备方法和应用
FR3138315A1 (fr) 2022-07-27 2024-02-02 Virbac Produit à usage vétérinaire et procédé pour sa fabrication
AU2024240033A1 (en) * 2023-03-17 2025-09-11 Bimini, Llc Gastrointestinal health supplements
PE20251232A1 (es) * 2023-12-21 2025-04-29 Agrovet Market S A Composicion oral en forma de gel bioadhesivo a base de isoxazolina
CN119174733B (zh) * 2024-11-22 2025-03-25 济南广盛源生物科技有限公司 一种氟雷拉纳咀嚼片及其制备方法和用途
CN120346171A (zh) * 2025-03-13 2025-07-22 湖南尚成生物科技有限公司 一种弗雷拉纳咀嚼片及其制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001037667A1 (en) * 1999-11-25 2001-05-31 Novartis Ag Combination of n-phenyl-n'-benzoyl urea derivative and nectin compounds for parasite control
WO2007079162A1 (en) * 2005-12-30 2007-07-12 E. I. Du Pont De Nemours And Company Isoxazolines for controlling invertebrate pests
CN101190223A (zh) * 2006-11-29 2008-06-04 天津市润拓生物技术有限公司 一种犬猫用双羟萘酸噻嘧啶咀嚼片
US20080293645A1 (en) * 2007-05-25 2008-11-27 Schneider Lawrence F Antiparasitic combination and method for treating domestic animals
WO2009024541A2 (en) * 2007-08-17 2009-02-26 Intervet International B.V. Isoxazoline compositions and their use as antiparasitics
RU2356534C2 (ru) * 2003-07-30 2009-05-27 Новартис Аг Привлекательная эластичная жевательная ветеринарная композиция
WO2009080250A2 (en) * 2007-12-24 2009-07-02 Syngenta Participations Ag Insecticidal compounds
WO2010070068A2 (en) * 2008-12-19 2010-06-24 Novartis Ag Organic compounds

Family Cites Families (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB819681A (en) * 1957-01-24 1959-09-09 Wellcome Found Improvements in and relating to quaternary ammonium compounds and the preparation thereof
US3486186A (en) 1967-05-08 1969-12-30 Hollymatic Corp Molding apparatus
US3887964A (en) 1972-01-24 1975-06-10 Formax Inc Food patty molding machine
US3952478A (en) 1974-10-10 1976-04-27 Formax, Inc. Vacuum sheet applicator
US4054967A (en) 1975-10-20 1977-10-25 Formax, Inc. Food patty molding machine
US4284652A (en) 1977-01-24 1981-08-18 The Quaker Oats Company Matrix, product therewith, and process
US4182003A (en) 1978-02-28 1980-01-08 Formax, Inc. Food patty molding machine
US4338702A (en) 1979-03-29 1982-07-13 Holly Harry H Apparatus for making a ground food patty
US4334339A (en) 1980-05-12 1982-06-15 Hollymatic Corporation Mold device with movable compression insert
US4356595A (en) 1980-11-07 1982-11-02 Formax, Inc. Method and apparatus for molding food patties
US4327076A (en) 1980-11-17 1982-04-27 Life Savers, Inc. Compressed chewable antacid tablet and method for forming same
US4343068A (en) 1981-01-19 1982-08-10 Holly James A Method and apparatus for unidirectional formation of a plug-formed patty with cleanout feature
US4372008A (en) 1981-04-23 1983-02-08 Formax, Inc. Food patty molding machine with multi-orifice fill passage and stripper plate
US4393085A (en) 1981-08-13 1983-07-12 General Foods Corporation Enzyme digestion for a dog food of improved palatability
IE53474B1 (en) 1981-09-17 1988-11-23 Warner Lambert Co A chewable comestible product and process for its production
CH657506A5 (de) 1981-12-10 1986-09-15 Hollymatic Ag Portioniermaschine zum fuellen von hohlraeumen mit verformbarem material und verwendung derselben.
