AR110468A1 - Formulaciones de buprenorfina de liberación sostenida y método de tratamiento - Google Patents
Formulaciones de buprenorfina de liberación sostenida y método de tratamientoInfo
- Publication number
- AR110468A1 AR110468A1 ARP170102519A ARP170102519A AR110468A1 AR 110468 A1 AR110468 A1 AR 110468A1 AR P170102519 A ARP170102519 A AR P170102519A AR P170102519 A ARP170102519 A AR P170102519A AR 110468 A1 AR110468 A1 AR 110468A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- pharmaceutical composition
- injectable pharmaceutical
- composition according
- acyl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Reivindicación 1: Una composición farmacéuticamente inyectable, que comprende: una solución de 3-acil-buprenorfina o una sal farmacéuticamente aceptable de la misma, en un solvente orgánico biocompatible, en donde la composición farmacéutica inyectable exhibe un perfil de liberación estable, el cual se mantiene durante una semana cuando es inyectado a un paciente o a un animal. Reivindicación 2: La composición farmacéutica inyectable de acuerdo con la reivindicación 1, en donde el grupo acilo comprende un grupo alquilcarbonilo y en donde una porción alquilo del grupo alquilcarbonilo es una cadena lineal o ramificada, que tiene 1 - 20 átomos de carbono. Reivindicación 3: La composición farmacéutica inyectable de acuerdo con la reivindicación 1, en donde el grupo acilo comprende un grupo arilcarbonilo y en donde una porción arilo del grupo arilcarbonilo es un grupo aromático que tiene 6 - 18 carbonos. Reivindicación 4: La composición farmacéutica inyectable de acuerdo con una cualquiera de las reivindicaciones 1 - 3, en donde el solvente orgánico biocompatible se selecciona entre el grupo que consiste en N-metil-2-pirrolidona, acetato de etilo, etanol, butanol, 2-butanol, isobutanol, isopropanol, glicerina, benzoato de bencilo, dimetilsulfóxido, N,N-dimetilacetamida, propilenglicol, dimetilglicol, alcohol bencílico y una combinación de dos o más de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662394168P | 2016-09-13 | 2016-09-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR110468A1 true AR110468A1 (es) | 2019-04-03 |
Family
ID=61619029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170102519A AR110468A1 (es) | 2016-09-13 | 2017-09-13 | Formulaciones de buprenorfina de liberación sostenida y método de tratamiento |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US10744132B2 (es) |
| EP (1) | EP3512518B1 (es) |
| JP (1) | JP6929367B2 (es) |
| KR (1) | KR102244500B1 (es) |
| CN (1) | CN109789137B (es) |
| AR (1) | AR110468A1 (es) |
| AU (1) | AU2017325910B2 (es) |
| BR (1) | BR112019004923A2 (es) |
| CA (1) | CA3033046C (es) |
| CL (1) | CL2019000624A1 (es) |
| CO (1) | CO2019003632A2 (es) |
| DK (1) | DK3512518T3 (es) |
| ES (1) | ES2934721T3 (es) |
| FI (1) | FI3512518T3 (es) |
| HR (1) | HRP20230062T8 (es) |
| HU (1) | HUE060906T2 (es) |
| LT (1) | LT3512518T (es) |
| MX (1) | MX2019002675A (es) |
| MY (1) | MY196269A (es) |
| PE (1) | PE20190707A1 (es) |
| PH (1) | PH12019500466A1 (es) |
| PL (1) | PL3512518T3 (es) |
| PT (1) | PT3512518T (es) |
| RS (1) | RS63894B1 (es) |
| RU (1) | RU2747306C2 (es) |
| SG (1) | SG11201901294QA (es) |
| SI (1) | SI3512518T1 (es) |
| TW (1) | TWI743193B (es) |
| WO (1) | WO2018050043A1 (es) |
| ZA (1) | ZA201900890B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1057075C (zh) * | 1997-09-10 | 2000-10-04 | 中国石油化工总公司 | 低碳烯烃直接水合连续生产低碳醇的方法 |
| NZ766474A (en) * | 2018-05-11 | 2023-03-31 | Alar Pharmaceuticals Inc | Long-acting injectable formulations and crystalline forms of buprenorphine derivatives |
| CN113226288B (zh) * | 2018-12-27 | 2023-04-28 | 昱展新药生技股份有限公司 | 纳曲酮注射型缓释制剂 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60015370T2 (de) | 1999-08-27 | 2006-03-09 | Southern Research Institute, Birmingham | Injizierbare buprenorphinhaltige mikrosphärenzusammensetzungen und ihre verwendung zur reduktion von heroin- und alkoholkonsum |
