RU2622605C2 - Устройство трансдермальной доставки лекарств - Google Patents
Устройство трансдермальной доставки лекарств Download PDFInfo
- Publication number
- RU2622605C2 RU2622605C2 RU2015138281A RU2015138281A RU2622605C2 RU 2622605 C2 RU2622605 C2 RU 2622605C2 RU 2015138281 A RU2015138281 A RU 2015138281A RU 2015138281 A RU2015138281 A RU 2015138281A RU 2622605 C2 RU2622605 C2 RU 2622605C2
- Authority
- RU
- Russia
- Prior art keywords
- skin
- housing
- microneedle assembly
- drug delivery
- reservoir
- Prior art date
Links
- 238000013271 transdermal drug delivery Methods 0.000 title claims abstract description 47
- 239000003814 drug Substances 0.000 claims abstract description 73
- 229940079593 drug Drugs 0.000 claims abstract description 68
- 230000002146 bilateral effect Effects 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 18
- 238000012377 drug delivery Methods 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims abstract description 7
- 238000012546 transfer Methods 0.000 claims abstract description 4
- 239000000463 material Substances 0.000 claims description 20
- 239000012790 adhesive layer Substances 0.000 claims description 16
- 239000012530 fluid Substances 0.000 claims description 16
- 238000004891 communication Methods 0.000 claims description 7
- 230000007246 mechanism Effects 0.000 claims description 7
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 229940126601 medicinal product Drugs 0.000 claims 1
- 230000037317 transdermal delivery Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 91
- 239000012528 membrane Substances 0.000 description 14
- 238000013461 design Methods 0.000 description 9
- 239000010410 layer Substances 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 210000000434 stratum corneum Anatomy 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000012229 microporous material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000037368 penetrate the skin Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000036316 preload Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 229960005475 antiinfective agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000037237 body shape Effects 0.000 description 1
- BAUGPFZKDROCKT-UHFFFAOYSA-N butyl acetate;ethene Chemical compound C=C.CCCCOC(C)=O BAUGPFZKDROCKT-UHFFFAOYSA-N 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000036558 skin tension Effects 0.000 description 1
- 238000005476 soldering Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
- A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
- A61M2005/14252—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
- A61M2005/1587—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body suitable for being connected to an infusion line after insertion into a patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361770639P | 2013-02-28 | 2013-02-28 | |
| US61/770,639 | 2013-02-28 | ||
| PCT/IB2014/059345 WO2014132240A1 (en) | 2013-02-28 | 2014-02-28 | Transdermal drug delivery device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015138281A RU2015138281A (ru) | 2017-03-20 |
| RU2622605C2 true RU2622605C2 (ru) | 2017-06-16 |
Family
ID=51427583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015138281A RU2622605C2 (ru) | 2013-02-28 | 2014-02-28 | Устройство трансдермальной доставки лекарств |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10183156B2 (https=) |
