RU2660580C2 - Растворимый медиатор - Google Patents

Растворимый медиатор Download PDF

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RU2660580C2
RU2660580C2 RU2014122847A RU2014122847A RU2660580C2 RU 2660580 C2 RU2660580 C2 RU 2660580C2 RU 2014122847 A RU2014122847 A RU 2014122847A RU 2014122847 A RU2014122847 A RU 2014122847A RU 2660580 C2 RU2660580 C2 RU 2660580C2
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cells
soluble
cell
glycoprotein
protein
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RU2014122847A
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Russian (ru)
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RU2014122847A (ru
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САНЧЕЗ Эстер БАНДАЛА
Джеймс ДРОМИ
Леонард Чарльз ХАРРИСОН
Юйся ЧЖАН
Марям РАШИДИ
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Дзе Уолтер Энд Элиза Холл Инститьют Оф Медикал Рисёч
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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RU2014122847A 2011-11-15 2012-11-15 Растворимый медиатор RU2660580C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161560254P 2011-11-15 2011-11-15
US61/560,254 2011-11-15
US201261705633P 2012-09-26 2012-09-26
US61/705,633 2012-09-26
PCT/AU2012/001411 WO2013071355A1 (en) 2011-11-15 2012-11-15 Soluble mediator

Publications (2)

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RU2014122847A RU2014122847A (ru) 2015-12-27
RU2660580C2 true RU2660580C2 (ru) 2018-07-06

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RU2014122847A RU2660580C2 (ru) 2011-11-15 2012-11-15 Растворимый медиатор

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US (5) US9585969B2 (enExample)
EP (2) EP2750690B1 (enExample)
JP (1) JP6004594B2 (enExample)
KR (1) KR102134326B1 (enExample)
CN (1) CN103930123B (enExample)
AU (1) AU2012339618B2 (enExample)
BR (1) BR112014011758A2 (enExample)
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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2750690B1 (en) * 2011-11-15 2018-11-07 The Walter and Eliza Hall Institute of Medical Research Soluble mediator
WO2013185165A1 (en) * 2012-06-14 2013-12-19 The Walter And Eliza Hall Institute Of Medical Research Cd-52 antibodies and their use in determining and enhancing an immune response in a subject
EP2919799B1 (en) * 2012-11-15 2021-02-24 The Walter and Eliza Hall Institute of Medical Research Soluble mediator
EP3250602A1 (en) * 2015-01-26 2017-12-06 Cellectis T cell receptor knock out engineered immune cells, endowed with chimeric antigen receptors binding to cd123 for the treatment of relapsed/refractory acute myeloid lymphoma or blastic plasmacytoid dendritic cell neoplasm
EP3935073A4 (en) * 2019-03-07 2022-11-23 The Walter and Eliza Hall Institute of Medical Research IMMUNOSUPPRESSIVE GLYCOFORMS OF SOLUBLE CD52
AU2019201584B1 (en) * 2019-03-07 2019-12-05 Macquarie University Immunosuppressive glycoforms of soluble cd52
CN111909235B (zh) * 2019-05-08 2022-12-06 广西大学 一种利用Trans Well小室分离精子释放蛋白的方法
WO2021011678A1 (en) * 2019-07-15 2021-01-21 Bristol-Myers Squibb Company Anti-trem-1 antibodies and uses thereof
CN114315937B (zh) * 2022-01-13 2024-08-09 甘肃智仑新材料科技有限公司 一种压驱、压裂用生物质纳米增渗剂及其制备方法和应用
CN120927976B (zh) * 2025-08-12 2026-07-07 青岛山大齐鲁医院(山东大学齐鲁医院(青岛)) 检测抗dlat自身抗体的试剂在制备检测和/或诊断免疫介导的坏死性肌病的产品中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005036123A2 (en) * 2003-09-26 2005-04-21 Beckman Coulter, Inc. Methods for substantially simultaneous evaluation of a sample containing a cellular target and a soluble analyte
RU2369636C2 (ru) * 2003-05-23 2009-10-10 Уайт Лиганд gitr и связанные с лигандом gitr молекулы и антитела и варианты их применения
RU2403262C2 (ru) * 2003-06-11 2010-11-10 Уайт Выделенный полипептид ib альфа гликопротеина тромбоцитов человека, слитый белок, молекула днк (варианты), экспрессирующий вектор (варианты), клетка (варианты), способ экспрессии полипептида, способ экспрессии слитого белка, фармацевтическая композиция (варианты), способ ингибирования прикрепления клетки крови к биологической ткани в биологической системе, способ ингибирования прикрепления белка к биологической ткани в биологической системе и способ лечения нарушения

