RU2417782C1 - Method of treating paunch acidosis - Google Patents

Abstract

FIELD: medicine, veterinary. ^ SUBSTANCE: invention can be applied in veterinary medicine, in particular, for treatment of ruminant animals with paunch acidosis. Method includes peroral application of calcium acetate in dose 150-300 g 2 times per day, preliminarily solved in warm water. ^ EFFECT: method makes it possible to reduce terms of animals/ recovery in two times. ^ 1 tbl, 1 ex

Description

The present invention relates to the field of animal husbandry, in particular to veterinary medicine, and can be used in the treatment of animals with rumen acidosis.

Known methods for treating scar acidosis by washing the scar with 1% sodium chloride solution or 2% sodium bicarbonate solution with the introduction after washing 1-2 liters of fresh scar content from a healthy cow or feeding 200 g of yeast and 1-2 liters of milk ( Internal non-contagious diseases of farm animals / B.M. Anokhin, V.M. Danilevsky, L.G. Zamarin and others; Edited by V.M. Danilevsky. - M .: Agropromizdat, 1991. - P.193), feeding the enzyme preparation of macerobacillin GZx in a daily dose of 10-12 g for 2-3 days or more (Kondrakhin I.P.D diagnostics and therapy of internal animal diseases / I. Kondrakhin, V. Levchenko. - M .: Aquarium-Print, 2005. - P.97).

There is also a method of treating scar acidosis by feeding sodium bicarbonate 100-150 g with 500-1000 ml of water 2 times a day (Internal non-communicable diseases of farm animals / B.M. Anokhin, V.M. Danilevsky, L.G. Zamarin and dr .; Edited by V.M.Danilevsky. - M.: Agropromizdat, 1991. - P.193) - prototype.

The disadvantage of this known method is that after oral administration of sodium bicarbonate in the specified dose in animals, a pronounced tympanic scar is always noted, therefore it is not effective enough.

The objective of the invention is to increase the effectiveness of treatment of animals with rumen acidosis.

This is achieved by the fact that calcium acetate, which is a natural scar metabolite, is used as a therapeutic agent. It is known for its use in veterinary medicine in the treatment of atony of the pre-stomachs of ruminants (RU 2341251 C1, A61K 31/00 (2006.01), 12.20.2008).

A method for the treatment of scar acidosis by oral administration of calcium acetate at 150-300 g 2 times a day, previously dissolved in warm water.

Example. The experiment was carried out during the stall period on 55 cows with rumen acidosis. All animals were divided into 5 groups (control and 4 experimental) with 11 animals each (see table).

Table Therapeutic efficacy of oral calcium acetate for cicatricial acidosis in cows Indicator Group Control 1st experienced 2nd experienced 3rd experienced 4th experienced one 2 3 four 5 6 The name of the drug Sodium bicarbonate Calcium acetate Single dose, g 150 150 200 250 300 Daily dose, g 300 300 400 500 600 Before giving the drug: 1) pH of the contents of the scar 5.48 ± 0.21 5.41 ± 0.18 5.38 ± 0.20 5.50 ± 0.22 5.46 ± 0.18 2) the number of scar reduction in 5 minutes 3.3 ± 0.2 3.0 ± 0.1 3.1 ± 0.2 3.4 ± 0.4 2.9 ± 0.2 3) blood acid capacity, mg / dl 382 ± 3 372 ± 2 358 ± 3 378 ± 5 360 ± 4 After giving the drug through: 24 hours 1) pH of the contents of the scar 6.02 ± 0.15 6.21 ± 0.20 6.30 ± 0.18 6.32 ± 0.16 6.36 ± 0.12 2) the number of scar reduction in 5 minutes 5.7 ± 0.3 5.6 ± 0.1 6.2 ± 0.3 6.6 ± 0.2 7.6 ± 0.4

one 2 3 four 5 6 3) blood acid capacity, mg / dl 390 ± 2 393 ± 3 401 ± 4 408 ± 5 444 ± 5 48 hours 1) pH of rumen contents 6.45 ± 0.17 6.51 ± 0.18 6.47 ± 0.20 6.51 ± 0.14 6.90 ± 0.12 2) the number of scar reduction in 5 minutes 6.5 ± 0.2 6.8 ± 0.3 7.1 ± 0.4 7.5 ± 0.3 11.2 ± 0.5 3) blood acid capacity, mg / dl 423 ± 4 428 ± 3 452 ± 4 456 ± 5 498 ± 6 72 hours 1) pH of rumen contents 6.66 ± 0.11 6.70 ± 0.15 6.80 ± 0.18 6.84 ± 0.14 2) the number of scar reduction in 5 minutes 6.9 ± 0.3 7.2 ± 0.4 10.6 ± 0.6 10.8 ± 0.4 3) blood acid capacity, mg / dl 442 ± 4 447 ± 3 493 ± 3 501 ± 6 96 hours 1) pH of rumen contents 6.72 ± 0.08 6.78 ± 0.10 2) the number of scar reduction in 5 minutes 10.5 ± 0.4 10.9 ± 0.5 3) blood acid capacity, mg / dl 466 ± 3 477 ± 4

Cows of the control group were orally administered sodium bicarbonate of 150 g per head 2 times a day, cows of the 1st, 2nd, 3rd and 4th experimental groups were orally administered calcium acetate, respectively, 150 g, 200 g, 250 g and 300 g per head 2 times a day. Each single dose of sodium bicarbonate (for cows of the control group) and calcium acetate (for cows of the experimental groups) was dissolved in 2 l of warm water immediately before use.

According to the results of the experiment in cows of the control group, clinical recovery was noted after daily use of sodium bicarbonate for 96 hours.

In cows of the 1st experimental group, clinical recovery was noted, as in animals of the control group, after daily use of calcium acetate for 96 hours.

In cows of the 2nd and 3rd experimental groups, clinical recovery was observed after daily use of calcium acetate for 72 hours, i.e. 24 hours earlier than in animals of the control group.

In cows of the 4th experimental group, clinical recovery was noted after daily use of calcium acetate for 48 hours, i.e. 48 hours earlier than in animals of the control group.

Thus, calcium acetate is a highly effective therapeutic agent for scar acidosis. At the same time, the optimal therapeutic dose of calcium acetate was 600 g for cows, which were fed 300 g 2 times a day.

The use of calcium acetate at a dose of 600 g per head per day led to the recovery of all animals after 48 hours and a reduction in the time of their clinical recovery by 2 times compared with the control.

Claims (1)

A method for the treatment of rumen acidosis in ruminants, such as cows, by oral administration of calcium acetate, 150-300 g 2 times a day, previously dissolved in 2 l of warm water.