RU2578420C2 - Иммуностимулирующие и вакцинные композиции - Google Patents

Иммуностимулирующие и вакцинные композиции Download PDF

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Publication number
RU2578420C2
RU2578420C2 RU2012152952/15A RU2012152952A RU2578420C2 RU 2578420 C2 RU2578420 C2 RU 2578420C2 RU 2012152952/15 A RU2012152952/15 A RU 2012152952/15A RU 2012152952 A RU2012152952 A RU 2012152952A RU 2578420 C2 RU2578420 C2 RU 2578420C2
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Russia
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mannans
kda
antigen
composition
composition according
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RU2012152952/15A
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English (en)
Russian (ru)
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RU2012152952A (ru
Inventor
Джеффри Алан ПЕТЕРШ
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Эсенд Байофармасьютикалз Пти Лтд
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Priority claimed from AU2010901997A external-priority patent/AU2010901997A0/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55583Polysaccharides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
RU2012152952/15A 2010-05-10 2011-05-10 Иммуностимулирующие и вакцинные композиции RU2578420C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US33308610P 2010-05-10 2010-05-10
AU2010901997 2010-05-10
US61/333,086 2010-05-10
AU2010901997A AU2010901997A0 (en) 2010-05-10 Immunostimulatory and vaccine compositions
AU2010904060A AU2010904060A0 (en) 2010-09-09 Immunostimulatory and vaccine compositions
AU2010904060 2010-09-09
PCT/AU2011/000542 WO2011140595A2 (en) 2010-05-10 2011-05-10 Immunostimulatory and vaccine compositions

Publications (2)

Publication Number Publication Date
RU2012152952A RU2012152952A (ru) 2014-06-20
RU2578420C2 true RU2578420C2 (ru) 2016-03-27

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RU2012152952/15A RU2578420C2 (ru) 2010-05-10 2011-05-10 Иммуностимулирующие и вакцинные композиции

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US (1) US9597392B2 (https=)
EP (1) EP2574170A4 (https=)
JP (1) JP6096111B2 (https=)
CN (1) CN102985095B (https=)
AU (1) AU2011226992B2 (https=)
BR (1) BR112012028893A2 (https=)
CA (1) CA2798856C (https=)
RU (1) RU2578420C2 (https=)
WO (1) WO2011140595A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2801097C1 (ru) * 2022-10-28 2023-08-01 федеральное государственное бюджетное образовательное учреждение высшего образования "Приволжский исследовательский медицинский университет" Министерства здравоохранения Российской Федерации Высокомолекулярное соединение, стимулирующее выработку собственного интерферона-γ

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2725450T3 (es) 2007-07-02 2019-09-24 Etubics Corp Métodos y composiciones para la producción de un vector adenoviral para su uso en vacunaciones múltiples
IN2014CN04251A (https=) * 2011-11-09 2015-07-17 Ascend Biopharmaceuticals Ltd
WO2014031178A1 (en) 2012-08-24 2014-02-27 Etubics Corporation Replication defective adenovirus vector in vaccination
ES2503516B1 (es) * 2013-04-03 2015-09-09 Inmunotek, S.L. Complejo inmunogénico para vacunación y método de obtención
CA2973109A1 (en) 2015-01-09 2016-07-14 Etubics Corporation Methods and compositions for ebola virus vaccination
KR102193635B1 (ko) 2015-01-09 2020-12-21 이투빅스 코포레이션 복합 면역요법을 위한 방법 및 조성물
WO2016172249A1 (en) * 2015-04-20 2016-10-27 Etubics Corporation Methods and compositions for combination immunotherapy
JP7084881B2 (ja) 2016-06-22 2022-06-15 アルカームス インコーポレーテッド Il-10の免疫刺激特性および抗炎症特性を調節するための組成物および方法
FI3833378T3 (fi) 2018-08-06 2025-06-16 Nielsen Biosciences Inc Syylien hoito
US11197910B1 (en) * 2020-08-19 2021-12-14 Vitruviae LLC Fusion proteins for the diagnosis, prophylaxis and treatment of infectious diseases
EP4304606A4 (en) * 2021-03-12 2025-08-20 Childrens Medical Center POLYSACCHARIDE-BASED ADJUVANTS FOR VIRUS VACCINES
CN113616799B (zh) * 2021-07-13 2023-08-29 中国科学院长春应用化学研究所 一种疫苗载体、其制备方法及应用
JPWO2024117232A1 (https=) * 2022-11-30 2024-06-06

