RU2400217C1 - Method of treating preventricular atony in ruminants - Google Patents

Abstract

FIELD: medicine. ^ SUBSTANCE: invention refers to veterinary medicine. The method provides oral introduction of potassium acetate taken in dosage 0.1-0.3 g per 1 kg of body weight and pre-dissolved in warm water in the ratio 1:9. ^ EFFECT: method allows reducing the recovery time in animals. ^ 1 tbl, 1 ex

Description

The present invention relates to the field of animal husbandry, in particular to veterinary medicine, and can be used in the treatment of animals with atony of the pancreas.

Known methods of treating atony of the pancreas by prescribing: inside - enzyme preparations of maserobacillin GXx, amylosubtilin GXx, baker's and brewer's yeast, propionic acid; subcutaneously - insulin, carbohaline, pilocarpine, tincture of white hellebore; intravenously - hypertonic solutions of sodium chloride or calcium chloride (Internal non-communicable diseases of cattle. Edited by P.S. Ionov. Ed. 3rd, revised and additional - M .: Kolos, 1975. - P.9- 12; Internal non-communicable diseases of farm animals. Edited by N.G. Sharabrin. 5th edition, revised and supplemented - M .: Kolos, 1976. - P.186-192; Internal non-communicable diseases of farm animals / B .M. Anokhin, V.M. Danilevsky, L.G. Zamarin and others. Edited by V.M. Danilevsky. - M .: Agropromizdat, 1991. - P.188-190; RU 2134578 CI, 08.20.1999 ; Workshop on internal diseases of animals. / By general edition of honored scientists of the Russian Federation, professors A.V. Korobov and G.G.Shcherbakov, 2nd ed. rev .-- St. Petersburg: Lan, 2004. - P.120-121; IP Kondrakhin Diagnostics and therapy internal diseases of animals / N. Kondrakhin, V. Levchenko. - M.: Aquarium-Print, 2005. - P.89-91).

There is also known a method of treating atony of the pre-stomachs of ruminants by oral administration of calcium acetate (RU 2341251 CI, 20.12.2008) (prototype).

The disadvantage of this method is the low therapeutic efficacy in atony of the pancreas.

The objective of the invention is to increase the effectiveness of treatment of animals with atony of the pancreas.

This is achieved by the fact that potassium acetate, which is a natural scar metabolite, is used as a therapeutic agent. It is known for its use in veterinary medicine as a diuretic (Subbotin V.M., Subbotina S.G., Aleksandrov ND. Modern medicines in veterinary medicine. Series "Veterinary medicine and animal husbandry. Rostov-on-Don:" Phoenix " , 2001 - S. 140).

A method is proposed for treating atony of the pre-stomachs of ruminants by introducing potassium acetate into the body, in which the animals are prescribed inside the potassium acetate in a dose of 0.1-0.3 g per 1 kg of body weight, previously dissolved in warm water in a ratio of 1: 9.

Example. The experiment was conducted during the stall period on 44 cows in which atony of the stomach was noted. All animals were divided into 4 groups (control and three experimental) with 11 animals each (see table).

Table Therapeutic efficacy of oral administration of potassium acetate in atony of the pancreas in cows Indicators Group control 1st experienced 2nd experienced 3rd experienced A single dose of the drug, g / kg body weight. 0.4 0.1 0.2 0.3 Recovered animals (%) after giving the drug: 1 time one hundred 81.82 90.91 one hundred 2 times - 18.18 9.09 - Recovery time (min) after giving the drug: 1 time 106-139 19-25 17-21 18-23 2 times - 8-13 9 -

The cows of the control group were treated by oral administration of calcium acetate in a dose of 0.4 g per 1 kg of body weight, previously dissolved in a ratio of 1: 9 in water heated to the body temperature of the animal.

According to the results of the experiment in animals of the control group, after a single use of calcium acetate, recovery was observed in 100% of the animals. In this case, the animals recovered within 106-139 minutes after the use of calcium acetate. Calculations showed that the weighted average length of the recovery period was 126 minutes.

