IL262139B - Bet protein degraders - Google Patents

Bet protein degraders

Info

Publication number
IL262139B
IL262139B IL262139A IL26213918A IL262139B IL 262139 B IL262139 B IL 262139B IL 262139 A IL262139 A IL 262139A IL 26213918 A IL26213918 A IL 26213918A IL 262139 B IL262139 B IL 262139B
Authority
IL
Israel
Prior art keywords
bet protein
protein degraders
degraders
bet
protein
Prior art date
Application number
IL262139A
Other languages
English (en)
Hebrew (he)
Other versions
IL262139A (en
Original Assignee
Univ Michigan Regents
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan Regents filed Critical Univ Michigan Regents
Publication of IL262139A publication Critical patent/IL262139A/en
Publication of IL262139B publication Critical patent/IL262139B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
IL262139A 2016-04-12 2018-10-04 Bet protein degraders IL262139B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662321499P 2016-04-12 2016-04-12
US201662393888P 2016-09-13 2016-09-13
PCT/US2017/026278 WO2017180417A1 (en) 2016-04-12 2017-04-06 Bet protein degraders

Publications (2)

Publication Number Publication Date
IL262139A IL262139A (en) 2018-11-29
IL262139B true IL262139B (en) 2021-05-31

Family

ID=58548921

Family Applications (1)

Application Number Title Priority Date Filing Date
IL262139A IL262139B (en) 2016-04-12 2018-10-04 Bet protein degraders

Country Status (15)

Country Link
US (1) US10633386B2 (cg-RX-API-DMAC7.html)
EP (1) EP3442976B1 (cg-RX-API-DMAC7.html)
JP (1) JP7072519B2 (cg-RX-API-DMAC7.html)
KR (1) KR20180132861A (cg-RX-API-DMAC7.html)
CN (1) CN109311890B (cg-RX-API-DMAC7.html)
AU (1) AU2017250076B2 (cg-RX-API-DMAC7.html)
BR (1) BR112018070859A2 (cg-RX-API-DMAC7.html)
CA (1) CA3020541A1 (cg-RX-API-DMAC7.html)
IL (1) IL262139B (cg-RX-API-DMAC7.html)
MX (1) MX384905B (cg-RX-API-DMAC7.html)
RU (1) RU2752677C2 (cg-RX-API-DMAC7.html)
SG (1) SG11201808729WA (cg-RX-API-DMAC7.html)
UA (1) UA123168C2 (cg-RX-API-DMAC7.html)
WO (1) WO2017180417A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201806969B (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
UA123168C2 (uk) 2021-02-24
US10633386B2 (en) 2020-04-28
US20190169195A1 (en) 2019-06-06
MX384905B (es) 2025-03-14
RU2018139537A3 (cg-RX-API-DMAC7.html) 2020-08-11
EP3442976B1 (en) 2022-07-20
SG11201808729WA (en) 2018-11-29
RU2018139537A (ru) 2020-05-14
AU2017250076A1 (en) 2018-11-08
JP2019511528A (ja) 2019-04-25
RU2752677C2 (ru) 2021-07-29
JP7072519B2 (ja) 2022-05-20
EP3442976A1 (en) 2019-02-20
MX2018012379A (es) 2019-07-04
CN109311890A (zh) 2019-02-05
IL262139A (en) 2018-11-29
CN109311890B (zh) 2021-08-31
CA3020541A1 (en) 2017-10-19
AU2017250076B2 (en) 2021-07-22
BR112018070859A2 (pt) 2019-02-05
WO2017180417A1 (en) 2017-10-19
KR20180132861A (ko) 2018-12-12
ZA201806969B (en) 2019-12-18

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