RU2638913C2 - Системы и способы для обнаружения частиц в полезном агенте - Google Patents
Системы и способы для обнаружения частиц в полезном агенте Download PDFInfo
- Publication number
- RU2638913C2 RU2638913C2 RU2014152326A RU2014152326A RU2638913C2 RU 2638913 C2 RU2638913 C2 RU 2638913C2 RU 2014152326 A RU2014152326 A RU 2014152326A RU 2014152326 A RU2014152326 A RU 2014152326A RU 2638913 C2 RU2638913 C2 RU 2638913C2
- Authority
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- Russia
- Prior art keywords
- image
- beneficial agent
- liquid beneficial
- particles
- intensity
- Prior art date
Links
- 239000002245 particle Substances 0.000 title claims abstract description 169
- 238000000034 method Methods 0.000 title claims abstract description 72
- 239000007788 liquid Substances 0.000 claims abstract description 104
- 238000001514 detection method Methods 0.000 claims abstract description 30
- 238000005286 illumination Methods 0.000 claims abstract description 10
- 230000035945 sensitivity Effects 0.000 claims abstract description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 162
- 230000009286 beneficial effect Effects 0.000 claims description 150
- 102000004169 proteins and genes Human genes 0.000 claims description 31
- 108090000623 proteins and genes Proteins 0.000 claims description 31
- 230000003287 optical effect Effects 0.000 claims description 25
- 238000004458 analytical method Methods 0.000 claims description 15
- 238000009826 distribution Methods 0.000 claims description 8
- 230000005855 radiation Effects 0.000 claims description 7
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 5
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 5
- 230000005284 excitation Effects 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 3
- 102000036639 antigens Human genes 0.000 claims description 3
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- 238000010191 image analysis Methods 0.000 claims description 3
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- 150000003384 small molecules Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 4
- 238000003384 imaging method Methods 0.000 description 16
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 12
- 229940098773 bovine serum albumin Drugs 0.000 description 12
- 238000010586 diagram Methods 0.000 description 9
- 238000001370 static light scattering Methods 0.000 description 9
- 238000007689 inspection Methods 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 229940071643 prefilled syringe Drugs 0.000 description 6
- 238000003672 processing method Methods 0.000 description 6
- 238000000149 argon plasma sintering Methods 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 238000002296 dynamic light scattering Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 238000003703 image analysis method Methods 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
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- 239000000178 monomer Substances 0.000 description 4
- 239000000356 contaminant Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
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- 230000002776 aggregation Effects 0.000 description 2
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- 230000036425 denaturation Effects 0.000 description 2
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- 230000001419 dependent effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000002105 nanoparticle Substances 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000012086 standard solution Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 description 2
- 239000002451 tumor necrosis factor inhibitor Substances 0.000 description 2
