RU2557949C1 - Method of treating radiation and interstitial cystitis - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: method involves instilling the Colegel ADL gel preparation every second day from the 1^st to 20^th day, and then Colegel DNK L two times a week from the 21^st to 56^th day.

EFFECT: invention enables relieving pain symptomatic, reducing the rate and length of recurrences in the patients.

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Description

The invention relates to medicine, in particular to methods for treating cystitis.

A known method of treating cystitis, including antibiotic therapy and irrigation of the bladder cavity with an oxygenated antiseptic solution (RF Patent No. 2362595, IPC A61K 31/155, publ. 2009).

The disadvantage of this method is that the oxygenated antiseptic solution does not have a long-term effect, since it does not adhere to the urothelium of the bladder and is excreted shortly after administration, it is necessary to repeatedly carry out a rather complicated (only medical staff) and painful procedure for the patient.

A known method of local, including intravesical, therapy of chronic cystitis (RF Patent No. 2270678, IPC АКК 31/495, publ. 2006), which consists in the intravesical administration of a 0.5% dioxidine solution with the simultaneous introduction of the drug Enterosgel.

The disadvantage of this method is the weak adhesion of the injected dioxidine solution to the walls of urothelium, as well as the need for the introduction of Enterosgel, which can reduce the concentration of dioxidine.

The objective of the invention is to remedy these disadvantages, increase the effectiveness of treatment and reduce the likelihood of relapse due to the introduction of therapeutically active and gel preparations with increased adhesion to the walls of urothelium.

To solve this problem, it was proposed in the treatment of radiation and interstitial cystitis to instill the gel preparation "Kolegel-ADL" from 1 to 20 days every other day, and then "Kolegel-DNA-L" from 21 to 56 days two times a week.

The proposed treatment regimens using these therapeutically active drugs can reduce pain symptoms, reduce the frequency and duration of relapses of cystitis.

The implementation of the method shown in specific clinical examples.

Example 1

Patient D., 48 years old, received radiation therapy for cervical cancer. After the end of the course, symptoms of pollakiuria, dysuria, nocturia, and pain began to be noted. For day 22 urination, at night 5. Total 27 urination per day. The average bladder capacity is 85 ml. The intensity of pain according to YOUR - 8 points. Diagnosis: Radiation cystitis.

The treatment was carried out as follows.

In a pre-emptied bladder, therapeutically effective amounts in a therapeutically effective amount are injected via syringe through a catheter according to the following scheme:

1-20 day - "Kolegel-ADL" on the 1st installation of 20 ml every other day,

21-56 day - "Kolegel-DNA-L" for 1 installation of 20 ml 2 times a week. Further, it is advisable to leave 1-2 days off and repeat the procedure.

After intravesical therapy using this technique, the frequency of urination decreased to 12 episodes per day. Bubble capacity increased to 170 ml. The intensity of pain according to YOUR decreased to 3 points.

During the 6 months of observation, the patient's condition remained stable.

Example 2

Patient S., 42 years old, suffers from interstitial cystitis since 24 years. Relapses up to 10 per year. The frequency of urination up to 40 times a day. The bladder capacity during cystoscopy is 60 ml. The intensity of YOUR pain syndrome is 9 points.

The treatment was carried out according to the scheme described in example 1.

After the course of this therapy, the frequency of urination decreased to 18 per day, the capacity of the bladder increased to 115 ml, the pain intensity according to YOUR decreased to 5 points.

Over 6 months of follow-up, 1 relapse was noted.

According to the proposed method, treatment was performed in 31 patients. All patients after treatment according to the proposed schemes noted a decrease in discomfort and burning in the urethra during the first week of treatment. The frequency of urination as a result of treatment decreased by an average of 33% in the first three weeks of treatment. The number of nightly urination in patients also decreased significantly, on average 3 times. During treatment according to the proposed schemes, stabilization of the glucosamine layer is observed in patients with various forms of cystitis. The use of these treatment regimens is highly effective and safe.

Claims (1)

A method of treating radiation and interstitial cystitis, including the installation of the gel preparation "Kolegel-ADL" from 1 to 20 days every other day, and then "Kolegel-DNA-L" from 21 to 56 days two times a week.