RU2742691C2 - Cd3-связывающий домен - Google Patents
Cd3-связывающий домен Download PDFInfo
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- RU2742691C2 RU2742691C2 RU2017105120A RU2017105120A RU2742691C2 RU 2742691 C2 RU2742691 C2 RU 2742691C2 RU 2017105120 A RU2017105120 A RU 2017105120A RU 2017105120 A RU2017105120 A RU 2017105120A RU 2742691 C2 RU2742691 C2 RU 2742691C2
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- ser
- gly
- antigen
- thr
- ala
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| PCT/EP2014/002177 WO2015018527A1 (en) | 2013-08-07 | 2014-08-07 | ANTIBODY BINDING SITES SPECIFIC FOR EGFRvIII |
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| RU2017105120A RU2017105120A (ru) | 2018-09-10 |
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| MY176522A (en) | 2013-11-04 | 2020-08-13 | Ichnos Sciences SA | Production of t cell retargeting hetero-dimeric immunoglobulins |
| US11773166B2 (en) | 2014-11-04 | 2023-10-03 | Ichnos Sciences SA | CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production |
| IL319047A (en) | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
| US11702477B2 (en) | 2015-11-06 | 2023-07-18 | Orionis Biosciences BV | Bi-functional chimeric proteins and uses thereof |
| IL313608A (en) | 2015-12-09 | 2024-08-01 | Hoffmann La Roche | Antibody against CD20 type II to reduce the formation of antibodies against drugs |
| JP6991979B2 (ja) | 2016-02-05 | 2022-03-04 | オリオニス バイオサイエンシズ ビーブイ | Ｃｄ８結合物質 |
| CN110603266A (zh) | 2016-06-02 | 2019-12-20 | 豪夫迈·罗氏有限公司 | 用于治疗癌症的ii型抗cd20抗体和抗cd20/cd3双特异性抗体 |
| EP3252078A1 (en) | 2016-06-02 | 2017-12-06 | F. Hoffmann-La Roche AG | Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer |
| WO2018054484A1 (en) | 2016-09-23 | 2018-03-29 | Biontech Ag | Bispecific trivalent antibodies binding to claudin 6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases |
| EP3576765B1 (en) | 2017-02-06 | 2025-07-16 | Orionis Biosciences, Inc. | Targeted engineered interferon and uses thereof |
| WO2018155611A1 (ja) | 2017-02-24 | 2018-08-30 | 中外製薬株式会社 | 薬学的組成物、抗原結合分子、治療方法、およびスクリーニング方法 |
| EP3366704A1 (en) | 2017-02-28 | 2018-08-29 | Affimed GmbH | Antibodies specific for mmp1/hla-a2 complex |
| JP7164544B2 (ja) | 2017-04-11 | 2022-11-01 | インヒブルクス インコーポレイテッド | 制約されたｃｄ３結合を有する多重特異性ポリペプチド構築物およびそれを使用する方法 |
| EP3409322A1 (en) | 2017-06-01 | 2018-12-05 | F. Hoffmann-La Roche AG | Treatment method |
| WO2018224441A1 (en) * | 2017-06-05 | 2018-12-13 | Numab Innovation Ag | Novel anti-cd3 antibodies |
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| US11472880B2 (en) | 2017-08-14 | 2022-10-18 | Morphosys Ag | Humanized antibodies for CD3 |
| KR101973060B1 (ko) * | 2017-10-20 | 2019-04-26 | 주식회사 녹십자 | 항-cd3 항체 및 이를 포함하는 암 치료용 약학적 조성물 |
| EP3502140A1 (en) * | 2017-12-21 | 2019-06-26 | F. Hoffmann-La Roche AG | Combination therapy of tumor targeted icos agonists with t-cell bispecific molecules |
| US20200399373A1 (en) * | 2018-02-14 | 2020-12-24 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule and combination |
| AU2019235523B2 (en) * | 2018-03-14 | 2025-12-18 | Novimmune Sa | Anti-CD3 epsilon antibodies and methods of use thereof |
| CN112218686A (zh) | 2018-04-11 | 2021-01-12 | 印希比股份有限公司 | 具有受限cd3结合的多特异性多肽构建体以及相关方法和用途 |
| EP3802608B1 (en) * | 2018-05-24 | 2025-04-30 | Janssen Biotech, Inc. | Anti-cd3 antibodies and uses thereof |
| WO2020023553A1 (en) * | 2018-07-24 | 2020-01-30 | Inhibrx, Inc. | Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same |
| KR20210049863A (ko) | 2018-08-23 | 2021-05-06 | 리제너론 파아마슈티컬스, 인크. | 항-Fc 엡실론-R1 알파 (FCERIA) 항체, FCERIA 및 CD3에 결합하는 이중특이적 항원-결합 분자 및 이들의 용도 |
| JP7611820B2 (ja) | 2018-10-11 | 2025-01-10 | インヒブルクス バイオサイエンシズ インコーポレイテッド | Ｄｌｌ３シングルドメイン抗体およびその治療用組成物 |
| AU2019439345B2 (en) * | 2019-03-29 | 2024-08-08 | Green Cross Corporation | Fusion protein comprising anti-mesothelin antibody, anti-CD3 antibody or anti-EGFR antibody, bispecific or trispecific antibody comprising same, and uses thereof |
| EP4097129A1 (en) | 2020-01-29 | 2022-12-07 | Inhibrx, Inc. | Cd28 single domain antibodies and multivalent and multispecific constructs thereof |