- 239000012901 Milli-Q water Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 206010054094 Tumour necrosis Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000012615 aggregate Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
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- 238000009792 diffusion process Methods 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- -1 for example Substances 0.000 description 1
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- 238000010255 intramuscular injection Methods 0.000 description 1
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- 239000000203 mixture Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229940116540 protein supplement Drugs 0.000 description 1
- 235000005974 protein supplement Nutrition 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
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- 238000013024 troubleshooting Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/90—Investigating the presence of flaws or contamination in a container or its contents
- G01N21/9018—Dirt detection in containers
- G01N21/9027—Dirt detection in containers in containers after filling
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
- G01N15/075—Investigating concentration of particle suspensions by optical means
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261651211P | 2012-05-24 | 2012-05-24 | |
| US61/651,211 | 2012-05-24 | ||
| US13/841,143 US10132736B2 (en) | 2012-05-24 | 2013-03-15 | Methods for inspection of protein particles in a liquid beneficial agent |
| US13/841,143 | 2013-03-15 | ||
| PCT/US2013/042481 WO2013177434A2 (en) | 2012-05-24 | 2013-05-23 | Systems and methods for detection of particles in a beneficial agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2014152326A RU2014152326A (ru) | 2016-07-20 |
| RU2638913C2 true RU2638913C2 (ru) | 2017-12-18 |
Family
ID=49622069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014152326A RU2638913C2 (ru) | 2012-05-24 | 2013-05-23 | Системы и способы для обнаружения частиц в полезном агенте |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10132736B2 (enExample) |
| EP (2) | EP3835753A3 (enExample) |
| JP (1) | JP2015517677A (enExample) |
| CN (1) | CN104487816A (enExample) |
| CA (1) | CA2873671A1 (enExample) |
| IN (1) | IN2014DN09753A (enExample) |
| MX (1) | MX337973B (enExample) |
| NZ (1) | NZ631595A (enExample) |
| RU (1) | RU2638913C2 (enExample) |
| SG (1) | SG11201407660SA (enExample) |
| WO (1) | WO2013177434A2 (enExample) |
| ZA (1) | ZA201408386B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU213288U1 (ru) * | 2021-02-14 | 2022-09-05 | Общество С Ограниченной Ответственностью "Нп Вижн" | Оптический измеритель численной концентрации наночастиц |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI840888B (zh) | 2011-08-29 | 2024-05-01 | 美商安美基公司 | 用於非破壞性檢測-流體中未溶解粒子之方法及裝置 |
| JP6247743B2 (ja) * | 2013-04-22 | 2017-12-13 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 注射デバイスに取り付けるための補助デバイス |
| GB2539504B (en) | 2015-06-19 | 2019-04-17 | Aqua21 Ltd | Absorption Sensor for Measuring Substance Concentration |
| EP3350574B1 (en) * | 2015-09-16 | 2021-12-15 | Thermo Electron Scientific Instruments LLC | Image analysis system and method |
| WO2017200939A1 (en) | 2016-05-16 | 2017-11-23 | Abbvie Inc. | Systems and methods for identifying protein aggregates in biotherapeutics |
| DE102016012585A1 (de) * | 2016-10-21 | 2018-04-26 | Seidenader Maschinenbau Gmbh | Vorrichtung zur Detektion von Luftblasen in einem mit Flüssigkeit befüllten Behälter |
| CN110023950B (zh) * | 2016-10-28 | 2023-08-08 | 拜克门寇尔特公司 | 物质准备评估系统 |
