RU2717545C2 - Комбинации противоглистных агентов и способы их применения - Google Patents

Комбинации противоглистных агентов и способы их применения Download PDF

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Publication number
RU2717545C2
RU2717545C2 RU2017138118A RU2017138118A RU2717545C2 RU 2717545 C2 RU2717545 C2 RU 2717545C2 RU 2017138118 A RU2017138118 A RU 2017138118A RU 2017138118 A RU2017138118 A RU 2017138118A RU 2717545 C2 RU2717545 C2 RU 2717545C2
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RU
Russia
Prior art keywords
spp
macrocyclic lactone
dirofilaria immitis
resistant
ivermectin
Prior art date
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RU2017138118A
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English (en)
Russian (ru)
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RU2017138118A (ru
RU2017138118A3 (enExample
Inventor
Бренда БОНДЕЗЕН
Лэнс ХЭММЕРЛЭНД
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Мериал, Инк.
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Publication of RU2017138118A publication Critical patent/RU2017138118A/ru
Publication of RU2017138118A3 publication Critical patent/RU2017138118A3/ru
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15Depsipeptides; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2017138118A 2015-04-02 2016-04-01 Комбинации противоглистных агентов и способы их применения RU2717545C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562142304P 2015-04-02 2015-04-02
US62/142,304 2015-04-02
PCT/US2016/025714 WO2016161369A1 (en) 2015-04-02 2016-04-01 Anthelmintic combinations and methods of use thereof

Publications (3)

Publication Number Publication Date
RU2017138118A RU2017138118A (ru) 2019-05-06
RU2017138118A3 RU2017138118A3 (enExample) 2019-07-24
RU2717545C2 true RU2717545C2 (ru) 2020-03-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017138118A RU2717545C2 (ru) 2015-04-02 2016-04-01 Комбинации противоглистных агентов и способы их применения

Country Status (18)

Country Link
US (1) US10993988B2 (enExample)
EP (1) EP3277303B1 (enExample)
JP (1) JP6899330B2 (enExample)
KR (1) KR20170132330A (enExample)
CN (1) CN107567334A (enExample)
AU (1) AU2016244022A1 (enExample)
BR (1) BR112017020975A2 (enExample)
CA (1) CA2981489A1 (enExample)
CL (1) CL2017002474A1 (enExample)
CO (1) CO2017011284A2 (enExample)
ES (1) ES2851345T3 (enExample)
IL (1) IL254783B (enExample)
MX (1) MX381319B (enExample)
MY (1) MY187835A (enExample)
PH (1) PH12017501806A1 (enExample)
RU (1) RU2717545C2 (enExample)
SG (1) SG11201708008TA (enExample)
WO (1) WO2016161369A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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RU2747149C1 (ru) * 2017-11-29 2021-04-28 ЗОЕТИС СЕРВИСИЗ ЭлЭлСи Анти-эндопаразитарные депсипептиды

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EP3541789A1 (en) * 2016-11-16 2019-09-25 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds
WO2018148392A1 (en) * 2017-02-08 2018-08-16 Merial, Inc. In vivo model for parasitic worm infection and methods for evaluating antiparasitic compounds, including compounds active against canine heartworm
KR20200090165A (ko) 2017-11-23 2020-07-28 세바 상뜨 아니말르 기생충 감염 치료용 목시텍틴 함유 조성물
AR116524A1 (es) * 2018-10-04 2021-05-19 Elanco Tiergesundheit Ag Potenciación de tratamiento de helmintos
IL312412A (en) 2021-11-01 2024-06-01 Boehringer Ingelheim Vetmedica Gmbh Pyrrolopyridazine compounds against worms

Citations (3)

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US6159932A (en) * 1995-06-02 2000-12-12 Bayer Aktiengesellschaft Endoparasiticidal compositions
US20110046072A1 (en) * 2008-05-07 2011-02-24 Bayer Animal Health Gmbh Solid pharmaceutical formulation with delayed release
RU2452180C2 (ru) * 2010-08-31 2012-06-10 Общество с ограниченной ответственностью "Научно-внедренческое предприятие "Астрафарм" Комплексная антипаразитарная композиция

