PL2550963T3 - Estry kwasu amidooksymokarboksylowego pentamidyny jako proleki i ich zastosowanie jako leki - Google Patents

Estry kwasu amidooksymokarboksylowego pentamidyny jako proleki i ich zastosowanie jako leki

Info

Publication number
PL2550963T3
PL2550963T3 PL11175252T PL11175252T PL2550963T3 PL 2550963 T3 PL2550963 T3 PL 2550963T3 PL 11175252 T PL11175252 T PL 11175252T PL 11175252 T PL11175252 T PL 11175252T PL 2550963 T3 PL2550963 T3 PL 2550963T3
Authority
PL
Poland
Prior art keywords
pentamidine
prodrugs
medicament
carboxylic acid
acid esters
Prior art date
Application number
PL11175252T
Other languages
English (en)
Polish (pl)
Inventor
Bernd Clement
Joscha Kotthaus
Jürke Kotthaus
Dennis Schade
Original Assignee
Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co. Kg filed Critical Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co. Kg
Publication of PL2550963T3 publication Critical patent/PL2550963T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL11175252T 2011-07-25 2011-07-25 Estry kwasu amidooksymokarboksylowego pentamidyny jako proleki i ich zastosowanie jako leki PL2550963T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11175252.3A EP2550963B1 (de) 2011-07-25 2011-07-25 Pentamidin-Amidoximsäureesters als Prodrugs und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
PL2550963T3 true PL2550963T3 (pl) 2017-08-31

Family

ID=46514404

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11175252T PL2550963T3 (pl) 2011-07-25 2011-07-25 Estry kwasu amidooksymokarboksylowego pentamidyny jako proleki i ich zastosowanie jako leki

Country Status (19)

Country Link
US (1) US20130085180A1 (enExample)
EP (1) EP2550963B1 (enExample)
JP (2) JP2014529579A (enExample)
KR (1) KR20140097108A (enExample)
CN (1) CN103874491A (enExample)
AU (1) AU2012288968B2 (enExample)
BR (1) BR112014001787A2 (enExample)
CA (1) CA2842355A1 (enExample)
DK (1) DK2550963T3 (enExample)
ES (1) ES2610652T3 (enExample)
HR (1) HRP20170013T1 (enExample)
HU (1) HUE030245T2 (enExample)
LT (1) LT2550963T (enExample)
PL (1) PL2550963T3 (enExample)
PT (1) PT2550963T (enExample)
RS (1) RS55557B1 (enExample)
RU (1) RU2608388C2 (enExample)
SI (1) SI2550963T1 (enExample)
WO (1) WO2013014059A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104968340A (zh) * 2012-12-21 2015-10-07 沃利克斯制药股份有限公司 治疗肝脏疾病或病状的用途和方法
US11420946B2 (en) 2017-09-27 2022-08-23 Ohio State Innovation Foundation Methods and compositions for inhibition of STAT3
US12594265B2 (en) 2017-09-27 2026-04-07 Ohio State Innovation Foundation Methods and compositions for inhibition of STAT3
US10835581B2 (en) 2017-11-28 2020-11-17 University of Pittsburgh—of the Commonwealth System of Higher Education Method of treating insulin resistance
BR112021012138A2 (pt) * 2018-12-20 2021-08-31 Auransa Inc. Análogos de pentamidina e seus usos
CN121263405A (zh) * 2023-04-07 2026-01-02 奥润沙公司 喷他脒类似物多晶型物、制剂及其方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4321444A1 (de) * 1993-06-28 1995-01-05 Bernd Prof Dr Clement Pharmazeutische Zubereitung
US5723495A (en) * 1995-11-16 1998-03-03 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents
US6569853B1 (en) * 2000-11-06 2003-05-27 Combinatorx, Incorporated Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders
DE102008007381A1 (de) 2008-02-01 2009-08-13 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg Amidine und Guanidine und deren Derivate zur Behandlung von Krankheiten