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8317576D0 (en) 1983-06-29 1983-08-03 Shaw A S W Consumer tobacco products
US4588580B2 (en) 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
US4904475A (en) 1985-05-03 1990-02-27 Alza Corporation Transdermal delivery of drugs from an aqueous reservoir
GB8514665D0 (en) 1985-06-11 1985-07-10 Eroceltique Sa Oral pharmaceutical composition
US4788062A (en) 1987-02-26 1988-11-29 Alza Corporation Transdermal administration of progesterone, estradiol esters, and mixtures thereof
US4816258A (en) 1987-02-26 1989-03-28 Alza Corporation Transdermal contraceptive formulations
US4927408A (en) 1988-10-03 1990-05-22 Alza Corporation Electrotransport transdermal system
US5792294A (en) 1995-11-16 1998-08-11 Otis Elevator Company Method of replacing sheave liner
JP4334866B2 (ja) * 2000-10-09 2009-09-30 アイシス イノヴェイション リミテッド 治療用抗体
DE60233744D1 (de) 2001-09-20 2009-10-29 Univ Texas Bestimmung der zirkulierenden therapeutischen antikörper, antigene sowie antigen-antikörper-komplexe mit elisa-tests
WO2005062893A2 (en) * 2003-12-22 2005-07-14 Genzyme Corporation Anti-cd52 antibody treatment for diabetes
WO2008028229A1 (en) 2006-09-05 2008-03-13 The Walter And Eliza Hall Institute Of Medical Research Methods of identifying markers
ES2606048T3 (es) 2008-05-30 2017-03-17 University Of Louisville Research Foundation, Inc. Células facilitadoras humanas
EP2542258A4 (en) 2010-03-04 2013-08-21 Vet Therapeutics Inc ON CD52 MONOCLONAL ANTIBODIES
EP2750690B1 (en) 2011-11-15 2018-11-07 The Walter and Eliza Hall Institute of Medical Research Soluble mediator

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2369636C2 (ru) * 2003-05-23 2009-10-10 Уайт Лиганд gitr и связанные с лигандом gitr молекулы и антитела и варианты их применения
RU2403262C2 (ru) * 2003-06-11 2010-11-10 Уайт Выделенный полипептид ib альфа гликопротеина тромбоцитов человека, слитый белок, молекула днк (варианты), экспрессирующий вектор (варианты), клетка (варианты), способ экспрессии полипептида, способ экспрессии слитого белка, фармацевтическая композиция (варианты), способ ингибирования прикрепления клетки крови к биологической ткани в биологической системе, способ ингибирования прикрепления белка к биологической ткани в биологической системе и способ лечения нарушения
WO2005036123A2 (en) * 2003-09-26 2005-04-21 Beckman Coulter, Inc. Methods for substantially simultaneous evaluation of a sample containing a cellular target and a soluble analyte

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALBITAR M. et al. Free circulating soluble CD52 as a tumor marker in chronic lymphocytic leukemia and its implication in therapy with anti-CD52 antibodies. Cancer. 2004 Sep 1; 101(5):999-1008. *
KIRCHHOFF C. et al. New insights into the origin, structure and role of CD52: a major component of the mammalian sperm glycocalyx. Cells Tissues Organs. 2001; 168(1-2):93-104. *
KIRCHHOFF C. et al. New insights into the origin, structure and role of CD52: a major component of the mammalian sperm glycocalyx. Cells Tissues Organs. 2001; 168(1-2):93-104. ALBITAR M. et al. Free circulating soluble CD52 as a tumor marker in chronic lymphocytic leukemia and its implication in therapy with anti-CD52 antibodies. Cancer. 2004 Sep 1; 101(5):999-1008. *

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