RU2535992C2 - Биспецифические связывающие агенты с межвидовой специфичностью - Google Patents

Биспецифические связывающие агенты с межвидовой специфичностью Download PDF

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Publication number
RU2535992C2
RU2535992C2 RU2009136913/10A RU2009136913A RU2535992C2 RU 2535992 C2 RU2535992 C2 RU 2535992C2 RU 2009136913/10 A RU2009136913/10 A RU 2009136913/10A RU 2009136913 A RU2009136913 A RU 2009136913A RU 2535992 C2 RU2535992 C2 RU 2535992C2
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RU
Russia
Prior art keywords
seq
cdr
presented
region
human
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RU2009136913/10A
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English (en)
Russian (ru)
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RU2009136913A (ru
Inventor
Маттиас КЛИНГЕР
Тобиас Раум
Дорис РАУ
Сюзанна МАНГОЛЬД
Роман КИШЕЛЬ
Ральф ЛУТТЕРБЮЗЕ
Патрик Хоффманн
Петер КУФЕР
Original Assignee
Эмджен Рисерч (Мьюник) Гмбх
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Application filed by Эмджен Рисерч (Мьюник) Гмбх filed Critical Эмджен Рисерч (Мьюник) Гмбх
Priority claimed from PCT/EP2008/002663 external-priority patent/WO2008119566A2/en
Publication of RU2009136913A publication Critical patent/RU2009136913A/ru
Application granted granted Critical
Publication of RU2535992C2 publication Critical patent/RU2535992C2/ru

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  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2009136913/10A 2007-04-03 2008-04-03 Биспецифические связывающие агенты с межвидовой специфичностью RU2535992C2 (ru)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
EP07006988.5 2007-04-03
EP07006988 2007-04-03
EP07006990 2007-04-03
EP07006990.1 2007-04-03
US91366807P 2007-04-24 2007-04-24
US60/913,668 2007-04-24
EP07020640 2007-10-22
EP07020641.2 2007-10-22
EP07020641 2007-10-22
EP07020646 2007-10-22
EP07020646.1 2007-10-22
EP07020640.4 2007-10-22
EP08004741.8 2008-03-13
EP08004741 2008-03-13
PCT/EP2008/002663 WO2008119566A2 (en) 2007-04-03 2008-04-03 Cross-species-specific bispecific binders

Publications (2)

Publication Number Publication Date
RU2009136913A RU2009136913A (ru) 2011-06-20
RU2535992C2 true RU2535992C2 (ru) 2014-12-20

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RU2009136913/10A RU2535992C2 (ru) 2007-04-03 2008-04-03 Биспецифические связывающие агенты с межвидовой специфичностью

Country Status (8)

Country Link
JP (1) JP2010524435A (OSRAM)
DK (1) DK2155788T3 (OSRAM)
ES (1) ES2390243T3 (OSRAM)
NZ (1) NZ580746A (OSRAM)
PT (1) PT2155788E (OSRAM)
RS (1) RS52492B (OSRAM)
RU (1) RU2535992C2 (OSRAM)
SI (1) SI2155788T1 (OSRAM)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
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PT2520590T (pt) * 2007-04-03 2018-11-14 Amgen Res Munich Gmbh Domínio de ligação específico de espécies cruzadas
WO2008119566A2 (en) * 2007-04-03 2008-10-09 Micromet Ag Cross-species-specific bispecific binders
JP2014500879A (ja) * 2010-11-16 2014-01-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂｃｍａ発現に相関性を有する疾患を治療する因子及び方法
CN107903325B (zh) * 2011-05-16 2021-10-29 埃泰美德(香港)有限公司 多特异性fab融合蛋白及其使用方法
BR112013029893A2 (pt) * 2011-05-21 2017-05-30 Macrogenics Inc molécula de ligação a cd3, anticorpo de ligação a cd3, diacorpo de ligação a cd3 e composição farmacêutica
PE20210107A1 (es) 2013-12-17 2021-01-19 Genentech Inc Anticuerpos anti-cd3 y metodos de uso
BR112016022819A2 (pt) * 2014-05-28 2018-01-16 Hoffmann La Roche uso de um método, método para a produção de um anticorpo com reatividade cruzada para humano e cinomolgo e anticorpo com reatividade cruzada para humano e cinomolgo
CA2955947A1 (en) * 2014-07-25 2016-01-28 Cytomx Therapeutics, Inc. Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same
MX384418B (es) * 2014-07-31 2025-03-14 Amgen Res Munich Gmbh Constructo de anticuerpo de cadena individual biespecífico con distribución mejorada de tejido.
CN107709363A (zh) * 2015-05-01 2018-02-16 基因泰克公司 掩蔽抗cd3抗体和使用方法
CN109476756B (zh) 2016-03-15 2022-05-31 埃泰美德(香港)有限公司 一种多特异性Fab融合蛋白及其用途
CN109923128A (zh) 2016-11-15 2019-06-21 基因泰克公司 用于用抗cd20/抗cd3双特异性抗体进行治疗的给药
US10426424B2 (en) 2017-11-21 2019-10-01 General Electric Company System and method for generating and performing imaging protocol simulations
CN118772288A (zh) 2018-02-08 2024-10-15 豪夫迈·罗氏有限公司 双特异性抗原结合分子和使用方法
US12460000B2 (en) 2018-09-07 2025-11-04 Itabmed (Hk) Limited Anti-CD19 and anti-CD3 bispecific antigen binding proteins and uses thereof
US20230067182A1 (en) * 2019-11-29 2023-03-02 Boe Technology Group Co., Ltd. Data Processing Device and Method, and Computer Readable Storage Medium
KR20220113790A (ko) 2019-12-13 2022-08-16 제넨테크, 인크. 항-ly6g6d 항체 및 사용 방법
JP2022087602A (ja) * 2020-12-01 2022-06-13 株式会社バイオピーク 組換え大腸菌による有用タンパク質の生産性を向上するための培養方法
KR20240007171A (ko) 2021-05-14 2024-01-16 제넨테크, 인크. 모수네투주맙 및 폴라투주맙 베도틴을 이용한 cd20 양성 증식성 장애의 치료 방법
CN115932808B (zh) * 2022-11-04 2025-05-27 四川九洲电器集团有限责任公司 一种基于多特征融合的被动声纳智能探测方法