| EP (1) | EP2961471B1 (https=) |
| JP (2) | JP6522523B2 (https=) |
| KR (3) | KR102571835B1 (https=) |
| CN (2) | CN105073179B (https=) |
| AU (1) | AU2014222308B2 (https=) |
| BR (1) | BR112015020328B1 (https=) |
| CA (1) | CA2901568C (https=) |
| MX (1) | MX360121B (https=) |
| RU (1) | RU2622605C2 (https=) |
| WO (1) | WO2014132240A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107613853A (zh) * | 2015-01-23 | 2018-01-19 | 马尔西奥·马克·阿布雷乌 | 用于皮肤处理的设备和方法 |
| PL3325081T3 (pl) | 2015-07-24 | 2021-12-20 | Sorrento Therapeutics, Inc. | Sposoby dostarczania limfatycznego środków czynnych |
| BR112018001292A2 (pt) | 2015-07-24 | 2018-09-11 | Kimberly Clark Co | métodos para melhor liberação de agentes ativos a tumores |
| BR112018012526B1 (pt) * | 2015-12-21 | 2022-08-09 | Medrx Co., Ltd | Alojamento de aplicador de adesivo de microagulha, e, aplicador de adesivo de microagulha |
| KR101672671B1 (ko) * | 2016-03-03 | 2016-11-03 | 김경원 | 석션 니들 부재와 결합되는 환형 밀착캡을 갖는 오토 인젝터 핸드피스 |
| JP6726512B2 (ja) * | 2016-03-31 | 2020-07-22 | コスメディ製薬株式会社 | マイクロニードルアプリケータ |
| US11311708B2 (en) * | 2016-04-29 | 2022-04-26 | Sorrento Therapeutics, Inc. | Microneedle array assembly and fluid delivery apparatus having such an assembly |
| CA3031059C (en) * | 2016-07-18 | 2023-04-04 | Siemens Healthcare Diagnostics Inc. | Biofouling prevention of wearable sensors and methods of use and calibration related thereto |
| KR101933767B1 (ko) * | 2016-09-05 | 2018-12-28 | (의료)길의료재단 | 발기부전 환자를 위한 콘돔 |
| US11266344B2 (en) | 2016-09-21 | 2022-03-08 | Samsung Electronics Co., Ltd. | Method for measuring skin condition and electronic device therefor |
| WO2018096534A1 (en) | 2016-11-22 | 2018-05-31 | Sorrel Medical Ltd. | Apparatus for delivering a therapeutic substance |
| WO2018132430A1 (en) * | 2017-01-10 | 2018-07-19 | A.T. Still Universiy | Fluid infusion system |
| JP6931217B2 (ja) * | 2017-03-28 | 2021-09-01 | コスメディ製薬株式会社 | 水溶性シート状製剤のアプリケータ |
| US11541015B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
| WO2018213579A1 (en) * | 2017-05-17 | 2018-11-22 | Massachusetts Institute Of Technology | Self-actuating articles |
| USD895109S1 (en) * | 2017-10-18 | 2020-09-01 | Roche Diabetes Care, Inc. | Inserter for an infusion set |
| CN109718421B (zh) * | 2017-10-27 | 2022-04-29 | 研能科技股份有限公司 | 穿戴式人体胰岛素注入供液装置 |
| AU2019269636A1 (en) | 2018-05-17 | 2020-11-19 | Massachusetts Institute Of Technology | Systems for electrical stimulation |
| EP3603489A1 (fr) * | 2018-08-03 | 2020-02-05 | PKvitality | Système de surveillance corporelle avec liaison séparable |
| AU2019352635B2 (en) * | 2018-10-02 | 2024-12-19 | WearOptimo Pty Ltd | Actuator system |
| WO2020069568A1 (en) | 2018-10-02 | 2020-04-09 | WearOptimo Pty Ltd | Treatment delivery system |
| EP3744368B1 (en) | 2018-10-05 | 2026-02-18 | LTS Device Technologies Ltd | Triggering sequence |
| DE102019200563A1 (de) * | 2019-01-17 | 2020-07-23 | Lts Lohmann Therapie-Systeme Ag | Applikator |
| CN109966636B (zh) * | 2019-04-17 | 2025-01-24 | 苏州微亮生物科技有限公司 | 一种给药导入装置 |
| BR112022005788A2 (pt) | 2019-10-01 | 2022-06-21 | Unomedical As | Conector |
| JP2023505231A (ja) | 2019-12-05 | 2023-02-08 | ソレント・セラピューティクス・インコーポレイテッド | リンパ管送達デバイスによる抗ｐｄ－１または抗ｐｄ－ｌ１治療剤の投与による癌の処置方法 |
