JP7597500B2 - Il-4rアンタゴニストを投与することによるワクチンの有効性を増強する方法 - Google Patents

Il-4rアンタゴニストを投与することによるワクチンの有効性を増強する方法 Download PDF

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JP7597500B2
JP7597500B2 JP2018543637A JP2018543637A JP7597500B2 JP 7597500 B2 JP7597500 B2 JP 7597500B2 JP 2018543637 A JP2018543637 A JP 2018543637A JP 2018543637 A JP2018543637 A JP 2018543637A JP 7597500 B2 JP7597500 B2 JP 7597500B2
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amino acid
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JP2019505554A (ja
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リサ・パーセル・ンガンボ
ニール・グラハム
アンドリュー・ジェイ・マーフィー
ロバート・エヴァンス
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Regeneron Pharmaceuticals Inc
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JP2018543637A 2016-02-19 2017-02-17 Il-4rアンタゴニストを投与することによるワクチンの有効性を増強する方法 Active JP7597500B2 (ja)

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JP2022152120A JP7813209B2 (ja) 2016-02-19 2022-09-26 Il-4rアンタゴニストを投与することによるワクチンの有効性を増強する方法
JP2024087570A JP2024112987A (ja) 2016-02-19 2024-05-30 Il-4rアンタゴニストを投与することによるワクチンの有効性を増強する方法

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US201662297257P 2016-02-19 2016-02-19
US62/297,257 2016-02-19
US201662409936P 2016-10-19 2016-10-19
US62/409,936 2016-10-19
PCT/US2017/018487 WO2017143270A1 (en) 2016-02-19 2017-02-17 Methods for enhancing efficacy of a vaccine by administering an il-4r antagonist

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JP2022152120A Active JP7813209B2 (ja) 2016-02-19 2022-09-26 Il-4rアンタゴニストを投与することによるワクチンの有効性を増強する方法
JP2024087570A Abandoned JP2024112987A (ja) 2016-02-19 2024-05-30 Il-4rアンタゴニストを投与することによるワクチンの有効性を増強する方法

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JP2024087570A Abandoned JP2024112987A (ja) 2016-02-19 2024-05-30 Il-4rアンタゴニストを投与することによるワクチンの有効性を増強する方法

