RU2752677C2 - Деструкторы белка вет - Google Patents
Деструкторы белка вет Download PDFInfo
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- RU2752677C2 RU2752677C2 RU2018139537A RU2018139537A RU2752677C2 RU 2752677 C2 RU2752677 C2 RU 2752677C2 RU 2018139537 A RU2018139537 A RU 2018139537A RU 2018139537 A RU2018139537 A RU 2018139537A RU 2752677 C2 RU2752677 C2 RU 2752677C2
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- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07K—PEPTIDES
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
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| EP3455219A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
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| CN109422751B (zh) * | 2017-09-03 | 2022-04-22 | 上海美志医药科技有限公司 | 一类具有降解酪氨酸蛋白激酶jak3活性的化合物 |
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| JP7168773B2 (ja) * | 2018-09-30 | 2022-11-09 | 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ | イソインドリン化合物、その調製方法、医薬組成物および使用 |
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| CN113453679B (zh) | 2018-12-20 | 2025-07-08 | C4医药公司 | 靶向蛋白降解 |
| CA3126009A1 (en) * | 2019-01-07 | 2020-07-16 | Dana-Farber Cancer Institute, Inc. | Small molecule degraders of fkbp12 via recruitment of von hippel-lindau e3 ubiquitin ligase (vhl) e3 ubiquitin ligase, and uses in dtag systems |
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| CN115697989B (zh) | 2020-02-26 | 2025-03-18 | 上海睿跃生物科技有限公司 | 原肌球蛋白受体激酶(trk)降解化合物和使用方法 |
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| CN113387932B (zh) * | 2020-03-14 | 2023-05-09 | 成都先导药物开发股份有限公司 | 一种诱导brd4蛋白降解的双功能化合物 |
| CN112920176B (zh) * | 2020-05-25 | 2022-11-04 | 四川大学华西医院 | 可诱导prc2蛋白复合物核心亚基降解的双功能化合物和药物组合物及应用 |
| CN116490186B (zh) | 2020-08-05 | 2025-10-31 | C4医药公司 | 用于ret的靶向降解的化合物 |
| WO2022051616A1 (en) * | 2020-09-03 | 2022-03-10 | Board Of Regents Of The University Of Nebraska | Cdk targeted heterobifunctional small molecule proteolysis targeting chimeras |
| AR125768A1 (es) | 2021-05-05 | 2023-08-09 | Biogen Ma Inc | Compuestos para la degradación dirigida de la tirosina cinasa de bruton |
| CN113336801B (zh) * | 2021-06-08 | 2023-08-22 | 中国人民解放军空军军医大学 | 含有bet抑制剂的四价铂配合物与应用 |
| EP4366834A1 (en) | 2021-07-07 | 2024-05-15 | Biogen MA Inc. | Compounds for targeting degradation of irak4 proteins |
| US20240343733A1 (en) | 2021-07-07 | 2024-10-17 | Biogen Ma Inc. | Compounds for targeting degradation of irak4 proteins |
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| AU2017250076A1 (en) | 2018-11-08 |
| JP2019511528A (ja) | 2019-04-25 |
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| EP3442976A1 (en) | 2019-02-20 |
| MX2018012379A (es) | 2019-07-04 |
| CN109311890A (zh) | 2019-02-05 |
| IL262139A (en) | 2018-11-29 |
| CN109311890B (zh) | 2021-08-31 |
| CA3020541A1 (en) | 2017-10-19 |
| AU2017250076B2 (en) | 2021-07-22 |
| BR112018070859A2 (pt) | 2019-02-05 |
| WO2017180417A1 (en) | 2017-10-19 |
| KR20180132861A (ko) | 2018-12-12 |
| ZA201806969B (en) | 2019-12-18 |
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