US4535505A (en) 1982-11-23 1985-08-20 Holly Systems, Inc. Method and apparatus for forming a patty to accommodate tissue fiber flow
US4608731A (en) 1983-01-11 1986-09-02 Holly Systems, Inc. Food patty with improved void structure, shape, and strength and method and apparatus for forming said patty
US4609543A (en) 1983-11-14 1986-09-02 Nabisco Brands, Inc. Soft homogeneous antacid tablet
US4597135A (en) 1984-02-21 1986-07-01 Holly Systems, Inc. Food patty forming method and apparatus employing two or more agitator bars
DE3406497A1 (de) 1984-02-23 1985-09-05 Mueller Bernhard Willi Werner Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
US4768941A (en) 1986-06-16 1988-09-06 Hollymatic Corporation Food patty and machine and method for making thereof
US4697308A (en) 1986-10-29 1987-10-06 Formax, Inc. Patty molding mechanism for whole fiber food product
DE3636882C1 (de) 1986-10-30 1988-05-19 Schreiber Berthold Vorrichtung zur feinblasigen Einleitung eines Gases in eine Fluessigkeit
US4714620A (en) 1986-12-12 1987-12-22 Warner-Lambert Company Soft, sugarless aerated confectionery composition
US4780931A (en) 1987-02-13 1988-11-01 Marlen Research Corporation Feeding device for patty forming machine
US4821376A (en) 1988-06-02 1989-04-18 Formax, Inc. Seal-off for food patty molding machine with multi-orifice fill passage and stripper plate
US4997671A (en) 1988-09-09 1991-03-05 Nabisco Brands, Inc. Chewy dog snacks
US4872241A (en) 1988-10-31 1989-10-10 Formax, Inc. Patty molding mechanism for fibrous food product
US4935243A (en) 1988-12-19 1990-06-19 Pharmacaps, Inc. Chewable, edible soft gelatin capsule
US5021025A (en) 1989-09-12 1991-06-04 Wagner Richard C Method and machine for making food patties
US4975039A (en) 1989-09-18 1990-12-04 Dare Gary L Food molding and portioning apparatus
US4996743A (en) 1990-01-29 1991-03-05 Formax, Inc. Mold plate drive linkage
US5022888A (en) 1990-05-03 1991-06-11 Formax, Inc. Co-forming apparatus for food patty molding machine
US5262167A (en) 1990-12-20 1993-11-16 Basf Corporation Edible, non-baked low moisture cholestyramine composition
US5380535A (en) 1991-05-28 1995-01-10 Geyer; Robert P. Chewable drug-delivery compositions and methods for preparing the same
JP2575325B2 (ja) 1991-06-18 1997-01-22 サクマ製菓株式会社 キャンディ
US5439924A (en) 1991-12-23 1995-08-08 Virbac, Inc. Systemic control of parasites
TW376319B (en) 1993-04-28 1999-12-11 Janssen Pharmaceutica Nv Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine
AU690994B2 (en) 1994-05-20 1998-05-07 Elanco Animal Health Ireland Limited Chewable flubendazole tablets for companion animals
US5637313A (en) 1994-12-16 1997-06-10 Watson Laboratories, Inc. Chewable dosage forms
GB9508443D0 (en) 1995-04-26 1995-06-14 Gilbertson & Page Biscuit for working racing or sporting dogs
AUPN290395A0 (en) 1995-05-10 1995-06-01 Virbac (Australia) Pty Limited Canine anthelmintic preparation
US5578336A (en) 1995-06-07 1996-11-26 Monte; Woodrow C. Confection carrier for vitamins, enzymes, phytochemicals and ailmentary vegetable compositions and method of making
PE10898A1 (es) 1995-06-13 1998-03-20 American Home Prod Formulaciones orales de etodolac s (+)-
US5606889A (en) 1995-09-19 1997-03-04 G & H Technology, Inc. Reusable initiator for use in triggering high-load actuators
DE19628776A1 (de) 1996-07-17 1998-01-22 Bayer Ag Oral applizierbare Granulate von Hexahydropyrazinderivaten
US5730650A (en) 1996-08-29 1998-03-24 Progressive Technology Of Wisconsin, Inc. Food patty molding machine
