BR0114802A - Trìmeros de n-alquilglicina capazes de bloquear a substáncias quìmicas, estìmulos térmicos ou mediadores da inflamação de receptores neuronais, e composições que os contêm - Google Patents
Trìmeros de n-alquilglicina capazes de bloquear a substáncias quìmicas, estìmulos térmicos ou mediadores da inflamação de receptores neuronais, e composições que os contêmInfo
- Publication number
- BR0114802A BR0114802A BR0114802-8A BR0114802A BR0114802A BR 0114802 A BR0114802 A BR 0114802A BR 0114802 A BR0114802 A BR 0114802A BR 0114802 A BR0114802 A BR 0114802A
- Authority
- BR
- Brazil
- Prior art keywords
- ethyl
- inflammation
- mediators
- compositions containing
- chemical substances
- Prior art date
Links
- 206010061218 Inflammation Diseases 0.000 title abstract 3
- 230000000903 blocking effect Effects 0.000 title abstract 3
- 230000004054 inflammatory process Effects 0.000 title abstract 3
- 239000000126 substance Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000001537 neural effect Effects 0.000 title abstract 2
- 239000013638 trimer Substances 0.000 title abstract 2
- -1 2- (2,4-dichlorophenyl) ethyl Chemical group 0.000 abstract 6
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 1
- 108090000862 Ion Channels Proteins 0.000 abstract 1
- 102000004310 Ion Channels Human genes 0.000 abstract 1
- 102000006541 Ionotropic Glutamate Receptors Human genes 0.000 abstract 1
- 108010008812 Ionotropic Glutamate Receptors Proteins 0.000 abstract 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 210000000929 nociceptor Anatomy 0.000 abstract 1
- 108091008700 nociceptors Proteins 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
Abstract
"TRìMEROS DE N-ALQUILGLICINA CAPAZES DE BLOQUEAR A SUBSTáNCIAS QUìMICAS, ESTìMULOS TéRMICOS OU MEDIADORES DA INFLAMAçãO DE RECEPTORES NEURONAIS, E COMPOSIçõES QUE OS CONTêM". Os trímeros de N-alquilglicina (I), onde R~ 1~, é 2-(2,4-diclorofenil) etil, 3-metil-butil, 2-(metil-carbonilamina) etil, 2-(N-imidazolil) etil ou 3-(N,N-dimetilamina) propil; R~ 2~ é 2-(2,4-diclorofenil) etil, 2-(4-metoxifenil) etil, 3,3-difenilpropil ou 3-(N,N-dietilamina) propil; e R~ 3~ é N,N-dietilamina-propil, 3,3-difenilpropil ou 2-[2-(N-metil)pirrolidinil] etil,são capazes de bloquear os canais iónicos que são ativados por substâncias químicas exógenas, por estímulos térmicos ou mediadores da inflamação, tais como os nociceptores VR1 e os receptores ionotrópicos de glutamato, e são úteis para tratar transtornos mediados pela atividade de ditos receptores.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200002458A ES2169691B1 (es) | 2000-10-11 | 2000-10-11 | Trimeros de n-alquilglicina capaces de bloquear la respuesta a sustancias quimicas, estimulos termicos o mediadores de la inflamacion de receptores neuronales, y composiciones que los contienen. |
| PCT/ES2001/000384 WO2002030956A1 (es) | 2000-10-11 | 2001-10-11 | Trimeros de n-alquilglicina capaces de bloquear la respuesta a sustancias quimicas, estimulos termicos o mediadores de la inflamacion de receptores neuronales, y composiciones que los contienen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0114802A true BR0114802A (pt) | 2003-09-23 |
Family
ID=8495245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0114802-8A BR0114802A (pt) | 2000-10-11 | 2001-10-11 | Trìmeros de n-alquilglicina capazes de bloquear a substáncias quìmicas, estìmulos térmicos ou mediadores da inflamação de receptores neuronais, e composições que os contêm |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20040033958A1 (pt) |
| EP (1) | EP1338605A1 (pt) |
| JP (1) | JP2004511491A (pt) |
| KR (1) | KR20030048056A (pt) |
| AU (1) | AU2001293882A1 (pt) |
| BR (1) | BR0114802A (pt) |
| CA (1) | CA2425520A1 (pt) |
| ES (1) | ES2169691B1 (pt) |
| MX (1) | MXPA03003158A (pt) |
| WO (1) | WO2002030956A1 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2195787B1 (es) * | 2002-05-20 | 2005-06-01 | Diverdrugs, S.L. | Compuestos capaces de bloquear la respuesta a sustancias quimicas o estimulos termicos o mediadores de la inflamacion de los nociceptores, un metodo para su obtencion y composiciones que los continen. |
| BRPI0409470A (pt) * | 2003-04-15 | 2006-05-02 | Merck Patent Gmbh | identificação de trìmeros de n-alquilglicina para indução de apoptose |
| WO2012028959A1 (en) | 2010-08-31 | 2012-03-08 | Pablo Villoslada | Agonists of neurotrophin receptors and their use as medicaments |
| WO2012098281A2 (es) | 2011-01-19 | 2012-07-26 | Universidad Miguel Hernández De Elche | Péptidos moduladores de receptores trp y sus usos |
| CN108347916B (zh) | 2015-10-14 | 2022-02-08 | 先时迈纳米生物科技股份有限公司 | 一种减少冰晶形成的组合物及其方法 |
| CN111563445A (zh) * | 2020-04-30 | 2020-08-21 | 徐宇轩 | 一种基于卷积神经网络的显微镜下岩性识别方法 |
| DE102022104759A1 (de) | 2022-02-28 | 2023-08-31 | SCi Kontor GmbH | Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747458A (en) * | 1995-06-07 | 1998-05-05 | Chiron Corporation | Urokinase receptor ligands |
-
2000
- 2000-10-11 ES ES200002458A patent/ES2169691B1/es not_active Expired - Fee Related
-
2001
- 2001-10-11 BR BR0114802-8A patent/BR0114802A/pt not_active IP Right Cessation
- 2001-10-11 WO PCT/ES2001/000384 patent/WO2002030956A1/es not_active Application Discontinuation
- 2001-10-11 JP JP2002534341A patent/JP2004511491A/ja active Pending
- 2001-10-11 KR KR10-2003-7005128A patent/KR20030048056A/ko not_active Application Discontinuation
- 2001-10-11 CA CA002425520A patent/CA2425520A1/en not_active Abandoned
- 2001-10-11 EP EP01974349A patent/EP1338605A1/en not_active Withdrawn
- 2001-10-11 MX MXPA03003158A patent/MXPA03003158A/es unknown
- 2001-10-11 US US10/398,947 patent/US20040033958A1/en not_active Abandoned
- 2001-10-11 AU AU2001293882A patent/AU2001293882A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2169691B1 (es) | 2004-03-16 |
| ES2169691A1 (es) | 2002-07-01 |
| MXPA03003158A (es) | 2004-12-06 |
| JP2004511491A (ja) | 2004-04-15 |
| CA2425520A1 (en) | 2002-04-18 |
| KR20030048056A (ko) | 2003-06-18 |
| AU2001293882A1 (en) | 2002-04-22 |
| EP1338605A1 (en) | 2003-08-27 |
| WO2002030956A1 (es) | 2002-04-18 |
| US20040033958A1 (en) | 2004-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A,7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2021 DE 29/09/2009. |