| TWI888487B (zh) * | 2020-02-14 | 2025-07-01 | 日商協和麒麟股份有限公司 | 與ｃｄ３結合之雙特異性抗體 |
| PH12022500023A1 (en) | 2020-05-27 | 2024-03-11 | Janssen Biotech Inc | Proteins comprising cd3 antigen binding domains and uses thereof |
| KR20230079409A (ko) * | 2020-09-29 | 2023-06-07 | 이노벤트 바이오로직스 (쑤저우) 컴퍼니, 리미티드 | 항-cd3 항체 및 이의 용도 |
| AU2021443863A1 (en) | 2021-04-30 | 2023-10-26 | F. Hoffmann-La Roche Ag | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibody |
| CN117321078A (zh) | 2021-04-30 | 2023-12-29 | 豪夫迈·罗氏有限公司 | 针对用抗cd20/抗cd3双特异性抗体和抗cd79b抗体药物缀合物进行组合治疗的给药 |
| WO2022263507A1 (en) | 2021-06-17 | 2022-12-22 | Boehringer Ingelheim International Gmbh | Novel tri-specific binding molecules |
| CA3244652A1 (en) | 2021-12-31 | 2025-05-22 | Kyinno Biotechnology Co., Ltd. | Anti-GPRC5D Antibodies and Their Use |
| CN116375868A (zh) * | 2021-12-31 | 2023-07-04 | 康源博创生物科技(北京)有限公司 | 一种抗cd3的人源化抗体及其在制备双特异性抗体中的应用 |
| CA3251878A1 (en) | 2022-03-23 | 2023-09-28 | Genentech, Inc. | COMBINED TREATMENT COMBINING AN ANTI-CD20/ANTI-CD3 BISPECIFIC ANTIBODY AND CHEMOTHERAPY |
| EP4508081A1 (en) | 2022-04-13 | 2025-02-19 | F. Hoffmann-La Roche AG | Pharmaceutical compositions of anti-cd20/anti-cd3 bispecific antibodies and methods of use |
| WO2024088987A1 (en) | 2022-10-26 | 2024-05-02 | F. Hoffmann-La Roche Ag | Combination therapy for the treatment of cancer |
| WO2024152963A1 (zh) * | 2023-01-18 | 2024-07-25 | 贝达药业股份有限公司 | 抗cd3的人源化抗体及其应用 |
| WO2025224084A1 (en) | 2024-04-22 | 2025-10-30 | Engimmune Therapeutics Ag | Proteins comprising t cell receptor constant domains |
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| DE60124912T2 (de) | 2001-09-14 | 2007-06-14 | Affimed Therapeutics Ag | Multimerische, einzelkettige, Tandem-Fv-Antikörper |
| US8101722B2 (en) | 2004-02-16 | 2012-01-24 | Micromet Ag | Less immunogenic binding molecules |
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| EP2938636A2 (en) * | 2012-12-28 | 2015-11-04 | AbbVie Inc. | High-throughput system and method for identifying antibodies having specific antigen binding activities |
| US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
| WO2014116846A2 (en) | 2013-01-23 | 2014-07-31 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
| HUE054057T2 (hu) * | 2013-08-07 | 2021-08-30 | Affimed Gmbh | EGFRvIII specifikus antitest-kötõhelyek |
| US9212225B1 (en) * | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
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- 2015-08-05 SI SI201531457T patent/SI3177646T1/sl unknown
- 2015-08-05 JP JP2017506890A patent/JP6669722B2/ja active Active
- 2015-08-06 US US14/820,462 patent/US10066015B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100015087A1 (en) * | 1997-12-01 | 2010-01-21 | Istituto Superiore Di Sanita | Hiv-1 tat, or derivatives thereof for prophylactic and therapeutic vaccination |
| EP2295577A2 (en) * | 1999-03-09 | 2011-03-16 | ZymoGenetics, Inc. | Human cytokine as ligand of the z-alpha receptor and uses thereof |
| RU2506275C2 (ru) * | 2007-11-01 | 2014-02-10 | Астеллас Фарма Инк. | Иммуносупрессорные полипептиды и нуклеиновые кислоты |
| EP2698431A1 (en) * | 2011-03-30 | 2014-02-19 | Chugai Seiyaku Kabushiki Kaisha | Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017529067A (ja) | 2017-10-05 |
| BR112017002422B1 (pt) | 2024-02-20 |
| CA2957462A1 (en) | 2016-02-11 |
| EP3177646A1 (en) | 2017-06-14 |
| DK3177646T3 (da) | 2020-12-07 |
| SI3177646T1 (sl) | 2021-04-30 |
| CN107001468B (zh) | 2021-04-09 |
| AU2015299039A1 (en) | 2017-03-02 |
| EP3177646B1 (en) | 2020-10-07 |
| CN107001468A (zh) | 2017-08-01 |
| US10066015B2 (en) | 2018-09-04 |
| WO2016020444A1 (en) | 2016-02-11 |
| CA2957462C (en) | 2023-10-17 |
| RU2017105120A (ru) | 2018-09-10 |
| US20160039934A1 (en) | 2016-02-11 |
| LT3177646T (lt) | 2021-01-11 |
| RU2017105120A3 (Direct) | 2019-02-20 |
| HUE051919T2 (hu) | 2021-04-28 |
| BR112017002422A2 (pt) | 2017-11-28 |
| EP2982693A1 (en) | 2016-02-10 |
| AU2015299039B2 (en) | 2021-01-21 |
| JP6669722B2 (ja) | 2020-03-18 |
| HRP20202024T1 (hr) | 2021-02-19 |
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