RU2538683C2 - КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ (Р13К) И ИНГИБИТОРА mTOR - Google Patents
КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ (Р13К) И ИНГИБИТОРА mTOR Download PDFInfo
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- RU2538683C2 RU2538683C2 RU2011121508/15A RU2011121508A RU2538683C2 RU 2538683 C2 RU2538683 C2 RU 2538683C2 RU 2011121508/15 A RU2011121508/15 A RU 2011121508/15A RU 2011121508 A RU2011121508 A RU 2011121508A RU 2538683 C2 RU2538683 C2 RU 2538683C2
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- Prior art keywords
- cancer
- rapamycin
- dependent
- mtor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08168044 | 2008-10-31 | ||
| EP08168044.9 | 2008-10-31 | ||
| PCT/EP2009/064274 WO2010049481A1 (en) | 2008-10-31 | 2009-10-29 | Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014115188/15A Division RU2014115188A (ru) | 2008-10-31 | 2014-04-15 | КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ(PI3K) И ИНГИБИТОРА mTOR |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2011121508A RU2011121508A (ru) | 2012-12-10 |
| RU2538683C2 true RU2538683C2 (ru) | 2015-01-10 |
Family
ID=40332588
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011121508/15A RU2538683C2 (ru) | 2008-10-31 | 2009-10-29 | КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ (Р13К) И ИНГИБИТОРА mTOR |
| RU2014115188/15A RU2014115188A (ru) | 2008-10-31 | 2014-04-15 | КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ(PI3K) И ИНГИБИТОРА mTOR |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014115188/15A RU2014115188A (ru) | 2008-10-31 | 2014-04-15 | КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ(PI3K) И ИНГИБИТОРА mTOR |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20110195966A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2349275B1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP2012506898A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20110090911A (cg-RX-API-DMAC7.html) |
| CN (2) | CN102202668A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009309616B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0921802A8 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2736361C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2627677T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2011004585A (cg-RX-API-DMAC7.html) |
| RU (2) | RU2538683C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010049481A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100048914A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal Cyp17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| US8476431B2 (en) * | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
| WO2010056754A2 (en) | 2008-11-11 | 2010-05-20 | The Board Regents Of The University Of Texas System | Inhibition of mammalian target of rapamycin |
| BRPI1008745A2 (pt) | 2009-02-05 | 2019-09-17 | Tokai Pharmaceuticals Inc | pró-fármacos de inibidores esteroidais de cyp17/antiandrogênios |
| US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| US10391059B2 (en) | 2009-11-11 | 2019-08-27 | Rapamycin Holdings, Inc. | Oral rapamycin nanoparticle preparations and use |
| GB2478556A (en) * | 2010-03-09 | 2011-09-14 | Myrovlytis Technology Ventures Ltd | A composition for use in the treatment of Birt-Hogg-Dubô sydrome |
| ES2570183T3 (es) * | 2011-02-16 | 2016-05-17 | Novartis Ag | Combinaciones de agentes terapéuticos para uso en el tratamiento de enfermedades neurodegenerativas |
| CN106619647A (zh) * | 2011-02-23 | 2017-05-10 | 因特利凯有限责任公司 | 激酶抑制剂的组合及其用途 |