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RU2179862C1 (ru) * 2000-12-26 2002-02-27 Общество с ограниченной ответственностью Научно-производственный центр "МедБиоСпектр" Лекарственное средство для предотвращения отторжения трансплантата, моноклональное антитело к cd3-антигену т-лимфоцитов человека, гибридома и способ лечения больных, имеющих реакцию острого отторжения трансплантата после пересадки почки
WO2004106383A1 (en) * 2003-05-31 2004-12-09 Micromet Ag Pharmaceutical composition comprising a bispecific antibody for epcam
WO2005118635A2 (en) * 2004-06-03 2005-12-15 Novimmune S.A. Anti-cd3 antibodies and methods of use thereof
WO2007033230A2 (en) * 2005-09-12 2007-03-22 Novimmune S.A. Anti-cd3 antibody formulations
WO2007042261A2 (en) * 2005-10-11 2007-04-19 Micromet Ag Compositions comprising cross-species-specific antibodies and uses thereof

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US7235641B2 (en) * 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
RU2179862C1 (ru) * 2000-12-26 2002-02-27 Общество с ограниченной ответственностью Научно-производственный центр "МедБиоСпектр" Лекарственное средство для предотвращения отторжения трансплантата, моноклональное антитело к cd3-антигену т-лимфоцитов человека, гибридома и способ лечения больных, имеющих реакцию острого отторжения трансплантата после пересадки почки
WO2004106383A1 (en) * 2003-05-31 2004-12-09 Micromet Ag Pharmaceutical composition comprising a bispecific antibody for epcam
WO2005118635A2 (en) * 2004-06-03 2005-12-15 Novimmune S.A. Anti-cd3 antibodies and methods of use thereof
WO2007033230A2 (en) * 2005-09-12 2007-03-22 Novimmune S.A. Anti-cd3 antibody formulations
WO2007042261A2 (en) * 2005-10-11 2007-04-19 Micromet Ag Compositions comprising cross-species-specific antibodies and uses thereof

Non-Patent Citations (1)

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Title
REUSCH U. et al., "Anti-CD3 x anti-epidermal growth factor receptor (EGFR) bispecific antibody redirects T-cell cytolytic activity to EGFR-positive cancers in vitro and in an animal model." Clin Cancer Res. (2006); 12(1):183-90. SEN M. et al., "Use of anti-CD3 x anti-HER2/neu bispecific antibody for redirecting cytotoxicity of activated T cells toward HER2/neu+ tumors." J Hematother Stem Cell Res. (2001);10(2):247-60. PORTOLES P. et al., "Monoclonal antibodies to murine CD3[epsilon] define distinct epitopes, one of which may interact with CD4 during T cell activation", J Immunology (1989); 142(12): 4169-4175. *

Also Published As

Publication number Publication date
NZ580746A (en) 2012-05-25
PT2155788E (pt) 2012-09-25
JP2010524435A (ja) 2010-07-22
ES2390243T3 (es) 2012-11-07
SI2155788T1 (sl) 2012-11-30
RS52492B (sr) 2013-02-28
RU2009136913A (ru) 2011-06-20
DK2155788T3 (da) 2012-10-08

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