| JP7649574B2 (ja) | 2020-10-06 | 2025-03-21 | イオフロー・カンパニー・リミテッド | 薬液注入装置 |
| KR102548189B1 (ko) * | 2020-10-20 | 2023-06-28 | 이오플로우(주) | 약액 주입 장치 |
| CN117813128A (zh) | 2021-01-22 | 2024-04-02 | 索伦托药业有限公司 | 用于微升级淋巴递送冠状病毒疫苗的装置 |
| WO2022192594A2 (en) | 2021-03-11 | 2022-09-15 | Sorrento Therapeutics, Inc. | Nucleic acid molecules and vaccines comprising same for the prevention and treatment of coronavirus infections and disease |
| US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12178979B2 (en) | 2021-10-13 | 2024-12-31 | Satio, Inc. | Dermal patch for delivering a pharmaceutical |
| US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
| US12053284B2 (en) | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11452474B1 (en) | 2021-04-14 | 2022-09-27 | Satio, Inc. | Dual lever dermal patch system |
| US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12048543B2 (en) | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
| US12214346B2 (en) | 2021-10-13 | 2025-02-04 | Satio, Inc. | Dermal patch with a diagnostic test strip |
| US20240279339A1 (en) | 2021-06-09 | 2024-08-22 | Vivasor, Inc. | Method of treating cancer by administration of an anti-pd-1 or anti-pd-l1 therapeutic agent via a lymphatic microneedle delivery device |
| CN117836023A (zh) | 2021-07-23 | 2024-04-05 | 康沃特克有限公司 | 具有穿刺机构的端口 |
| JP2024531337A (ja) | 2021-08-18 | 2024-08-29 | ソレント・セラピューティクス・インコーポレイテッド | リンパ系を標的化する治療剤 |
| CN115738042B (zh) * | 2022-11-15 | 2026-02-24 | 中国人民解放军联勤保障部队第九〇〇医院 | 一种纽扣式自动镇痛装置 |
| CN116585606A (zh) * | 2023-06-15 | 2023-08-15 | 徕兄健康科技(威海)有限责任公司 | 一种可自调节的局部麻醉用微针贴片 |
| WO2025129128A1 (en) | 2023-12-15 | 2025-06-19 | Vivasor, Inc. | Compositions and methods for non-viral delivery of therapeutic compounds |
| KR20250136558A (ko) * | 2024-03-08 | 2025-09-16 | 주식회사 케어메디 | 약물 주입 장치의 주입관을 대상체에 삽입시키기 위한 어플리케이터 및 이를 포함하는 약물 주입 시스템 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU85338U1 (ru) * | 2009-02-24 | 2009-08-10 | Государственное образовательное учреждение высшего профессионального образования "Курский государственный технический университет" | Устройство для трансдермальной доставки лекарственных средств |
| US20110022002A1 (en) * | 2008-12-16 | 2011-01-27 | Medtronic Minimed, Inc. | Needle insertion systems and methods |
| US20110172637A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Drug delivery device including tissue support structure |
| US20110172601A1 (en) * | 2010-01-08 | 2011-07-14 | Beebe David J | Bladder Arrangement For Microneedle-Based Drug Delivery Device |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0429842B1 (en) | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
| US5279544A (en) | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
| TW279133B (https=) | 1990-12-13 | 1996-06-21 | Elan Med Tech | |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| IE72524B1 (en) | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
| US6186982B1 (en) | 1998-05-05 | 2001-02-13 | Elan Corporation, Plc | Subcutaneous drug delivery device with improved filling system |
| CA2313698C (en) * | 1997-12-11 | 2008-04-15 | Alza Corporation | Device for enhancing transdermal agent flux |
| ES2182379T3 (es) | 1997-12-22 | 2003-03-01 | Alza Corp | Membrana de regulacion del regimen de liberacion para dispositivos de administracion controlada de farmacos. |