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4749566A (en) * 1984-11-29 1988-06-07 Sanofi Pharmaceutical composition comprising a combination of at least one immunotoxin and at least one mannose-containing polymer
WO2005047507A1 (en) * 2003-11-12 2005-05-26 The Austin Research Institute Dna-carrier conjugate
WO2008037033A1 (en) * 2006-09-29 2008-04-03 The Macfarlane Burnet Institute For Medical Research And Public Health Limited Flu vaccine admixture of mannan and flu antigen

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3362951A (en) 1965-12-21 1968-01-09 Farkas Alexander Polysaccharide product derived from the juice of the aloe plant and methods for preparing same
US4735935A (en) 1985-12-17 1988-04-05 Carrington Laboratories, Inc. Process for preparation of aloe products products, produced thereby and compositions thereof
US5308838A (en) 1982-05-07 1994-05-03 Carrington Laboratories, Inc. Uses of aloe products
US4861761A (en) 1984-06-28 1989-08-29 Dr. Madis Laboratories, Inc. Aloeferon isolation, manufacturing and its applications
EP0823438A3 (en) 1987-01-07 1999-09-15 Imperial Cancer Research Technology Limited Human mucin cone protein: peptide fragments and antibodies thereto, and uses thereof in diagnostic and therapeutic methods
US6222020B1 (en) 1987-01-07 2001-04-24 Imperial Cancer Research Technology Limited Antigens derived from the core protein of the human mammary epithelial mucin
US5643578A (en) 1992-03-23 1997-07-01 University Of Massachusetts Medical Center Immunization by inoculation of DNA transcription unit
US5744144A (en) 1993-07-30 1998-04-28 University Of Pittsburgh University Patent Committee Policy And Procedures Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof
AUPM322393A0 (en) 1993-12-24 1994-01-27 Austin Research Institute, The Mucin carbohydrate compounds and their use in immunotherapy
ATE475668T1 (de) 1994-01-27 2010-08-15 Univ Massachusetts Medical Immunisierung durch impfung von dns transkriptionseinheit
US5939400A (en) 1996-02-26 1999-08-17 The Board Of Trustees Of The Leland Stanford Junior University DNA vaccination for induction of suppressive T cell response
US6110898A (en) 1996-05-24 2000-08-29 University Of Maryland, Baltimore DNA vaccines for eliciting a mucosal immune response
US5824659A (en) 1996-09-04 1998-10-20 Board Of Regents, The University Of Texas System Cytoprotective oligosaccharide from Aloe preventing damage to the skin immune system by UV radiation
ATE341339T1 (de) 1996-12-20 2006-10-15 Merck & Co Inc Zusammensetzungen von rekombinanten papillomavirus vakzinen
ES2357960T3 (es) 1997-05-08 2011-05-04 Oncothyreon Inc. Procedimiento para generar células t activadas y células presentadoras de antígenos pulsadas con antígenos.
CA2329897A1 (en) 1998-04-28 1999-11-04 Galenica Pharmaceuticals, Inc. Polysaccharide-antigen conjugates
IL125608A0 (en) 1998-07-30 1999-03-12 Yeda Res & Dev Tumor associated antigen peptides and use of same as anti-tumor vaccines
DE19917195B4 (de) 1999-04-16 2006-09-28 Immatics Biotechnologies Gmbh Peptid zur Auslösung einer Immunreaktion gegen Tumorzellen, diese enthaltende pharmzeutische Zusammensetzungen, dessen Verwendungen, dafür codierende Nukleinsäure und diese Nukleinsäure enthaltender Expressionsvektor
JP2003510094A (ja) 1999-09-08 2003-03-18 トランジェーヌ、ソシエテ、アノニム Muc−1由来のペプチド
EP1257565A4 (en) 2000-02-01 2005-04-06 Austin Research Inst DERIVED FROM MUCIN-1 ANTIGENE AND ITS USE IN IMMUNOTHERAPY
AUPQ797700A0 (en) * 2000-06-06 2000-06-29 Austin Research Institute, The Vaccine
US7196072B2 (en) 2000-07-10 2007-03-27 University Of Mississippi High molecular weight polysaccharide fraction from Aloe vera with immunostimulatory activity
ATE265218T1 (de) * 2000-08-10 2004-05-15 Ocean Nutrition Canada Ltd Chlorella zubereitungen mit immunmodulatorischen eigenschaften
NZ538812A (en) 2002-08-15 2009-02-28 3M Innovative Properties Co Immunostimulatory compositions and methods of stimulating an immune response
AU2003256912A1 (en) 2002-08-16 2004-03-03 Yeda Research And Development Co. Ltd. Tumor associated antigen, peptides thereof, and use of same as anti-tumor vaccines
WO2005044861A1 (en) 2003-10-31 2005-05-19 Wyeth Holdings Corporation Polysaccharides of helicobacter pylori
US20060084629A1 (en) 2004-10-15 2006-04-20 Alvin Needleman Immune system activating formula composed of selected long chain polysaccharides from natural sources
JP2006241023A (ja) * 2005-03-01 2006-09-14 Asahi Breweries Ltd 消化管組織における抗菌ペプチドの発現誘導または産生促進剤
JP2006241020A (ja) * 2005-03-01 2006-09-14 Asahi Breweries Ltd 免疫系賦活剤
EP1988896A4 (en) 2006-02-22 2011-07-27 3M Innovative Properties Co CONJUGATES TO MODIFY IMMUNE REACTIONS
ES2776100T3 (es) 2006-03-31 2020-07-29 Massachusetts Inst Technology Sistema para el suministro dirigido de agentes terapéuticos
JP2009544291A (ja) 2006-07-25 2009-12-17 フォージー ヴァクシンズ ピーティーワイ エルーティーディー ムチン1(muc1)t細胞エピトープ由来ペプチド含有癌ワクチン
AU2007300543A1 (en) 2006-09-26 2008-04-03 Alexion Pharmaceuticals, Inc. Compositions and methods for enhancing an adjuvant
US20080149123A1 (en) 2006-12-22 2008-06-26 Mckay William D Particulate material dispensing hairbrush with combination bristles