For the treatment of animals of the 1st, 2nd and 3rd experimental groups, potassium acetate was prescribed inside, respectively, in doses of 0.1; 0.2 and 0.3 g per 1 kg of body weight. If necessary, the drug in the same doses was prescribed again, 30 minutes after its first use. Before each use, the required amount of potassium acetate was dissolved in a ratio of 1: 9 in water, heated to the body temperature of the animal.

In the 1st experimental group, after the first use of potassium acetate at a dose of 0.1 g per 1 kg of body weight, clinical recovery occurred in 81.82% of the animals, and after its repeated use, in 18.18%. Moreover, after the first use of potassium acetate in animals, clinical recovery was observed after 19-25 minutes, and after its repeated use, after 8-13 minutes.

In the 2nd experimental group, after the first use of potassium acetate at a dose of 0.2 g per 1 kg of body weight, clinical recovery occurred in 90.91% of the animals, and after its repeated use, in 9.09%. Moreover, after the first use of potassium acetate in animals, clinical recovery was observed after 17-21 minutes, and after its repeated use - after 9 minutes.

In the 3rd experimental group, after the first use of potassium acetate at a dose of 0.3 g per 1 kg of body weight, clinical recovery occurred in 100% of the animals. Moreover, clinical recovery was observed after 18-23 minutes. Calculations showed that the weighted average duration of the clinical recovery period was 19.3 minutes.

Thus, potassium acetate is a highly effective therapeutic agent for atony of ruminants in the pancreas.

The optimal therapeutic dose of potassium acetate was 0.3 g per 1 kg of body weight.

The use of potassium acetate at a dose of 0.3 g per 1 kg of body weight led to the recovery of all animals after the first administration of the drug and a reduction in the time of their clinical recovery by 6.5 times compared with the control.

Information sources

1. Internal non-communicable diseases of cattle. Ed. P.S. Ionova. Ed. 3rd, rev. and add. - M .: Kolos, 1975 - S.9-12.

2. Internal non-communicable diseases of farm animals. Ed. N.G. Sharabrina. Ed. 5th, fix and add. - M .: Kolos, 1976 - S.186-192.

3. Internal non-communicable diseases of farm animals / B. M. Anokhin, V. M. Danilevsky, L. G. Zamarin and others. Ed. V.M.Danilevsky. - M.: Agropromizdat, 1991 .-- P.188-190.

4. SU 1257890 A, A61K 31/19. A method for the treatment of atony of the stomach of ruminants / Lee A.Ch., Mametov Sh.V. Applicant and patent holder Kyrgyz Research Institute of Life Sciences, - No. 2548965 / 30-15; declared 12/01/1977; publ. 05/15/1986

5. RU 2134578 CI, A61K 31/185. A method for the treatment of atony of the pre-stomachs of ruminants / Li A.Ch., Lazareva S.A., Lazarev A.V. - No. 98105273/13; declared 03/12/1998; publ. 08/20/1999

6. RU 2341251 CI, A61K 31/00. A method for the treatment of atony of the stomach of ruminants / Li A.Ch., Chernyaevsky A.P. Patent holder of the Belgorod State Agricultural Academy, No. 2007106500/13; declared 02.20.2007; publ. December 20, 2008

7. Workshop on internal diseases of animals / Under the general editorship of Honored Scientists of the Russian Federation, Professors A.V. Korobov and G.G. Scherbakov, 2nd ed. corrected - SPb .: Doe, 2004. - S.120-121.

8. Kondrakhin I.P. Diagnostics and therapy of internal diseases of animals / I. Kondrakhin, V. Levchenko. - M .: Aquarium-Print, 2005. - P.89-91.

9. Subbotin V.M., Subbotin S.G., Alexandrov N.D. Modern medicines in veterinary medicine. Series "Veterinary medicine and livestock." Rostov-on-Don: “Phoenix”, 2001. - P.140.

Claims (1)

A method for the treatment of atony of the preventricles of ruminants, characterized in that the treatment, for example, of cows, is carried out by oral administration of potassium acetate in a dose of 0.1-0.3 g per 1 kg of body weight, previously dissolved in a ratio of 1: 9, water heated to the body temperature of the animal.