| US5957895A (en) | 1998-02-20 | 1999-09-28 | Becton Dickinson And Company | Low-profile automatic injection device with self-emptying reservoir |
| US6251079B1 (en) * | 1998-09-30 | 2001-06-26 | C. R. Bard, Inc. | Transthoracic drug delivery device |
| AUPP985099A0 (en) | 1999-04-20 | 1999-05-13 | Usf Filtration And Separations Group Inc. | Membrane filtration manifold system |
| US6623457B1 (en) | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
| HK1048604B (en) * | 1999-12-10 | 2006-05-04 | Alza Corporation | Device and method for enhancing microprotrusion skin piercing |
| US20030014014A1 (en) | 2000-02-10 | 2003-01-16 | Zvi Nitzan | Drug delivery device and method |
| WO2001070309A1 (en) * | 2000-03-23 | 2001-09-27 | Antares Pharma, Inc. | Single use disposable jet injector |
| US6537242B1 (en) * | 2000-06-06 | 2003-03-25 | Becton, Dickinson And Company | Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance |
| US6656147B1 (en) | 2000-07-17 | 2003-12-02 | Becton, Dickinson And Company | Method and delivery device for the transdermal administration of a substance |
| CA2425312C (en) * | 2000-10-13 | 2010-02-16 | Alza Corporation | Microprotrusion member retainer for impact applicator |
| AU2002333554C1 (en) * | 2001-09-12 | 2008-12-11 | Becton, Dickinson And Company | Microneedle-based pen device for drug delivery and method for using same |
| AU2002330083A1 (en) | 2001-09-21 | 2003-04-01 | Biovalve Technologies, Inc. | Gas pressure actuated microneedle arrays, and systems and methods relating to same |
| US7429258B2 (en) * | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
| US7858112B2 (en) | 2002-02-28 | 2010-12-28 | Lintec Corporation | Percutaneous absorption system and percutaneous absorption method |
| US6780171B2 (en) * | 2002-04-02 | 2004-08-24 | Becton, Dickinson And Company | Intradermal delivery device |
| US7115108B2 (en) | 2002-04-02 | 2006-10-03 | Becton, Dickinson And Company | Method and device for intradermally delivering a substance |
| US7047070B2 (en) | 2002-04-02 | 2006-05-16 | Becton, Dickinson And Company | Valved intradermal delivery device and method of intradermally delivering a substance to a patient |
| KR20120087197A (ko) * | 2002-07-19 | 2012-08-06 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 마이크로 니들 장치, 마이크로 니들 장치를 사용하는 방법 및 마이크로 니들 장치를 송출하는 방법 |
| EP1590034B1 (en) | 2002-10-07 | 2014-05-14 | Biovalve Technologies, Inc. | Microneedle array patch |
| EP1475113A1 (en) | 2003-05-08 | 2004-11-10 | Novo Nordisk A/S | External needle inserter |
| CN2657686Y (zh) * | 2003-09-25 | 2004-11-24 | 李玉红 | 输液器针头助扎定位支架 |
| KR20060099520A (ko) | 2003-10-21 | 2006-09-19 | 노보 노르디스크 에이/에스 | 의료용 피부 장착 장치 |
| AU2004283018A1 (en) | 2003-10-21 | 2005-05-06 | Novo Nordisk A/S | Medical injection device mountable to the skin |
| EP2179754B1 (en) | 2003-10-23 | 2016-06-01 | Novo Nordisk A/S | Medical injection device mountable to the skin |
| WO2005049108A2 (en) | 2003-11-13 | 2005-06-02 | Alza Corporation | System and method for transdermal delivery |
| RU2006119485A (ru) * | 2003-12-18 | 2008-01-27 | Ново Нордиск А/С (DK) | Струйное устройство для инъекций и способ ввода лекарств через кожу |
| CA2560840C (en) | 2004-03-24 | 2014-05-06 | Corium International, Inc. | Transdermal delivery device |
