RU2753869C2 - Способы повышения эффективности вакцины путем введения антагониста il-4r - Google Patents
Способы повышения эффективности вакцины путем введения антагониста il-4r Download PDFInfo
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- RU2753869C2 RU2753869C2 RU2018133011A RU2018133011A RU2753869C2 RU 2753869 C2 RU2753869 C2 RU 2753869C2 RU 2018133011 A RU2018133011 A RU 2018133011A RU 2018133011 A RU2018133011 A RU 2018133011A RU 2753869 C2 RU2753869 C2 RU 2753869C2
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662297257P | 2016-02-19 | 2016-02-19 | |
| US62/297,257 | 2016-02-19 | ||
| US201662409936P | 2016-10-19 | 2016-10-19 | |
| US62/409,936 | 2016-10-19 | ||
| PCT/US2017/018487 WO2017143270A1 (en) | 2016-02-19 | 2017-02-17 | Methods for enhancing efficacy of a vaccine by administering an il-4r antagonist |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018133011A RU2018133011A (ru) | 2020-03-19 |
| RU2018133011A3 RU2018133011A3 (cg-RX-API-DMAC10.html) | 2020-05-26 |
| RU2753869C2 true RU2753869C2 (ru) | 2021-08-24 |
Family
ID=58192407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018133011A RU2753869C2 (ru) | 2016-02-19 | 2017-02-17 | Способы повышения эффективности вакцины путем введения антагониста il-4r |
Country Status (17)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| KR102502640B1 (ko) | 2012-08-21 | 2023-02-23 | 사노피 바이오테크놀로지 | Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법 |
| CN118286417A (zh) | 2012-09-07 | 2024-07-05 | 瑞泽恩制药公司 | 以il-4r拮抗剂治疗特应性皮炎的方法 |
| TWI755763B (zh) | 2013-06-04 | 2022-02-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| IL315136A (en) | 2014-02-21 | 2024-10-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4rantagonist |
| PT3110848T (pt) | 2014-09-24 | 2024-03-05 | Regeneron Pharma | Métodos para tratamento de infeção cutânea por administração de um antagonista do il-4r |
| CA3246946A1 (en) | 2014-11-14 | 2025-11-29 | Sanofi Biotechnology | Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist |
| EP3454878A4 (en) * | 2016-05-10 | 2020-07-29 | Hennepin Healthcare Research Institute | CYTOKINE IMMUNOMODULATORS AND SIGNALING METHODS |
| KR102872485B1 (ko) * | 2016-09-01 | 2025-10-20 | 리제너론 파아마슈티컬스, 인크. | Il-4r 길항제를 투여함에 의해 알레르기를 예방하거나 치료하기 위한 방법 |
| WO2019028367A1 (en) | 2017-08-04 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES |
| PT3515465T (pt) | 2017-08-18 | 2024-03-04 | Regeneron Pharma | Métodos para o tratamento de uma dermatite atópica grave mediante a administração de um inibidor de il-4r |
| US11034768B2 (en) | 2017-10-30 | 2021-06-15 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an IL-4R antagonist |
| MX2020012064A (es) | 2018-05-13 | 2021-04-13 | Regeneron Pharma | Metodos para tratar la dermatitis atopica administrando un inhibidor de il-4r. |
| WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
| MA55204A (fr) * | 2019-03-06 | 2022-01-12 | Regeneron Pharma | Inhibiteurs de la voie il-4/il-13 pour une efficacité améliorée dans le traitement du cancer |
| KR20210143246A (ko) | 2019-03-21 | 2021-11-26 | 리제너론 파아마슈티컬스, 인크. | 알레르기 치료용 il-4/il-13 경로 억제제 및 형질 세포 절제의 병용 |
| KR20220034878A (ko) | 2019-07-16 | 2022-03-18 | 사노피 바이오테크놀로지 | Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법 |
| US11504426B2 (en) | 2019-08-05 | 2022-11-22 | Regeneron Pharmaceuticals, Inc. | Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist |
| JP7736667B2 (ja) | 2019-08-05 | 2025-09-09 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｉｌ－４ｒアンタゴニストを投与することによるアトピー性皮膚炎の治療方法 |
| EP3992974A1 (en) | 2020-11-02 | 2022-05-04 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
| CA3161037A1 (en) | 2019-12-09 | 2021-06-17 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
| KR20220158821A (ko) * | 2020-03-27 | 2022-12-01 | 리제너론 파아마슈티컬스, 인크. | Il-4r 길항제를 투여함에 의해 아토피 피부염을 치료하기 위한 방법 |
| WO2023004420A1 (en) * | 2021-07-22 | 2023-01-26 | Icahn School Of Medicine At Mount Sinai | Dual-blockade of il-4 signaling and immune checkpoint proteins for treating cancer |
