RU2718918C2 - Антагонисты рецептора cfr1 для лечения врожденной гиперплазии коры надпочечников - Google Patents

Антагонисты рецептора cfr1 для лечения врожденной гиперплазии коры надпочечников Download PDF

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RU2718918C2
RU2718918C2 RU2016133972A RU2016133972A RU2718918C2 RU 2718918 C2 RU2718918 C2 RU 2718918C2 RU 2016133972 A RU2016133972 A RU 2016133972A RU 2016133972 A RU2016133972 A RU 2016133972A RU 2718918 C2 RU2718918 C2 RU 2718918C2
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crf
nbi
acth
present
receptor antagonist
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RU2016133972A
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RU2016133972A3 (cg-RX-API-DMAC7.html
RU2016133972A (ru
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Димитри Э. ГРИГОРИАДИС
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Ньюрокрайн Байосайенсиз, Инк.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2016133972A 2014-01-21 2015-01-21 Антагонисты рецептора cfr1 для лечения врожденной гиперплазии коры надпочечников RU2718918C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461929941P 2014-01-21 2014-01-21
US61/929,941 2014-01-21
US201461981033P 2014-04-17 2014-04-17
US61/981,033 2014-04-17
US201462069155P 2014-10-27 2014-10-27
US62/069,155 2014-10-27
PCT/US2015/012315 WO2015112642A1 (en) 2014-01-21 2015-01-21 Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia

Related Child Applications (1)

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RU2020112197A Division RU2812318C2 (ru) 2014-01-21 2015-01-21 Антагонисты рецептора cfr1 для лечения врожденной гиперплазии коры надпочечников

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RU2016133972A RU2016133972A (ru) 2018-03-05
RU2016133972A3 RU2016133972A3 (cg-RX-API-DMAC7.html) 2018-09-26
RU2718918C2 true RU2718918C2 (ru) 2020-04-15

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Cited By (1)

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US11951112B2 (en) 2021-04-12 2024-04-09 Maxim Masiutin Method of treating late-onset congenital adrenal hyperplasia due to 21-hydroxylase deficiency by individually tailored glucocorticoid regimen

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BR112020002967A2 (pt) * 2017-08-14 2020-08-11 Spruce Biosciences, Inc. antagonistas de receptor de fator de liberação de corticotropina
EP4438124A3 (en) * 2018-04-27 2024-12-18 Spruce Biosciences, Inc. Methods for treating testicular and ovarian adrenal rest tumors
JP7532328B2 (ja) * 2018-12-07 2024-08-13 ニューロクライン バイオサイエンシーズ,インコーポレイテッド 先天性副腎過形成を処置するためのcrf1受容体アンタゴニスト、その医薬製剤および固体形態
TW202446384A (zh) * 2018-12-07 2024-12-01 美商紐羅克里生物科學有限公司 用於治療先天性腎上腺增生之crf1受體拮抗劑、醫藥配方及其固體形式
JP2022541550A (ja) * 2019-07-19 2022-09-26 スプルース バイオサイエンシーズ,インク. 先天性副腎過形成を処置する方法
CA3152590A1 (en) * 2019-09-27 2021-04-01 Evan Smith Crf receptor antagonists and methods of use
IL298901A (en) * 2020-06-10 2023-02-01 Neurocrine Biosciences Inc Crf1 receptor antagonist for the treatment of congenital adrenal hyperplasia
EP4175572A4 (en) 2020-08-12 2024-03-27 Spruce Biosciences, Inc. Methods and compositions for treating polycystic ovary syndrome
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Cited By (1)

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Publication number Priority date Publication date Assignee Title
US11951112B2 (en) 2021-04-12 2024-04-09 Maxim Masiutin Method of treating late-onset congenital adrenal hyperplasia due to 21-hydroxylase deficiency by individually tailored glucocorticoid regimen

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CN106102740A (zh) 2016-11-09
RU2016133972A3 (cg-RX-API-DMAC7.html) 2018-09-26
US10905690B2 (en) 2021-02-02
IL246783B (en) 2021-10-31
BR112016016975A2 (pt) 2017-08-08
AU2022263460B2 (en) 2024-10-17
EP4450070A1 (en) 2024-10-23
MX2022000080A (es) 2022-02-03
AU2020207774B2 (en) 2022-08-04
IL286782A (en) 2021-10-31
WO2015112642A1 (en) 2015-07-30
KR102258522B1 (ko) 2021-05-31
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