RU2583068C2 - Система и способ автоматического образования жидких смесей и работы с ними - Google Patents
Система и способ автоматического образования жидких смесей и работы с ними Download PDFInfo
- Publication number
- RU2583068C2 RU2583068C2 RU2011139195/13A RU2011139195A RU2583068C2 RU 2583068 C2 RU2583068 C2 RU 2583068C2 RU 2011139195/13 A RU2011139195/13 A RU 2011139195/13A RU 2011139195 A RU2011139195 A RU 2011139195A RU 2583068 C2 RU2583068 C2 RU 2583068C2
- Authority
- RU
- Russia
- Prior art keywords
- fluid channel
- valve
- fluid
- channel
- microfluidic
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 156
- 238000000034 method Methods 0.000 title claims abstract description 50
- 230000015572 biosynthetic process Effects 0.000 title abstract description 62
- 239000000203 mixture Substances 0.000 title description 33
- 239000012530 fluid Substances 0.000 claims abstract description 308
- 239000011541 reaction mixture Substances 0.000 claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000011049 filling Methods 0.000 claims abstract description 16
- 239000003153 chemical reaction reagent Substances 0.000 claims description 51
- 150000001875 compounds Chemical class 0.000 claims description 21
- 229910000831 Steel Inorganic materials 0.000 claims description 17
- 239000010959 steel Substances 0.000 claims description 17
- 238000002156 mixing Methods 0.000 claims description 16
- 239000011521 glass Substances 0.000 claims description 12
- 230000001360 synchronised effect Effects 0.000 claims description 9
- -1 polyethylene Polymers 0.000 claims description 8
- 239000004696 Poly ether ether ketone Substances 0.000 claims description 7
- 239000004698 Polyethylene Substances 0.000 claims description 7
- JUPQTSLXMOCDHR-UHFFFAOYSA-N benzene-1,4-diol;bis(4-fluorophenyl)methanone Chemical compound OC1=CC=C(O)C=C1.C1=CC(F)=CC=C1C(=O)C1=CC=C(F)C=C1 JUPQTSLXMOCDHR-UHFFFAOYSA-N 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 229920002530 polyetherether ketone Polymers 0.000 claims description 7
- 229920000573 polyethylene Polymers 0.000 claims description 7
- 229920002379 silicone rubber Polymers 0.000 claims description 7
- 239000004945 silicone rubber Substances 0.000 claims description 7
- 229920001169 thermoplastic Polymers 0.000 claims description 7
- 239000004416 thermosoftening plastic Substances 0.000 claims description 7
- 239000004809 Teflon Substances 0.000 claims description 6
- 229920006362 Teflon® Polymers 0.000 claims description 6
- 230000005855 radiation Effects 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 3
- 238000013459 approach Methods 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 abstract description 27
- 239000000126 substance Substances 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 6
- 210000004369 blood Anatomy 0.000 abstract description 3
- 239000008280 blood Substances 0.000 abstract description 3
- 238000012742 biochemical analysis Methods 0.000 abstract description 2
- 210000002966 serum Anatomy 0.000 description 39
- 239000000243 solution Substances 0.000 description 30
- 238000011534 incubation Methods 0.000 description 18
- 238000005259 measurement Methods 0.000 description 14
- 238000002798 spectrophotometry method Methods 0.000 description 11