US5655436A (en) 1996-08-29 1997-08-12 Progressive Technology Of Manitowoc, Inc. Food patty molding machine
US6086940A (en) 1996-10-25 2000-07-11 T.F.H. Publications, Inc. High starch content dog chew
US6093427A (en) 1997-09-03 2000-07-25 T.F.H.Publications, Inc. Vegetable-based dog chew
US6110521A (en) 1996-10-25 2000-08-29 T.F.H. Publications, Inc. Wheat and casein dog chew with modifiable texture
US5827565A (en) 1996-10-25 1998-10-27 T.F.H. Publications, Inc. Process for making an edible dog chew
US5753255A (en) 1997-02-11 1998-05-19 Chavkin; Leonard Chewable molded tablet containing medicinally active substances
DK1065936T3 (da) 1998-03-23 2009-11-02 Gen Mills Inc Indkapsling af bestanddele i spiselige produkter
US6093441A (en) 1998-07-15 2000-07-25 Tfh Publications, Inc. Heat modifiable peanut dog chew
US6270790B1 (en) 1998-08-18 2001-08-07 Mxneil-Ppc, Inc. Soft, convex shaped chewable tablets having reduced friability
US6387381B2 (en) 1998-09-24 2002-05-14 Ez-Med Company Semi-moist oral delivery system
US6060078A (en) 1998-09-28 2000-05-09 Sae Han Pharm Co., Ltd. Chewable tablet and process for preparation thereof
EP1129094A2 (en) * 1998-11-12 2001-09-05 Merck & Co., Inc. Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
US6159516A (en) 1999-01-08 2000-12-12 Tfh Publication, Inc. Method of molding edible starch
GB9902073D0 (en) 1999-01-29 1999-03-24 Nestle Sa Chewy confectionery product
US6500463B1 (en) 1999-10-01 2002-12-31 General Mills, Inc. Encapsulation of sensitive components into a matrix to obtain discrete shelf-stable particles
US6340672B1 (en) * 2000-02-16 2002-01-22 Phoenix Scientific, Inc. Parasiticidal formulation and a method of making this formulation
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
IT1317048B1 (it) 2000-06-23 2003-05-26 Sigma Tau Ind Farmaceuti Uso dell'acido pamoico o di un suo derivato, o di un suo analogo, perla preparazione di un medicamento per il trattamento di patologie
DE10031044A1 (de) 2000-06-26 2002-01-03 Bayer Ag Endoparasitizide Mittel zur freiwilligen oralen Aufnahme durch Tiere
AU2002242701B2 (en) 2001-01-31 2008-04-03 Bayer Intellectual Property Gmbh Herbicide-safener combination based on isoxozoline carboxylate safeners
EP1247456A3 (en) 2001-02-28 2003-12-10 Pfizer Products Inc. Palatable pharmaceutical compositions for companion animals
GB0108485D0 (en) 2001-04-04 2001-05-23 Pfizer Ltd Combination therapy
WO2003030653A2 (en) 2001-10-05 2003-04-17 Rubicon Scientific Llc Animal feeds including actives and methods of using same
WO2004014143A1 (en) * 2002-08-13 2004-02-19 Akzo Nobel Compositions and process for delivering an additive
US20040151759A1 (en) * 2002-08-16 2004-08-05 Douglas Cleverly Non-animal product containing veterinary formulations
US20040037869A1 (en) 2002-08-16 2004-02-26 Douglas Cleverly Non-animal product containing veterinary formulations
GB0219639D0 (en) 2002-08-22 2002-10-02 Prestwick Scient Capital Inc Novel piperidin-2,6-dione salts and their use for the treatment of stress-related affective disorders
US20040234579A1 (en) 2003-05-22 2004-11-25 Mark D. Finke, Inc. Dietary supplements and methods of preparing and administering dietary supplements
AU2008201605B2 (en) 2003-07-30 2010-04-29 Novartis Ag Palatable ductile chewable veterinary composition
US6987111B2 (en) 2003-08-06 2006-01-17 Alkermes Controlled Therapeutics, Ii Aripiprazole, olanzapine and haloperidol pamoate salts
