RU2748949C2 - Комбинация моноклональных антител агониста ох40 и агониста 4-1вв для лечения рака - Google Patents

Комбинация моноклональных антител агониста ох40 и агониста 4-1вв для лечения рака Download PDF

Info

Publication number
RU2748949C2
RU2748949C2 RU2018127164A RU2018127164A RU2748949C2 RU 2748949 C2 RU2748949 C2 RU 2748949C2 RU 2018127164 A RU2018127164 A RU 2018127164A RU 2018127164 A RU2018127164 A RU 2018127164A RU 2748949 C2 RU2748949 C2 RU 2748949C2
Authority
RU
Russia
Prior art keywords
agonist
ser
val
antibody
thr
Prior art date
Application number
RU2018127164A
Other languages
English (en)
Russian (ru)
Other versions
RU2018127164A3 (enExample
RU2018127164A (ru
Inventor
Хуа ЛУН
Арон Дэвид ТОЛЛ
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of RU2018127164A3 publication Critical patent/RU2018127164A3/ru
Publication of RU2018127164A publication Critical patent/RU2018127164A/ru
Application granted granted Critical
Publication of RU2748949C2 publication Critical patent/RU2748949C2/ru

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2018127164A 2016-01-25 2017-01-17 Комбинация моноклональных антител агониста ох40 и агониста 4-1вв для лечения рака RU2748949C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662286616P 2016-01-25 2016-01-25
US62/286,616 2016-01-25
PCT/IB2017/050244 WO2017130076A1 (en) 2016-01-25 2017-01-17 Combination of an ox40 agonist and a 4-1bb agonist monoclonal antibody for treating cancer

Publications (3)

Publication Number Publication Date
RU2018127164A3 RU2018127164A3 (enExample) 2020-02-28
RU2018127164A RU2018127164A (ru) 2020-02-28
RU2748949C2 true RU2748949C2 (ru) 2021-06-02

Family

ID=57956335

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018127164A RU2748949C2 (ru) 2016-01-25 2017-01-17 Комбинация моноклональных антител агониста ох40 и агониста 4-1вв для лечения рака

Country Status (12)