- 238000004458 analytical method Methods 0.000 description 10
- 230000008569 process Effects 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 8
- 238000010586 diagram Methods 0.000 description 8
- DCAYPVUWAIABOU-UHFFFAOYSA-N hexadecane Chemical compound CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 description 8
- 230000001105 regulatory effect Effects 0.000 description 8
- 230000001276 controlling effect Effects 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- 102000009027 Albumins Human genes 0.000 description 5
- 108010088751 Albumins Proteins 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 238000004737 colorimetric analysis Methods 0.000 description 5
- 230000006835 compression Effects 0.000 description 5
- 238000007906 compression Methods 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 239000003899 bactericide agent Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 238000009736 wetting Methods 0.000 description 4
- 238000005842 biochemical reaction Methods 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000005684 electric field Effects 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 238000012795 verification Methods 0.000 description 3
- VCUXVXLUOHDHKK-UHFFFAOYSA-N 2-(2-aminopyrimidin-4-yl)-4-(2-chloro-4-methoxyphenyl)-1,3-thiazole-5-carboxamide Chemical compound ClC1=CC(OC)=CC=C1C1=C(C(N)=O)SC(C=2N=C(N)N=CC=2)=N1 VCUXVXLUOHDHKK-UHFFFAOYSA-N 0.000 description 2
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000000022 bacteriostatic agent Substances 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 238000012864 cross contamination Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 238000002834 transmittance Methods 0.000 description 2
- STPKWKPURVSAJF-LJEWAXOPSA-N (4r,5r)-5-[4-[[4-(1-aza-4-azoniabicyclo[2.2.2]octan-4-ylmethyl)phenyl]methoxy]phenyl]-3,3-dibutyl-7-(dimethylamino)-1,1-dioxo-4,5-dihydro-2h-1$l^{6}-benzothiepin-4-ol Chemical compound O[C@H]1C(CCCC)(CCCC)CS(=O)(=O)C2=CC=C(N(C)C)C=C2[C@H]1C(C=C1)=CC=C1OCC(C=C1)=CC=C1C[N+]1(CC2)CCN2CC1 STPKWKPURVSAJF-LJEWAXOPSA-N 0.000 description 1
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 1
- 108010082126 Alanine transaminase Proteins 0.000 description 1
- 239000006391 Luria-Bertani Medium Substances 0.000 description 1
- AVYVHIKSFXVDBG-UHFFFAOYSA-N N-benzyl-N-hydroxy-2,2-dimethylbutanamide Chemical compound C(C1=CC=CC=C1)N(C(C(CC)(C)C)=O)O AVYVHIKSFXVDBG-UHFFFAOYSA-N 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 102000004139 alpha-Amylases Human genes 0.000 description 1
- 108090000637 alpha-Amylases Proteins 0.000 description 1
- 229940024171 alpha-amylase Drugs 0.000 description 1
- 238000012442 analytical experiment Methods 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000000326 densiometry Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- BJXYHBKEQFQVES-NWDGAFQWSA-N enpatoran Chemical compound N[C@H]1CN(C[C@H](C1)C(F)(F)F)C1=C2C=CC=NC2=C(C=C1)C#N BJXYHBKEQFQVES-NWDGAFQWSA-N 0.000 description 1
- 230000001973 epigenetic effect Effects 0.000 description 1
- 238000012921 fluorescence analysis Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000012933 kinetic analysis Methods 0.000 description 1
