RU2637795C2 - Анализ образцов для масс-цитометрии - Google Patents
Анализ образцов для масс-цитометрии Download PDFInfo
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- RU2637795C2 RU2637795C2 RU2015123440A RU2015123440A RU2637795C2 RU 2637795 C2 RU2637795 C2 RU 2637795C2 RU 2015123440 A RU2015123440 A RU 2015123440A RU 2015123440 A RU2015123440 A RU 2015123440A RU 2637795 C2 RU2637795 C2 RU 2637795C2
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- Prior art keywords
- ablation
- injector
- laser
- jet
- sample
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- 238000002679 ablation Methods 0.000 claims abstract description 158
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- 238000000095 laser ablation inductively coupled plasma mass spectrometry Methods 0.000 abstract description 8
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Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N15/1436—Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
- H01J49/0463—Desorption by laser or particle beam, followed by ionisation as a separate step
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/105—Ion sources; Ion guns using high-frequency excitation, e.g. microwave excitation, Inductively Coupled Plasma [ICP]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361812893P | 2013-04-17 | 2013-04-17 | |
| US61/812,893 | 2013-04-17 | ||
| PCT/CA2014/050387 WO2014169394A1 (en) | 2013-04-17 | 2014-04-17 | Sample analysis for mass cytometry |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015123440A RU2015123440A (ru) | 2017-05-22 |
| RU2637795C2 true RU2637795C2 (ru) | 2017-12-07 |
Family
ID=51730644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015123440A RU2637795C2 (ru) | 2013-04-17 | 2014-04-17 | Анализ образцов для масс-цитометрии |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US9589779B2 (OSRAM) |
| EP (2) | EP3690923A1 (OSRAM) |
| JP (1) | JP6230693B2 (OSRAM) |
| CN (1) | CN105190829B (OSRAM) |
| CA (2) | CA2895360C (OSRAM) |
| RU (1) | RU2637795C2 (OSRAM) |
| SG (2) | SG10201808165YA (OSRAM) |
| WO (1) | WO2014169394A1 (OSRAM) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150134373A (ko) | 2013-03-22 | 2015-12-01 | 에테하 취리히 | 레이저 어블레이션 셀 |
| US9589779B2 (en) | 2013-04-17 | 2017-03-07 | Fluidigm Canada Inc. | Sample analysis for mass cytometry |
| WO2015038784A1 (en) | 2013-09-13 | 2015-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | Multiplexed imaging of tissues using mass tags and secondary ion mass spectrometry |
| GB201403625D0 (en) * | 2014-02-28 | 2014-04-16 | Asrepresented By The Sec Dep Of Health And Human Services The | Multiplexed imaging of tissue samples by mass cytometry |
| WO2016042165A1 (en) * | 2014-09-18 | 2016-03-24 | Universiteit Gent | Laser ablation probe |
| US10139332B2 (en) * | 2014-12-29 | 2018-11-27 | Fluidigm Canada Inc. | Mass cytometry apparatus and methods |
| WO2016109825A1 (en) | 2014-12-31 | 2016-07-07 | Fluidigm Canada Inc. | Structured biological samples for analysis by mass cytometry |
| WO2016126988A1 (en) * | 2015-02-04 | 2016-08-11 | Fluidigm Canada Inc. | Laser enabled imaging mass cytometry |
| CA2980133A1 (en) | 2015-03-25 | 2016-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Single cell analysis using secondary ion mass spectrometry |
| US9797879B2 (en) | 2015-04-23 | 2017-10-24 | The Board Of Trustees Of The Leland Stanford Junior University | Method for multiplexed sample analysis by photoionizing secondary sputtered neutrals |
| EP3494591A1 (en) * | 2016-08-02 | 2019-06-12 | Fluidigm Canada Inc. | Laser ablation system |
| WO2018115415A1 (en) * | 2016-12-22 | 2018-06-28 | Advanced Osteotomy Tools - Aot Ag | Laser device and tissue characterizing method |
| US11092519B1 (en) * | 2017-02-06 | 2021-08-17 | Elemental Scientific Lasers, Llc | System and method for automated sampling and analysis |
| JP7078382B2 (ja) * | 2017-11-22 | 2022-05-31 | 藤太郎 今坂 | 飛行時間型質量分析装置及び質量分析方法 |
| US11892428B2 (en) | 2018-04-18 | 2024-02-06 | S.T.Japan Inc. | Laser ablation device and analysis apparatus |
