RU2685706C2 - Фармацевтические композиции, содержащие 15-гэпк, и способы лечения астмы и заболеваний легких с их применением - Google Patents
Фармацевтические композиции, содержащие 15-гэпк, и способы лечения астмы и заболеваний легких с их применением Download PDFInfo
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- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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| US201461926052P | 2014-01-10 | 2014-01-10 | |
| US61/926,052 | 2014-01-10 | ||
| PCT/US2015/011054 WO2015106215A2 (en) | 2014-01-10 | 2015-01-12 | Pharmaceutical compositions comprising 15-hepe and methods of treating asthma and lung disorders using same |
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| RU2019110980A Division RU2019110980A (ru) | 2014-01-10 | 2015-01-12 | Фармацевтические композиции, содержащие 15-гэпк, и способы лечения астмы и заболеваний легких с их применением |
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| RU2016132762A RU2016132762A (ru) | 2018-02-16 |
| RU2016132762A3 RU2016132762A3 (OSRAM) | 2018-09-20 |
| RU2685706C2 true RU2685706C2 (ru) | 2019-04-23 |
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| RU2019110980A RU2019110980A (ru) | 2014-01-10 | 2015-01-12 | Фармацевтические композиции, содержащие 15-гэпк, и способы лечения астмы и заболеваний легких с их применением |
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| RU2019110980A RU2019110980A (ru) | 2014-01-10 | 2015-01-12 | Фармацевтические композиции, содержащие 15-гэпк, и способы лечения астмы и заболеваний легких с их применением |
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| US (2) | US20150196521A1 (OSRAM) |
| EP (1) | EP3091959A4 (OSRAM) |
| JP (2) | JP2017505809A (OSRAM) |
| KR (1) | KR20160132372A (OSRAM) |
| CN (1) | CN106029051A (OSRAM) |
| AU (1) | AU2015204531B2 (OSRAM) |
| BR (1) | BR112016015997A2 (OSRAM) |
| CA (1) | CA2935986A1 (OSRAM) |
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| WO (1) | WO2015106215A2 (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6370775B2 (ja) | 2012-05-10 | 2018-08-08 | ソルテックス エヌエー エルエルシー | 天然の特異的炎症収束性メディエータおよびその前駆物質を含有する、抗炎症活性を有する油 |
| JP2016538288A (ja) | 2013-11-15 | 2016-12-08 | ディグニティ サイエンシス リミテッド | 多価不飽和ヒドロキシ脂肪酸の薬学的に許容される塩 |
| HK1247136A1 (zh) * | 2015-01-16 | 2018-09-21 | Afimmune Limited | 包含15-hepe的组合物和其使用方法 |
| EP3861995A1 (en) * | 2015-07-21 | 2021-08-11 | Affimune Limited | Compositions comprising 15-hepe for use in treating or preventing neurologic disease |
| WO2017041094A1 (en) | 2015-09-03 | 2017-03-09 | Solutex Na Llc | Compositions comprising omega-3 fatty acids, 17-hdha and 18- hepe and methods of using same |
| BR122023026625A2 (pt) | 2015-12-18 | 2024-01-16 | Afimmune Limited | Uso do ácido 15-hidroxieicosapentaenoico ou derivados farmaceuticamente aceitáveis do mesmo |
| US20210315851A1 (en) | 2020-04-03 | 2021-10-14 | Afimmune Limited | Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases |
| CN111481550A (zh) * | 2020-05-14 | 2020-08-04 | 王兆霖 | 含有噻托溴铵和阿福特罗的药物制剂 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020055538A1 (en) * | 2000-02-16 | 2002-05-09 | Serhan Charles N. | Aspirin-triggered lipid mediators |
| WO2003063793A2 (en) * | 2002-01-31 | 2003-08-07 | Pilot Therapeutics, Inc. | Fatty acid-containing compositions and methods for the treatment of cytokine mediated disorders |
| WO2012135032A2 (en) * | 2011-03-25 | 2012-10-04 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory particles |
| US20120264705A1 (en) * | 2012-01-26 | 2012-10-18 | Dignity Sciences Limited | Antimicrobial compositions comprising 15-hetre and methods of use thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05186342A (ja) * | 1992-01-10 | 1993-07-27 | Fujirebio Inc | 免疫調節作用を併せもつ抗炎症剤 |
| US20060160095A1 (en) * | 2002-12-13 | 2006-07-20 | Eirx Therapeutics Limited | Survivin |
| ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
| HRP20160373T1 (hr) * | 2005-03-16 | 2016-05-06 | Meda Pharma Gmbh & Co. Kg | Kombinacija antikolinergika i antagonista leukotrien receptora za liječenje bolesti dišnog sustava |
| JP5909183B2 (ja) * | 2010-08-19 | 2016-04-26 | 国立大学法人 東京大学 | オメガ３系脂肪酸由来の新規抗炎症性代謝物 |