WO2005016356A1 (en) 2003-08-08 2005-02-24 The Hartz Mountain Corporation Improved anthelmintic formulations
US7396819B2 (en) 2003-08-08 2008-07-08 Virbac Corporation Anthelmintic formulations
UA79571C2 (en) * 2003-12-04 2007-06-25 Basf Ag Metod for the protection of seeds from soil pests comprising
PE20051096A1 (es) 2004-02-04 2006-01-23 Novartis Ag Formas de sal de 4-(4-metilpiperazin-1-ilmetil)-n-[4-metil-3-(4-piridin-3-il)pirimidin-2-ilamino)fenil]-benzamida
JP4883296B2 (ja) 2004-03-05 2012-02-22 日産化学工業株式会社 イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
WO2005099692A1 (en) 2004-04-07 2005-10-27 Intervet International B.V Efficacious composition of a benzimidazole, an avermectin and praziquantel and related methods of use
CA2562015A1 (en) † 2004-04-09 2005-10-20 Janssen Pharmaceutica Nv Intermittent dosing regimens of apob secretion/mtp inhibitors for overweith and obese subjects
US20050234119A1 (en) 2004-04-16 2005-10-20 Soll Mark D Antiparasitical agents and methods for treating, preventing and controlling external parasites in animals
DE102004034043A1 (de) * 2004-07-13 2006-02-09 Krka Tovarna Zdravil, D.D. Feste pharmazeutische Zusammensetzung, die Mirtazapin enthält
US7348027B2 (en) * 2005-04-08 2008-03-25 Bayer Healthcare Llc Taste masked veterinary formulation
US7838532B2 (en) * 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
CA2608010A1 (en) * 2005-05-20 2006-11-23 Pfizer Limited Synergistic combinations of non-steroidal antiinflammatory drugs with alpha-delta-ligands
KR101416521B1 (ko) 2005-09-02 2014-07-16 닛산 가가쿠 고교 가부시키 가이샤 이속사졸린치환 벤즈아미드 화합물 및 유해 생물 방제제
US7955632B2 (en) 2005-12-07 2011-06-07 Bayer B.V. Process for manufacturing chewable dosage forms for drug delivery and products thereof
US20070128251A1 (en) 2005-12-07 2007-06-07 Piedmont Pharmaceuticals, Inc. Process for manufacturing chewable dosage forms for drug delivery and products thereof
US20090143410A1 (en) 2005-12-14 2009-06-04 Kanu Maganbhai Patel Isoxazolines for Controlling Invertebrate Pests
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
BRPI0707091B8 (pt) 2006-03-10 2018-02-14 Nissan Chemical Ind Ltd composto de isoxalina e benzaldoxima substituído ou um sal do mesmo; pesticida, agroquímico, endo- ou ecto-parasiticidapara mamíferos ou pássaros, inseticida e acaricida contendo como um ou mais ingredientes ativos selecionados a partir do composto de isoxalina substituído e o sal do mesmo
WO2007123855A2 (en) 2006-04-20 2007-11-01 E. I. Du Pont De Nemours And Company Pyrazolines for controlling invertebrate pests
TWI342532B (en) * 2006-07-10 2011-05-21 Himax Tech Inc Method for generating a gamma table
JP2008044880A (ja) * 2006-08-15 2008-02-28 Bayer Cropscience Ag 殺虫性イソオキサゾリン類
WO2008030469A2 (en) 2006-09-07 2008-03-13 Merial Limited Soft chewable, tablet, and long-acting injectable veterinary antibiotic formulations
US20090281059A1 (en) 2007-02-21 2009-11-12 Robert Falotico Coating for a medical device having an anti-thrombotic conjugate
JP5206993B2 (ja) 2007-03-07 2013-06-12 日産化学工業株式会社 イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
MX2009010071A (es) 2007-04-10 2009-10-16 Bayer Cropscience Ag Derivados de aril isoxazolina insecticidas.
JP2008260691A (ja) * 2007-04-10 2008-10-30 Bayer Cropscience Ag 殺虫性アリールイソオキサゾリン誘導体
MX2009011852A (es) 2007-05-03 2009-12-11 Merial Ltd Composiciones que comprenden compuestos macrolidos de alcoxieter de c-13 y compuestos de fenilpirazol.
