RU2591083C2 - Способы лечения псориаза с использованием антагонистов il-17 - Google Patents

Способы лечения псориаза с использованием антагонистов il-17 Download PDF

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RU2591083C2
RU2591083C2 RU2013120957/15A RU2013120957A RU2591083C2 RU 2591083 C2 RU2591083 C2 RU 2591083C2 RU 2013120957/15 A RU2013120957/15 A RU 2013120957/15A RU 2013120957 A RU2013120957 A RU 2013120957A RU 2591083 C2 RU2591083 C2 RU 2591083C2
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seq
patient
secukinumab
antibody
psoriasis
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RU2013120957/15A
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Russian (ru)
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RU2013120957A (ru
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Ахим ГЮТТНЕР
Маттиас МАШАСЕК
Чарис ПАПАВАССИЛИС
Оливер ЗАНДЕР
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Новартис Аг
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2013120957/15A 2010-10-08 2011-10-07 Способы лечения псориаза с использованием антагонистов il-17 RU2591083C2 (ru)

Applications Claiming Priority (3)

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US39138810P 2010-10-08 2010-10-08
US61/391,388 2010-10-08
PCT/EP2011/067522 WO2012045848A1 (en) 2010-10-08 2011-10-07 Methods of treating psoriasis using il-17 antagonists

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RU2016120615A Division RU2665954C1 (ru) 2010-10-08 2011-10-07 Способы лечения псориаза с использованием антагонистов il-17

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RU2013120957A RU2013120957A (ru) 2014-11-20
RU2591083C2 true RU2591083C2 (ru) 2016-07-10

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RU2013120957/15A RU2591083C2 (ru) 2010-10-08 2011-10-07 Способы лечения псориаза с использованием антагонистов il-17
RU2016120615A RU2665954C1 (ru) 2010-10-08 2011-10-07 Способы лечения псориаза с использованием антагонистов il-17

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US (9) US9717791B2 (cg-RX-API-DMAC7.html)
EP (5) EP3792281A1 (cg-RX-API-DMAC7.html)
JP (2) JP5537740B2 (cg-RX-API-DMAC7.html)
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CN (2) CN107029234A (cg-RX-API-DMAC7.html)
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UA117218C2 (uk) 2011-05-05 2018-07-10 Мерк Патент Гмбх Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
US20150064193A1 (en) * 2011-11-21 2015-03-05 Novartis Ag Methods of treating psoriatic arthritis (psa) using il-17 antagonists and psa response or non-response alleles
WO2014143540A1 (en) * 2013-03-15 2014-09-18 Amgen Inc. Methods for treating crohn's disease using an anti-il23 antibody
SG10201804954UA (en) * 2013-03-15 2018-07-30 Amgen Inc Methods for treating psoriasis using an anti-il-23 antibody
EP3033107A1 (en) * 2013-08-15 2016-06-22 Novartis AG Methods of treating generalized pustular psoriasis (gpp) using il-17 antagonists
US11421025B2 (en) 2013-12-27 2022-08-23 Osaka University Treatment of IL-17A diseases
RU2577228C2 (ru) * 2014-03-14 2016-03-10 Закрытое Акционерное Общество "Биокад" Анти-il-17-антитела, способ их получения и способ применения
MY184189A (en) * 2014-03-31 2021-03-24 Amgen K A Inc Methods of treating nail and scalp psoriasis
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US11548940B2 (en) * 2014-05-15 2023-01-10 Rani Therapeutics, Llc Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
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AR103172A1 (es) * 2014-12-22 2017-04-19 Novartis Ag Reducción selectiva de residuos de cisteina en anticuerpos il-17
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RU2754683C2 (ru) 2015-10-27 2021-09-06 Юсб Биофарма Срл Способы лечения с использованием анти-il-17a антител
EP4477265A3 (en) 2016-07-19 2025-03-19 Novartis AG Methods of treating new-onset plaque type psoriasis using il-17 antagonists
JP2019505516A (ja) * 2016-11-28 2019-02-28 ノバルティス アーゲー インターロイキン−17(il−17)アンタゴニストを使用してざ瘡を治療する方法
WO2018158741A1 (en) * 2017-03-03 2018-09-07 Novartis Ag Psoriasis disease modification following long-term treatment with an il-17 antagonist
WO2019040230A1 (en) * 2017-08-23 2019-02-28 Eli Lilly And Company TREATMENT OF GENITAL PSORIASIS
TWI725532B (zh) * 2018-09-11 2021-04-21 美商美國禮來大藥廠 治療牛皮癬之方法
CN114127108A (zh) 2019-07-30 2022-03-01 江苏恒瑞医药股份有限公司 Il-17拮抗剂治疗自身免疫疾病的方法
KR20220066318A (ko) 2019-09-20 2022-05-24 노파르티스 아게 인터류킨-17(il-17) 길항제를 사용한 자가면역 질환의 치료 방법
WO2022127842A1 (zh) * 2020-12-17 2022-06-23 上海华奥泰生物药业股份有限公司 靶向il-17a和il-36r的双特异性抗体及其应用
TW202246329A (zh) * 2021-03-03 2022-12-01 大陸商蘇州盛迪亞生物醫藥有限公司 抗il-17抗體治療自體免疫性疾病和炎症的方法
WO2023186174A1 (en) * 2022-04-01 2023-10-05 Zai Lab (Shanghai) Co., Ltd. Topical formulation comprising an il-17a binding molecule and uses thereof
CN116593718B (zh) * 2023-07-18 2023-09-15 军科正源(北京)药物研究有限责任公司 用于检测司库奇尤单抗抗药性抗体的试剂