- 238000002032 lab-on-a-chip Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 230000010363 phase shift Effects 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012883 sequential measurement Methods 0.000 description 1
- 239000010802 sludge Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000002723 toxicity assay Methods 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
- B01F25/4331—Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/028—Modular arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
- B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Micromachines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PLP-390250 | 2010-01-24 | ||
| PLP-390251 | 2010-01-24 | ||
| PL390251A PL390251A1 (pl) | 2010-01-24 | 2010-01-24 | Metoda i układ do wytwarzania kropli na żądanie w układzie mikroprzepływowym oraz tworzenia sekwencji kropli o arbitralnie zadanych kombinacjach stężeń roztworów wejściowych |
| PL390250A PL216402B1 (pl) | 2010-01-24 | 2010-01-24 | Zawór do zamykania przepływu płynu |
| PL393619A PL393619A1 (pl) | 2011-01-11 | 2011-01-11 | Układ do zasilania podukładu mikroprzepływowego płynami i odpowiedni podukład mikroprzepływowy |
| PLP-393619 | 2011-01-11 | ||
| PCT/PL2011/050002 WO2011090396A1 (en) | 2010-01-24 | 2011-01-21 | System and method for automated generation and handling of liquid mixtures |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2011139195A RU2011139195A (ru) | 2013-04-10 |
| RU2583068C2 true RU2583068C2 (ru) | 2016-05-10 |
Family
ID=43969415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011139195/13A RU2583068C2 (ru) | 2010-01-24 | 2011-01-21 | Система и способ автоматического образования жидких смесей и работы с ними |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9132396B2 (enExample) |
| EP (2) | EP2451577A1 (enExample) |
| JP (2) | JP2013527022A (enExample) |
| BR (1) | BRPI1106097A2 (enExample) |
| RU (1) | RU2583068C2 (enExample) |
| WO (1) | WO2011090396A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2663606C2 (ru) * | 2014-01-24 | 2018-08-07 | Бейкер Хьюз Инкорпорейтед | Система и способ обработки текучих сред |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013527022A (ja) * | 2010-01-24 | 2013-06-27 | インスチチュート・ケミィ・フィジズネジ・ポルスキージ・アカデミィ・ナウク | 液体混合物の自動形成及び操作システムと方法。 |
| FR2972198B1 (fr) | 2011-03-04 | 2017-02-10 | Centre Nat Rech Scient | Procede de suivi de reaction et systeme reactionnel pour sa mise en oeuvre |
| GB201115895D0 (en) | 2011-09-14 | 2011-10-26 | Embl | Microfluidic device |
| PL397071A1 (pl) | 2011-11-21 | 2013-05-27 | Scope Fluidics Spólka Z Ograniczona Odpowiedzialnoscia | Sposób oznaczania parametrów biochemicznych plynu ustrojowego |
| WO2013082316A1 (en) * | 2011-11-29 | 2013-06-06 | Caliper Life Sciences, Inc. | Systems and methods for sampling of amplification products |
| US9689029B2 (en) | 2011-12-02 | 2017-06-27 | Caliper Life Sciences, Inc. | Systems and methods for sampling of amplification products |
| PL398979A1 (pl) | 2012-04-25 | 2013-10-28 | Scope Fluidics Spólka Z Ograniczona Odpowiedzialnoscia | Urzadzenie mikroprzeplywowe i uklad mikroprzeplywowy obejmujacy jedno lub wiecej urzadzen mikroprzeplywowych |
| PL2864497T3 (pl) | 2012-06-26 | 2017-01-31 | Curiosity Diagnostics Sp Z O O | Metody wykonywania oznaczeń ilościowych |
