RU2535007C1 - Method of farm recovery from bovine necrobacteriosis - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: method involves intramuscular injections of a drug preparation. The drug preparation is presented by a mixture of a medical solution of formaldehyde and normal saline at the weight portion ratio (2-6):(994-998). First, the preparation is injected into ill, latently ill and healthy animals starting from 3-month-old calves in two doses of 5-6 ml every 7-8 days during the period from September to November. Thereafter, the injections are continued for the ill animals only, but for no more than 5 weeks, and 5-7 days after the last injection the remaining ill animals are detected and isolated.

EFFECT: method enables recovering the farm effectively from necrobacteriosis.

1 tbl, 5 ex

Description

The invention relates to the field of veterinary medicine, in particular to methods for improving the health of cattle necrobacteriosis.

A known method of healing farms from necrobacteriosis with different epizootic situations by non-specific methods (see http://dis.podelise.ru/text/index-8610.html), which provides, in particular, the combined use of necrogel in the form of ointments from groups of antibiotics and sulfonamides and tetracin in the form of injections, which is a composite of antibiotics, prolangers and analgesic substances.

However, antibiotics have many side effects and their use can lead to unpredictable results, especially the introduction of 23 injections of tetracin. In addition, the method is long, since the entire duration of treatment is 810 days.

A known method for the prevention and treatment of necrobacteriosis in cattle (see RF patent No. 2098127 according to class IPC A61K 39/116, publ. 10.12.1997), contributing to the improvement of farms and consists in subcutaneous administration of the associated vaccine "Nekovak", which has a preventive and therapeutic action. The vaccine is administered in a dose of 5 cm ³ twice with an interval of 28-30 days. The vaccine contains inactivated cultures of microorganism strains, selected according to the breadth of the immunogenic spectrum and selected for maximum immunogenic and antigenic activity, as well as an adjuvant - aluminum hydroxide and saline, for example, saline.

However, the method involves the use of an associated vaccine, which contains components of the causative agent of necrobacteriosis, which can provoke a disease in an infected livestock, which will, in turn, lead to the spread of the disease and the rebooting of susceptible animals. In addition, the method does not take into account the resistance of the entire animal population.

Closest to the claimed is a method for the treatment and prevention of necrobacteriosis in cattle (see RF patent No. 2262936 according to class IPC A61K 31/7048, publ. July 20, 2004), which ensures the recovery of the economy from necrobacteriosis and consists in the intramuscular injection of a drug containing tylosin tartrate, gelatin, lanolin, polyethylene siloxane and water, moreover, the drug is administered intramuscularly into a massive muscle group, three times, with an interval of 2-3 days in doses of 0.15-0.25 ml per 10 kg of animal weight.

However, the method involves the use of a multicomponent preparation, the introduction of which will lead to an excessive load on the immune system of the animal. In addition, the method, like the previous analogue, does not take into account the resistance of animals and depends on the infection of the livestock.

The invention is aimed at solving the problem of creating a simple and effective way of healing farms from necrobacteriosis, taking into account the dependence of the therapeutic effect on the season of the year and allowing to ensure stable well-being of farms to necrobacteriosis of cattle in the shortest possible time, regardless of the infection of the livestock.

To solve the problem in a method of healing farms from necrobacteriosis of cattle, which consists in the intramuscular injection of a drug, according to the invention, a mixture of a medical solution of formaldehyde and isotonic sodium chloride solution is used as the drug in the ratio of weight parts (2-6) :( 994 -998), at the same time, the drug is first administered to sick, latently sick and healthy animals, starting from calves of 3 months of age, twice with an interval of 7-8 days between injections in Oz 5-6 ml in the period from September to November, after which the drug continues to be administered on a weekly basis only sick animals, but no more than 5 weeks, followed by 5-7 days after the last treatment of the remaining patients identify animals and they are isolated.

