ES2169691B1 - Trimeros de n-alquilglicina capaces de bloquear la respuesta a sustancias quimicas, estimulos termicos o mediadores de la inflamacion de receptores neuronales, y composiciones que los contienen. - Google Patents
Trimeros de n-alquilglicina capaces de bloquear la respuesta a sustancias quimicas, estimulos termicos o mediadores de la inflamacion de receptores neuronales, y composiciones que los contienen.Info
- Publication number
- ES2169691B1 ES2169691B1 ES200002458A ES200002458A ES2169691B1 ES 2169691 B1 ES2169691 B1 ES 2169691B1 ES 200002458 A ES200002458 A ES 200002458A ES 200002458 A ES200002458 A ES 200002458A ES 2169691 B1 ES2169691 B1 ES 2169691B1
- Authority
- ES
- Spain
- Prior art keywords
- ethyl
- mediators
- inflammation
- response
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000126 substance Substances 0.000 title abstract 4
- 206010061218 Inflammation Diseases 0.000 title abstract 3
- 230000004054 inflammatory process Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000001537 neural effect Effects 0.000 title abstract 2
- -1 2- (2,4-dichlorophenyl) ethyl Chemical group 0.000 abstract 10
- 230000000903 blocking effect Effects 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 239000013638 trimer Substances 0.000 abstract 2
- 108090000862 Ion Channels Proteins 0.000 abstract 1
- 102000004310 Ion Channels Human genes 0.000 abstract 1
- 102000006541 Ionotropic Glutamate Receptors Human genes 0.000 abstract 1
- 108010008812 Ionotropic Glutamate Receptors Proteins 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 210000000929 nociceptor Anatomy 0.000 abstract 1
- 108091008700 nociceptors Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Trímeros de N-alquilglicina capaces de bloquear la respuesta a sustancias químicas, estímulos térmicos o mediadores de la inflamación de receptores neuronales, y composiciones que los contienen. Los trímeros de N-alquilglicina (I), donde R{sub,1} es 2-(2,4-diclorofenil)etilo, 3-metil-butilo, 2- (metilcarbonilamino)etilo, 2-(N-imidazolil)etilo o 3-(N,N- dimetilamino)propilo; R{sub,2} es 2-(2,4-diclorofenil)etilo, 2- (4-metoxifenil)etilo, 3,3-difenilpropilo o 3- (N,N-dietilamino) propilo; y R{sub,3} es N,N-dietil-aminopropilo, 3,3-difenil- propilo o 2-[2-(N-metil)pirrolidil] etilo, son capaces de bloquear los canales iónicos que se activan por sustancias químicas exógenas, por estímulos térmicos o por mediadores de la inflamación, tales como los nociceptores VR1 y los receptores ionotrópicos de glutamato, y son útiles para tratar trastornos mediados por la actividad de dichos receptores.
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002458A ES2169691B1 (es) | 2000-10-11 | 2000-10-11 | Trimeros de n-alquilglicina capaces de bloquear la respuesta a sustancias quimicas, estimulos termicos o mediadores de la inflamacion de receptores neuronales, y composiciones que los contienen. |
JP2002534341A JP2004511491A (ja) | 2000-10-11 | 2001-10-11 | 化学物質、熱刺激またはニューロン受容体炎症のメディエーターに対する応答を遮断することが可能なn−アルキルグリシントリマーおよび該トリマーを含有する組成物 |
MXPA03003158A MXPA03003158A (es) | 2000-10-11 | 2001-10-11 | Trimeros de n-alquilglicina capaces de bloquear la respuesta a sustancias quimicas, estimulos termicos o mediadores de la inflamacion de receptores neuronales; y composiciones que los contienen . |
PCT/ES2001/000384 WO2002030956A1 (es) | 2000-10-11 | 2001-10-11 | Trimeros de n-alquilglicina capaces de bloquear la respuesta a sustancias quimicas, estimulos termicos o mediadores de la inflamacion de receptores neuronales, y composiciones que los contienen |
CA002425520A CA2425520A1 (en) | 2000-10-11 | 2001-10-11 | N-alkylglycine trimeres capable of blocking the response to chemical substances, heat stimuli or mediators of neuronal receptor inflammation and compositions containing said trimeres |
BR0114802-8A BR0114802A (pt) | 2000-10-11 | 2001-10-11 | Trìmeros de n-alquilglicina capazes de bloquear a substáncias quìmicas, estìmulos térmicos ou mediadores da inflamação de receptores neuronais, e composições que os contêm |
EP01974349A EP1338605A1 (en) | 2000-10-11 | 2001-10-11 | N-alkylglycine trimeres capable of blocking the response to chemical substances, heat stimuli or mediators of neuronal receptor inflammation and compositions containing said trimeres |