| BR112013022697A2 (pt) * | 2011-03-07 | 2019-09-24 | Fond Telethon | inibidores de fosforilação de tfeb e usos dos mesmos |
| NZ615593A (en) * | 2011-04-25 | 2015-05-29 | Novartis Ag | Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor |
| EP2705181B1 (en) * | 2011-05-04 | 2016-12-21 | Intellikine, LLC | Combination pharmaceutical compositions and uses thereof |
| EP2771337B1 (en) | 2011-09-27 | 2017-08-02 | Novartis AG | 3-(pyrimidin-4-yl)-oxazolidin-2-ones as inhibitors of mutant idh |
| CN106924741A (zh) * | 2011-11-08 | 2017-07-07 | 因特利凯有限责任公司 | 使用多种药剂的治疗方案 |
| CN104363914A (zh) | 2011-11-23 | 2015-02-18 | 因特利凯有限责任公司 | 使用mTOR抑制剂的增强的治疗方案 |
| UY34632A (es) * | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
| RU2012112128A (ru) * | 2012-03-29 | 2013-10-10 | Холин Максим Николаевич | ИНГИБИТОРЫ СИГНАЛЬНОГО ПУТИ PI3K/AKT/IKK/NF-kB, ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫЕ СОЛИ И СОДЕРЖАЩИЕ ИХ КОМПОЗИЦИИ ДЛЯ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ ВИРУСНЫХ ЗАБОЛЕВАНИЙ |
| US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
| WO2014160328A1 (en) | 2013-03-13 | 2014-10-02 | The Board Of Regents Of The University Of Texas System | Mtor inhibitors for prevention of intestinal polyp growth |
| CN105682662A (zh) | 2013-03-14 | 2016-06-15 | 马里兰大学巴尔的摩校区 | 雄激素受体减量调节剂及其用途 |
| AU2014229313B2 (en) | 2013-03-14 | 2016-07-28 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH |
| MX2015011899A (es) | 2013-03-15 | 2016-05-05 | Genentech Inc | Metodos para el tratamiento de cáncer y prevención de resistencia a los fármacos para el cáncer. |
| CR20200177A (es) | 2013-05-01 | 2020-06-28 | Hoffmann La Roche | Compuestos de biheteroarilo (divisional 2015-0589) |
| BR112016002970A2 (pt) | 2013-08-12 | 2017-09-12 | Tokai Pharmaceuticals Inc | biomarcadores para o tratamento de distúrbios neoplásicos que usa terapias direcionadas ao androgênio |
| CN103483345B (zh) * | 2013-09-25 | 2016-07-06 | 中山大学 | Pi3k激酶抑制剂、包含其的药物组合物及其应用 |
| US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
| EP3708680B8 (en) | 2015-04-15 | 2023-08-30 | University of Massachusetts | Compositions and methods for xi chromosome reactivation |
| US10576076B2 (en) | 2015-05-20 | 2020-03-03 | Novartis Ag | Pharmaceutical combination of everolimus with dactolisib |
| US10441584B2 (en) | 2016-11-23 | 2019-10-15 | Novartis Ag | Methods of enhancing immune response |
| US10596165B2 (en) | 2018-02-12 | 2020-03-24 | resTORbio, Inc. | Combination therapies |
| KR20210158019A (ko) | 2020-06-23 | 2021-12-30 | 주식회사 온코빅스 | 포스파티딜이노시톨 3-키나제(pi3k) 억제제로써 pten 과오종 증후군에 의한 종양 세포의 성장 또는 증식을 억제하는데 유용한 신규한 피리미딘 유도체 및 이의 약제학적으로 허용가능한 염, 및 이를 유효성분으로 함유하는 약제학적 조성물 |
| CN112294967A (zh) * | 2020-09-30 | 2021-02-02 | 四川大学 | 一种mTOR抑制剂与抗癌药物的用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2282461C2 (ru) * | 2000-06-26 | 2006-08-27 | Стрессджен Байотекнолоджиз Корпорейшн | Лечение инфекции, вызываемой вирусом папилломы человека |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0516592A (pt) * | 2004-10-13 | 2008-09-23 | Wyeth Corp | composto de fórmula |
| US20080200486A1 (en) * | 2005-07-20 | 2008-08-21 | Heidi Lane | Combination Of Organic Compounds |
| CA2628920C (en) * | 2005-11-22 | 2015-12-29 | Kudos Pharmaceuticals Limited | Pyrido-,pyrazo- and pyrimido-pyrimidine derivatives as mtor inhibitors |
| JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| WO2007087395A2 (en) * | 2006-01-25 | 2007-08-02 | Osi Pharmaceuticals, Inc. | UNSATURATED mTOR INHIBITORS |
| WO2007120897A2 (en) * | 2006-04-13 | 2007-10-25 | The Trustees Of Columbia University In The City Of New York | Compositions and intraluminal devices for inhibiting vascular stenosis |