| CN106772975B (zh) * | 2017-01-19 | 2019-08-13 | 宁波纳美致生物科技有限公司 | 针对细胞或组织不同深度超分辨率显微成像的照明系统 |
| JP2020524123A (ja) * | 2017-05-31 | 2020-08-13 | ニプロ株式会社 | ガラス容器の評価方法 |
| EP3688446A2 (en) * | 2017-09-29 | 2020-08-05 | Apple Inc. | Resolve path optical sampling architectures |
| SG11202007756XA (en) * | 2018-03-30 | 2020-09-29 | Amgen Inc | Camera-based drug container inspection |
| JP7116419B2 (ja) * | 2018-10-04 | 2022-08-10 | 国立研究開発法人産業技術総合研究所 | 粒子測定装置、較正方法、および測定装置 |
| WO2020131666A1 (en) | 2018-12-17 | 2020-06-25 | Amgen Inc. | Sheet lighting for particle detection in drug product containers |
| CN109883905A (zh) * | 2019-03-07 | 2019-06-14 | 南京理工大学 | 水下粒径在线测量系统及方法 |
| WO2021173604A1 (en) * | 2020-02-24 | 2021-09-02 | Des-Case Corporation | Apparatuses, systems, and methods for providing a smart liquid information indicator |
| CN112730174A (zh) * | 2020-12-17 | 2021-04-30 | 华南理工大学 | 一种实时监测结晶过程中类球形颗粒浓度的方法 |
| WO2022168434A1 (ja) * | 2021-02-05 | 2022-08-11 | 株式会社堀場製作所 | 粒子分析装置、粒子分析方法、及び、粒子分析装置用プログラム |
| JP7281500B2 (ja) * | 2021-05-17 | 2023-05-25 | 東亜建設工業株式会社 | 画像データの取得方法および取得システム |
| US20230394696A1 (en) * | 2022-06-02 | 2023-12-07 | University Of Central Florida Research Foundation, Inc. | Systems and methods for image-based characterization of fluid in an enclosed container |
| TWI863605B (zh) * | 2023-10-03 | 2024-11-21 | 住華科技股份有限公司 | 溶液的粒子濃度分佈的檢測方法 |
| DE102025101336A1 (de) | 2024-01-19 | 2025-07-24 | Abbvie Inc. | Zusammensetzungen von clostridium botulinum neurotoxin serotyp a und verbesserte trocknungsprozesse |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5674410A (en) * | 1993-07-20 | 1997-10-07 | Dainippon Screen Manufacturing Co., Ltd. | Chemical agent producing device and method thereof |
| WO2005099408A2 (en) * | 2004-04-10 | 2005-10-27 | Michael Trainer | Methods and apparatus for determining particle characterics by measuring scattered light |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3627423A (en) | 1970-02-17 | 1971-12-14 | Schering Corp | Method and apparatus for detecting particular matter in sealed liquids |
| US3713743A (en) | 1970-11-25 | 1973-01-30 | Agricultural Control Syst | Forward scatter optical turbidimeter apparatus |
| US3830969A (en) | 1971-10-14 | 1974-08-20 | Princeton Electronic Prod | System for detecting particulate matter |
| FR2276581A1 (fr) | 1974-06-27 | 1976-01-23 | Kolikovitcher Irene | Appareil pour le controle d'ampoules pharmaceutiques |
| JPS56104233A (en) * | 1980-01-25 | 1981-08-19 | Kanebo Ltd | Counter for microscopic object in liquid |
| US4814868A (en) | 1987-10-02 | 1989-03-21 | Quadtek, Inc. | Apparatus and method for imaging and counting moving particles |
| JPH01308942A (ja) | 1988-06-08 | 1989-12-13 | Mitsubishi Electric Corp | 固体表面付着微粒子計数装置 |
| JPH03156370A (ja) | 1989-11-15 | 1991-07-04 | Hitachi Ltd | 免疫測定方法および装置 |
| US5269937A (en) | 1990-10-23 | 1993-12-14 | Cetus Corporation | HPLC light scattering detector for biopolymers |
| JPH0720049A (ja) * | 1993-07-05 | 1995-01-24 | Nippondenso Co Ltd | 液体性状検出装置 |
| US5835211A (en) | 1996-03-28 | 1998-11-10 | Particle Sizing Systems, Inc. | Single-particle optical sensor with improved sensitivity and dynamic size range |
| JP3731700B2 (ja) | 1997-12-25 | 2006-01-05 | 興和株式会社 | 蛍光粒子撮像装置 |
| CA2439307A1 (en) * | 2001-02-23 | 2002-09-06 | Genicon Sciences Corporation | Methods for providing extended dynamic range in analyte assays |
| US7430047B2 (en) * | 2004-03-09 | 2008-09-30 | Gerald Walter Budd | Small container fluid dynamics to produce optimized inspection conditions |
| EP1630550A1 (en) * | 2004-08-27 | 2006-03-01 | Moller & Devicon A/S | Methods and apparatuses of detecting foreign particles or faults in a plurality of filled containers |