Country Link
US (1) US20190031765A1 (enExample)
EP (1) EP3408294A1 (enExample)
JP (1) JP6783312B2 (enExample)
KR (2) KR20180103150A (enExample)
CN (1) CN108473587A (enExample)
AU (2) AU2017211540B2 (enExample)
BR (1) BR112018014016A2 (enExample)
CA (1) CA2955184A1 (enExample)
HK (1) HK1259253A1 (enExample)
MX (1) MX2018008995A (enExample)
RU (1) RU2748949C2 (enExample)
WO (1) WO2017130076A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
JP7297672B2 (ja) 2017-04-13 2023-06-26 アジェナス インコーポレイテッド 抗cd137抗体およびその使用方法
CA3057748A1 (en) 2017-04-20 2018-10-25 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
WO2018229222A1 (en) 2017-06-14 2018-12-20 Adc Therapeutics Sa Dosage regimes for the administration of an anti-cd19 adc
AU2018301393B2 (en) 2017-07-11 2025-02-27 Compass Therapeutics Llc Agonist antibodies that bind human CD137 and uses thereof
WO2019089753A2 (en) 2017-10-31 2019-05-09 Compass Therapeutics Llc Cd137 antibodies and pd-1 antagonists and uses thereof
US11851497B2 (en) 2017-11-20 2023-12-26 Compass Therapeutics Llc CD137 antibodies and tumor antigen-targeting antibodies and uses thereof
CN111936507B (zh) * 2018-03-23 2022-11-01 苏州丁孚靶点生物技术有限公司 Ox40抗原多肽及其用途
EP3773720A4 (en) 2018-04-10 2022-01-05 Wuxi Biologics (Shanghai) Co. Ltd. MONOCLONAL ANTIBODIES AGAINST HUMAN 4-1BB, METHOD OF MANUFACTURING AND USING THEREOF
CN110357961B (zh) * 2018-04-10 2022-08-23 无锡智康弘义生物科技有限公司 抗人4-1bb单克隆抗体及其制备方法和用途
CN113286616A (zh) 2018-05-23 2021-08-20 Adc治疗有限公司 分子佐剂
CA3107019A1 (en) 2018-07-23 2020-01-30 Magenta Therapeutics, Inc. Use of anti-cd137 antibody drug conjugate (adc) in allogeneic cell therapy
US20220370606A1 (en) 2018-12-21 2022-11-24 Pfizer Inc. Combination Treatments Of Cancer Comprising A TLR Agonist
US10442866B1 (en) * 2019-01-23 2019-10-15 Beijing Mabworks Biotech Co. Ltd Antibodies binding OX40 and uses thereof
KR20220003572A (ko) 2019-04-24 2022-01-10 하이델베르크 파마 리서치 게엠베하 아마톡신 항체-약물 결합체 및 이의 용도
EP3976043A1 (en) * 2019-05-24 2022-04-06 Pfizer Inc. Combination therapies using cdk inhibitors
CR20220126A (es) 2019-09-25 2022-06-07 Pfizer Moduladores de sting (estimulador de genes de interferón)
GB201917254D0 (en) 2019-11-27 2020-01-08 Adc Therapeutics Sa Combination therapy
MX2022008412A (es) 2020-01-07 2022-08-08 Univ Texas Variantes de enzima que agotan metiltioadenosina/adenosina mejorada humana para terapia de cancer.
KR20220132555A (ko) 2020-01-29 2022-09-30 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 Nrg1 융합체를 사용한 암 치료를 위한 egfr/her2 티로신 키나제 억제제 및/또는 her2/her3 항체의 사용
KR20220133238A (ko) 2020-01-29 2022-10-04 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 Nrg1 융합체가 있는 암의 치료를 위한 포지오티닙의 용도
AU2021276332A1 (en) 2020-05-19 2022-11-17 Boehringer Ingelheim International Gmbh Binding molecules for the treatment of cancer
WO2022002063A1 (zh) * 2020-06-30 2022-01-06 和铂医药(上海)有限责任公司 一种4-1bb结合蛋白及其应用
CN114515335A (zh) * 2020-11-19 2022-05-20 百奥泰生物制药股份有限公司 抗ox40抗体在治疗肿瘤或癌症中的应用
GB202102396D0 (en) 2021-02-19 2021-04-07 Adc Therapeutics Sa Molecular adjuvant
US11964978B2 (en) 2021-03-18 2024-04-23 Pfizer Inc. Modulators of STING (stimulator of interferon genes)
CN117529500A (zh) * 2021-05-27 2024-02-06 柳韩洋行 Ox40激动剂及其用途
WO2023036041A1 (zh) * 2021-09-09 2023-03-16 广东东阳光药业有限公司 抗4-1bb的激动型抗体及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2010129045A (ru) * 2007-12-14 2012-01-20 Бристоль-Мейерз Сквибб Компани (US) Связывающие молекулы к рецептору ох40 человека
US20120237498A1 (en) * 2010-09-09 2012-09-20 Pfizer Inc 4-1bb binding molecules
WO2015179236A1 (en) * 2014-05-21 2015-11-26 Pfizer Inc. Combination of an anti-ccr4 antibody and a 4-1bb agonist for treating cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
PT1060247E (pt) 1998-02-24 2008-12-22 Sisters Of Providence In Orego Composições que contêm um agente de ligação ao receptor ox-40 ou um ácido nucleico que codifica para o mesmo e métodos para melhorar a resposta imunitária específica do antigénio
DE69942671D1 (de) 1998-12-01 2010-09-23 Facet Biotech Corp Humanisierte antikoerper gegen gamma-interferon
CA2588157A1 (en) 2004-11-17 2006-05-26 Board Of Regents, The University Of Texas System Cancer immunotherapy incorporating p53
EP1896030A1 (en) 2005-06-03 2008-03-12 Pfizer Products Incorporated Combinations of erbb2 inhibitors with other therapeutic agents in the treatment of cancer
WO2013002823A1 (en) 2011-06-30 2013-01-03 Michelin Recherche Et Technique S.A. Methods and apparatus for installing a tread ring upon a tire carcass
CA2863818A1 (en) 2012-02-06 2013-08-15 Brendan CURTI Cancer treatment and monitoring methods using ox40 agonists
JP2017501167A (ja) 2013-12-17 2017-01-12 ジェネンテック, インコーポレイテッド Ox40結合アゴニスト及びpd−1軸結合アンタゴニストを含む併用療法
JP6876629B2 (ja) * 2015-06-16 2021-05-26 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung Pd−l1アンタゴニスト併用療法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2010129045A (ru) * 2007-12-14 2012-01-20 Бристоль-Мейерз Сквибб Компани (US) Связывающие молекулы к рецептору ох40 человека
US20120237498A1 (en) * 2010-09-09 2012-09-20 Pfizer Inc 4-1bb binding molecules
WO2015179236A1 (en) * 2014-05-21 2015-11-26 Pfizer Inc. Combination of an anti-ccr4 antibody and a 4-1bb agonist for treating cancer