| KR20090108124A (ko) * | 2007-02-06 | 2009-10-14 | 노파르티스 아게 | Pi 3-키나제 억제제 및 그의 사용 방법 |
| WO2008103636A1 (en) * | 2007-02-20 | 2008-08-28 | Novartis Ag | Imidazoquinolines as dual lipid kinase and mtor inhibitors |
| EP2231147A2 (en) * | 2007-12-13 | 2010-09-29 | Novartis AG | Combinations of therapeutic agents for treating cancer |
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2009
- 2009-10-29 US US13/123,956 patent/US20110195966A1/en not_active Abandoned
- 2009-10-29 WO PCT/EP2009/064274 patent/WO2010049481A1/en not_active Ceased
- 2009-10-29 CN CN2009801431736A patent/CN102202668A/zh active Pending
- 2009-10-29 KR KR1020117009771A patent/KR20110090911A/ko not_active Ceased
- 2009-10-29 EP EP09744391.5A patent/EP2349275B1/en not_active Not-in-force
- 2009-10-29 MX MX2011004585A patent/MX2011004585A/es active IP Right Grant
- 2009-10-29 AU AU2009309616A patent/AU2009309616B2/en not_active Ceased
- 2009-10-29 ES ES09744391.5T patent/ES2627677T3/es active Active
- 2009-10-29 CA CA2736361A patent/CA2736361C/en not_active Expired - Fee Related
- 2009-10-29 BR BRPI0921802A patent/BRPI0921802A8/pt not_active IP Right Cessation
- 2009-10-29 JP JP2011533721A patent/JP2012506898A/ja not_active Withdrawn
- 2009-10-29 RU RU2011121508/15A patent/RU2538683C2/ru not_active IP Right Cessation
- 2009-10-29 CN CN201510402018.9A patent/CN105030784A/zh active Pending
-
2014
- 2014-04-15 RU RU2014115188/15A patent/RU2014115188A/ru not_active Application Discontinuation
- 2014-09-05 JP JP2014181069A patent/JP2015013883A/ja not_active Withdrawn
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2015
- 2015-11-24 US US14/950,869 patent/US20160136175A1/en not_active Abandoned
-
2016
- 2016-07-06 JP JP2016134514A patent/JP2017002058A/ja not_active Ceased
-
2018
- 2018-01-16 US US15/872,043 patent/US20180133226A1/en not_active Abandoned
- 2018-07-20 JP JP2018136756A patent/JP2018197243A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2282461C2 (ru) * | 2000-06-26 | 2006-08-27 | Стрессджен Байотекнолоджиз Корпорейшн | Лечение инфекции, вызываемой вирусом папилломы человека |
Non-Patent Citations (2)
| Title |
|---|
| CHEN CY et al. [Effects of mTOR inhibitor rapamycin on Smad 3 protein and collagen type I expression in rat myocardial fibroblasts infected with coxsackie virus B 3]. Zhonghua Xin Xue Guan Bing Za Zhi. 2008 Feb;36(2):156-60. Реферат [он-лайн] [найдено 2013-09-11] (Найдено из базы данных PubMed PMID: 19099956 ). * |
| KU 0063794 (CID 16736987) Create date 2007-09-27 Реферат [он-лайн] [найдено 2013-09-09] (Найдено из Интернет: www.pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=16736987) * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102202668A (zh) | 2011-09-28 |
| RU2014115188A (ru) | 2015-10-20 |
| RU2011121508A (ru) | 2012-12-10 |
| EP2349275B1 (en) | 2017-03-08 |
| BRPI0921802A8 (pt) | 2018-03-13 |
| JP2018197243A (ja) | 2018-12-13 |
| JP2015013883A (ja) | 2015-01-22 |
| EP2349275A1 (en) | 2011-08-03 |
| AU2009309616A2 (en) | 2011-07-07 |
| AU2009309616B2 (en) | 2014-02-13 |
| US20110195966A1 (en) | 2011-08-11 |
| JP2017002058A (ja) | 2017-01-05 |
| KR20110090911A (ko) | 2011-08-10 |
| US20180133226A1 (en) | 2018-05-17 |
| CA2736361C (en) | 2017-10-10 |
| ES2627677T3 (es) | 2017-07-31 |
| CA2736361A1 (en) | 2010-05-06 |
| US20160136175A1 (en) | 2016-05-19 |
| CN105030784A (zh) | 2015-11-11 |
| BRPI0921802A2 (pt) | 2016-09-27 |
| MX2011004585A (es) | 2011-06-01 |
| AU2009309616A1 (en) | 2010-05-06 |
| JP2012506898A (ja) | 2012-03-22 |
| WO2010049481A1 (en) | 2010-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20191030 |