RU2721948C2 - Комбинации соединений, модулирующих nmda-рецептор - Google Patents
Комбинации соединений, модулирующих nmda-рецептор Download PDFInfo
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- RU2721948C2 RU2721948C2 RU2016146714A RU2016146714A RU2721948C2 RU 2721948 C2 RU2721948 C2 RU 2721948C2 RU 2016146714 A RU2016146714 A RU 2016146714A RU 2016146714 A RU2016146714 A RU 2016146714A RU 2721948 C2 RU2721948 C2 RU 2721948C2
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- nmda receptor
- receptor antagonist
- glyx
- ketamine
- effective amount
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/US2015/029477 WO2015171770A1 (en) | 2014-05-06 | 2015-05-06 | Combinations of nmdar modulating compounds |
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| RU2017107558A (ru) | 2014-09-15 | 2018-10-18 | Руджен Холдингс (Кайман) Лимитед | Производные пирролопиримидина в качестве антагонистов nmda-рецептора nr2b |
| WO2016049048A1 (en) * | 2014-09-22 | 2016-03-31 | Rugen Holdings (Cayman) Limited | Treatment of anxiety disorders and autism spectrum disorders |
| US10221182B2 (en) | 2015-02-04 | 2019-03-05 | Rugen Holdings (Cayman) Limited | 3,3-difluoro-piperidine derivatives as NR2B NMDA receptor antagonists |
| JP2018521007A (ja) * | 2015-05-22 | 2018-08-02 | ヴィスタゲン セラピューティクス、インコーポレイテッド | Ｌ−４−クロロキヌレニンの治療的使用 |
| KR102613179B1 (ko) | 2015-06-01 | 2023-12-14 | 뤼겐 홀딩스 (케이맨) 리미티드 | Nr2b nmda 수용체 길항제로서의 3,3-디플루오로피페리딘 카바메이트 헤테로사이클릭 화합물 |
| CN108601814A (zh) * | 2015-10-16 | 2018-09-28 | 西北大学 | 用于治疗精神分裂症、双相障碍、认知损害和重度抑郁障碍的非典型抗精神病药和nmda调节剂的药物组合 |
| AU2016337507B2 (en) * | 2015-10-16 | 2019-09-19 | Impact Biosciences Corp. | Methods and compositions for treating traumatic brain injury |
| JP6967532B2 (ja) * | 2016-05-25 | 2021-11-17 | ナショナル ヘルス リサーチ インスティテューツNational Health Research Institutes | 付加的抗うつ剤組成物及びその使用方法 |
| US11000526B2 (en) | 2016-11-22 | 2021-05-11 | Rugen Holdings (Cayman) Limited | Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders |
| CN107550907A (zh) * | 2017-08-29 | 2018-01-09 | 昆明医科大学 | 治疗精神分裂症的药物及验证药物的动物模型构建方法 |
| RU2020118505A (ru) * | 2017-12-05 | 2022-01-10 | Наурекс Инк. | Комбинация модуляторов nmda-рецептора (рапастинеля) для применения в комбинированной терапии (расстройства сна и цнс) |
| ES2907692T3 (es) | 2017-12-29 | 2022-04-26 | Celon Pharma Sa | Composición de ketamina de polvo seco para su administración por vía pulmonar en la depresión resistente al tratamiento |
| CN110343050B (zh) | 2018-04-04 | 2021-09-24 | 上海键合医药科技有限公司 | 芳香类化合物及其制备方法和用途 |
| CN109223785A (zh) * | 2018-10-29 | 2019-01-18 | 中国药科大学 | 犬尿喹啉酸或其衍生物在制备改善慢性精神应激相关病理损伤药物中的应用 |
| CN113557028A (zh) * | 2019-01-11 | 2021-10-26 | 诺雷克斯股份有限公司 | 雷帕替奈的盐和晶型 |
| EP3923938B1 (en) * | 2019-02-14 | 2025-04-16 | Seyltx, Inc. | Ifenprodil or radiprodil for treating idiopathic pulmonary fibrosis |
| EP4051276B1 (en) | 2019-10-28 | 2025-08-06 | Seyltx, Inc. | Use of glutamate 2b receptor antagonists and sigma receptor agonsists as antitussives |
| CN113234036B (zh) * | 2021-05-12 | 2023-07-14 | 斯莱普泰(上海)生物医药科技有限公司 | Nmda受体拮抗剂及其用途 |
| KR20230056971A (ko) * | 2021-10-21 | 2023-04-28 | 삼육대학교산학협력단 | 신규 케타민 유도체를 포함하는 우울증 예방 또는 치료용 약학적 조성물 |