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4749566A (en) * 1984-11-29 1988-06-07 Sanofi Pharmaceutical composition comprising a combination of at least one immunotoxin and at least one mannose-containing polymer
WO2005047507A1 (en) * 2003-11-12 2005-05-26 The Austin Research Institute Dna-carrier conjugate
WO2008037033A1 (en) * 2006-09-29 2008-04-03 The Macfarlane Burnet Institute For Medical Research And Public Health Limited Flu vaccine admixture of mannan and flu antigen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Apostolopoulos V. Et al. Aldehyde-mannan antigen complexes target the MHC class I antigen-presentation pathway // Eur J Immunol., 2000, Jun;30(6):1714-23. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2801097C1 (ru) * 2022-10-28 2023-08-01 федеральное государственное бюджетное образовательное учреждение высшего образования "Приволжский исследовательский медицинский университет" Министерства здравоохранения Российской Федерации Высокомолекулярное соединение, стимулирующее выработку собственного интерферона-γ

Also Published As

Publication number Publication date
EP2574170A4 (en) 2013-11-20
JP2013527854A (ja) 2013-07-04
CA2798856C (en) 2019-04-23
BR112012028893A2 (pt) 2017-12-12
US20130251741A1 (en) 2013-09-26
AU2011226992A1 (en) 2011-11-24
JP6096111B2 (ja) 2017-03-15
AU2011226992B2 (en) 2012-03-22
EP2574170A2 (en) 2013-04-03
WO2011140595A2 (en) 2011-11-17
US9597392B2 (en) 2017-03-21
CN102985095B (zh) 2016-05-18
WO2011140595A3 (en) 2012-01-05
RU2012152952A (ru) 2014-06-20
CA2798856A1 (en) 2011-11-17
CN102985095A (zh) 2013-03-20

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Effective date: 20200511