JP4997571B2 - マイクロ流体デバイスおよびそれを用いた分析装置 - Google Patents
マイクロ流体デバイスおよびそれを用いた分析装置 Download PDFInfo
- Publication number
- JP4997571B2 JP4997571B2 JP2007324005A JP2007324005A JP4997571B2 JP 4997571 B2 JP4997571 B2 JP 4997571B2 JP 2007324005 A JP2007324005 A JP 2007324005A JP 2007324005 A JP2007324005 A JP 2007324005A JP 4997571 B2 JP4997571 B2 JP 4997571B2
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- Japan
- Prior art keywords
- electrode
- flow
- microfluidic device
- electrode pair
- gap
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
- F04B19/006—Micropumps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/3031—Micromixers using electro-hydrodynamic [EHD] or electro-kinetic [EKI] phenomena to mix or move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/088—Channel loops
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Landscapes
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Micromachines (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Description
10 マイクロポンプ
11 マイクロ流路
12 第1の流入口
13 第2の流入口
14 流出口
15 十字状交差流路
16 送液ポンプ
17 吸引ポンプ
18 側壁
20 生理食塩水
22 血小板試料
23 血小板凝集惹起剤
30 マイクロミキサー
31 交流電源
32 顕微鏡
33 CCDカメラ
34 データ収集解析装置
35 プロセス制御装置
36 モニター
40 電極対
41 マイクロミキサー
42 マイクロポンプ
43 時計回り循環用のマイクロポンプ
44 反時計回り循環用のマイクロポンプ
45 試料基板
46 電極基板
47 スペーサー
50 対向基板
51 第1電極対
52 第2電極対
53 第3電極対
100 基板
Claims (7)
- 流体を挟み対向して配置される第1及び第2基板と、
該第1基板の流体が接する面に、対向して配置される電極対と
を備え、該電極対の電極間ギャップが鉛直方向を向いており、前記電極対に交流電圧が印加されることにより前記電極間ギャップに沿って反重力方向に前記流体が流れることを特徴とするマイクロ流体デバイス。 - 前記電極対に接して鉛直方向に前記流体を流すマイクロ流路が形成されていることを特徴とする請求項1記載のマイクロ流体デバイス。
- 前記電極対に接して水平方向に前記流体を流すマイクロ流路が形成されていることを特徴とする請求項1記載のマイクロ流体デバイス。
- 前記第1及び第2基板の間において前記流体が循環して流れることを特徴とする請求項1記載のマイクロ流体デバイス。
- 請求項1乃至4いずれかに記載のマイクロ流体デバイスを用いることを特徴とする分析装置。
- 流体を挟み対向して配置される第1及び第2基板と、
該第1基板の流体が接する面に、対向して配置される電極対と
を備え、該電極対の電極間ギャップが鉛直方向に対して斜めに向いており、前記電極対に交流電圧が印加されることにより前記電極間ギャップに沿って反重力方向斜めに前記流体が流れることを特徴とするマイクロ流体デバイス。 - 前記電極対として、
前記電極間ギャップが鉛直方向を向いている第1電極対と、
前記電極間ギャップが鉛直方向に対して斜めに向いている第2電極対と、
前記電極間ギャップが鉛直方向に対して前記第2電極の電極間ギャップとは逆の斜めに向いている第3電極対と
を備え、これら3つの電極対の端が近接して配置され、三叉状に構成されていることを特徴とする請求項6記載のマイクロ流体デバイス。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007324005A JP4997571B2 (ja) | 2006-12-19 | 2007-12-14 | マイクロ流体デバイスおよびそれを用いた分析装置 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006340628 | 2006-12-19 | ||
JP2006340628 | 2006-12-19 | ||
JP2007324005A JP4997571B2 (ja) | 2006-12-19 | 2007-12-14 | マイクロ流体デバイスおよびそれを用いた分析装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008175812A JP2008175812A (ja) | 2008-07-31 |
JP4997571B2 true JP4997571B2 (ja) | 2012-08-08 |
Family
ID=39639441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007324005A Active JP4997571B2 (ja) | 2006-12-19 | 2007-12-14 | マイクロ流体デバイスおよびそれを用いた分析装置 |
Country Status (4)
Country | Link |
---|---|
US (2) | US20080237046A1 (ja) |
EP (1) | EP1972374B1 (ja) |
JP (1) | JP4997571B2 (ja) |
AT (1) | ATE530255T1 (ja) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1758982A1 (en) * | 2004-06-16 | 2007-03-07 | Ares Trading S.A. | Dielectrophoretic process for retaining polarizable target-particles and device for performing that process |
JP2008003074A (ja) * | 2006-05-26 | 2008-01-10 | Furuido:Kk | マイクロ流体デバイス、計測装置及びマイクロ流体撹拌方法 |
JP5219869B2 (ja) * | 2009-02-05 | 2013-06-26 | 興和株式会社 | マイクロ化学チップ装置 |
DE102009025007A1 (de) * | 2009-06-11 | 2011-01-05 | Technische Universität Ilmenau | Vorrichtung und Verfahren zur Überführung von Fluidproben in regelmäßige Probensequenzen, sowie Verfahren zur Manipulation letzterer |
