RU2543721C2 - Цитратная соль 9е-15-(2-пирролидин-1-ил-этокси)-7,12,25-триокса-19,21,24-триазатетрацикло[18.3.1.1(2,5).1(14,18)]гексакоза-1(24),2,4,9,14,16,18(26),20,22-нонаена - Google Patents

Цитратная соль 9е-15-(2-пирролидин-1-ил-этокси)-7,12,25-триокса-19,21,24-триазатетрацикло[18.3.1.1(2,5).1(14,18)]гексакоза-1(24),2,4,9,14,16,18(26),20,22-нонаена Download PDF

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RU2543721C2
RU2543721C2 RU2012105044/04A RU2012105044A RU2543721C2 RU 2543721 C2 RU2543721 C2 RU 2543721C2 RU 2012105044/04 A RU2012105044/04 A RU 2012105044/04A RU 2012105044 A RU2012105044 A RU 2012105044A RU 2543721 C2 RU2543721 C2 RU 2543721C2
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Russia
Prior art keywords
citrate
ray diffraction
salt
peaks
citrate salt
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RU2012105044/04A
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English (en)
Russian (ru)
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RU2012105044A (ru
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Брайан ДАЙМОК
Чэнь Хсия Анджелин ЛИ
Энтони Деодония ВИЛЬЯМ
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СиТиАй БИОФАРМА КОРП.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RU2012105044/04A 2009-07-15 2010-07-14 Цитратная соль 9е-15-(2-пирролидин-1-ил-этокси)-7,12,25-триокса-19,21,24-триазатетрацикло[18.3.1.1(2,5).1(14,18)]гексакоза-1(24),2,4,9,14,16,18(26),20,22-нонаена RU2543721C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22560909P 2009-07-15 2009-07-15
US61/225,609 2009-07-15
PCT/SG2010/000265 WO2011008172A1 (en) 2009-07-15 2010-07-14 9e-15-(2-pyrrolidin-1-yl-ethoxy)-7,12,25-trioxa-19,21,24-triaza- tetracyclo[18.3.1.1(2,5).1(14)18)]hexacosa-1(24),2,4,9,14,16,18(26),20,22-nonaene citrate salt

Publications (2)

Publication Number Publication Date
RU2012105044A RU2012105044A (ru) 2013-08-20
RU2543721C2 true RU2543721C2 (ru) 2015-03-10

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RU2012105044/04A RU2543721C2 (ru) 2009-07-15 2010-07-14 Цитратная соль 9е-15-(2-пирролидин-1-ил-этокси)-7,12,25-триокса-19,21,24-триазатетрацикло[18.3.1.1(2,5).1(14,18)]гексакоза-1(24),2,4,9,14,16,18(26),20,22-нонаена

Country Status (18)

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US (1) US9062074B2 (https=)
EP (1) EP2454266B1 (https=)
JP (2) JP6013911B2 (https=)
CN (1) CN102762577B (https=)
AR (2) AR077483A1 (https=)
BR (1) BR112012000750B1 (https=)
CA (1) CA2768210C (https=)
DK (1) DK2454266T3 (https=)
ES (1) ES2429525T3 (https=)
HR (1) HRP20130941T1 (https=)
MX (1) MX2012000680A (https=)
PL (1) PL2454266T3 (https=)
PT (1) PT2454266E (https=)
RU (1) RU2543721C2 (https=)
SI (1) SI2454266T1 (https=)
SM (1) SMT201300112B (https=)
TW (1) TWI537276B (https=)
WO (1) WO2011008172A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113559075A (zh) 2014-11-17 2021-10-29 康泰科思特生物制药公司 奥那司酮延长释放组合物和方法
AU2016326657B2 (en) 2015-09-25 2019-10-24 Context Biopharma, Inc. Methods of making onapristone intermediates
EP3389632A4 (en) 2015-12-15 2019-11-06 Context Biopharma Inc. AMORPHIC ONAPRISTON COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF
WO2018102369A1 (en) 2016-11-30 2018-06-07 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2130460C1 (ru) * 1993-05-27 1999-05-20 Новартис Аг Производные тетрагидропирана и фармацевтическая композиция на их основе
WO2007058627A1 (en) * 2005-11-16 2007-05-24 S*Bio Pte Ltd Oxygen linked pyrimidine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078682A2 (en) * 2003-03-05 2004-09-16 Irm Llc Cyclic compounds and compositions as protein kinase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2130460C1 (ru) * 1993-05-27 1999-05-20 Новартис Аг Производные тетрагидропирана и фармацевтическая композиция на их основе
WO2007058627A1 (en) * 2005-11-16 2007-05-24 S*Bio Pte Ltd Oxygen linked pyrimidine derivatives

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Publication number Publication date
CA2768210A1 (en) 2011-01-20
DK2454266T3 (da) 2013-09-08
CA2768210C (en) 2017-08-15
EP2454266A1 (en) 2012-05-23
CN102762577A (zh) 2012-10-31
AR114987A2 (es) 2020-11-11
RU2012105044A (ru) 2013-08-20
BR112012000750B1 (pt) 2021-05-25
JP2015164941A (ja) 2015-09-17
TWI537276B (zh) 2016-06-11
JP2012533539A (ja) 2012-12-27
AR077483A1 (es) 2011-08-31
SMT201300112B (it) 2013-11-08
SI2454266T1 (sl) 2013-10-30
BR112012000750A2 (pt) 2016-08-09
ES2429525T3 (es) 2013-11-15
BR112012000750A8 (pt) 2018-02-06
US20120196876A1 (en) 2012-08-02
HRP20130941T1 (hr) 2013-11-08
CN102762577B (zh) 2015-01-07
JP6013911B2 (ja) 2016-10-25
WO2011008172A1 (en) 2011-01-20
EP2454266B1 (en) 2013-07-10
US9062074B2 (en) 2015-06-23
MX2012000680A (es) 2012-02-28
HK1178159A1 (en) 2013-09-06
PT2454266E (pt) 2013-10-10
TW201107336A (en) 2011-03-01
PL2454266T3 (pl) 2014-01-31

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