| DE102013217959A1 (de) * | 2013-09-09 | 2015-03-12 | Efficient Robotics Gmbh | Mikrofluidikanalyse-Bauelement und Herstellungsverfahren |
| CN106573242B (zh) * | 2014-08-06 | 2019-01-08 | J·舒福莱企业公司 | 在微米流体设备或毫米流体设备中使反应剂液滴和试剂液滴融合或接触的方法 |
| US10775370B2 (en) | 2015-07-17 | 2020-09-15 | Stat-Diagnostica & Innovation, S.L. | Fluidic system for performing assays |
| WO2017030949A1 (en) | 2015-08-14 | 2017-02-23 | Massachusetts Institute Of Technology | Multi-phase oscillatory flow reactor |
| CN105670929B (zh) * | 2016-03-14 | 2017-11-17 | 江苏大学 | 一种用于细胞培养条件优化控制的微流控实验装置与方法 |
| WO2017192098A1 (en) * | 2016-05-04 | 2017-11-09 | Clearbridge Biomedics Pte Ltd | Systems and methods for enriching target cells in a sample |
| RU2739327C2 (ru) * | 2016-06-14 | 2020-12-23 | Селплай С.Р.Л. | Набор и способ скрининга |
| GB2553519B (en) * | 2016-09-02 | 2019-12-18 | Fluidic Analytics Ltd | Improvements in or relating to a fluid flow controller for microfluidic devices |
| WO2018075069A1 (en) * | 2016-10-21 | 2018-04-26 | Hewlett-Packard Development Company, L.P. | Droplet generator |
| CN107321398B (zh) * | 2017-06-27 | 2019-11-26 | 中国科学院长春光学精密机械与物理研究所 | 一种液滴自发形成与控制的系统及方法 |
| JP6936085B2 (ja) * | 2017-09-06 | 2021-09-15 | 株式会社日立プラントサービス | マイクロリアクタシステム |
| CN107446820B (zh) * | 2017-09-28 | 2021-01-05 | 清华大学 | 基于微流控芯片的单细胞采样与原位检测质谱接口装置 |
| GB201717103D0 (en) * | 2017-10-18 | 2017-11-29 | Tech Partnership Plc | Fluid ejector system |
| CN107930710A (zh) * | 2017-11-27 | 2018-04-20 | 深圳华炎微测医疗科技有限公司 | 化学发光检测微流控芯片和化学发光检测微流控芯片体系以及它们的应用 |
| CN210427605U (zh) * | 2018-06-07 | 2020-04-28 | 洛阳华清天木生物科技有限公司 | 一种微液滴处理装置 |
| CN110577888B (zh) * | 2018-06-07 | 2023-08-29 | 洛阳华清天木生物科技有限公司 | 一种微流控芯片及包括其的系统 |
| CN210146032U (zh) * | 2018-06-07 | 2020-03-17 | 洛阳华清天木生物科技有限公司 | 一种用于微液滴定量分割与融合的装置及芯片 |
| EP3613498A1 (en) * | 2018-08-24 | 2020-02-26 | Université de Liège | Microfluidic module for co-encapsulation in droplets |
| US11298701B2 (en) | 2018-11-26 | 2022-04-12 | King Instrumentation Technologies | Microtiter plate mixing control system |
| WO2020163174A1 (en) * | 2019-02-04 | 2020-08-13 | Illumina, Inc. | Microfluidic droplet generators |
| CN112403539A (zh) * | 2019-08-23 | 2021-02-26 | 无锡源清天木生物科技有限公司 | 一种微流控芯片 |
| CN112403538A (zh) * | 2019-08-23 | 2021-02-26 | 无锡源清天木生物科技有限公司 | 一种液滴生成与融合的装置及其方法 |
| CN110787851B (zh) * | 2019-10-25 | 2020-12-04 | 浙江大学 | 基于压力驱动的多通道液滴定量量取装置与量取方法 |
| US11376812B2 (en) | 2020-02-11 | 2022-07-05 | Helicoid Industries Inc. | Shock and impact resistant structures |
| US12275227B2 (en) | 2020-02-11 | 2025-04-15 | Helicoid Industries, Inc. | Composite materials and structures |
| CN111804354B (zh) * | 2020-04-07 | 2021-09-21 | 苏州大学 | 液滴无损转移装置及方法、液滴微反应方法 |
| CN112495269A (zh) * | 2020-12-14 | 2021-03-16 | 北京大学 | 一种生成装置 |
| US11852297B2 (en) | 2021-06-01 | 2023-12-26 | Helicoid Industries Inc. | Containers and methods for protecting pressure vessels |
| US11346499B1 (en) | 2021-06-01 | 2022-05-31 | Helicoid Industries Inc. | Containers and methods for protecting pressure vessels |
| CN113797986B (zh) * | 2021-10-11 | 2023-05-26 | 苏州美翎生物医学科技有限公司 | 一种可微调毛细管同轴排列的微流控芯片 |
| JP2025526269A (ja) | 2022-06-27 | 2025-08-13 | ヘリコイド インダストリーズ インコーポレイテッド | 空気力学的構造物の前縁保護のための高耐衝撃性強化繊維 |
