AU2017211540B2 - Combination of an OX40 agonist and a 4-1BB agonist monoclonal antibody for treating cancer - Google Patents
Combination of an OX40 agonist and a 4-1BB agonist monoclonal antibody for treating cancer Download PDFInfo
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Classifications
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- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Immunology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
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| AU2020210145A AU2020210145A1 (en) | 2016-01-25 | 2020-07-27 | Combination of an OX40 agonist and a 4-1BB agonist monoclonal antibody for treating cancer |
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| US201662286616P | 2016-01-25 | 2016-01-25 | |
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| PCT/IB2017/050244 WO2017130076A1 (en) | 2016-01-25 | 2017-01-17 | Combination of an ox40 agonist and a 4-1bb agonist monoclonal antibody for treating cancer |
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| AU2017211540A1 AU2017211540A1 (en) | 2018-07-19 |
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| AU2020210145A Abandoned AU2020210145A1 (en) | 2016-01-25 | 2020-07-27 | Combination of an OX40 agonist and a 4-1BB agonist monoclonal antibody for treating cancer |
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| AU2020210145A Abandoned AU2020210145A1 (en) | 2016-01-25 | 2020-07-27 | Combination of an OX40 agonist and a 4-1BB agonist monoclonal antibody for treating cancer |
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| EP (1) | EP3408294A1 (enExample) |
| JP (1) | JP6783312B2 (enExample) |
| KR (2) | KR20210013777A (enExample) |
| CN (1) | CN108473587A (enExample) |
| AU (2) | AU2017211540B2 (enExample) |
| BR (1) | BR112018014016A2 (enExample) |
| CA (1) | CA2955184A1 (enExample) |
| HK (1) | HK1259253A1 (enExample) |
| MX (1) | MX2018008995A (enExample) |
| RU (1) | RU2748949C2 (enExample) |
| WO (1) | WO2017130076A1 (enExample) |
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| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| WO2018191502A2 (en) | 2017-04-13 | 2018-10-18 | Agenus Inc. | Anti-cd137 antibodies and methods of use thereof |
| US20200129637A1 (en) | 2017-04-20 | 2020-04-30 | Adc Therapeutics Sa | Combination therapy with an anti-axl antibody-drug conjugate |
| EP3638373B1 (en) | 2017-06-14 | 2024-09-04 | ADC Therapeutics SA | Dosage regimes for the administration of an anti-cd19 adc |
| SG10201913147WA (en) | 2017-07-11 | 2020-02-27 | Compass Therapeutics Llc | Agonist antibodies that bind human cd137 and uses thereof |
| US11718679B2 (en) | 2017-10-31 | 2023-08-08 | Compass Therapeutics Llc | CD137 antibodies and PD-1 antagonists and uses thereof |
| US11851497B2 (en) | 2017-11-20 | 2023-12-26 | Compass Therapeutics Llc | CD137 antibodies and tumor antigen-targeting antibodies and uses thereof |
| WO2019178852A1 (zh) * | 2018-03-23 | 2019-09-26 | 苏州丁孚靶点生物技术有限公司 | Ox40抗原多肽及其用途 |
| WO2019196868A1 (en) | 2018-04-10 | 2019-10-17 | Wuxi Biologics (Shanghai) Co., Ltd. | A monoclonal antibody against human 4-1bb, method for preparing the same, and use thereof |
| CN110357961B (zh) * | 2018-04-10 | 2022-08-23 | 无锡智康弘义生物科技有限公司 | 抗人4-1bb单克隆抗体及其制备方法和用途 |
| EP3796942A1 (en) | 2018-05-23 | 2021-03-31 | ADC Therapeutics SA | Molecular adjuvant |
| EP3826626A4 (en) | 2018-07-23 | 2022-07-06 | Magenta Therapeutics, Inc. | USE OF ANTI-CD137 ANTIBODY-DRUG CONJUGATE (ADC) IN ALLOGENE CELL THERAPY |
| US20220370606A1 (en) | 2018-12-21 | 2022-11-24 | Pfizer Inc. | Combination Treatments Of Cancer Comprising A TLR Agonist |
| US10442866B1 (en) * | 2019-01-23 | 2019-10-15 | Beijing Mabworks Biotech Co. Ltd | Antibodies binding OX40 and uses thereof |
| SG11202110287QA (en) | 2019-04-24 | 2021-10-28 | Heidelberg Pharma Res Gmbh | Amatoxin antibody-drug conjugates and uses thereof |
| EP3976043A1 (en) * | 2019-05-24 | 2022-04-06 | Pfizer Inc. | Combination therapies using cdk inhibitors |
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| WO2017130076A1 (en) | 2017-08-03 |
| AU2017211540A1 (en) | 2018-07-19 |
| KR20180103150A (ko) | 2018-09-18 |
| KR20210013777A (ko) | 2021-02-05 |
| RU2018127164A (ru) | 2020-02-28 |
| AU2020210145A1 (en) | 2020-08-13 |
| CN108473587A (zh) | 2018-08-31 |
| MX2018008995A (es) | 2019-01-10 |
| US20190031765A1 (en) | 2019-01-31 |
| JP6783312B2 (ja) | 2020-11-11 |
| JP2019506403A (ja) | 2019-03-07 |
| BR112018014016A2 (pt) | 2019-02-05 |
| HK1259253A1 (zh) | 2019-11-29 |
| RU2748949C2 (ru) | 2021-06-02 |
| RU2018127164A3 (enExample) | 2020-02-28 |
| EP3408294A1 (en) | 2018-12-05 |
| CA2955184A1 (en) | 2017-07-25 |
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