AU2008247327B2 (en) * 2007-05-07 2013-08-22 Jurox Pty Ltd Improved dosage form and process
SI2155699T1 (sl) 2007-05-15 2015-12-31 Merial, Inc. Ariloazol-2-il cianoetilamino spojine, postopek njihove izdelave in postopek njihove uporabe
ES2445651T3 (es) 2007-06-13 2014-03-04 E. I. Du Pont De Nemours And Company Insecticidas de isoxazolina
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
LT2957284T (lt) * 2007-06-27 2018-04-10 E. I. Du Pont De Nemours And Company Kovos su gyvūnų kenkėjais būdas
JP5316808B2 (ja) 2007-06-29 2013-10-16 日産化学工業株式会社 置換イソキサゾリン又はエノンオキシム化合物および有害生物防除剤
ITCL20070039A1 (it) 2007-07-10 2009-01-11 Michele Neri Bombolo a pressione costante con tubo estrusore a proboscide e valvola dosatrice, agganciato ad una struttura su cui scorre, azionato da una fonte di pressione controllata, utilizzabile in particolare per la estrusione-lavorazione di tutte le paste:
KR20100064382A (ko) 2007-09-10 2010-06-14 닛산 가가쿠 고교 가부시키 가이샤 치환 이속사졸린 화합물 및 유해생물 방제제
ES2731881T3 (es) 2007-09-25 2019-11-19 Formulex Pharma Innovations Ltd Composiciones que comprenden compuestos activos lipófilos y método para su preparación
CN101809004B (zh) 2007-10-03 2012-12-26 杜邦公司 用于控制无脊椎害虫的萘异噁唑啉化合物
EP2317856A1 (en) 2008-07-09 2011-05-11 Basf Se Pesticidal mixtures comprising isoxazoline compounds ii
KR101608456B1 (ko) 2008-07-09 2016-04-01 닛산 가가쿠 고교 가부시키 가이샤 이속사졸린 치환 안식향산 아미드 화합물의 제조 방법
WO2010003923A1 (en) 2008-07-09 2010-01-14 Basf Se Pestcidal active mixtures comprising isoxazoline compounds i
JP2010026724A (ja) * 2008-07-17 2010-02-04 Fujitsu Ltd Ｗｅｂページ提供装置、ｗｅｂページのランキング連動方法及びそのプログラム
CA2732217A1 (en) 2008-09-04 2010-03-11 Peter Renold Insecticidal compounds
US9820977B2 (en) 2008-10-03 2017-11-21 Bayer Healthcare Llc Systemic treatment of blood-sucking and blood-consuming parasites by oral administration of a parasiticidal agent
MY153715A (en) 2008-11-14 2015-03-13 Merial Ltd Enantiomerically enriched aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof
EP2364147A2 (en) 2008-11-19 2011-09-14 Merial Limited Compositions comprising 1-arylpyrazole alone or in combination with formamidine for the treatment of parasitic infection
CN102282154B (zh) 2008-12-04 2015-07-01 梅瑞尔公司 二聚的阿佛菌素和米尔倍霉素衍生物
CA2747060A1 (en) 2008-12-18 2010-07-15 Novartis Ag Isoxazolines derivatives and their use as pesticide
JP5715065B2 (ja) * 2008-12-23 2015-05-07 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 有害動物を駆除するための置換アミジン化合物
WO2010084067A2 (en) 2009-01-22 2010-07-29 Syngenta Participations Ag Insecticidal compounds
BRPI1006543A2 (pt) 2009-04-01 2015-08-25 Basf Se "compostos de isoxazolina, composição agrícola, composição veterinária, uso de composto, método para o controle de pragas invertebradas, material de propagação de plantas e método para o tratamento, controle, prevenção ou proteção de animais contra infestação ou infecção por parasitas"
NZ584629A (en) * 2009-04-15 2010-12-24 Jurox Pty Ltd Anthelmintic formulation
WO2011011235A1 (en) 2009-07-22 2011-01-27 Temple University - Of The Commonwealth System Of Higher Education Treatment of disorders associated with g protein-coupled receptor 35 (gpr35)
TWI487486B (zh) * 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
EP2513104B1 (en) 2009-12-17 2016-03-16 Merial, Inc. Antiparasitic dihydroazole compounds and compositions comprising same
WO2011092287A1 (en) 2010-02-01 2011-08-04 Basf Se Substituted ketonic isoxazoline compounds and derivatives for combating animal pests
EP2538788A1 (en) 2010-02-25 2013-01-02 Syngenta Participations AG Pesticidal mixtures containing isoxazoline derivatives and insecticide or nematoicidal biological agent
