RU2715227C2 - Композиция для введения нуклеиновой кислоты в клетки - Google Patents
Композиция для введения нуклеиновой кислоты в клетки Download PDFInfo
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- RU2715227C2 RU2715227C2 RU2017122022A RU2017122022A RU2715227C2 RU 2715227 C2 RU2715227 C2 RU 2715227C2 RU 2017122022 A RU2017122022 A RU 2017122022A RU 2017122022 A RU2017122022 A RU 2017122022A RU 2715227 C2 RU2715227 C2 RU 2715227C2
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- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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| EP3034539A1 (en) | 2014-12-19 | 2016-06-22 | Ethris GmbH | Compositions for introducing nucleic acid into cells |
| JP2018520155A (ja) | 2015-06-30 | 2018-07-26 | エスリス ゲーエムベーハーｅｔｈｒｉｓ ＧｍｂＨ | ポリリボヌクレオチドをコードするａｔｐ結合カセットファミリーおよびその製剤 |
| WO2018010815A1 (en) * | 2016-07-15 | 2018-01-18 | Biontech Rna Pharmaceuticals Gmbh | Formulation for administration of rna |
| BR112020013974A8 (pt) * | 2018-01-11 | 2022-10-18 | Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Ggmbh | Formulação para administração de rna |
| CN112153985B (zh) | 2018-04-25 | 2024-03-01 | 埃泽瑞斯公司 | 用于颗粒制剂的防冻剂 |
| CN119733057A (zh) * | 2019-12-17 | 2025-04-01 | 根特大学 | 包含聚丙烯亚胺的非病毒载体 |
| CN111249476B (zh) * | 2020-02-19 | 2023-09-26 | 深圳厚存纳米药业有限公司 | 泊洛沙姆和/或泊洛沙胺与脂质组合中性复合物纳米粒 |
| JP2024507394A (ja) | 2021-02-26 | 2024-02-19 | エスリス ゲーエムベーハー | エアロゾル形成用の製剤および核酸を送達するためのエアロゾル |
| EP4404979A4 (en) * | 2021-09-22 | 2025-10-08 | Sirnaomics Inc | PHARMACEUTICAL COMPOSITIONS OF NANOPARTICLES WITH REDUCED NANOPARTICLE SIZE AND IMPROVED POLYDISPERSITY INDEX |
| CN116549626A (zh) * | 2022-01-27 | 2023-08-08 | 深圳瑞吉生物科技有限公司 | 一种载核酸脂质纳米颗粒冻干制剂及其制备方法与应用 |
| CN120129532A (zh) | 2022-08-26 | 2025-06-10 | 埃泽瑞斯公司 | 稳定的脂质或类脂质纳米颗粒悬浮液 |
| EP4327829A1 (en) | 2022-08-26 | 2024-02-28 | Ethris GmbH | Stabilization of lipid or lipidoid nanoparticle suspensions |
| WO2024240962A1 (en) | 2023-05-25 | 2024-11-28 | Ethris Gmbh | Gm-csf-encoding nucleic acids, pharmaceutical compositions, methods and uses thereof |
| CN116478410B (zh) * | 2023-06-20 | 2023-09-12 | 觅投克(北京)生物医学技术有限公司 | 一种菊糖修饰的聚乙烯亚胺衍生物及其制备方法和应用 |
| WO2025045767A1 (en) | 2023-08-25 | 2025-03-06 | Ethris Gmbh | Stabilized lipid and lipidoid nanoparticle formulations with specific surfactant properties for enhanced pharmaceutical applications |
| WO2025064850A1 (en) | 2023-09-22 | 2025-03-27 | BioNTech SE | Rna constructs with n-terminal degrons to enhance an immune response |
| WO2025106754A1 (en) | 2023-11-15 | 2025-05-22 | BioNTech SE | Coronavirus vaccine |
| KR20250071877A (ko) | 2023-11-15 | 2025-05-22 | 바이오엔테크 에스이 | Sars-cov-2 면역원성 조성물 |
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2014
- 2014-12-19 EP EP14199439.2A patent/EP3034539A1/en not_active Withdrawn
-
2015
- 2015-12-18 CN CN201580068845.7A patent/CN107001627B/zh active Active
- 2015-12-18 KR KR1020177019543A patent/KR102142180B1/ko active Active
- 2015-12-18 JP JP2017533008A patent/JP6745272B2/ja active Active
- 2015-12-18 US US15/537,096 patent/US11020487B2/en active Active
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- 2015-12-18 WO PCT/EP2015/080669 patent/WO2016097377A1/en not_active Ceased
- 2015-12-18 DK DK15823330.4T patent/DK3242903T3/da active
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| DK3242903T3 (da) | 2021-09-27 |
| JP2018502956A (ja) | 2018-02-01 |
| KR102142180B1 (ko) | 2020-08-07 |
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| CA2971284A1 (en) | 2016-06-23 |
| CA2971284C (en) | 2023-01-10 |
| BR112017012482B1 (pt) | 2021-10-19 |
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| CN107001627B (zh) | 2020-01-14 |
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| EP3242903A1 (en) | 2017-11-15 |
| CN107001627A (zh) | 2017-08-01 |
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| JP6745272B2 (ja) | 2020-08-26 |
| ES2887404T3 (es) | 2021-12-22 |
| KR20170097124A (ko) | 2017-08-25 |
| US20180236090A1 (en) | 2018-08-23 |
| AU2015366220B2 (en) | 2019-09-19 |
| EP3242903B1 (en) | 2021-07-28 |
| WO2016097377A1 (en) | 2016-06-23 |
| RU2017122022A (ru) | 2018-12-24 |
| US11020487B2 (en) | 2021-06-01 |
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