RU2608388C2 - Сложные эфиры пентамидин-амидоксим кислот как пролекарства и их применение в качестве лекарственных средств - Google Patents

Сложные эфиры пентамидин-амидоксим кислот как пролекарства и их применение в качестве лекарственных средств Download PDF

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RU2608388C2
RU2608388C2 RU2014106867A RU2014106867A RU2608388C2 RU 2608388 C2 RU2608388 C2 RU 2608388C2 RU 2014106867 A RU2014106867 A RU 2014106867A RU 2014106867 A RU2014106867 A RU 2014106867A RU 2608388 C2 RU2608388 C2 RU 2608388C2
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pentamidine
diseases
treatment
prodrugs
prevention
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RU2014106867A
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English (en)
Russian (ru)
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RU2014106867A (ru
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Бернд КЛЕМЕНТ
Йоша КОТТХАУЗ
Юрке КОТТХАУЗ
Деннис ШАДЕ
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Дритте Патентпортфолио Бетайлигунгсгезельшафт Мбх Унд Ко.Кг
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2014106867A 2011-07-25 2012-07-19 Сложные эфиры пентамидин-амидоксим кислот как пролекарства и их применение в качестве лекарственных средств RU2608388C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11175252.3A EP2550963B1 (de) 2011-07-25 2011-07-25 Pentamidin-Amidoximsäureesters als Prodrugs und ihre Verwendung als Arzneimittel
EP11175252.3 2011-07-25
PCT/EP2012/064171 WO2013014059A1 (de) 2011-07-25 2012-07-19 Pentamidin-amidoximsäureesters als prodrugs und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
RU2014106867A RU2014106867A (ru) 2015-08-27
RU2608388C2 true RU2608388C2 (ru) 2017-01-18

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RU2014106867A RU2608388C2 (ru) 2011-07-25 2012-07-19 Сложные эфиры пентамидин-амидоксим кислот как пролекарства и их применение в качестве лекарственных средств

Country Status (19)

Country Link
US (1) US20130085180A1 (enExample)
EP (1) EP2550963B1 (enExample)
JP (2) JP2014529579A (enExample)
KR (1) KR20140097108A (enExample)
CN (1) CN103874491A (enExample)
AU (1) AU2012288968B2 (enExample)
BR (1) BR112014001787A2 (enExample)
CA (1) CA2842355A1 (enExample)
DK (1) DK2550963T3 (enExample)
ES (1) ES2610652T3 (enExample)
HR (1) HRP20170013T1 (enExample)
HU (1) HUE030245T2 (enExample)
LT (1) LT2550963T (enExample)
PL (1) PL2550963T3 (enExample)
PT (1) PT2550963T (enExample)
RS (1) RS55557B1 (enExample)
RU (1) RU2608388C2 (enExample)
SI (1) SI2550963T1 (enExample)
WO (1) WO2013014059A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2015007945A (es) 2012-12-21 2016-02-16 Verlyx Pharma Inc Usos y métodos para el tratamiento de enfermedades o afecciones hepáticas.
CA3077053A1 (en) 2017-09-27 2019-04-04 Ohio State Innovation Foundation Methods and compositions for inhibition of stat3
US12594265B2 (en) 2017-09-27 2026-04-07 Ohio State Innovation Foundation Methods and compositions for inhibition of STAT3
US10835581B2 (en) 2017-11-28 2020-11-17 University of Pittsburgh—of the Commonwealth System of Higher Education Method of treating insulin resistance
CN113766914B (zh) * 2018-12-20 2024-02-13 美商奥润沙公司 戊烷脒的类似物和其用途
JP2026513954A (ja) * 2023-04-07 2026-05-01 オーランサ インコーポレイテッド ペンタミジン類似体の多形体、製剤、およびその方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786383A (en) * 1993-06-28 1998-07-28 Clement; Bernd Pharmaceutical preparation
RU2286769C2 (ru) * 2000-11-06 2006-11-10 Комбинаторкс, Инкорпорейтед Комбинации лекарственных средств (например, хлорпромазина и пентамидина) для лечения неопластических нарушений
US20110028756A1 (en) * 2008-02-01 2011-02-03 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co. Kg Use of amidoxime carboxylic acid esters and n-hydroxyguanidine carboxylic acid esters for producing prodrugs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723495A (en) * 1995-11-16 1998-03-03 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786383A (en) * 1993-06-28 1998-07-28 Clement; Bernd Pharmaceutical preparation
RU2286769C2 (ru) * 2000-11-06 2006-11-10 Комбинаторкс, Инкорпорейтед Комбинации лекарственных средств (например, хлорпромазина и пентамидина) для лечения неопластических нарушений
US20110028756A1 (en) * 2008-02-01 2011-02-03 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co. Kg Use of amidoxime carboxylic acid esters and n-hydroxyguanidine carboxylic acid esters for producing prodrugs

Also Published As

Publication number Publication date
US20130085180A1 (en) 2013-04-04
RS55557B1 (sr) 2017-05-31
KR20140097108A (ko) 2014-08-06
HUE030245T2 (en) 2017-04-28
EP2550963B1 (de) 2016-10-12
HRP20170013T1 (hr) 2017-03-10
AU2012288968A1 (en) 2014-02-13
ES2610652T3 (es) 2017-04-28
AU2012288968B2 (en) 2017-01-05
CN103874491A (zh) 2014-06-18
RU2014106867A (ru) 2015-08-27
BR112014001787A2 (pt) 2017-02-21
SI2550963T1 (sl) 2017-05-31
PT2550963T (pt) 2017-01-19
JP2017039727A (ja) 2017-02-23
LT2550963T (lt) 2017-02-27
CA2842355A1 (en) 2013-01-31
EP2550963A1 (de) 2013-01-30
JP2014529579A (ja) 2014-11-13
DK2550963T3 (en) 2017-01-30
PL2550963T3 (pl) 2017-08-31
WO2013014059A1 (de) 2013-01-31

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Effective date: 20180720