RU2660712C2 - Способы детекции антицитомегаловирусных нейтрализующих антител - Google Patents

Способы детекции антицитомегаловирусных нейтрализующих антител Download PDF

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RU2660712C2
RU2660712C2 RU2014142815A RU2014142815A RU2660712C2 RU 2660712 C2 RU2660712 C2 RU 2660712C2 RU 2014142815 A RU2014142815 A RU 2014142815A RU 2014142815 A RU2014142815 A RU 2014142815A RU 2660712 C2 RU2660712 C2 RU 2660712C2
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hcmv
fluorescence
infection
host cell
level
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RU2014142815A
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RU2014142815A (ru
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Дэвид И. АНДЕРСОН
Ясминка БОЗИЦ
Бартелеми ОНТСОУКА
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Вэриэйшн Биотекнолоджиз, Инк.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/03—Herpetoviridae, e.g. pseudorabies virus
    • G01N2333/04—Varicella-zoster virus
    • G01N2333/045—Cytomegalovirus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Physiology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
RU2014142815A 2012-03-27 2013-03-27 Способы детекции антицитомегаловирусных нейтрализующих антител RU2660712C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261616204P 2012-03-27 2012-03-27
US61/616,204 2012-03-27
PCT/IB2013/001021 WO2013144722A2 (en) 2012-03-27 2013-03-27 Methods for detection of anti-cytomegalovirus neutralizing antibodies

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RU2014142815A RU2014142815A (ru) 2016-05-20
RU2660712C2 true RU2660712C2 (ru) 2018-07-09

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US (2) US10006096B2 (enExample)
EP (2) EP2831285B1 (enExample)
JP (1) JP6265344B2 (enExample)
KR (2) KR102146340B1 (enExample)
CN (2) CN119716047A (enExample)
AU (2) AU2013239383B2 (enExample)
BR (1) BR112014023913B1 (enExample)
CA (1) CA2867789C (enExample)
MX (1) MX354822B (enExample)
RU (1) RU2660712C2 (enExample)
WO (1) WO2013144722A2 (enExample)

Cited By (1)

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RU2817217C1 (ru) * 2019-12-04 2024-04-11 Чжухай Триномаб Фармасьютикал Ко., Лтд. Антитело к цитомегаловирусу человека и его применение

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KR102146340B1 (ko) * 2012-03-27 2020-08-24 배리에이션 바이오테크놀로지스 아이엔씨. 항-사이토메갈로바이러스 중화 항체를 탐지하기 위한 방법
US10611800B2 (en) 2016-03-11 2020-04-07 Pfizer Inc. Human cytomegalovirus gB polypeptide
JP6850483B2 (ja) * 2018-03-06 2021-03-31 株式会社ＣｅＳＰＩＡ Ｃｅｌｌ−ｂａｓｅｄ ａｓｓａｙ法に基づいたハイスループット抗体検出方法
WO2019232453A1 (en) * 2018-06-01 2019-12-05 Gravid Therapies, Inc. Methods, kits, and products for detection of cytomegalovirus infection
WO2020036811A1 (en) * 2018-08-14 2020-02-20 Merck Sharp & Dohme Corp. A virus neutralization assay utilizing imaging cytometry
US11629172B2 (en) 2018-12-21 2023-04-18 Pfizer Inc. Human cytomegalovirus gB polypeptide
CN111474339A (zh) * 2020-04-17 2020-07-31 浙江康佰裕生物科技有限公司 一种利用荧光标记痘病毒颗粒的方法及其应用
TWI871709B (zh) 2020-06-21 2025-02-01 美商輝瑞股份有限公司 人巨細胞病毒糖蛋白Ｂ（ｇＢ）多肽
CN112362649B (zh) * 2020-11-09 2024-07-12 长春金赛药业有限责任公司 一种rhGH中和抗体的检测方法
CN112945919B (zh) * 2021-01-29 2023-04-28 上海睿钰生物科技有限公司 一种病毒中和抗体的检测方法、系统及其应用
CN114859046B (zh) * 2021-04-30 2025-11-28 中国人民解放军军事科学院军事医学研究院 含高效价抗hcmv中和抗体原料血浆的筛选方法和抗hcmv中和抗体效价的检测方法
US20250157651A1 (en) * 2022-01-19 2025-05-15 Trustees Of Dartmouth College Systems and methods for deterring viral transmission using neural networks
WO2023154857A2 (en) * 2022-02-11 2023-08-17 Trustees Of Dartmouth College Systems and methods for identifying and treating primary and latent infections and/or determining time since infection
CN119192349A (zh) * 2024-07-18 2024-12-27 北京市延庆区疾病预防控制中心 用于检测黄连素抗性病毒的试剂及方法

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RU2491340C2 (ru) * 2007-10-10 2013-08-27 Зе Трастиз Оф Принстон Юнивесити Вакцина против цитомегаловируса и способ ее получения
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RU2817217C1 (ru) * 2019-12-04 2024-04-11 Чжухай Триномаб Фармасьютикал Ко., Лтд. Антитело к цитомегаловирусу человека и его применение

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CN119716047A (zh) 2025-03-28
MX2014011504A (es) 2015-03-13
WO2013144722A3 (en) 2013-11-28
EP3613431A1 (en) 2020-02-26
US10006096B2 (en) 2018-06-26
EP3613431B1 (en) 2023-01-11
EP2831285A4 (en) 2015-10-28
JP2015518140A (ja) 2015-06-25
US10161010B2 (en) 2018-12-25
JP6265344B2 (ja) 2018-01-24
KR20140146630A (ko) 2014-12-26
BR112014023913B1 (pt) 2022-08-09
AU2013239383B2 (en) 2018-10-04
US20180274044A1 (en) 2018-09-27
AU2018271276A1 (en) 2018-12-20
CA2867789A1 (en) 2013-10-03
CA2867789C (en) 2022-06-14
RU2014142815A (ru) 2016-05-20
KR102146340B1 (ko) 2020-08-24
EP2831285A2 (en) 2015-02-04
KR102314245B1 (ko) 2021-10-20
CN104321444A (zh) 2015-01-28
AU2018271276B2 (en) 2021-06-03
US20150044668A1 (en) 2015-02-12
EP2831285B1 (en) 2019-10-30
BR112014023913A2 (enExample) 2017-06-20
AU2013239383A1 (en) 2014-10-16
KR20200095575A (ko) 2020-08-10
WO2013144722A2 (en) 2013-10-03
MX354822B (es) 2018-03-21

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