| US7537590B2 (en) | 2004-07-30 | 2009-05-26 | Microchips, Inc. | Multi-reservoir device for transdermal drug delivery and sensing |
| EP1790375A4 (en) | 2004-08-12 | 2009-06-17 | Hisamitsu Pharmaceutical Co | TRANSDERMAL MEDICINE ADMINISTRATION WITH MICRONADEL |
| US7699802B2 (en) * | 2005-05-03 | 2010-04-20 | Pharmajet, Inc. | Needle-less injector |
| US7842008B2 (en) * | 2005-11-21 | 2010-11-30 | Becton, Dickinson And Company | Intradermal delivery device |
| TW200800223A (en) | 2005-12-21 | 2008-01-01 | Shire Pharmaceuticals Inc | Transdermal delivery of meptazinol |
| US20100209483A1 (en) | 2005-12-21 | 2010-08-19 | Richard Franklin | Transdermal delivery of meptazinol |
| ATE532553T1 (de) | 2006-02-10 | 2011-11-15 | Hisamitsu Pharmaceutical Co | Transdermales arzneiverabreichungsgerät mit mikronadeln |
| JP2007289482A (ja) * | 2006-04-26 | 2007-11-08 | Transcutaneous Technologies Inc | 経皮投与装置 |
| KR100886633B1 (ko) | 2006-07-14 | 2009-03-04 | 호남석유화학 주식회사 | 전면부에 피부를 통해 체내로 전달하고자 하는 물질의 수용공간을 갖는 피부 침투용 미세 돌기 장치 |
| EP2104525A4 (en) | 2006-12-29 | 2010-12-29 | Amir Genosar | HYPODERMIC RESERVOIR AND APPARATUS FOR DRUG DELIVERY |
| AU2008209537B2 (en) | 2007-01-22 | 2013-01-31 | Corium Pharma Solutions, Inc. | Applicators for microneedle arrays |
| US7828771B2 (en) * | 2007-07-26 | 2010-11-09 | Entra Pharmaceuticals, Inc. | Systems and methods for delivering drugs |
| US8592640B2 (en) * | 2009-08-11 | 2013-11-26 | Neodyne Biosciences, Inc. | Devices and methods for dressing applicators |
| JP5451613B2 (ja) * | 2007-08-06 | 2014-03-26 | アラーガン、インコーポレイテッド | デスモプレシン薬物送達のための方法及びデバイス |
| US20100121307A1 (en) | 2007-08-24 | 2010-05-13 | Microfabrica Inc. | Microneedles, Microneedle Arrays, Methods for Making, and Transdermal and/or Intradermal Applications |
| US7911480B2 (en) | 2007-10-08 | 2011-03-22 | Via Technologies, Inc. | Compression of multiple-sample-anti-aliasing tile data in a graphics pipeline |
| CN201216811Y (zh) | 2008-06-19 | 2009-04-08 | 陈青山 | 透皮给药微针阵列与软性成形面膜的集成结构 |
| WO2009158477A1 (en) | 2008-06-25 | 2009-12-30 | Us Worldmeds Llc | Skin patches and sustained-release formulations comprising lofexidine for transdermal and oral delivery |
| US8945050B2 (en) * | 2008-11-07 | 2015-02-03 | Becton, Dickinson And Company | Pen needle assembly for intradermal injection |
| CN101745177A (zh) | 2008-11-28 | 2010-06-23 | 上海百星药业有限公司 | 一次性使用并拥有自身动力的给药装置 |
| KR101030752B1 (ko) * | 2009-04-09 | 2011-04-26 | 한국생명공학연구원 | 유체전달을 조절할 수 있는 마이크로 니들 유닛 |
| US8690838B2 (en) | 2009-05-01 | 2014-04-08 | Nanbu Plastics Co., Ltd. | Transdermal administration device |
| CA2769102C (en) * | 2009-07-31 | 2017-09-19 | 3M Innovative Properties Company | Hollow microneedle arrays |
| DK2781228T3 (en) * | 2009-12-16 | 2016-03-21 | Becton Dickinson Co | A device for self-injection |
| US20110172638A1 (en) | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Drug delivery device including multi-functional cover |
| US20110172645A1 (en) | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Wearable drug delivery device including integrated pumping and activation elements |
| US20110172609A1 (en) | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Microneedle component assembly for drug delivery device |