KR10-2003-7005128A KR20030048056A (ko) | 2000-10-11 | 2001-10-11 | 화학 물질, 열 자극 또는 신경 수용체 염증의 매개체들에대한 반응을 차단하는 능력을 갖는 n-알킬글리신 트리머및 그를 포함하는 조성물 |
US10/398,947 US20040033958A1 (en) | 2000-10-11 | 2001-10-11 | N-alkylglycine trimeres capable of blocking the response to chemical substances, heat stimuli or mediators of neuronal receptor inflammation and compositions containing said trimeres |
AU2001293882A AU2001293882A1 (en) | 2000-10-11 | 2001-10-11 | N-alkylglycine trimeres capable of blocking the response to chemical substances,heat stimuli or mediators of neuronal receptor inflammation and compositions containing said trimeres |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002458A ES2169691B1 (es) | 2000-10-11 | 2000-10-11 | Trimeros de n-alquilglicina capaces de bloquear la respuesta a sustancias quimicas, estimulos termicos o mediadores de la inflamacion de receptores neuronales, y composiciones que los contienen. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2169691A1 ES2169691A1 (es) | 2002-07-01 |
ES2169691B1 true ES2169691B1 (es) | 2004-03-16 |
Family
ID=8495245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200002458A Expired - Fee Related ES2169691B1 (es) | 2000-10-11 | 2000-10-11 | Trimeros de n-alquilglicina capaces de bloquear la respuesta a sustancias quimicas, estimulos termicos o mediadores de la inflamacion de receptores neuronales, y composiciones que los contienen. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20040033958A1 (es) |
EP (1) | EP1338605A1 (es) |
JP (1) | JP2004511491A (es) |
KR (1) | KR20030048056A (es) |
AU (1) | AU2001293882A1 (es) |
BR (1) | BR0114802A (es) |
CA (1) | CA2425520A1 (es) |
ES (1) | ES2169691B1 (es) |
MX (1) | MXPA03003158A (es) |
WO (1) | WO2002030956A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2195787B1 (es) | 2002-05-20 | 2005-06-01 | Diverdrugs, S.L. | Compuestos capaces de bloquear la respuesta a sustancias quimicas o estimulos termicos o mediadores de la inflamacion de los nociceptores, un metodo para su obtencion y composiciones que los continen. |
AU2004230207A1 (en) * | 2003-04-15 | 2004-10-28 | Merck Patent Gmbh | Identification of N-alkylglycine trimers for induction of apoptosis |
HUE029393T2 (en) * | 2010-08-31 | 2017-03-28 | Bionure Farma S L | Neurotrophin receptor agonists and their use as medicaments |
WO2012098281A2 (es) | 2011-01-19 | 2012-07-26 | Universidad Miguel Hernández De Elche | Péptidos moduladores de receptores trp y sus usos |
WO2017066454A2 (en) | 2015-10-14 | 2017-04-20 | X-Therma, Inc. | Compositions and methods for reducing ice crystal formation |
CN111563445A (zh) * | 2020-04-30 | 2020-08-21 | 徐宇轩 | 一种基于卷积神经网络的显微镜下岩性识别方法 |
DE102022104759A1 (de) | 2022-02-28 | 2023-08-31 | SCi Kontor GmbH | Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5747458A (en) * | 1995-06-07 | 1998-05-05 | Chiron Corporation | Urokinase receptor ligands |
-
2000
- 2000-10-11 ES ES200002458A patent/ES2169691B1/es not_active Expired - Fee Related
-
2001
- 2001-10-11 US US10/398,947 patent/US20040033958A1/en not_active Abandoned
- 2001-10-11 AU AU2001293882A patent/AU2001293882A1/en not_active Abandoned
- 2001-10-11 KR KR10-2003-7005128A patent/KR20030048056A/ko not_active Application Discontinuation
- 2001-10-11 CA CA002425520A patent/CA2425520A1/en not_active Abandoned
- 2001-10-11 MX MXPA03003158A patent/MXPA03003158A/es unknown
- 2001-10-11 JP JP2002534341A patent/JP2004511491A/ja active Pending
- 2001-10-11 BR BR0114802-8A patent/BR0114802A/pt not_active IP Right Cessation
- 2001-10-11 WO PCT/ES2001/000384 patent/WO2002030956A1/es not_active Application Discontinuation
- 2001-10-11 EP EP01974349A patent/EP1338605A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2004511491A (ja) | 2004-04-15 |
EP1338605A1 (en) | 2003-08-27 |
BR0114802A (pt) | 2003-09-23 |
KR20030048056A (ko) | 2003-06-18 |
US20040033958A1 (en) | 2004-02-19 |
WO2002030956A1 (es) | 2002-04-18 |
MXPA03003158A (es) | 2004-12-06 |
CA2425520A1 (en) | 2002-04-18 |
ES2169691A1 (es) | 2002-07-01 |
AU2001293882A1 (en) | 2002-04-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 2169691B1 Country of ref document: ES |
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FD1A | Patent lapsed |
Effective date: 20100312 |