| US20230167171A1 (en) * | 2021-08-23 | 2023-06-01 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| CN118717989A (zh) * | 2024-05-27 | 2024-10-01 | 中国人民解放军军事科学院军事医学研究院 | Il-4r拮抗剂在制备预防和/或治疗流感病毒感染的药物中的应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010120511A2 (en) * | 2009-03-31 | 2010-10-21 | Altair Therapeutics, Inc. | Method of treating respiratory disorders |
| WO2013181696A1 (en) * | 2012-06-05 | 2013-12-12 | The Australian National University | Vaccination with interleukin-4 antagonists |
| WO2014039461A1 (en) * | 2012-09-07 | 2014-03-13 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| WO2014197470A1 (en) * | 2013-06-04 | 2014-12-11 | Regeneron Pharmaceuticals, Inc. | Mehods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r inhibitor |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2990420T (pt) | 2000-05-26 | 2017-03-16 | Immunex Corp | Uso de anticorpos de recetor de interleucina-4 e composições dos mesmos |
| AU2002360278A1 (en) | 2001-10-12 | 2003-11-11 | Coley Pharmaceutical Gmbh | Methods and products for enhancing immune responses using imidazoquinoline compounds |
| GB0217920D0 (en) * | 2002-04-23 | 2002-09-11 | Aventis Pharm Prod Inc | Interleukin-4 Gene Expression inhibitors |
| UA93653C2 (ru) | 2003-11-07 | 2011-03-10 | Иммунекс Корпорейшн | Выделенное антитело, kotopoe специфически связывается c человеческим рецептором il-4 (il-4r) |
| US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| CA2664343C (en) | 2006-10-02 | 2016-04-26 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human il-4 receptor |
| US8092804B2 (en) | 2007-12-21 | 2012-01-10 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4Rα)-173 |
| MX2010006735A (es) | 2007-12-21 | 2010-09-30 | Medimmune Ltd | Miembros de union para receptor alfa de interleucina-4 (il-4ra) - 173. |
| MX366337B (es) | 2010-10-06 | 2019-07-05 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-receptor de interleucina-4 (il-4r). |
| RS59354B1 (sr) * | 2013-06-21 | 2019-10-31 | Sanofi Biotechnology | Postupci lečenja nosne polipoze davanjem il-4r antagonista |
| KR20190062142A (ko) * | 2017-11-28 | 2019-06-05 | (주)비티엔 | 면역 증강 활성을 가지는 아미노산 미네랄 복합체 및 이를 포함하는 식품, 약학 또는 사료용 조성물 |
| US20210361700A1 (en) * | 2020-05-22 | 2021-11-25 | Trustees Of Tufts College | Nutritional supplement to combat covid-19 and aid vaccination |
-
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-
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-
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-
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-
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010120511A2 (en) * | 2009-03-31 | 2010-10-21 | Altair Therapeutics, Inc. | Method of treating respiratory disorders |
| WO2013181696A1 (en) * | 2012-06-05 | 2013-12-12 | The Australian National University | Vaccination with interleukin-4 antagonists |
| WO2014039461A1 (en) * | 2012-09-07 | 2014-03-13 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| WO2014197470A1 (en) * | 2013-06-04 | 2014-12-11 | Regeneron Pharmaceuticals, Inc. | Mehods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r inhibitor |
Non-Patent Citations (4)
| Title |
|---|
| BECK L. et al. Dupilumab Treatment in Adults With Moderate-To-Severe Atopic Dermatitis // N Engl J Med, 2014 Jul 10; 371(2):130-9. * |
| RYAN et al. Booster immunization of children with an acellular pertussis vaccine enhances Th2 cytokine production and serum IgE responses against pertussis toxin but not against common allergens // Clin Exp Immunol. 2000 Aug; 121(2): 193-200. * |
| RYAN et al. Booster immunization of children with an acellular pertussis vaccine enhances Th2 cytokine production and serum IgE responses against pertussis toxin but not against common allergens // Clin Exp Immunol. 2000 Aug; 121(2): 193-200. BECK L. et al. Dupilumab Treatment in Adults With Moderate-To-Severe Atopic Dermatitis // N Engl J Med, 2014 Jul 10; 371(2):130-9. * |
| WARFEL J. et al. Acellular Pertussis Vaccines Protect Against Disease but Fail to Prevent Infection and Transmission in a Nonhuman Primate Model // Proc Natl Acad Sci USA, 2014 Jan 14; 111(2):787-92, doi: 10.1073/pnas.1314688110.Epub 2013 Nov 25. * |
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