Also Published As

Publication number Publication date
WO2013014059A1 (de) 2013-01-31
RU2608388C2 (ru) 2017-01-18
ES2610652T3 (es) 2017-04-28
EP2550963B1 (de) 2016-10-12
LT2550963T (lt) 2017-02-27
JP2017039727A (ja) 2017-02-23
EP2550963A1 (de) 2013-01-30
RU2014106867A (ru) 2015-08-27
AU2012288968B2 (en) 2017-01-05
BR112014001787A2 (pt) 2017-02-21
CA2842355A1 (en) 2013-01-31
PT2550963T (pt) 2017-01-19
CN103874491A (zh) 2014-06-18
AU2012288968A1 (en) 2014-02-13
HUE030245T2 (en) 2017-04-28
HRP20170013T1 (hr) 2017-03-10
US20130085180A1 (en) 2013-04-04
DK2550963T3 (en) 2017-01-30
KR20140097108A (ko) 2014-08-06
RS55557B1 (sr) 2017-05-31
JP2014529579A (ja) 2014-11-13
SI2550963T1 (sl) 2017-05-31

Similar Documents

Publication Publication Date Title
PL2899182T3 (pl) Aryloalkilowe estry 4-aminopikolinianów oraz ich zastosowanie jako herbicydy
SMT202100220T1 (it) Metodi per ridurre il rischio di un evento cardiovascolare in un soggetto in terapia con statine usando l'estere etilico dell'acido eicosapentaenoico
ZA201105612B (en) Use of eicosapentaenoic acid ethyl ester for treating hypertriglyceridemia
EP2788003A4 (en) PHOSPHATESTER OF NORIBOGAIN
ZA201402803B (en) Antimicrobial mixture of aldehydes, organic acids and arganic acid esters
IL227644A0 (en) 6-amino-2-conversion-5-vinylsilylpyrimidine-4-carboxyl acids and esters and 4-amino-6-conversion-3-vinylsilylpyrimidine-2-carboxyl acids and esters as herbicides
IL233413A0 (en) Methods for producing fincol esters of 4-chloro-2-fluoro-3-converted-phenylboronic acid and methods for using them
PL2870134T3 (pl) Zastosowanie estrów kwasów karboksylowych jako smarów
EP2614152A4 (en) CATALYTIC DEHYDRATION OF MILKY ACID AND MILKIC ACID ESTERS
EP2660235A4 (en) METHOD FOR THE PRODUCTION OF ACRYLIC ACID AND / OR ESTER THEREOF AND POLYMER FROM ACRYLIC ACID AND / OR ESTER THEREOF
EP2788356A4 (en) SULFATESTER FROM NORIBOGAIN
ZA201401746B (en) Use and agrochemical composition of carboxylic acid dibutylamides
AP3787A (en) New form of administration of enkephalinase inhibitor
ZA201400087B (en) Fluorination of acrylate esters and derivatives
ZA201303357B (en) Ketocarboxylic acids, ketocarboxylic esters, methods of manufacture and uses thereof
SG10201701568XA (en) Alcohol-mediated esterification of carboxylic acids with carbonates
SI2550963T1 (sl) Estri amidoksim karboksilne kisline pentamidina kot predzdravila in njihova uporaba kot zdravila
PL2550966T3 (pl) Estry kwasu amidooksymokarboksylowego dabigatranu jako proleki i ich zastosowanie jako lek
IL233132A0 (en) Process for the preparation of esters of 5-fluoro-2-methyl-3-quinoline-2-ylmethylindol-1-yl-acetic acid
SG2014012587A (en) Process for preparation of methacrylic acid and methacrylic acid esters
SG2014012637A (en) Process for preparation of methacrylic acid and methacrylic acid ester
SG2014012561A (en) Process for preparation of methacrylic acid and methacrylic acid esters
ZA201307230B (en) Prodrugs of d-gamma-glutamyl-d-tryptophan and d-gamma-glutamyl-l-tryptophan