RU2747306C2 - Препараты бупренорфина с замедленным высвобождением - Google Patents

Препараты бупренорфина с замедленным высвобождением Download PDF

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Publication number
RU2747306C2
RU2747306C2 RU2019102895A RU2019102895A RU2747306C2 RU 2747306 C2 RU2747306 C2 RU 2747306C2 RU 2019102895 A RU2019102895 A RU 2019102895A RU 2019102895 A RU2019102895 A RU 2019102895A RU 2747306 C2 RU2747306 C2 RU 2747306C2
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Prior art keywords
buprenorphine
pharmaceutical composition
group
organic solvent
acylbuprenorphine
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RU2019102895A
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English (en)
Russian (ru)
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RU2019102895A (ru
RU2019102895A3 (https=
Inventor
Тон-Хо ЛИН
Юн-Шунь ВЕН
Цзюй-Вэй ЛЯН
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Алар Фармасьютикалс Инк.
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Publication of RU2019102895A publication Critical patent/RU2019102895A/ru
Publication of RU2019102895A3 publication Critical patent/RU2019102895A3/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2019102895A 2016-09-13 2017-09-12 Препараты бупренорфина с замедленным высвобождением RU2747306C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662394168P 2016-09-13 2016-09-13
US62/394,168 2016-09-13
PCT/CN2017/101327 WO2018050043A1 (en) 2016-09-13 2017-09-12 Sustained-release buprenorphine formulations background of invention

Publications (3)

Publication Number Publication Date
RU2019102895A RU2019102895A (ru) 2020-08-03
RU2019102895A3 RU2019102895A3 (https=) 2020-12-01
RU2747306C2 true RU2747306C2 (ru) 2021-05-04

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RU2019102895A RU2747306C2 (ru) 2016-09-13 2017-09-12 Препараты бупренорфина с замедленным высвобождением

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US (1) US10744132B2 (https=)
EP (1) EP3512518B1 (https=)
JP (1) JP6929367B2 (https=)
KR (1) KR102244500B1 (https=)
CN (1) CN109789137B (https=)
AR (1) AR110468A1 (https=)
AU (1) AU2017325910B2 (https=)
BR (1) BR112019004923A2 (https=)
CA (1) CA3033046C (https=)
CL (1) CL2019000624A1 (https=)
CO (1) CO2019003632A2 (https=)
DK (1) DK3512518T3 (https=)
ES (1) ES2934721T3 (https=)
FI (1) FI3512518T3 (https=)
HR (1) HRP20230062T8 (https=)
HU (1) HUE060906T2 (https=)
LT (1) LT3512518T (https=)
MX (1) MX374304B (https=)
MY (1) MY196269A (https=)
PE (1) PE20190707A1 (https=)
PH (1) PH12019500466A1 (https=)
PL (1) PL3512518T3 (https=)
PT (1) PT3512518T (https=)
RS (1) RS63894B1 (https=)
RU (1) RU2747306C2 (https=)
SG (1) SG11201901294QA (https=)
SI (1) SI3512518T1 (https=)
SM (1) SMT202300006T1 (https=)
TW (1) TWI743193B (https=)
WO (1) WO2018050043A1 (https=)
ZA (1) ZA201900890B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1057075C (zh) * 1997-09-10 2000-10-04 中国石油化工总公司 低碳烯烃直接水合连续生产低碳醇的方法
BR112020016576A2 (pt) 2018-05-11 2020-12-15 Alar Pharmaceuticals Inc. Formulações injetáveis de ação prolongada e formas cristalinas de derivados de buprenorfina
KR102898979B1 (ko) * 2018-12-27 2025-12-10 에일러 파마슈티컬스 아이엔씨. 주사가능한 날트렉손 서방형 약학 제제
EP3936112A1 (en) * 2020-07-07 2022-01-12 Occlugel Hydrophilic degradable microspheres for delivering buprenorphine
IL308211A (en) * 2021-05-05 2024-01-01 Lyndra Therapeutics Inc Gastric residence systems comprising methadone

Citations (5)

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Publication number Priority date Publication date Assignee Title
CN1500786A (zh) * 2002-11-12 2004-06-02 ���ŷ�������ҽԺ 新颖的丁丙诺啡酯衍生物及其制备方法，以及长效作用镇痛药学组合物
RU2008124805A (ru) * 2005-11-21 2009-12-27 Шеринг-Плоу Лтд. (CH) Фармацевтические композиции, содержащие бупренорфин
RU2435773C2 (ru) * 2006-03-28 2011-12-10 РЕКИТТ БЕНКАЙЗЕР ХЕЛТКЭА (Ю Кей) ЛИМИТЕД Производные бупренорфина и их применение
WO2011154725A2 (en) * 2010-06-08 2011-12-15 Reckitt Benckiser Healthcare (Uk) Limited Compositions
WO2015136253A1 (en) * 2014-03-10 2015-09-17 Indivior Uk Limited Sustained-release buprenorphine solutions

