RU2546661C2 - Кристаллическая форма 13-[(n-трет-бутоксикарбонил)-2'-о-гексаноил-3-фенилизосеринил]-10-диацетилбаккатина iii - Google Patents

Кристаллическая форма 13-[(n-трет-бутоксикарбонил)-2'-о-гексаноил-3-фенилизосеринил]-10-диацетилбаккатина iii Download PDF

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Publication number
RU2546661C2
RU2546661C2 RU2013124011/04A RU2013124011A RU2546661C2 RU 2546661 C2 RU2546661 C2 RU 2546661C2 RU 2013124011/04 A RU2013124011/04 A RU 2013124011/04A RU 2013124011 A RU2013124011 A RU 2013124011A RU 2546661 C2 RU2546661 C2 RU 2546661C2
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RU
Russia
Prior art keywords
crystalline form
phenylisoserinyl
hexanoyl
butoxycarbonyl
tert
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RU2013124011/04A
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English (en)
Russian (ru)
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RU2013124011A (ru
Inventor
Даниеле ЧИЧЕРИ
Андреа ГАМБИНИ
Маурицио РИКОТТИ
Никола САРДОНЕ
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Индена С.П.А.
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Publication of RU2013124011A publication Critical patent/RU2013124011A/ru
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Publication of RU2546661C2 publication Critical patent/RU2546661C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D305/06—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2013124011/04A 2010-10-29 2011-10-27 Кристаллическая форма 13-[(n-трет-бутоксикарбонил)-2'-о-гексаноил-3-фенилизосеринил]-10-диацетилбаккатина iii RU2546661C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10189373.3 2010-10-29
EP10189373A EP2447268A1 (en) 2010-10-29 2010-10-29 Crystalline form of 13-[(N-tert-butoxycarbonyl)-2'-O-hexanoyl-3-phenylisoserinyl]-10-deacetylbaccatin III
PCT/EP2011/068835 WO2012055952A1 (en) 2010-10-29 2011-10-27 Crystalline form of 13-[(n-tert-butoxycarbonyl)-2'-o-hexanoyl-3-phenylisoserinyl]-10-deacetylbaccatin iii

Publications (2)

Publication Number Publication Date
RU2013124011A RU2013124011A (ru) 2014-12-10
RU2546661C2 true RU2546661C2 (ru) 2015-04-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2013124011/04A RU2546661C2 (ru) 2010-10-29 2011-10-27 Кристаллическая форма 13-[(n-трет-бутоксикарбонил)-2'-о-гексаноил-3-фенилизосеринил]-10-диацетилбаккатина iii

Country Status (16)

Country Link
US (1) US9062018B2 (sl)
EP (2) EP2447268A1 (sl)
JP (1) JP5744215B2 (sl)
KR (2) KR20130086618A (sl)
CN (1) CN103209983B (sl)
AR (1) AR083588A1 (sl)
AU (1) AU2011322572B2 (sl)
CA (1) CA2814907C (sl)
DK (1) DK2632926T3 (sl)
ES (1) ES2528374T3 (sl)
MX (1) MX2013004722A (sl)
PL (1) PL2632926T3 (sl)
PT (1) PT2632926E (sl)
RU (1) RU2546661C2 (sl)
SI (1) SI2632926T1 (sl)
WO (1) WO2012055952A1 (sl)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006089207A2 (en) * 2005-02-18 2006-08-24 Abraxis Bioscience, Inc. Drugs with improved hydrophobicity for incorporation in medical devices
RU2284328C2 (ru) * 2001-11-29 2006-09-27 Дайити Фармасьютикал Ко., Лтд. Кристаллы производных таксана и способ их получения
WO2009126175A1 (en) * 2008-04-10 2009-10-15 Abraxis Bioscience, Llc Compositions of hydrophobic taxane derivatives and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2330101A1 (en) 2006-10-20 2011-06-08 Scinopharm Singapore Pte, Ltd. Process for making crystalline docetaxel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2284328C2 (ru) * 2001-11-29 2006-09-27 Дайити Фармасьютикал Ко., Лтд. Кристаллы производных таксана и способ их получения
WO2006089207A2 (en) * 2005-02-18 2006-08-24 Abraxis Bioscience, Inc. Drugs with improved hydrophobicity for incorporation in medical devices
WO2009126175A1 (en) * 2008-04-10 2009-10-15 Abraxis Bioscience, Llc Compositions of hydrophobic taxane derivatives and uses thereof

Also Published As

Publication number Publication date
AU2011322572B2 (en) 2015-02-19
KR101577177B1 (ko) 2015-12-14
JP2013540798A (ja) 2013-11-07
DK2632926T3 (en) 2015-01-12
KR20130086618A (ko) 2013-08-02
EP2447268A1 (en) 2012-05-02
JP5744215B2 (ja) 2015-07-08
MX2013004722A (es) 2013-08-29
WO2012055952A1 (en) 2012-05-03
CN103209983A (zh) 2013-07-17
RU2013124011A (ru) 2014-12-10
AU2011322572A1 (en) 2013-05-02
PL2632926T3 (pl) 2015-04-30
CA2814907A1 (en) 2012-05-03
US20140303240A1 (en) 2014-10-09
PT2632926E (pt) 2015-02-09
ES2528374T3 (es) 2015-02-09
US9062018B2 (en) 2015-06-23
CA2814907C (en) 2015-02-03
CN103209983B (zh) 2016-04-13
EP2632926B1 (en) 2014-12-10
EP2632926A1 (en) 2013-09-04
SI2632926T1 (sl) 2015-03-31
KR20150099614A (ko) 2015-08-31
AR083588A1 (es) 2013-03-06

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Effective date: 20201028