RU2517053C1 - Method of treatment of animals with surgical sepsis - Google Patents

Abstract

FIELD: veterinary medicine.

SUBSTANCE: kobaktan is administered intramuscularly at a dose of 2 ml per 50 kg of body weight daily for 7 days, glutoxim is administered subcutaneously at a dose of 3 mg per 1 kg of body weight once in 2 days in an amount of 10 injections, and also 1-3 sessions of hemosorption is carried out with the interval of 24-48 hours.

EFFECT: method enables to improve the efficiency of treatment while reducing mortality due to suppression of microbial factor, neutralisation and elimination of toxins from the body, normalisation of functional disorders.

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Description

The invention relates to veterinary medicine, namely to veterinary surgery, and can be used in the complex treatment of sick animals with surgical sepsis.

A known method of treating animals with sepsis, used in veterinary medicine, described by L.V. Lebedev et al. (Lebedev AB [et al.] General Veterinary Surgery - M., Kolos - 2000. - P.126-127). In this method, the complex of antiseptic therapy includes general and local measures: 1) mobilization of the body's defenses: good feeding and vitaminization of the body; 2) increase the reactivity of the body: intravenous administration of 1-2 liters of compatible blood, preserved with a 10% solution of calcium chloride (1:10), novocaine, hydrolysin, aminopeptide, polyglucin, glucose, 33% alcohol, ascorbic acid, thiamine solutions , riboflavin, pyridoxine, a 6% solution of folic acid; 3) taking measures to eliminate dehydration: providing animals with plenty of water and intravenous administration of an isotonic sodium chloride solution at a rate of 30-40 ml per kg of body weight per day; 4) removal of the parabiotic state of the nervous system: the use of novocaine with an antibiotic, intravenous administration of up to 100-150 ml of 10% sodium bromide solution for 3 days; 5) suppression of infection: intravenous administration of up to 10 ml of ampouled gentamicin in 0.25-0.5% solution of novocaine; camphor serum according to I.I. is prescribed to improve cardiovascular function. Kadykov, who also has antimicrobial and antitoxic effects. To replenish the energy deficit, neutralize and eliminate toxins, glucose, insulin are prescribed, and a solution of hexamethylenetetramine with caffeine and heparin is intravenously administered. For detoxification effect, hemodesis is used; 6) a decrease in sensitization, vascular permeability, cell membranes and normalization of the ratio of potassium and calcium, 30% sodium thiosulfate solution, 10% calcium chloride solution, diphenhydramine, pipolfen or suprastin are injected intravenously into the body; 7) improved feeding and maintenance; 8) ensuring the flow of exudate: drainage or even contrapertures are placed in the wound, surgical treatment is performed, a short novocaine block with antibiotics is used.

However, this method of treating animals with surgical sepsis is ineffective. The disadvantage is the wide range of drugs offered from various pharmacological groups without defining clear indications for choosing the optimal ones. An increase in the body's reactivity due to the use of a large number of vitamins and other medicines cannot provide the necessary therapeutic effect, it does not ensure the elimination of toxins from the body, creates an additional burden on the excretory system of the body, and remains highly lethal.

Common features with the prototype:

1) surgical treatment of the primary lesion (wound);

2) antibiotic therapy;

3) increasing the reactivity of the body;

4) elimination of dehydration;

5) detoxification therapy.

Features:

1) 1-3 sessions of hemosorption with an interval of 24-48 hours are used to neutralize and eliminate toxins from the body, eliminate dehydration, and also prevent DIC-syndrome;

2) to increase the reactivity of the body, once every 2 days, an immunomodulator of the systemic cytoprotective effect of glutixim is administered subcutaneously at a dose of 3 mg / kg body weight in the amount of 10 injections;

3) to suppress the infection, the antibiotic Cobactan is administered intramuscularly at a dose of 2 ml per 50 kg of animal body weight daily for 7 days.

The aim of the invention is to reduce mortality and increase the effectiveness of treatment of animals with surgical sepsis by suppressing the microbial factor, neutralizing and eliminating toxins from the body, and normalizing functional disorders.

This goal is achieved by the fact that in the method of treating animals with surgical sepsis, including surgical debridement, antibiotic therapy, increasing the body’s reactivity, eliminating dehydration and detoxification, suppressing the infection by intramuscular injection of the antibiotic Cobactan at a dose of 2 ml per 50 kg of live weight daily for 7 days, an increase in the reactivity of the body is provided by subcutaneous administration of 10 injections of glutoxim at a dose of 3 mg per 1 kg of body weight once every 2 days, neutralization and elimination from the body synovitis, dehydration elimination and prevention of DIC provide session hemosorption 1-3, which is carried out with an interval of 24-48 hours.

The method is as follows: in the operating room, equipped with special equipment and the necessary range of medicines and infusion media, veterinary personnel, in compliance with the general rules of aseptic and antiseptic, conduct surgical debridement of the primary septic focus. At the same time, the sick animal is injected intramuscularly with the antibiotic Cobactan at a dose of 2 ml per 50 kg of animal body weight, the course of treatment is 7 days.