CN102933563A (zh) 2010-04-08 2013-02-13 Ah美国42有限责任公司 作为杀虫剂和杀螨剂的取代的3,5-二苯基异噁唑啉衍生物
CN101919857B (zh) * 2010-05-05 2012-05-30 四川宝盛康药业有限公司 一种复方阿苯达唑咀嚼片及其应用和制备方法
EP2576523B1 (en) 2010-05-27 2016-01-13 E. I. du Pont de Nemours and Company Crystalline form of 4-[5 - [3 -chloro-5 -(trifluoromethyl)phenyl] -4,5 -dihydro-5 -(trifluoromethyl)-3 - isoxazolyl]-n-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1- naphthalenecarboxamide
US20130210623A1 (en) 2010-06-09 2013-08-15 Syngenta Crop Protection Llc Pesticidal mixtures including isoxazoline derivatives
US20130261069A1 (en) 2010-06-09 2013-10-03 Syngenta Crop Protection Llc Pesticidal mixtures comprising isoxazoline derivatives
US20130203591A1 (en) 2010-06-09 2013-08-08 Syngenta Crop Protection Llc Pesticidal mixtures including isoxazoline derivatives
UY33403A (es) 2010-06-17 2011-12-30 Novartis Ag Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales
DK178277B1 (da) 2010-06-18 2015-10-26 Novartis Tiergesundheit Ag Diaryloxazolinforbindelser til bekæmpelse af fiskelus
WO2012003231A1 (en) 2010-06-30 2012-01-05 Upsher-Smith Laboratories, Inc. Sustained release composition comprising an amine as active agent and a salt of a cyclic organic acid
WO2012007426A1 (en) 2010-07-13 2012-01-19 Basf Se Azoline substituted isoxazoline benzamide compounds for combating animal pests
JP2012046486A (ja) * 2010-07-30 2012-03-08 Sumitomo Chemical Co Ltd 動物外部寄生虫防除剤
EP2601190B1 (en) 2010-08-05 2018-07-04 Zoetis Services LLC Isoxazoline derivatives as antiparasitic agents
ES2793481T3 (es) 2010-09-24 2020-11-16 Zoetis Services Llc Oximas de isoxazolina como agentes antiparasitarios
MX2013003684A (es) 2010-10-12 2013-05-31 Bayer Ip Gmbh Productos masticables blandos no basados en almidon.
CN103260621B (zh) * 2010-12-27 2016-08-24 英特维特国际股份有限公司 外用局部异噁唑啉制剂
PH12014500537A1 (en) 2011-09-12 2014-04-21 Merial Inc Parasiticidal compositions comprising an isoxazoline active agent, methods and uses thereof
WO2013079407A1 (en) * 2011-11-29 2013-06-06 Novartis Ag Aryl derivatives for controlling ectoparasites
SG11201404595TA (en) * 2012-02-06 2014-09-26 Merial Ltd Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof
WO2013150055A1 (en) * 2012-04-04 2013-10-10 Intervet International B.V. Solid oral pharmaceutical compositions for isoxazoline compounds
US9532946B2 (en) 2012-11-20 2017-01-03 Intervet Inc. Manufacturing of semi-plastic pharmaceutical dosage units

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001037667A1 (en) * 1999-11-25 2001-05-31 Novartis Ag Combination of n-phenyl-n'-benzoyl urea derivative and nectin compounds for parasite control
RU2356534C2 (ru) * 2003-07-30 2009-05-27 Новартис Аг Привлекательная эластичная жевательная ветеринарная композиция
WO2007079162A1 (en) * 2005-12-30 2007-07-12 E. I. Du Pont De Nemours And Company Isoxazolines for controlling invertebrate pests
CN101190223A (zh) * 2006-11-29 2008-06-04 天津市润拓生物技术有限公司 一种犬猫用双羟萘酸噻嘧啶咀嚼片
US20080293645A1 (en) * 2007-05-25 2008-11-27 Schneider Lawrence F Antiparasitic combination and method for treating domestic animals
WO2009024541A2 (en) * 2007-08-17 2009-02-26 Intervet International B.V. Isoxazoline compositions and their use as antiparasitics
WO2009080250A2 (en) * 2007-12-24 2009-07-02 Syngenta Participations Ag Insecticidal compounds
WO2010070068A2 (en) * 2008-12-19 2010-06-24 Novartis Ag Organic compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2847348C1 (ru) * 2024-04-27 2025-10-03 Общество С Ограниченной Ответственностью "Научно-Исследовательский Центр "Фарматол" Противопаразитарное средство для лечения и профилактики эктопаразитозов собак.