| US8293790B2 (en) * | 2011-10-19 | 2012-10-23 | Dignity Sciences Limited | Pharmaceutical compositions comprising DGLA and benzoyl peroxide and methods of use thereof |
| US20130267598A1 (en) * | 2012-02-23 | 2013-10-10 | Dignity Sciences Limited | Pharmaceutical compositions comprising dgla, 15-ohepa, and/or 15-hetre and methods of reducing sebum production using same |
| JP6370775B2 (ja) * | 2012-05-10 | 2018-08-08 | ソルテックス エヌエー エルエルシー | 天然の特異的炎症収束性メディエータおよびその前駆物質を含有する、抗炎症活性を有する油 |
| GB201301626D0 (en) * | 2013-01-30 | 2013-03-13 | Dignity Sciences Ltd | Composition comprising 15-OHEPA and methods of using the same |
| MA41120A (fr) * | 2014-12-02 | 2017-10-10 | Afimmune Ltd | Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci |
-
2015
- 2015-01-12 CA CA2935986A patent/CA2935986A1/en not_active Abandoned
- 2015-01-12 BR BR112016015997A patent/BR112016015997A2/pt not_active Application Discontinuation
- 2015-01-12 CN CN201580008336.5A patent/CN106029051A/zh active Pending
- 2015-01-12 KR KR1020167021684A patent/KR20160132372A/ko not_active Withdrawn
- 2015-01-12 RU RU2016132762A patent/RU2685706C2/ru not_active IP Right Cessation
- 2015-01-12 RU RU2019110980A patent/RU2019110980A/ru unknown
- 2015-01-12 MX MX2016008953A patent/MX2016008953A/es unknown
- 2015-01-12 SG SG10202000496XA patent/SG10202000496XA/en unknown
- 2015-01-12 EP EP15735225.3A patent/EP3091959A4/en not_active Withdrawn
- 2015-01-12 JP JP2016563894A patent/JP2017505809A/ja not_active Ceased
- 2015-01-12 US US14/595,015 patent/US20150196521A1/en not_active Abandoned
- 2015-01-12 AU AU2015204531A patent/AU2015204531B2/en not_active Ceased
- 2015-01-12 SG SG11201605601UA patent/SG11201605601UA/en unknown
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2016
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- 2016-07-22 US US15/217,008 patent/US20160324820A1/en not_active Abandoned
- 2016-08-08 ZA ZA2016/05492A patent/ZA201605492B/en unknown
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2019
- 2019-08-15 JP JP2019149177A patent/JP2020002150A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020055538A1 (en) * | 2000-02-16 | 2002-05-09 | Serhan Charles N. | Aspirin-triggered lipid mediators |
| WO2003063793A2 (en) * | 2002-01-31 | 2003-08-07 | Pilot Therapeutics, Inc. | Fatty acid-containing compositions and methods for the treatment of cytokine mediated disorders |
| WO2012135032A2 (en) * | 2011-03-25 | 2012-10-04 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory particles |
| US20120264705A1 (en) * | 2012-01-26 | 2012-10-18 | Dignity Sciences Limited | Antimicrobial compositions comprising 15-hetre and methods of use thereof |
Non-Patent Citations (2)
| Title |
|---|
| WHEELOCK A.M. et al. American Journal of Respiratory and Critical Care Medicine // Allergic asthmatics exhibit altered response in oxylipin profile as compared to healthy and asthmatic controls after allergen provocation, 2011, 183:1, . * |
| WHEELOCK A.M. et al. American Journal of Respiratory and Critical Care Medicine // Allergic asthmatics exhibit altered response in oxylipin profile as compared to healthy and asthmatic controls after allergen provocation, 2011, 183:1, реферат. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2935986A1 (en) | 2015-07-16 |
| IL246623A0 (en) | 2016-08-31 |
| KR20160132372A (ko) | 2016-11-18 |
| RU2019110980A (ru) | 2019-08-26 |
| BR112016015997A2 (pt) | 2018-03-27 |
| PH12016501371A1 (en) | 2016-08-15 |
| WO2015106215A3 (en) | 2016-02-18 |
| EP3091959A4 (en) | 2017-09-20 |
| JP2020002150A (ja) | 2020-01-09 |
| SG10202000496XA (en) | 2020-03-30 |
| WO2015106215A2 (en) | 2015-07-16 |
| RU2016132762A (ru) | 2018-02-16 |
| US20150196521A1 (en) | 2015-07-16 |
| AU2015204531B2 (en) | 2019-11-14 |
| ZA201605492B (en) | 2018-11-28 |
| US20160324820A1 (en) | 2016-11-10 |
| SG11201605601UA (en) | 2016-08-30 |
| RU2016132762A3 (OSRAM) | 2018-09-20 |
| JP2017505809A (ja) | 2017-02-23 |
| CN106029051A (zh) | 2016-10-12 |
| AU2015204531A1 (en) | 2016-08-18 |
| EP3091959A2 (en) | 2016-11-16 |
| MX2016008953A (es) | 2017-02-02 |
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