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RO121631B1 (ro) 1999-08-27 2008-01-30 Southern Research Institute Compoziţie cu buprenorfină şi utilizarea acesteia pentru reducerea consumului de heroină şi/sau alcool
DE60329515D1 (de) 2002-10-25 2009-11-12 Euro Celtique Sa Analoga und prodrugs von buprenorphin
TWI226830B (en) * 2002-11-12 2005-01-21 Chi Mei Foundation Medical Ct Novel ester derivatives of buprenorphine and their preparation processes, and long acting analgesic pharmaceutical compositions
DE60224288T2 (de) 2002-11-25 2009-04-16 Chi Mei Foundation Medical Center Buprenorphinesterderivate, Verfahren zu ihrer Herstellung, und langwirksame analgetische Arzneimittel
WO2005117830A1 (en) 2004-06-04 2005-12-15 Camurus Ab Liquid depot formulations
ES2549115T3 (es) * 2006-09-22 2015-10-23 Zynerba Pharmaceuticals, Inc. Profármacos de buprenorfina administrables por vía transdérmica y composiciones resistentes al consumo excesivo de los mismos
US20090181068A1 (en) * 2008-01-14 2009-07-16 Dunn Richard L Low Viscosity Liquid Polymeric Delivery System
GB2481018B (en) 2010-06-08 2015-03-18 Rb Pharmaceuticals Ltd Injectable flowable composition comprising buprenorphine
FR2975912B1 (fr) 2011-05-30 2013-06-14 Flamel Tech Sa Composition a liberation controlee de buprenorphine
US9393211B2 (en) 2013-03-15 2016-07-19 Oakwood Laboratories LLC High drug load buprenorphine microspheres and method of producing same
GB201419091D0 (en) * 2014-10-27 2014-12-10 Camurus Ab Formulations

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1500786A (zh) * 2002-11-12 2004-06-02 ���ŷ�������ҽԺ 新颖的丁丙诺啡酯衍生物及其制备方法，以及长效作用镇痛药学组合物
RU2008124805A (ru) * 2005-11-21 2009-12-27 Шеринг-Плоу Лтд. (CH) Фармацевтические композиции, содержащие бупренорфин
RU2435773C2 (ru) * 2006-03-28 2011-12-10 РЕКИТТ БЕНКАЙЗЕР ХЕЛТКЭА (Ю Кей) ЛИМИТЕД Производные бупренорфина и их применение
WO2011154725A2 (en) * 2010-06-08 2011-12-15 Reckitt Benckiser Healthcare (Uk) Limited Compositions
WO2015136253A1 (en) * 2014-03-10 2015-09-17 Indivior Uk Limited Sustained-release buprenorphine solutions

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Publication number Publication date
US10744132B2 (en) 2020-08-18
FI3512518T3 (fi) 2023-01-31
PE20190707A1 (es) 2019-05-17
RU2019102895A (ru) 2020-08-03
TWI743193B (zh) 2021-10-21
ZA201900890B (en) 2021-08-25
WO2018050043A1 (en) 2018-03-22
CN109789137B (zh) 2023-01-13
PH12019500466A1 (en) 2020-01-20
SMT202300006T1 (it) 2023-03-17
AR110468A1 (es) 2019-04-03
LT3512518T (lt) 2023-02-10
TW201821077A (zh) 2018-06-16
AU2017325910A1 (en) 2019-02-21
MY196269A (en) 2023-03-24
DK3512518T3 (da) 2023-01-30
ES2934721T3 (es) 2023-02-24
EP3512518A1 (en) 2019-07-24
MX374304B (es) 2025-03-06
KR20190052021A (ko) 2019-05-15
BR112019004923A2 (pt) 2019-06-04
KR102244500B1 (ko) 2021-04-26
NZ750367A (en) 2021-01-29
RS63894B1 (sr) 2023-02-28
PL3512518T3 (pl) 2023-03-27
SG11201901294QA (en) 2019-03-28
JP6929367B2 (ja) 2021-09-01
MX2019002675A (es) 2019-08-01
AU2017325910B2 (en) 2020-08-27
RU2019102895A3 (https=) 2020-12-01
US20190142823A1 (en) 2019-05-16
EP3512518B1 (en) 2022-10-26
SI3512518T1 (sl) 2023-04-28
PT3512518T (pt) 2023-01-27
HUE060906T2 (hu) 2023-04-28
CN109789137A (zh) 2019-05-21
CO2019003632A2 (es) 2019-06-28
CL2019000624A1 (es) 2019-06-14
CA3033046A1 (en) 2018-03-22
JP2019529543A (ja) 2019-10-17
EP3512518A4 (en) 2020-06-03
HRP20230062T8 (hr) 2023-04-14
CA3033046C (en) 2021-09-07
HRP20230062T1 (hr) 2023-03-31

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