| WO2024059713A2 (en) | 2022-09-14 | 2024-03-21 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions of iboga alkaloids and methods of treatment |
| WO2025065271A1 (en) * | 2023-09-26 | 2025-04-03 | Liangzhu Laboratory | Methods and devices for treating depression |
| WO2025124571A1 (zh) * | 2023-12-14 | 2025-06-19 | 斯莱普泰(上海)生物医药科技有限公司 | Nmda受体拮抗剂及其用途 |
| CN119174765A (zh) * | 2024-09-04 | 2024-12-24 | 复旦大学附属中山医院 | Gsdme蛋白的小分子抑制剂在肿瘤及其免疫治疗中的作用 |
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| US20130310323A1 (en) * | 2009-10-05 | 2013-11-21 | Northwestern University | Methods of Treating Depression and Other Related Diseases |
| EA019351B1 (ru) * | 2008-07-03 | 2014-03-31 | ПАНМИРА ФАРМАСЬЮТИКАЛС, ЭлЭлСи | Антагонисты рецепторов простагландина d |
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| US5597809A (en) * | 1994-06-23 | 1997-01-28 | Massachusetts Eye & Ear Infirmary | Treatment of optic neuritis |
| EP2260844A1 (en) * | 2003-05-27 | 2010-12-15 | Merz Pharma GmbH & Co. KGaA | Combination of an NMDA Receptor Antagonist and a Selective Serotonin Reuptake Inhibitor for the Treatment of Depression and other Mood Disorders |
| GB0523998D0 (en) * | 2005-11-25 | 2006-01-04 | Merck Sharp & Dohme | Therapeutic agents |
| US20090275597A1 (en) * | 2008-05-02 | 2009-11-05 | Forest Laboratories Holdings Limited | Methods of treating cns disorders |
| EP2381941A4 (en) * | 2008-12-29 | 2012-08-01 | Univ Vanderbilt | 3.1.0 BICYCLIC GLYTI INHIBITORS AND METHOD FOR THE PRODUCTION AND USE THEREOF |
| EP2992877A1 (en) * | 2010-06-15 | 2016-03-09 | Grünenthal GmbH | Pharmaceutical combination for the treatment of pain |
| US9737531B2 (en) * | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| WO2013138322A1 (en) * | 2012-03-12 | 2013-09-19 | Janssen Pharmaceutica Nv | Esketamine for the treatment of treatment-refractory or treatment-resistant depression |
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| EA019351B1 (ru) * | 2008-07-03 | 2014-03-31 | ПАНМИРА ФАРМАСЬЮТИКАЛС, ЭлЭлСи | Антагонисты рецепторов простагландина d |
| US20130310323A1 (en) * | 2009-10-05 | 2013-11-21 | Northwestern University | Methods of Treating Depression and Other Related Diseases |
Non-Patent Citations (1)
| Title |
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| ZHANG X L ET AL., "A NMDA RECEPTOR GLYCINE SITE PARTIAL AGONIST, GLYX-13, SIMULTANEOUSLY ENCHANCES LTP AND REDUCES LTD AT SCHAFFER COLLATERAL-CA1 SYNAPSES IN HIPPOCAMPUS", NEUROPHARMACOLOGY, PERGAMON PRESS, VOL. 55, NO. 7, 01.12.1988. * |
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| JP2020138973A (ja) | 2020-09-03 |
| US20170072005A1 (en) | 2017-03-16 |
| AU2015256075A1 (en) | 2016-11-24 |
| JP2022159322A (ja) | 2022-10-17 |
| CN106659762A (zh) | 2017-05-10 |
| CA2947976A1 (en) | 2015-11-12 |
| BR112016025910A2 (pt) | 2017-08-15 |
| KR20170013890A (ko) | 2017-02-07 |
| JP2017514871A (ja) | 2017-06-08 |
| EP3139943A1 (en) | 2017-03-15 |
| EP3139943A4 (en) | 2018-07-18 |
| KR20220102662A (ko) | 2022-07-20 |
| MX2016014581A (es) | 2018-02-16 |
| WO2015171770A1 (en) | 2015-11-12 |
| RU2016146714A (ru) | 2018-06-06 |
| RU2016146714A3 (https=) | 2018-10-08 |
| AU2015256075B2 (en) | 2021-02-25 |
| BR112016025910A8 (pt) | 2021-07-13 |
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