AR083588A1 - Forma cristalina de 13-[(n-tert-butoxicarbonil)-2’-o-hexanoil-3-fenilsoserinil]-10-deacetilbaccatina iii y proceso para prepararla - Google Patents

Forma cristalina de 13-[(n-tert-butoxicarbonil)-2’-o-hexanoil-3-fenilsoserinil]-10-deacetilbaccatina iii y proceso para prepararla

Info

Publication number
AR083588A1
AR083588A1 ARP110103990A ARP110103990A AR083588A1 AR 083588 A1 AR083588 A1 AR 083588A1 AR P110103990 A ARP110103990 A AR P110103990A AR P110103990 A ARP110103990 A AR P110103990A AR 083588 A1 AR083588 A1 AR 083588A1
Authority
AR
Argentina
Prior art keywords
tert
phenylososinin
hexanoil
deacetilbaccatine
butoxicarbonil
Prior art date
Application number
ARP110103990A
Other languages
English (en)
Inventor
Daniele Ciceri
Andrea Gambini
Maurizio Ricotti
Nicola Sardone
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of AR083588A1 publication Critical patent/AR083588A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/04Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D305/06Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

13-[(N-tert-butoxicarbonil)-2’-O-hexanoil-3-fenilisoserinil]-10-deacetilbaccatina III en una forma cristalina; es decir la forma cristalina A.Reivindicación 3: La forma cristalina de 13-[(N-tert-butoxicarbonil)-2’-O-hexanoil-3-fenilisoserinil]-10-deacetilbaccatina III de acuerdo con la reivindicación 2, caracterizada porque la Forma cristalina A tiene un difractograma de XRPD que se caracteriza por los siguientes picos: 6,1; 9,1; 10,1; 10,6; 11,7; 13,0; 18,5; 19,8; 22,0 grados 2-q ± 0,2º.
ARP110103990A 2010-10-29 2011-10-28 Forma cristalina de 13-[(n-tert-butoxicarbonil)-2’-o-hexanoil-3-fenilsoserinil]-10-deacetilbaccatina iii y proceso para prepararla AR083588A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10189373A EP2447268A1 (en) 2010-10-29 2010-10-29 Crystalline form of 13-[(N-tert-butoxycarbonyl)-2'-O-hexanoyl-3-phenylisoserinyl]-10-deacetylbaccatin III

Publications (1)

Publication Number Publication Date
AR083588A1 true AR083588A1 (es) 2013-03-06

Family

ID=43886731

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110103990A AR083588A1 (es) 2010-10-29 2011-10-28 Forma cristalina de 13-[(n-tert-butoxicarbonil)-2’-o-hexanoil-3-fenilsoserinil]-10-deacetilbaccatina iii y proceso para prepararla

Country Status (16)

Country Link
US (1) US9062018B2 (es)
EP (2) EP2447268A1 (es)
JP (1) JP5744215B2 (es)
KR (2) KR101577177B1 (es)
CN (1) CN103209983B (es)
AR (1) AR083588A1 (es)
AU (1) AU2011322572B2 (es)
CA (1) CA2814907C (es)
DK (1) DK2632926T3 (es)
ES (1) ES2528374T3 (es)
MX (1) MX2013004722A (es)
PL (1) PL2632926T3 (es)
PT (1) PT2632926E (es)
RU (1) RU2546661C2 (es)
SI (1) SI2632926T1 (es)
WO (1) WO2012055952A1 (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1457492B1 (en) 2001-11-29 2008-01-02 Daiichi Sankyo Company, Limited Crystals of taxane derivative and process for their production
ES2663495T3 (es) * 2005-02-18 2018-04-13 Abraxis Bioscience, Llc Fármacos con hidrofobicidad mejorada para incorporación en dispositivos médicos
NZ576355A (en) 2006-10-20 2012-04-27 Scinopharm Singapore Pte Ltd Process for making crystalline anhydrous docetaxel
KR20150136137A (ko) 2008-04-10 2015-12-04 아브락시스 바이오사이언스, 엘엘씨 소수성 탁산 유도체의 조성물 및 그의 용도

Also Published As

Publication number Publication date
US9062018B2 (en) 2015-06-23
KR20130086618A (ko) 2013-08-02
CA2814907A1 (en) 2012-05-03
RU2013124011A (ru) 2014-12-10
AU2011322572B2 (en) 2015-02-19
AU2011322572A1 (en) 2013-05-02
KR20150099614A (ko) 2015-08-31
PT2632926E (pt) 2015-02-09
CN103209983A (zh) 2013-07-17
ES2528374T3 (es) 2015-02-09
WO2012055952A1 (en) 2012-05-03
EP2632926A1 (en) 2013-09-04
MX2013004722A (es) 2013-08-29
DK2632926T3 (en) 2015-01-12
CA2814907C (en) 2015-02-03
PL2632926T3 (pl) 2015-04-30
JP2013540798A (ja) 2013-11-07
KR101577177B1 (ko) 2015-12-14
US20140303240A1 (en) 2014-10-09
SI2632926T1 (sl) 2015-03-31
CN103209983B (zh) 2016-04-13
JP5744215B2 (ja) 2015-07-08
EP2632926B1 (en) 2014-12-10
EP2447268A1 (en) 2012-05-02
RU2546661C2 (ru) 2015-04-10

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