Hemosorption is performed according to the developed "Method of hemosorption in dogs" (Patent RU 2363420 C2, publ. 10.08.2009, Bull. No. 22). Extracorporeal blood purification is carried out with an interval of 24-48 hours, the total number of procedures directly depends on the condition of the sick animal and can be from one to three sessions. The duration of hemosorption was determined by the volume of perfusion through the mass exchanger, which was 1.5-2.5 bcc. After the hemosorption session was completed, the animal was subcutaneously injected with an immunomodulator of the cytoprotective effect of glutoxim at a dose of 3 mg per 1 kg of body weight, the drug was administered once every 2 days, the total number of injections was 10 injections.

The proposed method allows to increase the efficiency of treatment of animals with surgical sepsis and reduce mortality by suppressing the microbial factor, neutralizing and eliminating toxins from the body, and normalizing functional disorders.

As an example, we cite the following clinical observation.

Case history No. 0077.

08/15/2011, a dog of the German Shepherd breed, female, fawn, 6.5 years old, weight 36 kg with a penetrating stab wound of the abdominal wall, was admitted to the veterinary clinic. Clinical signs: body temperature - 41.5; pulse - 80 beats / min; breathing - 15. The general condition is severe, the animal is depressed, whines, the mucous membranes of the eyes and oral cavity are dry, anemic. The nose is dry, hot. The abdominal wall on the right in the area of the wound is covered with contaminated blood and exudate hair. On palpation, the wounded area fluctuates, a liquid serous discharge with an unpleasant odor is released.

In the analyzes of peripheral blood: leukocytes - 34 · 10 ⁹ / l, ESR 25 mm / h, lymphocytes 16%. Biochemical analyzes of venous blood: increased transaminases (AlAT 62 IU / l, AsAT 78 IU / l), total protein 56 g / l, urea 18 mmol. In urine tests, protein, 25 white blood cells in sight.

Diagnosis: "Surgical sepsis."

Treatment: 08/15/2011 - the animal underwent rehabilitation of the abdominal cavity. After the operation, the dog underwent 3 hemosorption sessions with an interval of 48 hours. Cobactan was administered intramuscularly at a dose of 1.5 ml once a day for 7 days, a 3% solution of Glutoxim was injected subcutaneously at a dose of 3.6 ml once every 2 days, No. 10, and hemosorption was repeated after 48 hours.

08/20/2011 - temperature: 39.5; pulse: 60; respiration: 10. General condition is satisfactory, the animal is lethargic, drinks water on its own, takes food selectively, physiological discharge in the normal range. The surgical wound is dry, there is no discharge.

In blood tests: white blood cells - 26 · 10 ⁹ / l, ESR 20 mm / h, lymphocytes 16%, AlAT 62 IU / l, AsAT 76 IU / l, total protein 51 g / l, urea 9 mmol. In urine tests, traces of protein, 8 white blood cells in sight.

08/25/2011 - temperature: 38.0; pulse: 60; respiration: 10. The general condition is satisfactory, the animal is mobile, responds to commands, takes water and food on its own, physiological excretions are in the normal range. The surgical wound is dry, not tense, there is no discharge. Skin sutures removed. Purpose: general observation.

In blood tests: leukocytes - 17 · 10 ⁹ / l, ESR 20 mm / h, lymphocytes 12%, AlAT 40 IU / l, AsAT 48 IU / l, total protein 40 g / l, urea 9 mmol. In urine tests, traces of protein, 5 white blood cells in sight.

09/05/2011: temperature: 38.0; pulse: 60; breathing: 10. General condition is satisfactory, the animal is mobile, responds to commands, takes water and food on its own, there is appetite, physiological discharge within normal limits. The surgical wound is dry.

In blood tests: white blood cells - 6 · 10 ⁹ / l, ESR 15 mm / h, lymphocytes 12%, AlAT 21 IU / l, AsAT 25 IU / l, total protein 34 g / l, urea 5 mmol. In urinalysis, a white blood cell is 0-1 in the field of view.

Outcome of the disease: recovery.

The results of the studies allow us to conclude that the use of the proposed method for the treatment of animals with surgical sepsis is highly effective and can be used in clinical practice.

application Table The dynamics of changes in the main indicators of blood and urine in a dog with surgical sepsis Observation time Indicators Appeal day 5 days 10 days 21 days 08/15/11 08/20/11 08/25/1 1 09/05/11 Blood White blood cells, 109 / l 34 26 17 6 Lymphocytes,% 16 16 12 12 ESR, mm / h 25 twenty twenty fifteen AlAT, ME / L 62 62 40 -> 1
Z. 1 AsAT, ME / L 78 76 48 25 Total protein, g / l 56 51 40 34 Urea, mol mol / L eighteen 9 9 5 Urine White blood cells 25 8 5 0-1 Protein +++ + + not found

Claims (1)

A method of treating animals with surgical sepsis, including surgical debridement, antibiotic therapy, increasing the body’s reactivity, eliminating dehydration and detoxification, characterized in that the infection is suppressed by intramuscular injection of Cobactan antibiotic at a dose of 2 ml per 50 kg of live weight daily for 7 days, increasing the reactivity of the body is provided by subcutaneous administration of 10 injections of glutoxim at a dose of 3 mg per 1 kg of body weight 1 time in 2 days, the neutralization and elimination of toxins from the body, elimination of ezvozhivaniya provide session hemosorption 1-3, which is carried out with an interval of 24-48 hours.