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US4134973A (en) 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
US20030129680A1 (en) 2001-10-31 2003-07-10 O'connor Thomas Patrick Multi-analyte assay device
US20070042354A1 (en) 2005-08-19 2007-02-22 Engelhard Eric K Detecting pathogens in companion animals
ATE515503T1 (de) * 2007-02-21 2011-07-15 Pfizer Ltd Antiparasitische benzofuranmittel
JP4734656B2 (ja) * 2007-03-30 2011-07-27 国立大学法人群馬大学 Pf1022類の製造法
US8809268B2 (en) 2008-10-29 2014-08-19 The Regents Of The University Of California Combination therapy to combat helminth resistance
BE1019407A5 (nl) 2009-11-06 2012-07-03 Momentum Animal Cure Bvba Middel voor het uitdrijven van parasieten bij mensen, dieren en vogels.
US20120295931A1 (en) 2010-02-05 2012-11-22 Lutz Juergen Spiroindoline compounds for use as anthelminthics
WO2011115840A2 (en) 2010-03-14 2011-09-22 Ibis Biosciences, Inc. Parasite detection via endosymbiont detection
AU2010249226C1 (en) 2010-12-08 2017-04-13 Zoetis Services Llc Anthelmintic formulation
AU2010101389C4 (en) 2010-12-08 2017-03-02 Jurox Pty Ltd Anthelmintic formulation
WO2013017678A1 (en) 2011-08-04 2013-02-07 Intervet International B.V. Novel spiroindoline compounds

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US6159932A (en) * 1995-06-02 2000-12-12 Bayer Aktiengesellschaft Endoparasiticidal compositions
US20110046072A1 (en) * 2008-05-07 2011-02-24 Bayer Animal Health Gmbh Solid pharmaceutical formulation with delayed release
RU2452180C2 (ru) * 2010-08-31 2012-06-10 Общество с ограниченной ответственностью "Научно-внедренческое предприятие "Астрафарм" Комплексная антипаразитарная композиция

Non-Patent Citations (1)

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Title
HARDER A ET AL, "Cyclooctadepsipeptides-an anthelmintically active class of compounds exhibiting a novel mode of action"// INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, ELSEVIER SCIENCE, AMSTERDAM, NL, (20030901), vol. 22, no. 3, pages 318 - 331. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2747149C1 (ru) * 2017-11-29 2021-04-28 ЗОЕТИС СЕРВИСИЗ ЭлЭлСи Анти-эндопаразитарные депсипептиды
RU2747149C9 (ru) * 2017-11-29 2021-06-29 ЗОЕТИС СЕРВИСИЗ ЭлЭлСи Анти-эндопаразитарные депсипептиды

Also Published As

Publication number Publication date
IL254783B (en) 2020-11-30
SG11201708008TA (en) 2017-10-30
MY187835A (en) 2021-10-26
MX381319B (es) 2025-03-12
CN107567334A (zh) 2018-01-09
BR112017020975A2 (pt) 2018-07-10
CA2981489A1 (en) 2016-10-06
KR20170132330A (ko) 2017-12-01
EP3277303A1 (en) 2018-02-07
RU2017138118A (ru) 2019-05-06
PH12017501806A1 (en) 2018-04-11
EP3277303B1 (en) 2020-12-02
CO2017011284A2 (es) 2018-01-31
RU2017138118A3 (enExample) 2019-07-24
AU2016244022A1 (en) 2017-10-26
ES2851345T3 (es) 2021-09-06
US10993988B2 (en) 2021-05-04
JP2018510195A (ja) 2018-04-12
JP6899330B2 (ja) 2021-07-07
CL2017002474A1 (es) 2018-03-23
WO2016161369A1 (en) 2016-10-06
IL254783A0 (en) 2017-12-31
US20170020955A1 (en) 2017-01-26
MX2017012510A (es) 2018-01-30

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