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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
KR102502640B1 (ko) 2012-08-21 2023-02-23 사노피 바이오테크놀로지 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법
CN118286417A (zh) 2012-09-07 2024-07-05 瑞泽恩制药公司 以il-4r拮抗剂治疗特应性皮炎的方法
TWI755763B (zh) 2013-06-04 2022-02-21 美商再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
TWI634900B (zh) 2013-07-11 2018-09-11 再生元醫藥公司 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法
IL315136A (en) 2014-02-21 2024-10-01 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4rantagonist
PT3110848T (pt) 2014-09-24 2024-03-05 Regeneron Pharma Métodos para tratamento de infeção cutânea por administração de um antagonista do il-4r
CA3246946A1 (en) 2014-11-14 2025-11-29 Sanofi Biotechnology Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist
EP3454878A4 (en) * 2016-05-10 2020-07-29 Hennepin Healthcare Research Institute CYTOKINE IMMUNOMODULATORS AND SIGNALING METHODS
KR102872485B1 (ko) * 2016-09-01 2025-10-20 리제너론 파아마슈티컬스, 인크. Il-4r 길항제를 투여함에 의해 알레르기를 예방하거나 치료하기 위한 방법
WO2019028367A1 (en) 2017-08-04 2019-02-07 Regeneron Pharmaceuticals, Inc. METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES
PT3515465T (pt) 2017-08-18 2024-03-04 Regeneron Pharma Métodos para o tratamento de uma dermatite atópica grave mediante a administração de um inibidor de il-4r
US11034768B2 (en) 2017-10-30 2021-06-15 Sanofi Biotechnology Methods for treating or preventing asthma by administering an IL-4R antagonist
MX2020012064A (es) 2018-05-13 2021-04-13 Regeneron Pharma Metodos para tratar la dermatitis atopica administrando un inhibidor de il-4r.
WO2020092015A1 (en) 2018-11-02 2020-05-07 University Of Rochester Therapeutic mitigation of epithelial infection
MA55204A (fr) * 2019-03-06 2022-01-12 Regeneron Pharma Inhibiteurs de la voie il-4/il-13 pour une efficacité améliorée dans le traitement du cancer
KR20210143246A (ko) 2019-03-21 2021-11-26 리제너론 파아마슈티컬스, 인크. 알레르기 치료용 il-4/il-13 경로 억제제 및 형질 세포 절제의 병용
KR20220034878A (ko) 2019-07-16 2022-03-18 사노피 바이오테크놀로지 Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법
US11504426B2 (en) 2019-08-05 2022-11-22 Regeneron Pharmaceuticals, Inc. Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist
JP7736667B2 (ja) 2019-08-05 2025-09-09 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Il-4rアンタゴニストを投与することによるアトピー性皮膚炎の治療方法
EP3992974A1 (en) 2020-11-02 2022-05-04 Sanofi Biotechnology Methods for treating digitally-identified il-4/il-13 related disorders
CA3161037A1 (en) 2019-12-09 2021-06-17 Sanofi Biotechnology Methods for treating digitally-identified il-4/il-13 related disorders
KR20220158821A (ko) * 2020-03-27 2022-12-01 리제너론 파아마슈티컬스, 인크. Il-4r 길항제를 투여함에 의해 아토피 피부염을 치료하기 위한 방법
WO2023004420A1 (en) * 2021-07-22 2023-01-26 Icahn School Of Medicine At Mount Sinai Dual-blockade of il-4 signaling and immune checkpoint proteins for treating cancer
US20230167171A1 (en) * 2021-08-23 2023-06-01 Regeneron Pharmaceuticals, Inc. Methods for treating atopic dermatitis by administering an il-4r antagonist
CN118717989A (zh) * 2024-05-27 2024-10-01 中国人民解放军军事科学院军事医学研究院 Il-4r拮抗剂在制备预防和/或治疗流感病毒感染的药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015534548A (ja) 2012-09-07 2015-12-03 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. Il−4rアンタゴニストを投与することによるアトピー性皮膚炎を処置するための方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2990420T (pt) 2000-05-26 2017-03-16 Immunex Corp Uso de anticorpos de recetor de interleucina-4 e composições dos mesmos
AU2002360278A1 (en) 2001-10-12 2003-11-11 Coley Pharmaceutical Gmbh Methods and products for enhancing immune responses using imidazoquinoline compounds
GB0217920D0 (en) * 2002-04-23 2002-09-11 Aventis Pharm Prod Inc Interleukin-4 Gene Expression inhibitors
UA93653C2 (ru) 2003-11-07 2011-03-10 Иммунекс Корпорейшн Выделенное антитело, kotopoe специфически связывается c человеческим рецептором il-4 (il-4r)
US7608693B2 (en) * 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
CA2664343C (en) 2006-10-02 2016-04-26 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human il-4 receptor
US8092804B2 (en) 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
MX2010006735A (es) 2007-12-21 2010-09-30 Medimmune Ltd Miembros de union para receptor alfa de interleucina-4 (il-4ra) - 173.
EP2414520A2 (en) 2009-03-31 2012-02-08 Altair Therapeutics, Inc. Methods of modulating an immune response to a viral infection
MX366337B (es) 2010-10-06 2019-07-05 Regeneron Pharma Formulaciones estabilizadas que contienen anticuerpos anti-receptor de interleucina-4 (il-4r).
HK1203358A1 (en) * 2012-06-05 2015-10-30 The Australian National University Vaccination with interleukin-4 antagonists
TWI755763B (zh) 2013-06-04 2022-02-21 美商再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
RS59354B1 (sr) * 2013-06-21 2019-10-31 Sanofi Biotechnology Postupci lečenja nosne polipoze davanjem il-4r antagonista
KR20190062142A (ko) * 2017-11-28 2019-06-05 (주)비티엔 면역 증강 활성을 가지는 아미노산 미네랄 복합체 및 이를 포함하는 식품, 약학 또는 사료용 조성물
US20210361700A1 (en) * 2020-05-22 2021-11-25 Trustees Of Tufts College Nutritional supplement to combat covid-19 and aid vaccination

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015534548A (ja) 2012-09-07 2015-12-03 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. Il−4rアンタゴニストを投与することによるアトピー性皮膚炎を処置するための方法

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