| JP5735773B2 (ja) * | 2010-03-29 | 2015-06-17 | シスメックス株式会社 | 生体成分分析方法及び生体成分分析装置 |
| EP2566568B1 (en) | 2010-05-04 | 2019-04-10 | Corium International, Inc. | Applicators for microneedles |
| WO2011140274A2 (en) | 2010-05-04 | 2011-11-10 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| US8668675B2 (en) | 2010-11-03 | 2014-03-11 | Flugen, Inc. | Wearable drug delivery device having spring drive and sliding actuation mechanism |
| US9017289B2 (en) | 2010-11-03 | 2015-04-28 | Covidien Lp | Transdermal fluid delivery device |
| CN102671291B (zh) * | 2011-03-14 | 2014-07-30 | 中国人民解放军军事医学科学院毒物药物研究所 | 基于渗透压为动力的可控微输注装置 |
| CN202173684U (zh) * | 2011-08-26 | 2012-03-28 | 吴翠岗 | 一种微针美容仪 |
| CN202590041U (zh) * | 2012-05-21 | 2012-12-12 | 王金峰 | 注射局部皮肤拉紧器 |
| CN202740542U (zh) * | 2012-08-06 | 2013-02-20 | 安徽理工大学 | 无针注射器的辅助注射装置 |
-
2014
- 2014-02-28 WO PCT/IB2014/059345 patent/WO2014132240A1/en not_active Ceased
- 2014-02-28 KR KR1020227006763A patent/KR102571835B1/ko active Active
- 2014-02-28 KR KR1020217026932A patent/KR102370538B1/ko active Active
- 2014-02-28 CN CN201480009137.1A patent/CN105073179B/zh not_active Expired - Fee Related
- 2014-02-28 US US14/762,844 patent/US10183156B2/en active Active
- 2014-02-28 AU AU2014222308A patent/AU2014222308B2/en not_active Ceased
- 2014-02-28 MX MX2015011071A patent/MX360121B/es active IP Right Grant
- 2014-02-28 BR BR112015020328-0A patent/BR112015020328B1/pt not_active IP Right Cessation
- 2014-02-28 KR KR1020157024861A patent/KR102295456B1/ko not_active Expired - Fee Related
- 2014-02-28 CN CN201910125304.3A patent/CN109621083B/zh not_active Expired - Fee Related
- 2014-02-28 JP JP2015559599A patent/JP6522523B2/ja not_active Expired - Fee Related
- 2014-02-28 RU RU2015138281A patent/RU2622605C2/ru not_active IP Right Cessation
- 2014-02-28 CA CA2901568A patent/CA2901568C/en active Active
- 2014-02-28 EP EP14757306.7A patent/EP2961471B1/en active Active
-
2018
- 2018-12-18 US US16/224,249 patent/US10953211B2/en not_active Expired - Fee Related
-
2019
- 2019-04-24 JP JP2019082664A patent/JP6839223B2/ja not_active Expired - Fee Related
-
2021
- 2021-02-18 US US17/178,817 patent/US11883622B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110022002A1 (en) * | 2008-12-16 | 2011-01-27 | Medtronic Minimed, Inc. | Needle insertion systems and methods |
| RU85338U1 (ru) * | 2009-02-24 | 2009-08-10 | Государственное образовательное учреждение высшего профессионального образования "Курский государственный технический университет" | Устройство для трансдермальной доставки лекарственных средств |
| US20110172637A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Drug delivery device including tissue support structure |
| US20110172601A1 (en) * | 2010-01-08 | 2011-07-14 | Beebe David J | Bladder Arrangement For Microneedle-Based Drug Delivery Device |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2622605C2 (ru) | Устройство трансдермальной доставки лекарств | |
| US9861801B2 (en) | Drug delivery device | |
| CN109475726B (zh) | 微针阵列组件、药物递送装置和用于大面积低压输注液体的方法 | |
| JP2022103381A (ja) | 経皮的薬物送達装置および方法 | |
| CN101678196B (zh) | 微针经皮给药装置 | |
| HK40050045A (en) | Microneedle array assembly, drug delivery device and method for administering liquid across a broad area at low pressure |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20190301 |