RU2644651C2 - Среда для культивирования клеток - Google Patents

Среда для культивирования клеток Download PDF

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Publication number
RU2644651C2
RU2644651C2 RU2012150346A RU2012150346A RU2644651C2 RU 2644651 C2 RU2644651 C2 RU 2644651C2 RU 2012150346 A RU2012150346 A RU 2012150346A RU 2012150346 A RU2012150346 A RU 2012150346A RU 2644651 C2 RU2644651 C2 RU 2644651C2
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cells
medium
concentration
ions
cell culture
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RU2012150346A
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English (en)
Russian (ru)
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RU2012150346A (ru
Inventor
Кристиан ЛЯЙСТ
Петра МАЙССНЕР
Йорг ШМИДТ
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Новартис Аг
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0031—Serum-free culture media
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/005—Protein-free medium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
RU2012150346A 2010-04-26 2011-04-25 Среда для культивирования клеток RU2644651C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32783610P 2010-04-26 2010-04-26
US61/327,836 2010-04-26
PCT/EP2011/056508 WO2011134920A1 (en) 2010-04-26 2011-04-25 Improved cell culture medium

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2018101201A Division RU2798069C2 (ru) 2010-04-26 2011-04-25 Улучшенная среда для культивирования клеток

Publications (2)

Publication Number Publication Date
RU2012150346A RU2012150346A (ru) 2014-06-10
RU2644651C2 true RU2644651C2 (ru) 2018-02-13

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2012150346A RU2644651C2 (ru) 2010-04-26 2011-04-25 Среда для культивирования клеток

Country Status (17)

Country Link
US (2) USRE48864E1 (OSRAM)
EP (1) EP2563904B1 (OSRAM)
JP (3) JP6347949B2 (OSRAM)
KR (1) KR101828623B1 (OSRAM)
CN (1) CN102858952B (OSRAM)
AU (1) AU2011246503B2 (OSRAM)
BR (1) BR112012027282B1 (OSRAM)
CA (1) CA2797356C (OSRAM)
DK (1) DK2563904T3 (OSRAM)
ES (1) ES2533074T3 (OSRAM)
IL (1) IL222452B (OSRAM)
MX (1) MX2012012526A (OSRAM)
PL (1) PL2563904T3 (OSRAM)
PT (1) PT2563904E (OSRAM)
RU (1) RU2644651C2 (OSRAM)
SG (1) SG185038A1 (OSRAM)
WO (1) WO2011134920A1 (OSRAM)

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US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9505833B2 (en) 2012-04-20 2016-11-29 Abbvie Inc. Human antibodies that bind human TNF-alpha and methods of preparing the same
US9150645B2 (en) 2012-04-20 2015-10-06 Abbvie, Inc. Cell culture methods to reduce acidic species
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US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
KR20150043523A (ko) 2012-09-02 2015-04-22 애브비 인코포레이티드 단백질 불균일성의 제어 방법
SG11201501460RA (en) 2012-09-11 2015-04-29 Coherus Biosciences Inc Correctly folded etanercept in high purity and excellent yield
US8921526B2 (en) 2013-03-14 2014-12-30 Abbvie, Inc. Mutated anti-TNFα antibodies and methods of their use
KR20150129033A (ko) 2013-03-14 2015-11-18 애브비 인코포레이티드 저 산성 종 조성물 및 이의 제조 및 사용 방법
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
CN105473614B (zh) 2013-08-20 2019-11-01 斯洛文尼亚莱柯制药股份有限公司 用于控制多肽的α-酰胺化和/或C-末端氨基酸分裂的细胞培养基和方法
EP3052640A2 (en) 2013-10-04 2016-08-10 AbbVie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US11390663B2 (en) 2013-10-11 2022-07-19 Regeneron Pharmaceuticals, Inc. Metabolically optimized cell culture
PL3055409T3 (pl) * 2013-10-11 2018-10-31 Regeneron Pharmaceuticals, Inc. Metabolicznie zoptymalizowana hodowla komórkowa
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
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ES2733298T3 (es) 2014-07-18 2019-11-28 Sandoz Ag Cuantificación de TNFR2:Fc plegado erróneamente
US10822584B2 (en) * 2015-12-17 2020-11-03 Life Technologies Corporation Pellets used in cell culture and methods of making thereof
ES2992543T3 (es) * 2016-04-05 2024-12-13 Pfizer Proceso de cultivo celular
JP6943972B2 (ja) * 2017-03-31 2021-10-06 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 灌流培地
US20200377918A1 (en) * 2017-03-31 2020-12-03 Boehringer Ingelheim International Gmbh Perfusion medium
EP3959305A1 (en) 2019-04-26 2022-03-02 Allogene Therapeutics, Inc. Methods of manufacturing allogeneic car t cells
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WO2021090888A1 (ja) * 2019-11-05 2021-05-14 味の素株式会社 タンパク質の製造方法
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Publication number Publication date
RU2018101201A (ru) 2019-02-21
WO2011134920A1 (en) 2011-11-03
BR112012027282B1 (pt) 2020-09-29
AU2011246503A1 (en) 2012-11-22
USRE48864E1 (en) 2021-12-28
MX2012012526A (es) 2012-11-23
JP6347949B2 (ja) 2018-06-27
KR101828623B1 (ko) 2018-02-12
US9428727B2 (en) 2016-08-30
US20130122543A1 (en) 2013-05-16
JP2019216728A (ja) 2019-12-26
IL222452B (en) 2019-03-31
JP2017012180A (ja) 2017-01-19
IL222452A0 (en) 2012-12-31
EP2563904A1 (en) 2013-03-06
JP6603628B2 (ja) 2019-11-06
KR20130058699A (ko) 2013-06-04
RU2018101201A3 (OSRAM) 2021-05-27
JP7034991B2 (ja) 2022-03-14
CN102858952B (zh) 2015-10-14
BR112012027282A2 (pt) 2015-09-22
CA2797356C (en) 2020-12-29
SG185038A1 (en) 2012-11-29
JP2013524825A (ja) 2013-06-20
PT2563904E (pt) 2015-05-12
RU2012150346A (ru) 2014-06-10
ES2533074T3 (es) 2015-04-07
CN102858952A (zh) 2013-01-02
DK2563904T3 (en) 2015-04-07
CA2797356A1 (en) 2011-11-03
PL2563904T3 (pl) 2015-06-30
AU2011246503B2 (en) 2013-09-26
EP2563904B1 (en) 2015-01-21

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