JP5166360B2 (ja) * | 2009-06-23 | 2013-03-21 | 株式会社島津製作所 | マイクロ反応装置を用いた細胞運動評価方法 |
US9050597B2 (en) * | 2009-11-04 | 2015-06-09 | Fluid Incorporated | PCR method and PCR device |
BRPI1106097A2 (pt) * | 2010-01-24 | 2017-06-27 | Inst Chemy Fizycznej Polskiej Akademi Nauk | sistema e método para produção e manipulação automazitada de misturas liquidas |
RU2679226C2 (ru) * | 2012-12-13 | 2019-02-06 | Конинклейке Филипс Н.В. | Картридж и устройство для подготовки биологического образца |
JP5783586B1 (ja) * | 2015-01-22 | 2015-09-24 | 有限会社フルイド | Pcr装置及びpcr方法 |
JP6745462B2 (ja) * | 2015-03-24 | 2020-08-26 | 国立大学法人 東京大学 | 流体デバイス、システム及び方法 |
CN110787848B (zh) * | 2019-11-13 | 2021-05-04 | 南京理工大学 | 一种微流控进样系统 |
US20240192116A1 (en) | 2021-04-15 | 2024-06-13 | Screensys Gmbh | Systems and methods for microscopic object handling |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04277425A (ja) * | 1991-03-05 | 1992-10-02 | Mitsubishi Electric Corp | 遮断器 |
GB9208357D0 (en) * | 1992-04-16 | 1992-06-03 | British Tech Group | Apparatus for separating a mixture |
JPH0958017A (ja) * | 1995-08-29 | 1997-03-04 | Matsushita Electric Ind Co Ltd | インクジェットプリンタ装置 |
US6641708B1 (en) * | 1996-01-31 | 2003-11-04 | Board Of Regents, The University Of Texas System | Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation |
DE19719862A1 (de) | 1997-05-12 | 1998-11-19 | Fraunhofer Ges Forschung | Mikromembranpumpe |
US6572830B1 (en) | 1998-10-09 | 2003-06-03 | Motorola, Inc. | Integrated multilayered microfludic devices and methods for making the same |
US20020023841A1 (en) * | 2000-06-02 | 2002-02-28 | Ahn Chong H. | Electrohydrodynamic convection microfluidic mixer |
US6537437B1 (en) * | 2000-11-13 | 2003-03-25 | Sandia Corporation | Surface-micromachined microfluidic devices |
WO2003011443A2 (en) * | 2001-07-27 | 2003-02-13 | President And Fellows Of Harvard College | Laminar mixing apparatus and methods |
NO20023398D0 (no) * | 2002-07-15 | 2002-07-15 | Osmotex As | Anordning og fremgangsmåte for transport av v¶ske gjennom materialer |
EP1758982A1 (en) * | 2004-06-16 | 2007-03-07 | Ares Trading S.A. | Dielectrophoretic process for retaining polarizable target-particles and device for performing that process |
JP2006058031A (ja) | 2004-08-17 | 2006-03-02 | Hitachi High-Technologies Corp | 化学分析装置 |
FR2876045B1 (fr) * | 2004-10-04 | 2006-11-10 | Commissariat Energie Atomique | Dispositif pour realiser la separation dielectrophoretique de particules contenues dans un fluide |
JP4462051B2 (ja) | 2005-01-28 | 2010-05-12 | 富士ゼロックス株式会社 | 微粒子分散液の濃縮方法、及び微粒子分散液の濃縮装置 |
JP4590557B2 (ja) * | 2005-05-20 | 2010-12-01 | 国立大学法人 東京大学 | マイクロミキサーおよび流体の撹拌方法並びに流体の混合方法 |
-
2007
- 2007-12-14 JP JP2007324005A patent/JP4997571B2/ja active Active
- 2007-12-18 US US12/000,897 patent/US20080237046A1/en not_active Abandoned
- 2007-12-18 EP EP07024503A patent/EP1972374B1/en active Active
- 2007-12-18 AT AT07024503T patent/ATE530255T1/de not_active IP Right Cessation
-
2011
- 2011-05-02 US US13/067,005 patent/US8313626B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20080237046A1 (en) | 2008-10-02 |
ATE530255T1 (de) | 2011-11-15 |
EP1972374B1 (en) | 2011-10-26 |
US8313626B2 (en) | 2012-11-20 |
EP1972374A2 (en) | 2008-09-24 |
JP2008175812A (ja) | 2008-07-31 |
EP1972374A3 (en) | 2009-05-06 |
US20110284375A1 (en) | 2011-11-24 |
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