| KR102524384B1 (ko) * | 2022-10-11 | 2023-04-24 | 한국표준과학연구원 | 동기화 동작 이중밸브를 사용한 미세유체 유속 정밀제어 장치 및 이를 이용한 미세유체 유속 정밀제어 방법 |
| WO2025079618A1 (ja) * | 2023-10-10 | 2025-04-17 | 株式会社ダイセル | マイクロ流体システム、マイクロ流体システムを用いる反応方法、及びポリマーの製造方法 |
| TW202535536A (zh) * | 2023-10-10 | 2025-09-16 | 日商大賽璐股份有限公司 | 微流體系統、使用微流體系統的反應方法及聚合物的製造方法 |
| CN118477710B (zh) * | 2024-07-12 | 2024-12-13 | 杭州聚致生物科技有限公司 | 一种用于dna分离分析的微流控电泳芯片 |
| CN120515509B (zh) * | 2025-07-23 | 2025-10-21 | 湖南宏怡生物科技有限公司 | 干式生化微流控检测芯片、干化学试纸及其组合 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001094635A2 (en) * | 2000-06-05 | 2001-12-13 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
| EA008075B1 (ru) * | 2003-07-16 | 2007-02-27 | Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг | Способ изготовления микрофлюидных устройств из пластинчатого композитного полуфабриката |
| WO2009037361A1 (en) * | 2007-09-20 | 2009-03-26 | Iline Microsystems, S.L. | Microfluidic device and method for fluid clotting time determination |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2097692B (en) | 1981-01-10 | 1985-05-22 | Shaw Stewart P D | Combining chemical reagents |
| EP1099483B1 (en) | 1999-11-11 | 2009-02-11 | Allegro Technologies Limited | Liquid droplet dispensing |
| TW593122B (en) * | 2001-02-13 | 2004-06-21 | Qinetiq Ltd | Microchannel device |
| JP2003190751A (ja) * | 2001-12-25 | 2003-07-08 | Minolta Co Ltd | 混合方法、混合装置、及び該混合装置を用いた検査装置 |
| EP2278337B1 (en) * | 2002-05-09 | 2019-06-26 | The University of Chicago | Device and method for pressure-driven plug transport and reaction |
| US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| JP4246642B2 (ja) * | 2004-01-15 | 2009-04-02 | 株式会社日立プラントテクノロジー | マイクロ流体システム |
| JP4551123B2 (ja) * | 2004-05-28 | 2010-09-22 | 株式会社日立プラントテクノロジー | マイクロ流体システム及びそれを用いる処理方法 |
| JP2006275023A (ja) * | 2005-03-30 | 2006-10-12 | Ebara Corp | 流量制御機構 |
| JP4640017B2 (ja) * | 2005-07-29 | 2011-03-02 | 株式会社日立プラントテクノロジー | 乳化装置 |
| JP2007304045A (ja) * | 2006-05-15 | 2007-11-22 | Nippon Sheet Glass Co Ltd | 試料供給機構、それを用いた試料供給方法、マイクロ化学システム、評価システム、及びインジェクターシステム |
| US20080166720A1 (en) | 2006-10-06 | 2008-07-10 | The Regents Of The University Of California | Method and apparatus for rapid nucleic acid analysis |
| JP4997571B2 (ja) * | 2006-12-19 | 2012-08-08 | 有限会社フルイド | マイクロ流体デバイスおよびそれを用いた分析装置 |
| US9011777B2 (en) * | 2008-03-21 | 2015-04-21 | Lawrence Livermore National Security, Llc | Monodisperse microdroplet generation and stopping without coalescence |
| JP2013527022A (ja) * | 2010-01-24 | 2013-06-27 | インスチチュート・ケミィ・フィジズネジ・ポルスキージ・アカデミィ・ナウク | 液体混合物の自動形成及び操作システムと方法。 |
-
2011
- 2011-01-21 JP JP2012549966A patent/JP2013527022A/ja active Pending
- 2011-01-21 US US13/263,229 patent/US9132396B2/en not_active Expired - Fee Related
- 2011-01-21 EP EP11705053A patent/EP2451577A1/en not_active Withdrawn
- 2011-01-21 BR BRPI1106097A patent/BRPI1106097A2/pt not_active IP Right Cessation
- 2011-01-21 RU RU2011139195/13A patent/RU2583068C2/ru not_active IP Right Cessation
- 2011-01-21 EP EP12158774.5A patent/EP2570187A3/en not_active Withdrawn
- 2011-01-21 WO PCT/PL2011/050002 patent/WO2011090396A1/en not_active Ceased
-
2015
- 2015-10-16 JP JP2015204571A patent/JP2016047528A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001094635A2 (en) * | 2000-06-05 | 2001-12-13 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