| TW200806317A (en) | 2006-03-20 | 2008-02-01 | Wyeth Corp | Methods for reducing protein aggregation |
| US9417176B2 (en) | 2007-01-19 | 2016-08-16 | Tudor Arvinte | Method and apparatus for detecting and registering properties of samples |
| EP2232231A4 (en) | 2007-12-04 | 2015-12-02 | Particle Measuring Syst | SYSTEMS AND METHODS FOR DETECTION OF NON-ORTHOGONAL PARTICLES |
| CN107121396B (zh) * | 2008-09-24 | 2020-06-30 | 曙光生命科学公司 | 用于检测分析物的方法 |
| NZ706187A (en) * | 2009-10-26 | 2016-09-30 | Nestec Sa | Assays for the detection of anti-tnf drugs and autoantibodies |
| JP5330317B2 (ja) | 2010-06-02 | 2013-10-30 | 株式会社日立ハイテクノロジーズ | 生体試料の分析方法および分析装置 |
| FR2963103B1 (fr) | 2010-07-22 | 2012-08-24 | Commissariat Energie Atomique | Procede d'estimation de la quantite d'entites deposees sur des microparticules en suspension dans une solution, dispositif associe et utilisation de ce dispositif |
| US8405033B2 (en) | 2010-07-30 | 2013-03-26 | Buglab Llc | Optical sensor for rapid determination of particulate concentration |
| TWI840888B (zh) | 2011-08-29 | 2024-05-01 | 美商安美基公司 | 用於非破壞性檢測-流體中未溶解粒子之方法及裝置 |
| DE102011084583A1 (de) | 2011-10-17 | 2013-04-18 | Zf Friedrichshafen Ag | Betätigungseinrichtung zum Betätigen von Schaltelementen |
-
2013
- 2013-03-15 US US13/841,143 patent/US10132736B2/en active Active
- 2013-05-23 NZ NZ631595A patent/NZ631595A/en not_active IP Right Cessation
- 2013-05-23 WO PCT/US2013/042481 patent/WO2013177434A2/en not_active Ceased
- 2013-05-23 RU RU2014152326A patent/RU2638913C2/ru not_active IP Right Cessation
- 2013-05-23 EP EP20204855.9A patent/EP3835753A3/en not_active Withdrawn
- 2013-05-23 SG SG11201407660SA patent/SG11201407660SA/en unknown
- 2013-05-23 EP EP13728872.6A patent/EP2856106A2/en not_active Withdrawn
- 2013-05-23 CA CA 2873671 patent/CA2873671A1/en not_active Abandoned
- 2013-05-23 CN CN201380039409.8A patent/CN104487816A/zh active Pending
- 2013-05-23 MX MX2014014340A patent/MX337973B/es active IP Right Grant
- 2013-05-23 JP JP2015514197A patent/JP2015517677A/ja active Pending
-
2014
- 2014-11-13 ZA ZA2014/08386A patent/ZA201408386B/en unknown
- 2014-11-18 IN IN9753DEN2014 patent/IN2014DN09753A/en unknown
-
2015
- 2015-04-20 US US14/691,322 patent/US10126226B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5674410A (en) * | 1993-07-20 | 1997-10-07 | Dainippon Screen Manufacturing Co., Ltd. | Chemical agent producing device and method thereof |
| WO2005099408A2 (en) * | 2004-04-10 | 2005-10-27 | Michael Trainer | Methods and apparatus for determining particle characterics by measuring scattered light |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU213288U1 (ru) * | 2021-02-14 | 2022-09-05 | Общество С Ограниченной Ответственностью "Нп Вижн" | Оптический измеритель численной концентрации наночастиц |
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201407660SA (en) | 2014-12-30 |
| EP3835753A2 (en) | 2021-06-16 |
| US20130316934A1 (en) | 2013-11-28 |
| WO2013177434A3 (en) | 2014-01-30 |
| MX337973B (es) | 2016-03-29 |
| US10126226B2 (en) | 2018-11-13 |
| US10132736B2 (en) | 2018-11-20 |
| IN2014DN09753A (enExample) | 2015-07-31 |
| NZ631595A (en) | 2016-05-27 |
| US20150226659A1 (en) | 2015-08-13 |
| CN104487816A (zh) | 2015-04-01 |
| EP3835753A3 (en) | 2021-09-22 |
| RU2014152326A (ru) | 2016-07-20 |
| MX2014014340A (es) | 2015-03-03 |
| CA2873671A1 (en) | 2013-11-28 |
| ZA201408386B (en) | 2015-11-25 |
| WO2013177434A2 (en) | 2013-11-28 |
| JP2015517677A (ja) | 2015-06-22 |
| EP2856106A2 (en) | 2015-04-08 |
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