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WO2012045848A1 (en) 2012-04-12
CA2813900C (en) 2017-01-10
US20230321231A1 (en) 2023-10-12
US20200171147A1 (en) 2020-06-04
DK2625199T3 (en) 2018-02-26
PH12013500660B1 (en) 2017-10-27
US20250161443A1 (en) 2025-05-22
CN107029234A (zh) 2017-08-11
KR20150018595A (ko) 2015-02-23
US10583190B2 (en) 2020-03-10
IL225310A (en) 2016-10-31
HK1247932A1 (en) 2018-10-05
US20130202610A1 (en) 2013-08-08
JP2013543501A (ja) 2013-12-05
MA34646B1 (fr) 2013-11-02
NO2625199T3 (cg-RX-API-DMAC7.html) 2018-04-21
US20170304439A1 (en) 2017-10-26
HRP20180301T1 (hr) 2018-03-23
CA2813900A1 (en) 2012-04-12
US20250161444A1 (en) 2025-05-22
US20250161445A1 (en) 2025-05-22
TWI548419B (zh) 2016-09-11
EP2625199B1 (en) 2017-11-22
CL2013000930A1 (es) 2014-03-28
BR112013008501A2 (pt) 2016-08-16
EP2625199A1 (en) 2013-08-14
ES2660770T3 (es) 2018-03-26
CN103154031A (zh) 2013-06-12
TWI564022B (zh) 2017-01-01
JP5537740B2 (ja) 2014-07-02
KR20130110179A (ko) 2013-10-08
KR101620771B1 (ko) 2016-05-12
PH12013500660A1 (en) 2013-05-20
HUE038334T2 (hu) 2018-10-29
US20210162044A1 (en) 2021-06-03
CY1119942T1 (el) 2018-12-12
MX2013003916A (es) 2013-06-03
JP2014114288A (ja) 2014-06-26
SG188979A1 (en) 2013-05-31
TW201216984A (en) 2012-05-01
AU2011311482B2 (en) 2014-05-29
US20210113688A1 (en) 2021-04-22
US11534490B2 (en) 2022-12-27
SI2625199T1 (en) 2018-03-30
PL2625199T3 (pl) 2018-04-30
EP3299390A1 (en) 2018-03-28
EP4137514A1 (en) 2023-02-22
EP4670788A2 (en) 2025-12-31
RU2665954C1 (ru) 2018-09-05
IL225310A0 (en) 2013-06-27
PT2625199T (pt) 2018-02-28
US9717791B2 (en) 2017-08-01
AU2011311482A1 (en) 2013-04-04
RU2013120957A (ru) 2014-11-20
MX356279B (es) 2018-05-22
EP3792281A1 (en) 2021-03-17
LT2625199T (lt) 2018-03-12
KR20140097566A (ko) 2014-08-06
TW201630625A (zh) 2016-09-01

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