The sources of patent and scientific and technical information known to the authors do not describe a method for improving the economy of cattle necrobacteriosis based on a combination of the therapeutic effect of drug administration (based on a mixture of a formaldehyde medical solution with isotonic sodium chloride solution taken in certain concentrations), experimentally selected processing conditions (up to 7 times) and seasonality (in the autumn season), which ensures stable well-being in the shortest possible time (within 50 days) farms for necrobacteriosis of cattle regardless of livestock infection.

It is well known (see, for example, http://dis.podelise.ru/text/index-8610.html) that the incidence of cattle necrobacillosis is associated with resistance, which depends on the time of year. In winter and early spring and autumn, it decreases sharply, while the incidence increases.

However, a decrease in the incidence rate, in our opinion, is not a determining criterion in contrast to the generally accepted point of view when conducting recreational activities, since latent sick animals can also be present in the herd, which under certain conditions will become ill and the economy will again be unsuccessful.

The authors experimentally established that the therapeutic effect of the introduction of the drug based on a mixture of a medical solution of formaldehyde with an isotonic sodium chloride solution, depending on the season of the year, is a decisive link in the rehabilitation of cattle necrobacteriosis. Moreover, the introduction of the drug in the period from September to November provides the maximum therapeutic effect and allows you to create lasting well-being for this disease.

Double administration of the drug to all animals (both healthy and sick, regardless of the stage of manifestation of the clinical signs of the disease) allows treating sick animals, identifying latent patients and protecting healthy animals from infection by the causative agent of necrobacteriosis. Moreover, the treatment is carried out in all age groups of the livestock, starting from calves of 3 months of age, which may already be infected.

A single treatment of animals practically does not lead to a therapeutic effect. Possible relapse of the disease.

Removal of sick animals from the herd immediately after the second treatment leads to unjustified culling of productive cows (up to 30%).

Further weekly treatment of sick and latently sick animals for 5 weeks allows for maximum therapeutic effect. In the event that the animals remained ill after seven times of treatment, they must be isolated and not allowed to come into contact with a healthy herd.

It has been experimentally established that an increase in processing of more or less than 5 weeks does not provide persistent recovery of the economy from necrobacteriosis. Possible relapse of the disease.

The interval between injections of 7 days is due to the immunological restructuring of the body in relation to the causative agent of any infectious disease.

It was also experimentally established that the healing effect occurs when the livestock is processed in the autumn period - from September to November, and at other times of the year it does not provide recovery from necrobacteriosis, since, in our opinion, this may be due to the natural resistance of animals at this time of the year , which allows for immunological restructuring not only of individual animals, but of the whole population, creating herd immunity, and with the characteristics of the pathogen, which, in particular, is an anaerobic.

The foregoing allows us to conclude that there is a criterion of "inventive step" in the claimed solution.

The method is as follows.

Take the drug based on a mixture of a medical solution of formaldehyde and isotonic sodium chloride solution with a ratio of weight parts (2-6) :( 994-998).

Starting from the month of September and ending no later than the end of November, all animals in the herd, including calves of 3 months of age (sick, latently sick and healthy), are injected intramuscularly with a dose of 5-6 ml.

After 7-8 days, the treatment of all animals is repeated, after which treatment of only sick animals is continued once a week for 5 weeks also at a dose of 5-6 ml.

At the same time, healthy animals are in the same herd.

7 days after the last treatment, the remaining sick animals are identified and they are isolated from the herd in order to prevent recurrence of the disease.

Example 1

Evidence of a therapeutic effect depending on the seasonality of the treatment of animals.

In the same farm No. 1, sick animals were isolated from July to December. During this period, monthly, sick animals were injected intramuscularly with a preparation based on a mixture of a medical solution of formaldehyde and an isotonic sodium chloride solution at a ratio of weight parts (2: 998) in a dose of 5.5 ml. The animals were treated twice with an interval of 7 days between injections.

The results of the experiment are presented in table 1.