| EP3807922A4 (en) * | 2018-06-18 | 2022-03-23 | Fluidigm Canada Inc. | HIGH RESOLUTION IMAGING DEVICE AND METHOD |
| JP7489378B2 (ja) * | 2018-09-10 | 2024-05-23 | フリューダイム カナダ インコーポレイテッド | 高速変調サンプルイメージング装置及び方法 |
| CA3112257A1 (en) | 2018-09-10 | 2020-03-19 | Fluidigm Canada Inc. | Autofocus sample imaging apparatus and method |
| KR102577694B1 (ko) * | 2018-09-11 | 2023-09-12 | 주식회사 엘지에너지솔루션 | 검출 감도 향상을 위한 레이저 탈착-dart-ms 시스템 및 이에 사용되는 인터페이스 유닛 |
| CN111954917B (zh) * | 2018-09-11 | 2023-11-07 | 株式会社 Lg新能源 | 接口单元 |
| WO2020092236A1 (en) * | 2018-10-29 | 2020-05-07 | Fluidigm Canada Inc. | Inductively coupled plasma torch with reverse vortex flow and method of operation |
| CN109668818B (zh) * | 2018-12-26 | 2024-07-12 | 宁波大学 | 基于激光烧蚀的细胞分析装置及方法 |
| EP3911760A4 (en) * | 2019-01-15 | 2022-10-12 | Fluidigm Canada Inc. | DIRECT IONIZATION IN IMAGING MASS SPECTROMETRY |
| EP3712923A1 (en) * | 2019-03-18 | 2020-09-23 | ETH Zurich | Ion source for inductively coupled plasma mass spectrometry |
| CN114207775B (zh) | 2019-05-15 | 2023-06-06 | 上海宸安生物科技有限公司 | 用于质谱法的样品输送装置 |
| CA3140663A1 (en) * | 2019-06-18 | 2020-12-24 | Paul Corkum | Improved mass cytometry |
| US20230215714A1 (en) * | 2019-12-20 | 2023-07-06 | Standard Biotools Canada Inc. | Plasma and sampling geometries for imaging mass cytometry |
| JP7601422B2 (ja) * | 2020-02-19 | 2024-12-17 | エレメンタル・サイエンティフィック・レーザーズ・リミテッド・ライアビリティ・カンパニー | ホモジナイザの動きによる可変ビームサイズ |
| EP3943197A1 (en) * | 2020-07-20 | 2022-01-26 | The Provost, Fellows, Scholars and other Members of Board of Trinity College Dublin | Jet deposition using laser-produced dry aerosol |
| US11776801B2 (en) | 2020-09-18 | 2023-10-03 | Standard Biotools Canada Inc. | Inductively coupled plasma based atomic analysis systems and methods |
| US11443933B1 (en) * | 2020-10-30 | 2022-09-13 | Agilent Technologies, Inc. | Inductively coupled plasma mass spectrometry (ICP-MS) with ion trapping |
| JP2022131579A (ja) | 2021-02-26 | 2022-09-07 | キオクシア株式会社 | 分析装置および分析方法 |
| CA3211376A1 (en) | 2021-03-15 | 2022-09-22 | Mitchell A. Winnik | Metal-labeled polymer microbeads with control over labeling level |
| CN113218846A (zh) * | 2021-03-18 | 2021-08-06 | 上海交通大学 | 一种面向于单细胞质谱流式分析的icp装置 |
| CN117501408A (zh) * | 2021-04-14 | 2024-02-02 | 吉米亚分析公司 | 为icp-ms生成高产率负离子的系统 |
| AT525093B1 (de) * | 2021-10-05 | 2022-12-15 | Univ Wien Tech | Vorrichtung zur Aufnahme eines Feststoff-Probenmaterials |
| WO2024224612A1 (ja) * | 2023-04-28 | 2024-10-31 | 株式会社 イアス | レーザーアブレーションｉｃｐ分析方法及び分析装置 |
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- 2014-04-17 CN CN201480009995.6A patent/CN105190829B/zh active Active
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- 2014-04-17 SG SG10201808165YA patent/SG10201808165YA/en unknown
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- 2014-04-17 JP JP2016507962A patent/JP6230693B2/ja active Active
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Also Published As
| Publication number | Publication date |
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| US20180306695A1 (en) | 2018-10-25 |
| US20190271630A1 (en) | 2019-09-05 |
| US9952132B2 (en) | 2018-04-24 |
| EP2987177A4 (en) | 2016-11-30 |
| EP3690923A1 (en) | 2020-08-05 |
| US10705006B2 (en) | 2020-07-07 |
| US10241023B2 (en) | 2019-03-26 |
| CA2895360C (en) | 2023-05-02 |
| US11630050B2 (en) | 2023-04-18 |
| CA2895360A1 (en) | 2014-10-23 |
| CN105190829B (zh) | 2018-04-03 |
| CN105190829A (zh) | 2015-12-23 |
| WO2014169394A1 (en) | 2014-10-23 |
| US20220178809A1 (en) | 2022-06-09 |
| RU2015123440A (ru) | 2017-05-22 |
| US20170248507A1 (en) | 2017-08-31 |
| SG11201504874QA (en) | 2015-07-30 |
| CA3191952A1 (en) | 2014-10-23 |
| EP2987177A1 (en) | 2016-02-24 |
| JP6230693B2 (ja) | 2017-11-15 |
| JP2016522887A (ja) | 2016-08-04 |
| US20200408662A1 (en) | 2020-12-31 |
| SG10201808165YA (en) | 2018-10-30 |
| US11099116B2 (en) | 2021-08-24 |
| US20160056031A1 (en) | 2016-02-25 |
| EP2987177B1 (en) | 2020-01-08 |
| US9589779B2 (en) | 2017-03-07 |
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