RU2672583C2 - ИНГИБИТОРЫ TrkA КИНАЗЫ, ОСНОВАННЫЕ НА НИХ КОМПОЗИЦИИ И СПОСОБЫ - Google Patents

ИНГИБИТОРЫ TrkA КИНАЗЫ, ОСНОВАННЫЕ НА НИХ КОМПОЗИЦИИ И СПОСОБЫ Download PDF

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RU2672583C2
RU2672583C2 RU2016141646A RU2016141646A RU2672583C2 RU 2672583 C2 RU2672583 C2 RU 2672583C2 RU 2016141646 A RU2016141646 A RU 2016141646A RU 2016141646 A RU2016141646 A RU 2016141646A RU 2672583 C2 RU2672583 C2 RU 2672583C2
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Russia
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methyl
trifluoromethyl
pyrazol
benzamide
fluoro
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RU2016141646A
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Russian (ru)
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RU2016141646A3 (enExample
RU2016141646A (ru
Inventor
Хелен Митчелл
Марк Э. Фрэли
Эндрю Дж. КУК
И-Хэн Чэнь
Крейг А. Стамп
Сюй-Фан ЧЖАН
Кейси С. МакКОМАС
Кэти ШИРРИПА
Мелоди МакВЕРТЕР
Свати П. Мерсер
Керим Бабаоглу
Дунфан МЭН
Джейн ВУ
Пин ЛЮ
Харольд Б. ВУД
Цзяньмин Бао
Чунь Синг Ли
Цинхуа МАО
Чжици ЦИ
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Мерк Шарп И Доум Корп.
МСД Ар ЭНД Ди (ЧАЙНА) КО., ЛТД.
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
RU2016141646A 2014-03-26 2015-03-23 ИНГИБИТОРЫ TrkA КИНАЗЫ, ОСНОВАННЫЕ НА НИХ КОМПОЗИЦИИ И СПОСОБЫ RU2672583C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2014/074145 WO2015143654A1 (en) 2014-03-26 2014-03-26 TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
CNPCT/CN2014/074145 2014-03-26
PCT/US2015/021936 WO2015148344A2 (en) 2014-03-26 2015-03-23 Trka kinase inhibitors, compositions and methods thereof

Publications (3)

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RU2016141646A RU2016141646A (ru) 2018-04-27
RU2016141646A3 RU2016141646A3 (enExample) 2018-06-26
RU2672583C2 true RU2672583C2 (ru) 2018-11-16

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US (1) US9815846B2 (enExample)
EP (1) EP3122346B1 (enExample)
JP (1) JP2017512794A (enExample)
KR (1) KR20160128420A (enExample)
CN (1) CN106794161A (enExample)
AU (1) AU2015236428B2 (enExample)
BR (1) BR112016022069A2 (enExample)
CA (1) CA2943858A1 (enExample)
MX (1) MX2016012480A (enExample)
RU (1) RU2672583C2 (enExample)
WO (2) WO2015143654A1 (enExample)

Families Citing this family (24)

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Publication number Priority date Publication date Assignee Title
MX385843B (es) 2014-09-12 2025-03-18 Antibiotx Aps Uso antibacteriano de salicilanilidas halogenadas.
GB201509326D0 (en) 2015-05-29 2015-07-15 Antibio Tx Aps Novel use
GB201604484D0 (en) 2016-03-16 2016-04-27 Antibiotx Aps And Københavns Uni University Of Copenhagen Topical antibacterial compositions
JP6965083B2 (ja) * 2017-10-04 2021-11-10 公益財団法人微生物化学研究会 化合物、及び発光化合物
CN108794414B (zh) * 2018-06-22 2021-01-01 浙江大学 芳酰胺基取代的均三嗪类化合物及制备和应用
CN108997224B (zh) * 2018-08-28 2023-04-28 韶远科技（上海)有限公司 一种2-氯-5-氰基含氮六元杂环化合物的制备方法
MA54546A (fr) 2018-12-20 2022-03-30 Amgen Inc Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a
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