Also Published As

Publication number Publication date
US20210177749A1 (en) 2021-06-17
US20150057321A1 (en) 2015-02-26
CN109010296A (zh) 2018-12-18
CA2868381C (en) 2020-07-07
EP2833866B1 (en) 2018-11-21
AU2013245008A1 (en) 2014-10-16
US20170266165A1 (en) 2017-09-21
JP2015512435A (ja) 2015-04-27
ES2633611T5 (es) 2023-09-26
CN108685894B (zh) 2022-04-26
US20190201332A1 (en) 2019-07-04
RU2014144360A (ru) 2016-05-27
US12396945B2 (en) 2025-08-26
RU2017133665A (ru) 2019-02-07
AU2013245011A1 (en) 2014-10-23
NZ631100A (en) 2016-06-24
JP6148724B2 (ja) 2017-06-14
BR112014024832A2 (enExample) 2017-06-20
KR20140141633A (ko) 2014-12-10
US20170172986A1 (en) 2017-06-22
JP2015514103A (ja) 2015-05-18
CA2869242A1 (en) 2013-10-10
FI2833866T4 (fi) 2025-01-31
US20170172918A1 (en) 2017-06-22
JP6088637B2 (ja) 2017-03-01
EP2833866A1 (en) 2015-02-11
US11285101B2 (en) 2022-03-29
RU2017133665A3 (enExample) 2021-01-25
BR122022008957B1 (pt) 2023-02-07
CN104334159A (zh) 2015-02-04
US20170290766A1 (en) 2017-10-12
AU2019213359A1 (en) 2019-08-29
AU2017204246A1 (en) 2017-07-13
US20150057239A1 (en) 2015-02-26
US11712416B2 (en) 2023-08-01
ES2633611T3 (es) 2017-09-22
US20230320981A1 (en) 2023-10-12
ZA201406968B (en) 2015-06-24
RU2632965C2 (ru) 2017-10-11
EP2833867B1 (en) 2017-05-17
AU2017268487A1 (en) 2017-12-14
RU2014144001A (ru) 2016-05-27
AU2019246812A1 (en) 2019-10-31
US20170100377A1 (en) 2017-04-13
BR112014024833A8 (pt) 2022-08-09
US11337917B2 (en) 2022-05-24
WO2013150055A1 (en) 2013-10-10
US20190117565A1 (en) 2019-04-25
WO2013150052A1 (en) 2013-10-10
EP2833867A1 (en) 2015-02-11
CA2869242C (en) 2020-04-14
EP2833867B2 (en) 2023-05-10
BR112014024832B1 (pt) 2022-05-31
BR112014024833A2 (enExample) 2017-06-20
US20200000718A1 (en) 2020-01-02
ZA201608614B (en) 2023-11-29
BR112014024833B1 (pt) 2022-10-04
CA2868381A1 (en) 2013-10-10
US20170105972A1 (en) 2017-04-20
RU2646483C2 (ru) 2018-03-05
US20190117564A1 (en) 2019-04-25
KR102077874B1 (ko) 2020-02-14
US20220142984A1 (en) 2022-05-12
AU2013245008B2 (en) 2017-03-30
EP2833866B2 (en) 2024-11-27
CN108685894A (zh) 2018-10-23
AU2021266292B2 (en) 2025-02-06
CN104203214B (zh) 2018-05-25
AU2013245011B2 (en) 2017-11-23
AU2021266292A1 (en) 2021-12-09
AU2019246812B2 (en) 2021-08-12
US9770440B2 (en) 2017-09-26
CN104203214A (zh) 2014-12-10

Similar Documents

Publication Publication Date Title
RU2765231C2 (ru) Мягкие жевательные фармацевтические продукты
JP6408476B2 (ja) 半可塑性医薬投与単位の製造
DK2833866T3 (en) SOFT PHARMACEUTICAL CHAVE PRODUCTS