RU2553564C2 - Генетически модифицированный бактериальный штамм wsj-ia, продуцирующий изовалерилспирамицин i с высоким содержанием и высоким выходом - Google Patents

Генетически модифицированный бактериальный штамм wsj-ia, продуцирующий изовалерилспирамицин i с высоким содержанием и высоким выходом Download PDF

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RU2553564C2
RU2553564C2 RU2012158029/10A RU2012158029A RU2553564C2 RU 2553564 C2 RU2553564 C2 RU 2553564C2 RU 2012158029/10 A RU2012158029/10 A RU 2012158029/10A RU 2012158029 A RU2012158029 A RU 2012158029A RU 2553564 C2 RU2553564 C2 RU 2553564C2
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gene
strain
wsj
ist
streptomyces
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Игуан ВАН
Ян ЦЗЯН
Шэнву ЯН
Сяофэн ЧЖАО
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Шэнь Ян Тунлянь Груп Ко., Лтд
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    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
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    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
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    • C12R2001/465—Streptomyces
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  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
RU2012158029/10A 2010-07-23 2011-07-21 Генетически модифицированный бактериальный штамм wsj-ia, продуцирующий изовалерилспирамицин i с высоким содержанием и высоким выходом RU2553564C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2010102375954A CN101914482B (zh) 2010-07-23 2010-07-23 一株异戊酰螺旋霉素i组分高含量、高产量基因工程菌
CN201010237595.4 2010-07-23
PCT/CN2011/001194 WO2012009963A1 (zh) 2010-07-23 2011-07-21 用于生产异戊酰螺旋霉素i的基因工程菌wsj-ia

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RU2012158029A RU2012158029A (ru) 2014-08-27
RU2553564C2 true RU2553564C2 (ru) 2015-06-20

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US (1) US8759032B2 (de)
EP (1) EP2597152B1 (de)
JP (1) JP5719437B2 (de)
KR (1) KR101542243B1 (de)
CN (1) CN101914482B (de)
BR (1) BR112013001580A2 (de)
CA (1) CA2800326C (de)
MX (1) MX342493B (de)
MY (1) MY157302A (de)
RU (1) RU2553564C2 (de)
WO (1) WO2012009963A1 (de)

Families Citing this family (6)

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CN101914482B (zh) 2010-07-23 2012-07-04 中国医学科学院医药生物技术研究所 一株异戊酰螺旋霉素i组分高含量、高产量基因工程菌
CN105062948A (zh) * 2015-07-31 2015-11-18 天方药业有限公司 一种制备螺旋霉素碱产生菌生二素灰色链霉菌孢子的方法
CN107868789B (zh) 2015-12-31 2020-11-17 沈阳福洋医药科技有限公司 可利霉素生物合成基因簇
CN106172753A (zh) * 2016-08-23 2016-12-07 山西维尔生物乳制品有限公司 一种液态发酵剂接种装置及方法
CN111349595A (zh) * 2018-12-20 2020-06-30 沈阳福洋医药科技有限公司 一种螺旋霉素产生菌、可利霉素产生菌、构建方法、应用及提高产物产量的方法
WO2024074637A1 (en) * 2022-10-07 2024-04-11 Syngenta Crop Protection Ag Means and methods for controlling pathogens and pests in plants

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JPH06121677A (ja) * 1992-01-23 1994-05-06 Mercian Corp マクロライド抗生物質のアシル化酵素遺伝子の高発現方法
EP1905833B1 (de) * 2002-10-08 2015-08-12 Aventis Pharma S.A. Polypeptide, die an der Biosynthese von Spiramycinen beteiligt sind, Nukleotidsequenzen, die diese Polypetide kodieren, und ihre Anwendungen
CN1169947C (zh) * 2002-11-19 2004-10-06 中国医学科学院医药生物技术研究所 必特螺旋霉素的基因工程菌株螺旋霉素链霉菌wsj-195
CN101054553A (zh) * 2007-04-09 2007-10-17 中国医学科学院医药生物技术研究所 异戊酰螺旋霉素i基因工程菌株的构建
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CA2800326C (en) 2014-09-30
MY157302A (en) 2016-05-31
KR20130091335A (ko) 2013-08-16
BR112013001580A2 (pt) 2016-05-10
US8759032B2 (en) 2014-06-24
KR101542243B1 (ko) 2015-08-05
JP5719437B2 (ja) 2015-05-20
CN101914482B (zh) 2012-07-04
RU2012158029A (ru) 2014-08-27
WO2012009963A1 (zh) 2012-01-26
EP2597152A4 (de) 2014-04-16
CA2800326A1 (en) 2012-01-26
EP2597152A1 (de) 2013-05-29
JP2013532981A (ja) 2013-08-22
US20130130324A1 (en) 2013-05-23
CN101914482A (zh) 2010-12-15
EP2597152B1 (de) 2023-11-01
MX2013000944A (es) 2013-02-27
MX342493B (es) 2016-09-29

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