Table 1 Processing month The number of sick animals The number of recovered animals after double treatment Before processing After double processing goals % July 10 7 3 thirty% August 28 eighteen 9 35.7% September 24 8 16 66.7% October 12 four 8 66.7% November 32 13 19 59.4% December 44 7 37 84%

From table 1 it follows that in July, out of 10 sick animals, 3 (30%) heads recovered after double treatment, in August - 9 (35.7%) goals, etc. The largest percentage of recovered animals was observed from September to December.

Despite the fact that the greatest therapeutic effect was observed in December (84%), this fact cannot be taken as the basis for the beginning of health measures, since, taking into account the well-known point of view, the resistance of the animal organism decreases in January (see, for example, http: / /dis.podelise.ru/text/index-8610.html).

In this regard, the remaining 5 treatments necessary for the improvement of the economy must be completed, in extreme cases, by January 15.

It has been experimentally established that recreational activities (i.e., the first treatments) must begin in September, and end no later than November. Then the last 7th processing will be completed in mid-January.

Example 2

Justification of the efficiency of farm rehabilitation with a further increase in the multiplicity of drug treatments for sick animals.

In farm No. 2, in September, they double-treated all animals (sick, latent-sick, and healthy). Then within 3 weeks only sick animals were treated, i.e. the drug specified in example No. 1 was administered once a week. The herd was monitored for 6 months.

Health improvement did not happen. New sick animals appeared in the herd and disease relapses were recorded in some treated animals.

Example 3

In farm No. 3 with a total number of 701 heads, by the month of October, there were 96 animals with necrobacteriosis.

All animals in the herd (sick, latently sick and healthy) were injected intramuscularly with a preparation based on a mixture of a medical solution of formaldehyde and isotonic sodium chloride solution at a ratio of weight parts (2: 998) in a dose of 5.5 ml. The animals were treated twice with an interval of 7 days between injections.

After two treatments begun in the month of October, 41 sick animals out of 96 remained on the farm before treatment, i.e. 42.7%.

Then, only sick animals were treated for 5 weeks, i.e. the drug indicated above was administered once a week.

After five treatments, 26 animals recovered (out of 41 animals), the remaining 15 sick animals were delivered to a meat processing plant. The farm was prosperous for 3 years (observation period).

Example 4

In farm No. 4 with a total number of animals of 1,100 animals in the herd, 9-fold processing of animals was performed (from early September to early November) according to the scheme described in example 3. That is, at first, two animals were treated twice (sick, latently sick and healthy), and then only sick animals for 7 weeks, 1 time every week.

Health outcomes were not observed. The farm remained dysfunctional, in which animals with clinical signs of necrobacteriosis disease stood out.

Example 5

On 5 farms of the farm No. 5 with a total livestock of 3751 heads, the health-improving measures described in Example 3 were carried out. All farms were improved. After all treatments, 31 diseased animals were finally isolated, which were handed over to the meat processing plant.

The following year, only double treatment was repeated, but the total number of livestock. The farm was prosperous for 4 years (observation period).

Thus, the claimed method of healing farms from necrobacteriosis is effective and simple to implement, allows in the shortest possible time (about two months) to ensure stable well-being of farms to necrobacteriosis of cattle, regardless of infection of the livestock.

Claims (1)

A method of healing farms from necrobacteriosis of cattle, which consists in the intramuscular injection of a drug, characterized in that as a medicine, a mixture of a medical solution of formaldehyde and isotonic sodium chloride solution is used with a ratio of parts by weight (2-6) :( 994-998), in this case, at first, the drug is administered to sick, latent-sick and healthy animals, starting from calves of 3 months of age, twice with an interval of 7-8 days between injections at a dose of 5-6 ml from September to November b, after which the drug is continued to be administered weekly only to sick animals, but not more than 5 weeks, then 5-7 days after the last treatment, the remaining sick animals are identified and isolated.