RU2606622C2 - Агонисты рецепторов нейротрофинов и их применение в качестве лекарственных средств - Google Patents

Агонисты рецепторов нейротрофинов и их применение в качестве лекарственных средств Download PDF

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RU2606622C2
RU2606622C2 RU2013113634A RU2013113634A RU2606622C2 RU 2606622 C2 RU2606622 C2 RU 2606622C2 RU 2013113634 A RU2013113634 A RU 2013113634A RU 2013113634 A RU2013113634 A RU 2013113634A RU 2606622 C2 RU2606622 C2 RU 2606622C2
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compound according
disease
pharmaceutically acceptable
compound
cells
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Пабло ВИЛЛОСЛАДА
Анхель МЕССЕГУЭР
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Бионуре Фарма, С.Л.
Институт Д’Инвестигасионс Биомедикес Аугуст Пи И Суниер (Идибапс)
Консехо Супериор Де Инвестигасионес Сьентификас (Ксис)
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    • C07K5/08—Tripeptides
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    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
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RU2013113634A 2010-08-31 2011-08-31 Агонисты рецепторов нейротрофинов и их применение в качестве лекарственных средств RU2606622C2 (ru)

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US37882310P 2010-08-31 2010-08-31
US61/378,823 2010-08-31
PCT/IB2011/002562 WO2012028959A1 (en) 2010-08-31 2011-08-31 Agonists of neurotrophin receptors and their use as medicaments

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JP (1) JP5946454B2 (es)
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CN (1) CN103270022B (es)
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BR (1) BR112013004662B8 (es)
CA (1) CA2809774C (es)
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HR (1) HRP20160553T1 (es)
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PL (1) PL2611775T3 (es)
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Cited By (2)

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US11518763B2 (en) 2018-12-05 2022-12-06 Scohia Pharma, Inc. Macrocyclic compound and use thereof
RU2798235C2 (ru) * 2018-12-05 2023-06-19 Скохиа Фарма, Инк. Макроциклическое соединение и его применение

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EP2289886A1 (en) * 2009-08-31 2011-03-02 Institut d'Investigacions Biomédiques August PI I Sunyer Peptoid agonists of nerve growth factor and their use as medicaments
RU2606622C2 (ru) 2010-08-31 2017-01-10 Бионуре Фарма, С.Л. Агонисты рецепторов нейротрофинов и их применение в качестве лекарственных средств
WO2014100433A1 (en) * 2012-12-19 2014-06-26 Brown University Methods for treatment of microcephaly associated autism disorders
EP2950095B1 (en) * 2014-05-28 2018-08-29 Technische Universität Dresden Cell-based assay and screening methods for modulators of p75NTR signaling
WO2018039641A1 (en) * 2016-08-25 2018-03-01 Pharmatrophix, Inc. Methods and compounds for treating alcohol use disorders and associated diseases
KR101821118B1 (ko) 2016-09-06 2018-01-23 가톨릭대학교 산학협력단 감보그 산(gambogic acid)을 포함한 알러지성 질환 예방 또는 치료용 조성물
CN107802823A (zh) * 2017-10-27 2018-03-16 胡军 Sh2b衔接蛋白1在治疗帕金森病中的功能应用
CA3105879A1 (en) * 2018-07-18 2020-01-23 Manzanita Pharmaceuticals, Inc. Conjugates for delivering an anti-cancer agent to nerve cells, methods of use and methods of making thereof
TW202116297A (zh) * 2019-07-03 2021-05-01 西班牙商布爾奴爾法碼有限公司 組合療法之方法、組成物與套組
TW202131914A (zh) 2019-10-30 2021-09-01 西班牙商布爾奴爾法碼有限公司 用於神經疾病或病狀的治療之新治療方案

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RU2009105176A (ru) * 2009-02-16 2010-08-27 Учреждение Российской Академии медицинских наук Научно-исследовательский институт фармакологии имени В.В. Закусова (RU) Дипептидные миметики нейротрофинов ngf и bdnf

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11518763B2 (en) 2018-12-05 2022-12-06 Scohia Pharma, Inc. Macrocyclic compound and use thereof
RU2798235C2 (ru) * 2018-12-05 2023-06-19 Скохиа Фарма, Инк. Макроциклическое соединение и его применение
RU2798235C9 (ru) * 2018-12-05 2023-09-20 Скохиа Фарма, Инк. Макроциклическое соединение и его применение

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US10106577B2 (en) 2018-10-23
US20150005239A1 (en) 2015-01-01
US20170121367A1 (en) 2017-05-04
IL224972A (en) 2015-05-31
EP2611775B8 (en) 2016-06-08
CA2809774A1 (en) 2012-03-08
AU2011298091B2 (en) 2015-08-20
RU2013113634A (ru) 2014-10-10
EP2611775A1 (en) 2013-07-10
BR112013004662B8 (pt) 2021-12-28
JP5946454B2 (ja) 2016-07-06
CN103270022A (zh) 2013-08-28
CA2809774C (en) 2019-03-05
WO2012028959A1 (en) 2012-03-08
BR112013004662A2 (pt) 2016-08-02
DK2611775T3 (en) 2016-06-27
US9453047B2 (en) 2016-09-27
PL2611775T3 (pl) 2016-11-30
ES2575684T3 (es) 2016-06-30
HRP20160553T1 (hr) 2016-09-23
MX340233B (es) 2016-07-01
HUE029393T2 (en) 2017-03-28
BR112013004662B1 (pt) 2021-09-28
MX2013002329A (es) 2013-07-29
PT2611775E (pt) 2016-06-07
US20120052094A1 (en) 2012-03-01
SI2611775T1 (sl) 2017-01-31
EP2611775B1 (en) 2016-03-16
KR20130106384A (ko) 2013-09-27
KR101964954B1 (ko) 2019-04-03
AU2011298091A1 (en) 2013-04-18
US8791076B2 (en) 2014-07-29
CN103270022B (zh) 2015-08-19
JP2013536833A (ja) 2013-09-26

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