| EA008075B1 (ru) * | 2003-07-16 | 2007-02-27 | Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг | Способ изготовления микрофлюидных устройств из пластинчатого композитного полуфабриката |
| WO2009037361A1 (en) * | 2007-09-20 | 2009-03-26 | Iline Microsystems, S.L. | Microfluidic device and method for fluid clotting time determination |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2663606C2 (ru) * | 2014-01-24 | 2018-08-07 | Бейкер Хьюз Инкорпорейтед | Система и способ обработки текучих сред |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2570187A3 (en) | 2014-08-13 |
| JP2016047528A (ja) | 2016-04-07 |
| US9132396B2 (en) | 2015-09-15 |
| JP2013527022A (ja) | 2013-06-27 |
| RU2011139195A (ru) | 2013-04-10 |
| EP2570187A2 (en) | 2013-03-20 |
| WO2011090396A1 (en) | 2011-07-28 |
| US20120040472A1 (en) | 2012-02-16 |
| EP2451577A1 (en) | 2012-05-16 |
| BRPI1106097A2 (pt) | 2017-06-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2583068C2 (ru) | Система и способ автоматического образования жидких смесей и работы с ними | |
| US11066695B2 (en) | Droplet generating apparatus, system, and method | |
| Kaminski et al. | Controlled droplet microfluidic systems for multistep chemical and biological assays | |
| US8231844B2 (en) | Method and device for manipulating liquids in microfluidic systems | |
| JP4543986B2 (ja) | マイクロ総合分析システム | |
| CN104450891B (zh) | 基于微液滴的数字核酸扩增定量分析方法及系统 | |
| US7459128B2 (en) | Microfluidic mixing and dispensing | |
| EP1811305A1 (en) | A micro-volume liquid ejection system | |
| EP3366375B1 (en) | Liquid sending method using sample processing chip and liquid sending device for sample processing chip | |
| US20100294048A1 (en) | Sampling Device | |
| US9931630B2 (en) | Autonomous and programmable sequential flow of solutions in capillary microfluidics | |
| US20180221881A1 (en) | Specimen treatment chip, specimen treatment apparatus, and specimen treatment method | |
| WO2020007098A1 (zh) | 数字pcr芯片及包含它的液滴生成系统和检测系统 | |
| JP7071056B2 (ja) | 液体送液方法および液体送液装置 | |
| US20100304443A1 (en) | Sampling device | |
| EP2307882B1 (en) | System and method to prevent cross-contamination in assays performed in a microfludic channel | |
| WO2007021864A2 (en) | Methods and apparatuses for generating a seal between a conduit and a reservoir well | |
| Bae et al. | Syringe pump-embedded, on-demand sample supply and collection system for droplet 3D cell culture in digital microfluidics | |
| CN110116028A (zh) | 微流控实验装置及方法 | |
| EP4357787A2 (en) | Liquid dispensing system for a microfluidic sample carrier, microfluidic sample carrier sealing system including such liquid dispensing system, and method for dispensing sealing liquid using the same | |
| EP4434627A1 (en) | Device and method for producing a combinatorial microcompartment within a carrier phase | |
| GB2459085A (en) | Air-segmented micro-mixing system for chemical and biological applications | |
| Zhang | Droplets generation and sampling on demand with peristaltic pumping systems | |
| GB2447412A (en) | Versatile micro-mixing system with chemical and biological applications |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20180122 |