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ADLER AJ. "Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation", OncoImmunology, Vol. 2(1), p. e22837, 2013. *
ADLER AJ. "Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation", OncoImmunology, Vol. 2(1), p. e22837, 2013. QUI HZ et al. "CD134 Plus CD137 Dual Costimulation Induces Eomesodermin in CD4 T Cells to Program Cytotoxic Th1 Differentiation", J Immunol, 2011, Vol. 187(7), pp. 3555-3564. GRAY JC. "Optimising anti-tumour CD8 T-cell responses using combinations of immunomodulatory antibodies", Eur. J. Immunol, 2008, Vol. 38, pp. 2499-2511. LEE SJ et al. "4-1BB and OX40 Dual Costimulation Synergistically Stimulate Primary Specific CD8 T Cells for Robust Effector Function", J Immunol, 2004, Vol. 173, pp. 3002-3012. *
GRAY JC. "Optimising anti-tumour CD8 T-cell responses using combinations of immunomodulatory antibodies", Eur. J. Immunol, 2008, Vol. 38, pp. 2499-2511. *
LEE SJ et al. "4-1BB and OX40 Dual Costimulation Synergistically Stimulate Primary Specific CD8 T Cells for Robust Effector Function", J Immunol, 2004, Vol. 173, pp. 3002-3012. *
QUI HZ et al. "CD134 Plus CD137 Dual Costimulation Induces Eomesodermin in CD4 T Cells to Program Cytotoxic Th1 Differentiation", J Immunol, 2011, Vol. 187(7), pp. 3555-3564. *

Also Published As

Publication number Publication date
US20190031765A1 (en) 2019-01-31
BR112018014016A2 (pt) 2019-02-05
RU2018127164A3 (enExample) 2020-02-28
KR20180103150A (ko) 2018-09-18
KR20210013777A (ko) 2021-02-05
AU2017211540A1 (en) 2018-07-19
AU2017211540B2 (en) 2020-04-30
AU2020210145A1 (en) 2020-08-13
JP2019506403A (ja) 2019-03-07
JP6783312B2 (ja) 2020-11-11
CN108473587A (zh) 2018-08-31
CA2955184A1 (en) 2017-07-25
EP3408294A1 (en) 2018-12-05
RU2018127164A (ru) 2020-02-28
MX2018008995A (es) 2019-01-10
HK1259253A1 (zh) 2019-11-29
WO2017130076A1 (en) 2017-08-03

Similar Documents

Publication Publication Date Title
RU2748949C2 (ru) Комбинация моноклональных антител агониста ох40 и агониста 4-1вв для лечения рака
US10899840B2 (en) Combination of a PD-1 antagonist and a 4-1BB agonist for treating cancer
RU2705795C2 (ru) Лечение рака комбинацией антагониста pd-1 и динациклиба
TWI663983B (zh) 用於治療癌症之pd-1拮抗劑及vegfr抑制劑之組合
US10023649B2 (en) Method of treating cancer with a combination of an anti-CCR4 antibody and a 4-1BB agonist
JP7470105B2 (ja) 非マイクロサテライト高不安定性/ミスマッチ修復の良好な結腸直腸がんを処置するためのpd-1アンタゴニストおよびlag3アンタゴニストの組み合わせ
KR20230069957A (ko) 암을 갖는 환자의 치료를 위한 pd-1 길항제 및 lag3 길항제 및 렌바티닙 또는 이의 약학적으로 허용가능한 염의 병용 요법
US12534530B2 (en) Combination of a PD-1 antagonist and a VEGFR inhibitor for treating cancer
HK1233518A1 (en) Combination of an anti-ccr4 antibody and a 4-1bb agonist for treating cancer