| US7084150B2 (en) | 2002-10-25 | 2006-08-01 | Euro-Celtique S.A. | Analogs and prodrugs of buprenorphine |
| CN1263760C (zh) * | 2002-11-12 | 2006-07-12 | 财团法人奇美医院 | 新颖的丁丙诺啡酯衍生物及其制备方法，以及长效作用镇痛药学组合物 |
| TWI226830B (en) * | 2002-11-12 | 2005-01-21 | Chi Mei Foundation Medical Ct | Novel ester derivatives of buprenorphine and their preparation processes, and long acting analgesic pharmaceutical compositions |
| DE60224288T2 (de) * | 2002-11-25 | 2009-04-16 | Chi Mei Foundation Medical Center | Buprenorphinesterderivate, Verfahren zu ihrer Herstellung, und langwirksame analgetische Arzneimittel |
| BRPI0511807C8 (pt) | 2004-06-04 | 2021-05-25 | Camurus Ab | pré-formulação, processo de formação de uma pré-formulação e uso da mesma |
| RU2008124805A (ru) * | 2005-11-21 | 2009-12-27 | Шеринг-Плоу Лтд. (CH) | Фармацевтические композиции, содержащие бупренорфин |
| GB0606124D0 (en) | 2006-03-28 | 2006-05-03 | Reckitt Benckiser Healthcare | Buprenorphine derivatives and uses thereof |
| WO2008036980A1 (en) * | 2006-09-22 | 2008-03-27 | Alltranz Inc. | Transdermally deliverable buprenorphine prodrugs and abuse-resistant compositions thereof |
| US20090181068A1 (en) * | 2008-01-14 | 2009-07-16 | Dunn Richard L | Low Viscosity Liquid Polymeric Delivery System |
| GB2513267B (en) | 2010-06-08 | 2015-03-18 | Rb Pharmaceuticals Ltd | Injectable flowable composition comprising buprenorphine |
| GB2513060B (en) * | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
| FR2975912B1 (fr) * | 2011-05-30 | 2013-06-14 | Flamel Tech Sa | Composition a liberation controlee de buprenorphine |
| US9393211B2 (en) | 2013-03-15 | 2016-07-19 | Oakwood Laboratories LLC | High drug load buprenorphine microspheres and method of producing same |
| GB201404139D0 (en) * | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
| GB201419091D0 (en) * | 2014-10-27 | 2014-12-10 | Camurus Ab | Formulations |
-
2017
- 2017-09-12 BR BR112019004923A patent/BR112019004923A2/pt not_active Application Discontinuation
- 2017-09-12 US US16/098,864 patent/US10744132B2/en active Active
- 2017-09-12 ES ES17850245T patent/ES2934721T3/es active Active
- 2017-09-12 PE PE2019000487A patent/PE20190707A1/es unknown
- 2017-09-12 RS RS20230034A patent/RS63894B1/sr unknown
- 2017-09-12 RU RU2019102895A patent/RU2747306C2/ru active
- 2017-09-12 SI SI201731295T patent/SI3512518T1/sl unknown
- 2017-09-12 TW TW106131215A patent/TWI743193B/zh active
- 2017-09-12 EP EP17850245.6A patent/EP3512518B1/en active Active
- 2017-09-12 PL PL17850245.6T patent/PL3512518T3/pl unknown
- 2017-09-12 WO PCT/CN2017/101327 patent/WO2018050043A1/en unknown
- 2017-09-12 KR KR1020197009185A patent/KR102244500B1/ko active IP Right Grant
- 2017-09-12 LT LTEPPCT/CN2017/101327T patent/LT3512518T/lt unknown
- 2017-09-12 MX MX2019002675A patent/MX2019002675A/es active IP Right Grant
- 2017-09-12 AU AU2017325910A patent/AU2017325910B2/en active Active
- 2017-09-12 SG SG11201901294QA patent/SG11201901294QA/en unknown
- 2017-09-12 HR HRP20230062TT patent/HRP20230062T8/hr unknown
- 2017-09-12 HU HUE17850245A patent/HUE060906T2/hu unknown
- 2017-09-12 DK DK17850245.6T patent/DK3512518T3/da active
- 2017-09-12 FI FIEP17850245.6T patent/FI3512518T3/fi active
- 2017-09-12 MY MYPI2019000910A patent/MY196269A/en unknown
- 2017-09-12 CA CA3033046A patent/CA3033046C/en active Active
- 2017-09-12 JP JP2019535434A patent/JP6929367B2/ja active Active
- 2017-09-12 CN CN201780055635.3A patent/CN109789137B/zh active Active
- 2017-09-12 PT PT178502456T patent/PT3512518T/pt unknown
- 2017-09-13 AR ARP170102519A patent/AR110468A1/es unknown
-
2019
- 2019-02-12 ZA ZA2019/00890A patent/ZA201900890B/en unknown
- 2019-03-01 PH PH12019500466A patent/PH12019500466A1/en unknown
- 2019-03-12 CL CL2019000624A patent/CL2019000624A1/es unknown
- 2019-04-11 CO CONC2019/0003632A patent/CO2019003632A2/es unknown
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